Simvastatin
货号: 1693-250 产品名称: Simvastatin 品牌: Biovision 规格: 250 mg 3周到货 生化实验
Simvastatin
Product Overview
Product Name: Simvastatin
Alternate Name/Synonyms: MK-733; Synvinolin
Description: A synthetic analog of Lovastatin (Cat. No. 1692-50, 250). Cholesterol lowering drug and a competitive inhibitor of HMG-CoA (3-hydroxy-3-methylglutaryl coenzyme A) reductase. Inhibits the biosynthesis of isoprenoids and prevents small G protein activation.
Peptide Sequence: N/A
Appearance: White solid
Formulation: N/A
CAS Number: 79902-63-9
Molecular Formula: C₂₅H₃₈O₅
Molecular Weight: 418.57
Purity: ≥98% by HPLC
Solubility:DMSO (25 mg/ml) or Ethanol (30 mg/ml)
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from air and moisture
SMILES: CCC(C)(C)C(=O)OC1CC(C=C2C1C(C(C=C2)C)CCC3CC(CC(=O)O3)O)C
InChi: InChI=1S/C25H38O5/c1-6-25(4,5)24(28)30-21-12-15(2)11-17-8-7-16(3)20(23(17)21)10-9-19-13-18(26)14-22(27)29-19/h7-8,11,15-16,18-21,23,26H,6,9-10,12-14H2,1-5H3/t15-,16-,18+,19+,20-,21-,23-/m0/s1
InChi Key: RYMZZMVNJRMUDD-HGQWONQESA-N
PubChem CID: 54454
MDL Number: MFCD00072007
USAGE: For Research Use Only! Not For Use in Humans.
-20°C
![](http://thermofisher.jinpanbio.com/wp-content/uploads/2024/04/BZWZ.jpg)
1693-50 Simvastatin 品牌 Biovision
Simvastatin
货号: 1693-50 产品名称: Simvastatin 品牌: Biovision 规格: 50 mg 3周到货 生化实验
Simvastatin
Product Overview
Product Name: Simvastatin
Alternate Name/Synonyms: MK-733; Synvinolin
Description: A synthetic analog of Lovastatin (Cat. No. 1692-50, 250). Cholesterol lowering drug and a competitive inhibitor of HMG-CoA (3-hydroxy-3-methylglutaryl coenzyme A) reductase. Inhibits the biosynthesis of isoprenoids and prevents small G protein activation.
Peptide Sequence: N/A
Appearance: White solid
Formulation: N/A
CAS Number: 79902-63-9
Molecular Formula: C₂₅H₃₈O₅
Molecular Weight: 418.57
Purity: ≥98% by HPLC
Solubility:DMSO (25 mg/ml) or Ethanol (30 mg/ml)
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from air and moisture
SMILES: CCC(C)(C)C(=O)OC1CC(C=C2C1C(C(C=C2)C)CCC3CC(CC(=O)O3)O)C
InChi: InChI=1S/C25H38O5/c1-6-25(4,5)24(28)30-21-12-15(2)11-17-8-7-16(3)20(23(17)21)10-9-19-13-18(26)14-22(27)29-19/h7-8,11,15-16,18-21,23,26H,6,9-10,12-14H2,1-5H3/t15-,16-,18+,19+,20-,21-,23-/m0/s1
InChi Key: RYMZZMVNJRMUDD-HGQWONQESA-N
PubChem CID: 54454
MDL Number: MFCD00072007
USAGE: For Research Use Only! Not For Use in Humans.
-20°C
![](http://thermofisher.jinpanbio.com/wp-content/uploads/2024/04/BZWZ.jpg)
S3449-10 mg Simvastatin 品牌 LKT
Simvastatin
货号: S3449-10 mg 产品名称: Simvastatin 品牌: LKT 规格: 10 mg 三周到货 生化试验
Simvastatin
Description
A potent HMG-CoA reductase inhibitor and hypocholesterolemic agent. Inhibits cell proliferation of human glioma cells and of acute myeloid leukemia cells. Anti-carcinogenic during the promotion phase of radiation-induced mammary tumors.
Specifications
Cas No. 79902-63-9
Product ID S3449
Product Name Simvastatin
Chemical Name 2,2-Dimethylbutanoic acid (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester
Synonym Synvinolin; MK-733; Denan; Liponorm; Lodales; Simovil; Sinvacor; Sivastin; Zocor; Zocord
Formula Wt. 418.57
Melting Point 135-138 oC
Purity 97%
Solubility (mg/ml) DMSO 540; ethanol 160; methanol 200; water 0.03.
Store Temp Ambient
Ship Temp Ambient
References Inano H. Suzuki K. Onoda M. Wakabayashi K. Carcinogenesis. 18:1723-7 (1997). Kikuchi T. Nagata Y. Abe T. J Neurooncol. 34:233-9 (1997). Lishner M. Bar-Sef A. Elis A. Fabian I. J Investig Med. 49:319-24 (2001). Mol, M.J.et al Lancet 2:936 (198
室温
![](http://thermofisher.jinpanbio.com/wp-content/uploads/2024/04/BZWZ.jpg)
S3449-25 mg Simvastatin 品牌 LKT
Simvastatin
货号: S3449-25 mg 产品名称: Simvastatin 品牌: LKT 规格: 25 mg 三周到货 生化试验
Simvastatin
Description
A potent HMG-CoA reductase inhibitor and hypocholesterolemic agent. Inhibits cell proliferation of human glioma cells and of acute myeloid leukemia cells. Anti-carcinogenic during the promotion phase of radiation-induced mammary tumors.
Specifications
Cas No. 79902-63-9
Product ID S3449
Product Name Simvastatin
Chemical Name 2,2-Dimethylbutanoic acid (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester
Synonym Synvinolin; MK-733; Denan; Liponorm; Lodales; Simovil; Sinvacor; Sivastin; Zocor; Zocord
Formula Wt. 418.57
Melting Point 135-138 oC
Purity 97%
Solubility (mg/ml) DMSO 540; ethanol 160; methanol 200; water 0.03.
Store Temp Ambient
Ship Temp Ambient
References Inano H. Suzuki K. Onoda M. Wakabayashi K. Carcinogenesis. 18:1723-7 (1997). Kikuchi T. Nagata Y. Abe T. J Neurooncol. 34:233-9 (1997). Lishner M. Bar-Sef A. Elis A. Fabian I. J Investig Med. 49:319-24 (2001). Mol, M.J.et al Lancet 2:936 (198
室温
![](http://thermofisher.jinpanbio.com/wp-content/uploads/2024/04/BZWZ.jpg)
S6196 Simvastatin 品牌 Sigma
Simvastatin
货号: S6196 产品名称: Simvastatin 品牌: Sigma 规格: 5MG
![](http://thermofisher.jinpanbio.com/wp-content/uploads/2024/04/BZWZ.jpg)
567021-50MG Simvastatin, Sodium 品牌 Merck
Simvastatin, Sodium
货号: 567021-50MG 产品名称: Simvastatin, Sodium 品牌: Merck 规格: *** 3周到货 生化实验
Simvastatin, Sodium Salt
L-Type Calcium Channel Blocker VI
Carboxylate form of Simvastatin (Cat. No. 567020) that is active in whole cells and in cell-free preparations. Also available as a 10 mM solution in H2O (Cat. No. 567022).
产品信息
Form Beige solid
Molar mass 458.6
Hygrocopic 是的
Packaged under inert gas 是的
Purity ≥97% by HPLC
Solubility DMSO, EtOH, or H
Chemical formula C25H39O6 • Na
商店和运输信息
Storage -20°C
Ship Ambient Temperature Only
Standard Handling
-20°C
![](http://thermofisher.jinpanbio.com/wp-content/uploads/2024/04/BZWZ.jpg)
567022-5MG InSolution Simvastatin, Sodium Salt 品牌 Merck
InSolution Simvastatin, Sodium Salt
货号: 567022-5MG 产品名称: InSolution Simvastatin, Sodium Salt 品牌: Merck 规格: *** 3周到货 生化实验
InSolution™ Simvastatin, Sodium Salt
L-Type Calcium Channel Blocker VI
Carboxylate form of Simvastatin (Cat. No. 567020) that is active in whole cells and in cell-free assays. A lipophilic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor that blocks Ras function through inhibition of farnesylation. Also inhibits glucose-induced Ca2+-signaling and insulin secretion by blocking L-type Ca2+ channels in rat islet β-cells. Inhibits cell proliferation of human smooth muscle cells. The solid form of this compound (Cat. No. 567021) is also available.
产品信息
Form Liquid
Formulation A 10 mM (5 mg/1.09 ml) solution of Simvastatin, Sodium Salt (Cat. No. 567021) in H2O.
Molar mass 458.6
Protect from Light 是的
Avoid freeze/thaw 是的
Packaged under inert gas 是的
Cell permeable 是的
Reversible 是的
Purity ≥95% by HPLC
Chemical formula C25H39O6 •Na
商店和运输信息
Storage ≤ -70°C
Ship Dry Ice Only
Irritant
≤ -70°C
![](http://thermofisher.jinpanbio.com/wp-content/uploads/2024/04/BZWZ.jpg)
1965-50 Simvastatin 品牌 Tocris
Simvastatin
货号: 1965-50 产品名称: Simvastatin 品牌: Tocris 规格: 50 mg
![](http://thermofisher.jinpanbio.com/wp-content/uploads/2024/04/BZWZ.jpg)
S3449-100 mg Simvastatin 品牌 LKT
Simvastatin
货号: S3449-100 mg 产品名称: Simvastatin 品牌: LKT 规格: 100 mg 三周到货 生化试验
Simvastatin
Description
A potent HMG-CoA reductase inhibitor and hypocholesterolemic agent. Inhibits cell proliferation of human glioma cells and of acute myeloid leukemia cells. Anti-carcinogenic during the promotion phase of radiation-induced mammary tumors.
Specifications
Cas No. 79902-63-9
Product ID S3449
Product Name Simvastatin
Chemical Name 2,2-Dimethylbutanoic acid (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester
Synonym Synvinolin; MK-733; Denan; Liponorm; Lodales; Simovil; Sinvacor; Sivastin; Zocor; Zocord
Formula Wt. 418.57
Melting Point 135-138 oC
Purity 97%
Solubility (mg/ml) DMSO 540; ethanol 160; methanol 200; water 0.03.
Store Temp Ambient
Ship Temp Ambient
References Inano H. Suzuki K. Onoda M. Wakabayashi K. Carcinogenesis. 18:1723-7 (1997). Kikuchi T. Nagata Y. Abe T. J Neurooncol. 34:233-9 (1997). Lishner M. Bar-Sef A. Elis A. Fabian I. J Investig Med. 49:319-24 (2001). Mol, M.J.et al Lancet 2:936 (198
室温
![](http://thermofisher.jinpanbio.com/wp-content/uploads/2024/04/BZWZ.jpg)
S3449-50 mg Simvastatin 品牌 LKT
Simvastatin
货号: S3449-50 mg 产品名称: Simvastatin 品牌: LKT 规格: 50 mg 三周到货 生化试验
Simvastatin
Description
A potent HMG-CoA reductase inhibitor and hypocholesterolemic agent. Inhibits cell proliferation of human glioma cells and of acute myeloid leukemia cells. Anti-carcinogenic during the promotion phase of radiation-induced mammary tumors.
Specifications
Cas No. 79902-63-9
Product ID S3449
Product Name Simvastatin
Chemical Name 2,2-Dimethylbutanoic acid (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester
Synonym Synvinolin; MK-733; Denan; Liponorm; Lodales; Simovil; Sinvacor; Sivastin; Zocor; Zocord
Formula Wt. 418.57
Melting Point 135-138 oC
Purity 97%
Solubility (mg/ml) DMSO 540; ethanol 160; methanol 200; water 0.03.
Store Temp Ambient
Ship Temp Ambient
References Inano H. Suzuki K. Onoda M. Wakabayashi K. Carcinogenesis. 18:1723-7 (1997). Kikuchi T. Nagata Y. Abe T. J Neurooncol. 34:233-9 (1997). Lishner M. Bar-Sef A. Elis A. Fabian I. J Investig Med. 49:319-24 (2001). Mol, M.J.et al Lancet 2:936 (198
室温
![](http://thermofisher.jinpanbio.com/wp-content/uploads/2024/04/BZWZ.jpg)
S3449-500 mg Simvastatin 品牌 LKT
Simvastatin
货号: S3449-500 mg 产品名称: Simvastatin 品牌: LKT 规格: 500 mg 三周到货 生化试验
Simvastatin
Description
A potent HMG-CoA reductase inhibitor and hypocholesterolemic agent. Inhibits cell proliferation of human glioma cells and of acute myeloid leukemia cells. Anti-carcinogenic during the promotion phase of radiation-induced mammary tumors.
Specifications
Cas No. 79902-63-9
Product ID S3449
Product Name Simvastatin
Chemical Name 2,2-Dimethylbutanoic acid (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester
Synonym Synvinolin; MK-733; Denan; Liponorm; Lodales; Simovil; Sinvacor; Sivastin; Zocor; Zocord
Formula Wt. 418.57
Melting Point 135-138 oC
Purity 97%
Solubility (mg/ml) DMSO 540; ethanol 160; methanol 200; water 0.03.
Store Temp Ambient
Ship Temp Ambient
References Inano H. Suzuki K. Onoda M. Wakabayashi K. Carcinogenesis. 18:1723-7 (1997). Kikuchi T. Nagata Y. Abe T. J Neurooncol. 34:233-9 (1997). Lishner M. Bar-Sef A. Elis A. Fabian I. J Investig Med. 49:319-24 (2001). Mol, M.J.et al Lancet 2:936 (198
室温
![](http://thermofisher.jinpanbio.com/wp-content/uploads/2024/04/BZWZ.jpg)
10010344-100 Simvastatin 品牌 Cayman
Simvastatin
货号: 10010344-100 产品名称: Simvastatin 品牌: Cayman 规格: 100 mg 3周
Simvastatin
Cayman Chemical Item Number 10010344
Description
Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase is the rate-limiting enzyme in the cholesterol biosynthetic pathway and the target of the “statin” class of cholesterol-lowering drugs.1↗ Simvastatin is a competitive inhibitor of HMG-CoA reductase with a Ki value of 0.12 nM for the hydrolyzed, open ring form of the molecule.2↗ Simvastatin is marketed under the trade name Zocor™ and is often prescribed in combination with ezetimibe (Zetia) to treat dyslipidemia. This drug combination is known commercially as Vytorin™ or Inegy™. After 18 days of treatment with simvastatin in dogs at a dose of 8 mg/kg per day, plasma cholesterol levels were reduced by 33%.3↗ Simvastatin also suppresses TNF-induced NF-κB activation (IC50 ~ 13 µM), which potentiates apoptosis in human myeloid leukemia cells and thus may be useful in treating cancer.4↗
Synonyms MK 733
Formal Name 2,2-dimethyl-1S,2,3R,7S,8S,8aR-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester, butanoic acid
CAS Number 79902-63-9
Molecular Formula C25H38O5
Formula Weight 418.6
Formulation A crystalline solid
Purity ≥98%
λmax 238 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES C[C@H]1C=CC2=C[C@H](C)C[C@H](OC(C(C)(C)CC)=O)C2[C@H]1CC[C@@H]3C[C@@H](O)CC(O3)=O
InCHI Code 1S/C25H38O5/c1-6-25(4,5)24(28)30-21-12-15(2)11-17-8-7-16(3)20(23(17)21)10-9-19-13-18(26)14-22(27)29-19/h7-8,11,15-16,18-21,23,26H,6,9-10,12-14H2,1-5H3/t15-,16-,18+,19+,20-,21-,23/m0/s1
InCHI Key RYMZZMVNJRMUDD-OVOOIQHOSA-N
-20°C
![](http://thermofisher.jinpanbio.com/wp-content/uploads/2024/04/BZWZ.jpg)
10010345-1 Simvastatin (sodium salt) 品牌 Cayman
Simvastatin (sodium salt)
货号: 10010345-1 产品名称: Simvastatin (sodium salt) 品牌: Cayman 规格: 1 mg 3周
Simvastatin (sodium salt)
Cayman Chemical Item Number 10010345
Description HMG-CoA reductase is the rate-limiting enzyme in the cholesterol biosynthetic pathway and the target of the “statin” class of cholesterol-lowering drugs.1↗ Simvastatin is a competitive inhibitor of HMG-CoA reductase with a Ki value of 0.12 nM for the hydrolyzed, open ring form of the molecule.2↗ Simvastatin is marketed under the trade name Zocor™ and is often prescribed in combination with ezetimibe (Zetia) to treat dyslipidemia. This drug combination is known commercially as Vytorin or Inegy. In dogs, after 18 days of treatment with simvastatin at a dose of 8 mg/kg per day, plasma cholesterol levels were reduced by 33%.3↗ Simvastatin also suppresses TNF-induced NF-κB activation (IC50 ~ 13 µM), which potentiates apoptosis in human myeloid leukemia cells and thus, may be useful in treating cancer.4↗
Synonyms Zocor™
Formal Name (βR,δR,1S,2S,6R,8S,8aR)-8-(2,2-dimethyl-1-oxobutoxy)-1,2,6,7,8,8a-hexahydro-β,δ-dihydroxy-2,6-dimethyl-1-naphthaleneheptanoic acid, monosodium salt
CAS Number 101314-97-0
Molecular Formula C25H39O6 • Na
Formula Weight 458.6
Formulation A crystalline solid
Purity ≥98%
λmax 231, 238, 246 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES C[C@@H]1C[C@H](OC(C(C)(CC)C)=O)C2C(C=C[C@H](C)[C@@H]2CC[C@@H](O)C[C@@H](O)CC([O-])=O)=C1.[Na]
InCHI Code 1S/C25H40O6.Na/c1-6-25(4,5)24(30)31-21-12-15(2)11-17-8-7-16(3)20(23(17)21)10-9-18(26)13-19(27)14-22(28)29;/h7-8,11,15-16,18-21,23,26-27H,6,9-10,12-14H2,1-5H3,(H,28,29);/p-1/t15-,16-,18+,19+,20-,21-,23;/m0./s1
InCHI Key SVIXZYADIXSPPP-SBRLSJPESA-M
-20°C
![](http://thermofisher.jinpanbio.com/wp-content/uploads/2024/04/BZWZ.jpg)
10010345-5 Simvastatin (sodium salt) 品牌 Cayman
Simvastatin (sodium salt)
货号: 10010345-5 产品名称: Simvastatin (sodium salt) 品牌: Cayman 规格: 5 mg 3周
Simvastatin (sodium salt)
Cayman Chemical Item Number 10010345
Description HMG-CoA reductase is the rate-limiting enzyme in the cholesterol biosynthetic pathway and the target of the “statin” class of cholesterol-lowering drugs.1↗ Simvastatin is a competitive inhibitor of HMG-CoA reductase with a Ki value of 0.12 nM for the hydrolyzed, open ring form of the molecule.2↗ Simvastatin is marketed under the trade name Zocor™ and is often prescribed in combination with ezetimibe (Zetia) to treat dyslipidemia. This drug combination is known commercially as Vytorin or Inegy. In dogs, after 18 days of treatment with simvastatin at a dose of 8 mg/kg per day, plasma cholesterol levels were reduced by 33%.3↗ Simvastatin also suppresses TNF-induced NF-κB activation (IC50 ~ 13 µM), which potentiates apoptosis in human myeloid leukemia cells and thus, may be useful in treating cancer.4↗
Synonyms Zocor™
Formal Name (βR,δR,1S,2S,6R,8S,8aR)-8-(2,2-dimethyl-1-oxobutoxy)-1,2,6,7,8,8a-hexahydro-β,δ-dihydroxy-2,6-dimethyl-1-naphthaleneheptanoic acid, monosodium salt
CAS Number 101314-97-0
Molecular Formula C25H39O6 • Na
Formula Weight 458.6
Formulation A crystalline solid
Purity ≥98%
λmax 231, 238, 246 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES C[C@@H]1C[C@H](OC(C(C)(CC)C)=O)C2C(C=C[C@H](C)[C@@H]2CC[C@@H](O)C[C@@H](O)CC([O-])=O)=C1.[Na]
InCHI Code 1S/C25H40O6.Na/c1-6-25(4,5)24(30)31-21-12-15(2)11-17-8-7-16(3)20(23(17)21)10-9-18(26)13-19(27)14-22(28)29;/h7-8,11,15-16,18-21,23,26-27H,6,9-10,12-14H2,1-5H3,(H,28,29);/p-1/t15-,16-,18+,19+,20-,21-,23;/m0./s1
InCHI Key SVIXZYADIXSPPP-SBRLSJPESA-M
-20°C
![](http://thermofisher.jinpanbio.com/wp-content/uploads/2024/04/BZWZ.jpg)
10010345-10 Simvastatin (sodium salt) 品牌 Cayman
Simvastatin (sodium salt)
货号: 10010345-10 产品名称: Simvastatin (sodium salt) 品牌: Cayman 规格: 10 mg 3周
Simvastatin (sodium salt)
Cayman Chemical Item Number 10010345
Description HMG-CoA reductase is the rate-limiting enzyme in the cholesterol biosynthetic pathway and the target of the “statin” class of cholesterol-lowering drugs.1↗ Simvastatin is a competitive inhibitor of HMG-CoA reductase with a Ki value of 0.12 nM for the hydrolyzed, open ring form of the molecule.2↗ Simvastatin is marketed under the trade name Zocor™ and is often prescribed in combination with ezetimibe (Zetia) to treat dyslipidemia. This drug combination is known commercially as Vytorin or Inegy. In dogs, after 18 days of treatment with simvastatin at a dose of 8 mg/kg per day, plasma cholesterol levels were reduced by 33%.3↗ Simvastatin also suppresses TNF-induced NF-κB activation (IC50 ~ 13 µM), which potentiates apoptosis in human myeloid leukemia cells and thus, may be useful in treating cancer.4↗
Synonyms Zocor™
Formal Name (βR,δR,1S,2S,6R,8S,8aR)-8-(2,2-dimethyl-1-oxobutoxy)-1,2,6,7,8,8a-hexahydro-β,δ-dihydroxy-2,6-dimethyl-1-naphthaleneheptanoic acid, monosodium salt
CAS Number 101314-97-0
Molecular Formula C25H39O6 • Na
Formula Weight 458.6
Formulation A crystalline solid
Purity ≥98%
λmax 231, 238, 246 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES C[C@@H]1C[C@H](OC(C(C)(CC)C)=O)C2C(C=C[C@H](C)[C@@H]2CC[C@@H](O)C[C@@H](O)CC([O-])=O)=C1.[Na]
InCHI Code 1S/C25H40O6.Na/c1-6-25(4,5)24(30)31-21-12-15(2)11-17-8-7-16(3)20(23(17)21)10-9-18(26)13-19(27)14-22(28)29;/h7-8,11,15-16,18-21,23,26-27H,6,9-10,12-14H2,1-5H3,(H,28,29);/p-1/t15-,16-,18+,19+,20-,21-,23;/m0./s1
InCHI Key SVIXZYADIXSPPP-SBRLSJPESA-M
-20°C
![](http://thermofisher.jinpanbio.com/wp-content/uploads/2024/04/BZWZ.jpg)
10010345-25 Simvastatin (sodium salt) 品牌 Cayman
Simvastatin (sodium salt)
货号: 10010345-25 产品名称: Simvastatin (sodium salt) 品牌: Cayman 规格: 25 mg 3周
Simvastatin (sodium salt)
Cayman Chemical Item Number 10010345
Description HMG-CoA reductase is the rate-limiting enzyme in the cholesterol biosynthetic pathway and the target of the “statin” class of cholesterol-lowering drugs.1↗ Simvastatin is a competitive inhibitor of HMG-CoA reductase with a Ki value of 0.12 nM for the hydrolyzed, open ring form of the molecule.2↗ Simvastatin is marketed under the trade name Zocor™ and is often prescribed in combination with ezetimibe (Zetia) to treat dyslipidemia. This drug combination is known commercially as Vytorin or Inegy. In dogs, after 18 days of treatment with simvastatin at a dose of 8 mg/kg per day, plasma cholesterol levels were reduced by 33%.3↗ Simvastatin also suppresses TNF-induced NF-κB activation (IC50 ~ 13 µM), which potentiates apoptosis in human myeloid leukemia cells and thus, may be useful in treating cancer.4↗
Synonyms Zocor™
Formal Name (βR,δR,1S,2S,6R,8S,8aR)-8-(2,2-dimethyl-1-oxobutoxy)-1,2,6,7,8,8a-hexahydro-β,δ-dihydroxy-2,6-dimethyl-1-naphthaleneheptanoic acid, monosodium salt
CAS Number 101314-97-0
Molecular Formula C25H39O6 • Na
Formula Weight 458.6
Formulation A crystalline solid
Purity ≥98%
λmax 231, 238, 246 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES C[C@@H]1C[C@H](OC(C(C)(CC)C)=O)C2C(C=C[C@H](C)[C@@H]2CC[C@@H](O)C[C@@H](O)CC([O-])=O)=C1.[Na]
InCHI Code 1S/C25H40O6.Na/c1-6-25(4,5)24(30)31-21-12-15(2)11-17-8-7-16(3)20(23(17)21)10-9-18(26)13-19(27)14-22(28)29;/h7-8,11,15-16,18-21,23,26-27H,6,9-10,12-14H2,1-5H3,(H,28,29);/p-1/t15-,16-,18+,19+,20-,21-,23;/m0./s1
InCHI Key SVIXZYADIXSPPP-SBRLSJPESA-M
-20°C
![](http://thermofisher.jinpanbio.com/wp-content/uploads/2024/04/BZWZ.jpg)
BML-G244-0050 Simvastatin 品牌 Biomol
Simvastatin
货号: BML-G244-0050 产品名称: Simvastatin 品牌: Biomol 规格: 50 mg 3周到货 生化实验
Product Specification
Alternative Name:Zocor
Formula:C25H38O5
MW:418.6
CAS:79902-63-9
MI:14: 8539
RTECS:EK7798000
Purity:≥98% (TLC)
Appearance:White solid.
Solubility:Soluble in DMSO (>25mg/ml) or 100% ethanol (>25mg/ml); insoluble in water.
Long Term Storage:-20°C
Use/Stability:Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C.
-20°C
BML-G244-0250 Simvastatin 品牌 Biomol
Simvastatin
货号: BML-G244-0250 产品名称: Simvastatin 品牌: Biomol 规格: 250 mg 3周到货 生化实验
Product Specification
Alternative Name:Zocor
Formula:C25H38O5
MW:418.6
CAS:79902-63-9
MI:14: 8539
RTECS:EK7798000
Purity:≥98% (TLC)
Appearance:White solid.
Solubility:Soluble in DMSO (>25mg/ml) or 100% ethanol (>25mg/ml); insoluble in water.
Long Term Storage:-20°C
Use/Stability:Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C.
-20°C