Imatinib Mesylate (CGP-57148B, STI-571)
货号： 1625-100 产品名称： Imatinib Mesylate (CGP-57148B, STI-571) 品牌： Biovision 规格： 100 mg 3周到货 生化实验
Imatinib Mesylate (CGP-57148B, STI-571)
Product Overview
Product Name: Imatinib Mesylate (CGP-57148B, STI-571)
Alternate Name/Synonyms: CGP-57148B, STI-571
Description: An inhibitor of the bcr-abl tyrosine kinase. It acts by binding to the ATP binding site of bcr-abl. Imatinib also stimulates the entry of the bcr-abl tyrosine kinase into the nucleus, where it cannot perform its anti-apoptopic functions. It inhibits EOL-1 cell viability (IC₅₀ = 0.5 nM), phosphorylation of a fusion protein (IC₅₀ = 30 nM), and viability of BaF3 cells expressing Rhe-PDGFRα in the absence of IL-3 (IC₅₀ = 0.17 nM).
Peptide Sequence: N/A
Appearance: White to off-white solid
Formulation: N/A
CAS Number: 220127-57-1
Molecular Formula: C₂₉H₃₁N₇O.CH₄SO₃
Molecular Weight: 589.71
Purity: ≥99% by HPLC
Solubility:DMSO (100 mg/ml)
Storage Temp.: -20°C
Shipping Conditions: RT
Handling: Protect from air and moisture
SMILES: CC1=C(C=C(C=C1)NC(=O)C2=CC=C(C=C2)CN3CCN(CC3)C)NC4=NC=CC(=N4)C5=CN=CC=C5.CS(=O)(=O)O
InChi: InChI=1S/C29H31N7O.CH4O3S/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36;1-5(2,3)4/h3-13,18-19H,14-17,20H2,12H3,(H,32,37)(H,31,33,34);1H3,(H,2,3,4)
InChi Key: YLMAHDNUQAMNNX-UHFFFAOYSA-N
PubChem CID: 123596
MDL Number: MFCD04307699
USAGE: For Research Use Only! Not For Use in Humans.
-20°C
