月度归档：2023年05月

ALX-350-173-C100   [D-Asp3]-Microcystin-LR   品牌 Alexis

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[D-Asp3]-Microcystin-LR

货号： ALX-350-173-C100      产品名称： [D-Asp3]-Microcystin-LR   品牌： Alexis 规格： 100.micro.g 3周到货 生化实验

[D-Asp3]microcystin-LR
Isolated from Microcystis aeruginosa. Microcystin containing a leucine (L) in position 2 and arginine (R) in position 4. Additionally, the D-MeAsp at position 3 is demethylated to Asp. Hepatotoxic.
Product Specification
Alternative Name: Microcystin-LR (desmethylated)
Formula: C48H72N10O12
MW: 981.1
Source: Isolated from Microcystis aeruginosa.
Purity: ≥95% (HPLC)
Identity: Identity determined by MS.
Appearance: White to off-white powder or oily film adhered to inside of the vial.
Hazard: HIGHLY IRRITANT.
        MAY BE CARCINOGENIC.
        VERY TOXIC.
Solubility: Soluble in methanol or DMSO.
Long Term Storage: -20°C
Handling: For maximum product recovery after thawing, centrifuge the vial before opening the cap.

-20°C

12-367-K   GST-ATF2-(hu,19-96) Bulk   品牌 Millipore

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GST-ATF2-(hu,19-96) Bulk

货号： 12-367-K      产品名称： GST-ATF2-(hu,19-96) Bulk   品牌： Millipore 规格： UG 三周到货 生化实验

ATF2 (aa 19-96)
Description:
ATF2 (aa 19-96)
Trade Name:
Upstate (Millipore)
Qty/Pk:
1 mg
Applications:
ATF2 (aa 19-96) primarily used in Kinase Assays.
Key Applications:
Kinase Assay
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Entrez Gene Summary:
This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. The protein forms a homodimer or heterodimer with c-Jun and stimulates CRE-dependent transcription. The protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro; thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. Additional transcript variants have been identified but their biological validity has not been determined.
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UniProt Summary:
FUNCTION: SwissProt: P15336 # Transcriptional activator, probably constitutive, which binds to the cAMP-responsive element (CRE) (consensus: 5′- GTGACGT[AC][AG]-3′), a sequence present in many viral and cellular promoters. Interaction with JUN redirects JUN to bind to CRES preferentially over the 12-O-tetradecanoylphorbol-13-acetate response elements (TRES) as part of an ATF2-c-Jun complex.
SIZE: 487 amino acids; 52277 Da
SUBUNIT: Binds DNA as a dimer and can form a homodimer in the absence of DNA. Can form a heterodimer with JUN. Interacts with SMAD3 and SMAD4. Binds through its N-terminal region to UTF1 which acts as a coactivator of ATF2 transcriptional activity.
SUBCELLULAR LOCATION: Nucleus.
TISSUE SPECIFICITY: Abundant expression seen in the brain.
PTM: Phosphorylation of Thr-51 and Thr-53 by MAPK14 causes increased transcriptional activity. Also phosphorylated and activated by JNK.
SIMILARITY: SwissProt: P15336 ## Belongs to the bZIP family. ATF subfamily. & Contains 1 bZIP domain. & Contains 1 C2H2-type zinc finger.
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Species:
Human
Brand Family:
Upstate
Presentation:
50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.1mM EGTA, 0.1% 2-mercaptoethanol, 0.03% Brij-35, 1mM benzamidine, 0.2mM PMSF and 50% glycerol
Storage Conditions:
6 months at -20°C
Gene Symbol:
ATF2
MGC111558
CREB2
TREB7
CRE-BP1
CREBP1
HB16
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Product Name:
ATF2 (aa 19-96)
Quality Assurance:
Routinely evaluated by phosphorylation by JNK1α1/SAPK1c, active (Catalog #14-327).
UniProt Number:
P15336
Entrez Gene Number:
NM_001880.2

-20℃

ALX-350-174-C025   Microcystin-HtyR   品牌 Alexis

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Microcystin-HtyR

货号： ALX-350-174-C025      产品名称： Microcystin-HtyR   品牌： Alexis 规格： 25.micro.g 3周到货 生化实验

Microcystin-HtyR
Isolated from Microcystis aeruginosa. Microcystin containing a homotyrosine (Hty) in position 2 and arginine (R) in position 4. Hepatotoxic.
Product Specification
Alternative Name: [Hty2]microcystin-YR
Formula: C53H74N10O13
MW: 1059.2
Source: Isolated from Microcystis aeruginosa.
Purity: ≥95% (HPLC)
Identity: Identity determined by MS.
Appearance: White to off-white powder or oily film adhered to inside of the vial.
Hazard: HIGHLY IRRITANT.
        MAY BE CARCINOGENIC.
        TOXIC.
Solubility: Soluble in methanol or DMSO.
Long Term Storage: -20°C
Handling: For maximum product recovery after thawing, centrifuge the vial before opening the cap.

-20°C

ALX-350-174-C100   Microcystin-HtyR   品牌 Alexis

发表于由

Microcystin-HtyR

货号： ALX-350-174-C100      产品名称： Microcystin-HtyR   品牌： Alexis 规格： 100.micro.g 3周到货 生化实验

Microcystin-HtyR
Isolated from Microcystis aeruginosa. Microcystin containing a homotyrosine (Hty) in position 2 and arginine (R) in position 4. Hepatotoxic.
Product Specification
Alternative Name: [Hty2]microcystin-YR
Formula: C53H74N10O13
MW: 1059.2
Source: Isolated from Microcystis aeruginosa.
Purity: ≥95% (HPLC)
Identity: Identity determined by MS.
Appearance: White to off-white powder or oily film adhered to inside of the vial.
Hazard: HIGHLY IRRITANT.
        MAY BE CARCINOGENIC.
        TOXIC.
Solubility: Soluble in methanol or DMSO.
Long Term Storage: -20°C
Handling: For maximum product recovery after thawing, centrifuge the vial before opening the cap.

-20°C