标签归档：cayman

AF3008-50 mg   Capsaicin   品牌 Cayman

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Capsaicin

货号： AF3008-50 mg      产品名称： Capsaicin   品牌： Cayman 规格： 50 mg 3周

Capsaicin is the primary active component of the heat and pain-eliciting lipid-soluble fraction of the Capsicum pepper.1 Capsaicin is present in natural hot pepper extracts along with a number of impurities, including dihydrocapsaicin and several lesser impurities. Separation by HPLC is required in order to obtain capsaicin of consistently high purity and reproducible quality.2 VR1 is a heat-activated calcium ion channel which functions as part of the normal nociceptive pain pathway. Capsaicin elicits a sensation of burning pain by activation of VR1 on small, non-myelinated polymodal C-type nociceptive nerve fibers.3 Chronic application of capsaicin leads to desensitization of these pain fibers and has been widely exploited in various non-prescription pain remedies.

1Gannett, P.M., Nagel, D.L., Reilly, P.J., et al. The capsaicinoids: Their separation, synthesis, and mutagenicity. J Org Chem 53(5) 1064-1071 (1988).

2Hoffman, P.G., Lego, M.C., and Galetto, W.G. Separation and quantitation of red pepper major heat principles by reverse-phase high-pressure liquid chromatography. J Agric Food Chem 31(6) 1326-1330 (1983).

3Caterina, M.J., Schumacher, M.A., Tominaga, M., et al. The capsaicin receptor: A heat-activated ion channel in the pain pathway. Nature 389 816-824 (1997).

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Formal Name N-​[(4-​hydroxy-​3-​methoxyphenyl)methyl]-​6E-​8-​methyl-​nonenamide

CAS Number

404-86-4

Molecular Formula

C18H27NO3

Formula Weight

305.4

Formulation

A crystalline solid

Purity

≥95%

λmax

230, 281 nm

Stability

2 years

Storage

-20°C < -20°C

AF3008-1 g   Capsaicin   品牌 Cayman

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Capsaicin

货号： AF3008-1 g      产品名称： Capsaicin   品牌： Cayman 规格： 100mg 3周

Capsaicin is the primary active component of the heat and pain-eliciting lipid-soluble fraction of the Capsicum pepper.1 Capsaicin is present in natural hot pepper extracts along with a number of impurities, including dihydrocapsaicin and several lesser impurities. Separation by HPLC is required in order to obtain capsaicin of consistently high purity and reproducible quality.2 VR1 is a heat-activated calcium ion channel which functions as part of the normal nociceptive pain pathway. Capsaicin elicits a sensation of burning pain by activation of VR1 on small, non-myelinated polymodal C-type nociceptive nerve fibers.3 Chronic application of capsaicin leads to desensitization of these pain fibers and has been widely exploited in various non-prescription pain remedies.

1Gannett, P.M., Nagel, D.L., Reilly, P.J., et al. The capsaicinoids: Their separation, synthesis, and mutagenicity. J Org Chem 53(5) 1064-1071 (1988).

2Hoffman, P.G., Lego, M.C., and Galetto, W.G. Separation and quantitation of red pepper major heat principles by reverse-phase high-pressure liquid chromatography. J Agric Food Chem 31(6) 1326-1330 (1983).

3Caterina, M.J., Schumacher, M.A., Tominaga, M., et al. The capsaicin receptor: A heat-activated ion channel in the pain pathway. Nature 389 816-824 (1997).

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Formal Name N-​[(4-​hydroxy-​3-​methoxyphenyl)methyl]-​6E-​8-​methyl-​nonenamide

CAS Number

404-86-4

Molecular Formula

C18H27NO3

Formula Weight

305.4

Formulation

A crystalline solid

Purity

≥95%

λmax

230, 281 nm

Stability

2 years

Storage

-20°C < -20°C

10008513-25   未-Tocotrienol   品牌 Cayman

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未-Tocotrienol

货号： 10008513-25      产品名称： 未-Tocotrienol   品牌： Cayman 规格： 25 mg 3周

δ-Tocotrienol
Cayman Chemical Item Number 10008513
Description
The four tocopherols (α, β, δ, and γ) and four tocotrienols (α, β, δ, and γ) are forms of vitamin E, which is known for its antioxidant activity.1↗ Tocotrienols are found in high concentrations in palm oil and rice bran. Recent studies observe that tocotrienols may be more effective antioxidants than α-tocopherol, the most abundant form of vitamin E.2↗ At 0.1-10 µM, δ-tocotrienol significantly suppresses H2O2-induced cell death of rat striatal neurons and provides protection against S-nitrocysteine-induced cell death and SIN-1 cytotoxicity in a concentration dependant manner.2↗ At concentrations of 10 µM, δ-tocotrienol displays more inhibitory action on adhesiveness of HAECs to U937 monocytic cells, via inhibition of VCAM-1 expression, than α-tocopherol and other tocotrienols at the same concentration.3↗
Formal Name 3,​4-​dihydro-​2,​8-​dimethyl-​2R-​[(3E,​7E)-​4,​8,​12-​trimethyl-​3,​7,​11-​tridecatrienyl]-​2H-​1-​benzopyran-​6-​ol
CAS Number 25612-59-3
Molecular Formula C27H40O2
Formula Weight 396.6
Formulation A solution in ethanol
Purity ≥98%
λmax 298 nm
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES C/C(CC/C=C(C)​/CC/C=C(C)​/C)​=CCC[C@@]​1(C)​OC2=C(C)​C=C(O)​C=C2CC1 
InCHI Code 1S/C27H40O2/c1-20(2)​10-7-11-21(3)​12-8-13-22(4)​14-9-16-27(6)​17-15-24-19-25(28)​18-23(5)​26(24)​29-27/h10,12,14,18-19,28H,7-9,11,13,15-17H2,1-6H3/b21-12+,22-14+/t27-/m1/s1 
InCHI Key ODADKLYLWWCHNB-LDYBVBFYSA-N

-20°C

10008494-25   纬-Tocotrienol   品牌 Cayman

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纬-Tocotrienol

货号： 10008494-25      产品名称： 纬-Tocotrienol   品牌： Cayman 规格： 25 mg 3周

γ-Tocotrienol
Cayman Chemical Item Number 10008494
Description
The four tocopherols (α, β, δ, and γ) and four tocotrienols (α, β, δ, and γ) are forms of vitamin E, which is known for its antioxidant activity.1↗ Tocotrienols are found in high concentrations in palm oil and rice bran. Recent studies observe that tocotrienols may be more effective antioxidants than α-tocopherol, the most abundant form of vitamin E.2↗ Spontaneously hypertensive rats fed a diet which includes γ-tocotrienol show significant reduction of systolic blood pressure and an increase of nitric oxide synthase activity in blood vessels.3↗ γ-Tocotrienol at 20 µM induces apoptosis of malignant sympathoadrenal (+SA) murine mammary epithelial cells.4↗
Formal Name
3,​4-​dihydro-​2,​7,​8-​trimethyl-​2R-​[(3E,​7E)-​4,​8,​12-​trimethyl-​3,​7,​11-​tridecatrienyl]-​2H-​1-​benzopyran-​6-​ol
CAS Number 14101-61-2
Molecular Formula C28H42O2
Formula Weight 410.6
Formulation A solution in ethanol
Purity ≥98%
λmax 297 nm
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES C[C@]​1(CC/C=C(C)​/CC/C=C(C)​/CC/C=C(C)​/C)​OC2=C(C)​C(C)​=C(O)​C=C2CC1 
InCHI Code 1S/C28H42O2/c1-20(2)​11-8-12-21(3)​13-9-14-22(4)​15-10-17-28(7)​18-16-25-19-26(29)​23(5)​24(6)​27(25)​30-28/h11,13,15,19,29H,8-10,12,14,16-18H2,1-7H3/b21-13+,22-15+/t28-/m1/s1 
InCHI Key OTXNTMVVOOBZCV-WAZJVIJMSA-N

-20°C

90220-1   纬-Linolenic Acid   品牌 Cayman

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纬-Linolenic Acid

货号： 90220-1      产品名称： 纬-Linolenic Acid   品牌： Cayman 规格： 1 g 3周

α-Linolenoyl Ethanolamide
γ-Linolenic Acid
Cayman Chemical Item Number 90220
Description
γ-Linolenic acid (GLA) is an ω-6 fatty acid which can be elongated to arachidonic acid for endogenous eicosanoid synthesis. It is a weak LTB4 receptor antagonist, inhibiting [3H]-LTB4 binding to porcine neutrophil membranes with a Ki of 1 µM. GLA produces 53% inhibition at a 1 mg/kg dose in an in vivo model of LTB4-induced bronchoconstriction.1↗
1 Yagaloff, K.A., Franco, L., Simko, B., et al. Essential fatty acids are antagonists of the leukotriene B4 receptor. Prostaglandins Leukot Essent Fatty Acids 52 293-297 (1995).
Synonyms GLA
Formal Name 6Z,​9Z,​12Z-​octadecatrienoic acid
CAS Number 506-26-3
Molecular Formula C18H30O2
Formula Weight 278.4
Formulation A solution in ethanol
Purity >98%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere 
SMILES CCCCC/C=CC/C=CC/C=CCCCCC(=O)​O 
InCHI Code 1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)​20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)​/b7-6-,10-9-,13-12- 
InCHI Key VZCCETWTMQHEPK-QNEBEIHSSA-N 

-20°C

10229-1   尾-Amyloid (1-8, A2V) Peptide   品牌 Cayman

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尾-Amyloid (1-8, A2V) Peptide

货号： 10229-1      产品名称： 尾-Amyloid (1-8, A2V) Peptide   品牌： Cayman 规格： 1 ea 3周

β-Amyloid (1-8, A2V) Peptide Exclusive Cayman Chemical Item Number 10229 Description β-Amyloid peptide (1-42) aggregation results in the formation of neurotoxic fibrils or globular oligomers.1↗ The amyloid precursor protein (APP) mutation Ala673Val results in disease for homozygous carriers but not for heterozygous carriers. The mutation generates β-Amyloid peptide with valine at amino acid position two. Biochemical analysis of Aβ (1-42) aggregation suggests this small peptide may be a useful guide for developing β-amyloid peptide aggregation inhibitors.2↗ Synonyms Aβ 1-8 mutant,β-amyloid (1-8) dominant negative,Aβ Formula Weight 1004.0 Formulation 1 mg lyophilized peptide Stability 1 year Storage -20°C Shipping Room temperature in continental US; may vary elsewhere -20°C

10241-1   尾-Amyloid (1-8) Peptide   品牌 Cayman

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尾-Amyloid (1-8) Peptide

货号： 10241-1      产品名称： 尾-Amyloid (1-8) Peptide   品牌： Cayman 规格： 1 ea 3周

β-Amyloid (1-8) Peptide Exclusive Cayman Chemical Item Number 10241 Description β-Amyloid peptide (1-42) aggregation results in the formation of neurotoxic fibrils or globular oligomers. This peptide is the control compound for tests that use Cayman’s β-Amyloid (1-8, A2V) Peptide (Catalog No. 10229). The use of these peptides along with β-amyloid (1-40 or 1-42) peptides may provide guidance in developing β-amyloid peptide aggregation inhibitors. Synonyms Aβ Formula Weight 976.0 Formulation 1 mg of lyophilized peptide Stability 1 year Storage -20°C Shipping Room temperature in continental US; may vary elsewhere -20°C

10008377-25   伪-Tocotrienol   品牌 Cayman

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伪-Tocotrienol

货号： 10008377-25      产品名称： 伪-Tocotrienol   品牌： Cayman 规格： 25 mg 3周

α-Tocotrienol
Cayman Chemical Item Number 10008377
Description
The four tocopherols (α, β, δ, and γ) and four tocotrienols (α, β, δ, and γ) are forms of vitamin E, which is known for its antioxidant activity.1↗ Tocotrienols are found at high concentrations in palm oil and rice bran. Recent studies show tocotrienols may be more effective antioxidants than α-tocopherol, the most abundant form of vitamin E.2↗ Compared to other tocotrienols, α-tocotrienol exhibits the most potent neuroprotective actions in rat striatal neurons. At concentrations of 0.1-10 µM, α-tocotrienol significantly suppresses H2O2-induced cell death and provides protection against S-nitrocysteine-induced cell death and SIN-1 toxicity in a concentration dependent manner.2↗ HT4 cells, that are microinjected with 10−19 mol of α-tocotrienol into the cytosolic, are protected against glutamate-induced cell death by suppressing early activation of c-Src kinase and 12-lipoxygenase.3↗
Formal Name 3,​4-​dihydro-​2,​5,​7,​8-​tetramethyl-​2R-​[(3E,​7E)-​4,​8,​12-​trimethyl-​3,​7,​11-​tridecatrienyl)]-​2H-​1-​benzopyran-​6-​ol
CAS Number 58864-81-6
Molecular Formula C29H44O2
Formula Weight 424.7
Formulation A solution in ethanol
Purity ≥98%
λmax 289 nm
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES C[C@]​1(CC/C=C(C)​/CC/C=C(C)​/CC/C=C(C)​/C)​OC2=C(C)​C(C)​=C(O)​C(C)​=C2CC1
InCHI Code ​1S/C29H44O2/c1-20(2)​12-9-13-21(3)​14-10-15-22(4)​16-11-18-29(8)​19-17-26-25(7)​27(30)​23(5)​24(6)​28(26)​31-29/h12,14,16,30H,9-11,13,15,17-19H2,1-8H3/b21-14+,22-16+/t29-/m1/s1 
InCHI Key RZFHLOLGZPDCHJ-XZXLULOTSA-N

-20°C

10445-10   伪-Pyrrolidinopropiophenone (hydrochloride)   品牌 Cayman

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伪-Pyrrolidinopropiophenone (hydrochloride)

货号： 10445-10      产品名称： 伪-Pyrrolidinopropiophenone (hydrochloride)   品牌： Cayman 规格： 10 mg 3周

α-Pyrrolidinopropiophenone (hydrochloride) Cayman Chemical Item Number 10445 Description α-Pyrrolidinopropiophenone (hydrochloride) is an analog of the appetite suppressant diethylcathinone and is related to the designer drug 4’-methyl-α-pyrrolidinopropiophenone (MPPP). In male Wistar rats, it is metabolized to a variety of products, including cathinone, the main psychoactive alkaloid of kath (Catha edulis).1↗,2↗ α-Pyrrolidinopropiophenone (hydrochloride) is intended to be used for forensic applications. Synonyms α-PPP Formal Name 1-​phenyl-​2-​(1-​pyrrolidinyl)-​1-​propanone,​ monohydrochloride CAS Number 92040-10-3 Molecular Formula C13H17NO • HCl Formula Weight 239.7 Formulation A crystalline solid Purity ≥97% λmax 250 nm Stability 2 years Storage -20°C Shipping Room temperature in continental US; may vary elsewhere SMILES O=C(C(C)​N1CCCC1)​C2=CC=CC=C2.Cl InCHI Code ​1S/C13H17NO.ClH/c1-11(14-9-5-6-10-14)​13(15)​12-7-3-2-4-8-12;/h2-4,7-8,11H,5-6,9-10H2,1H3;1H InCHI Key VQCZQKJXTMYEQV-UHFFFAOYSA-N -20°C

10445-5   伪-Pyrrolidinopropiophenone (hydrochloride)   品牌 Cayman

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伪-Pyrrolidinopropiophenone (hydrochloride)

货号： 10445-5      产品名称： 伪-Pyrrolidinopropiophenone (hydrochloride)   品牌： Cayman 规格： 5 mg 3周

α-Pyrrolidinopropiophenone (hydrochloride) Cayman Chemical Item Number 10445 Description α-Pyrrolidinopropiophenone (hydrochloride) is an analog of the appetite suppressant diethylcathinone and is related to the designer drug 4’-methyl-α-pyrrolidinopropiophenone (MPPP). In male Wistar rats, it is metabolized to a variety of products, including cathinone, the main psychoactive alkaloid of kath (Catha edulis).1↗,2↗ α-Pyrrolidinopropiophenone (hydrochloride) is intended to be used for forensic applications. Synonyms α-PPP Formal Name 1-​phenyl-​2-​(1-​pyrrolidinyl)-​1-​propanone,​ monohydrochloride CAS Number 92040-10-3 Molecular Formula C13H17NO • HCl Formula Weight 239.7 Formulation A crystalline solid Purity ≥97% λmax 250 nm Stability 2 years Storage -20°C Shipping Room temperature in continental US; may vary elsewhere SMILES O=C(C(C)​N1CCCC1)​C2=CC=CC=C2.Cl InCHI Code ​1S/C13H17NO.ClH/c1-11(14-9-5-6-10-14)​13(15)​12-7-3-2-4-8-12;/h2-4,7-8,11H,5-6,9-10H2,1H3;1H InCHI Key VQCZQKJXTMYEQV-UHFFFAOYSA-N -20°C