InSolution Akt Inhibitor V, Triciribine
货号： 124038-2MG 产品名称： InSolution Akt Inhibitor V, Triciribine 品牌： Merck 规格： *** 3周到货 生化实验
InSolution™ Akt Inhibitor V, Triciribine
A cell-permeable and reversible tricyclic nucleoside that selectively inhibits the cellular phosphorylation/activation of Akt1/2/3 by targeting an Akt effector molecule other than PI 3-K or PDK. Exhibits little effect towards cellular signaling pathways mediated by PKC, PKA, SGK, Stat3, p38, ERK1/2, or JNK. Shown to preferentially induce apoptosis and growth arrest in cancer cells with aberrant Akt activity both in vitro (≥60% in cell proliferation at 20 µM) and in vivo (≥80% inhibition in tumor growth in mice at 1 mg/kg/day, i.p.).
产品信息
Form Liquid
Formulation A 2 mg/312 µl solution of Akt Inhibitor V, Triciribine (Cat. No. 124012) in DMSO.
Molar mass 320.3
Protect from Light 是的
Hygrocopic 是的
Avoid freeze/thaw 是的
Packaged under inert gas 是的
Purity ≥95% by HPLC
Chemical formula C13H16N6O4
RTECS RY8455000
CAS number 35943-35-2
商店和运输信息
Storage ≤ -70°C
Ship Dry Ice Only
Irritant
安全标示
R Phrase R: 36/38
Irritating to eyes and skin.
≤ -70°C
328010-500UG InSolution ERK Inhibitor II, FR180204 品牌 Merck
InSolution ERK Inhibitor II, FR180204
货号： 328010-500UG 产品名称： InSolution ERK Inhibitor II, FR180204 品牌： Merck 规格： *** 3周到货 生化实验
InSolution™ ERK Inhibitor II, FR180204
A cell-permeable pyrazolopyridazinamine that acts as a potent, ATP-competitive inhibitor of ERK1 and ERK2 (IC50 = 510 nM and 330 nM; Ki = 310 nM and 140 nM, respectively). Exhibits ~20-fold greater selectivity over p38α (IC50 = 10 µM) and shows little activity towards IKKα, MEK1, MKK4, PDGFRα, PKCα, Src, and Syk even at concentrations as high as 30 µM. Shown to inhibit TGF-β−induced AP-1 activation in Mv1Lu epithelial cells (IC50 of 3.1 µM). ERK Inhibitor II, Negative Control (Cat. No. 328008) and the solid form of this compound (Cat. No. 328007) are also available..
产品信息
Form Liquid
Formulation A 10 mM (500 µg/153 µl) solution of ERK Inhibitor II, FR180204 (Cat. No. 328007) in DMSO.
Molar mass 327.3
Protect from Light 是的
Hygrocopic 是的
Packaged under inert gas 是的
Purity ≥97% by HPLC
Chemical formula C18H13N7
商店和运输信息
Storage -20°C
Ship Dry Ice Only
Irritant
安全标示
R Phrase R: 36/38
Irritating to eyes and skin.
-20°C
529605-1MG InSolution PP1 Analog 品牌 Merck
InSolution PP1 Analog
货号： 529605-1MG 产品名称： InSolution PP1 Analog 品牌： Merck 规格： *** 三周 生化实验
InSolution™ PP1 Analog
A potent, reversible, ATP-competitive, and cell-permeable inhibitor of Src-family tyrosine kinases that is >800 times more selective for the I338G mutant v-Src (IC50 = 1.5 nM) compared to wild-type v-Src (IC50 = 1.0 µM). Also inhibits wild-type Fyn (IC50 = 600 nM). A 10 mM (1 mg/315 µl) solution of PP1 Analog (Cat. No. 529579) in DMSO.
产品信息
Form Liquid
Formulation A 10 mM (1 mg/315 µl) solution of PP1 Analog (Cat. No. 529579) in DMSO.
Molar mass 317.4
Protect from Light 是的
Hygrocopic 是的
Avoid freeze/thaw 是的
Packaged under inert gas 是的
Purity ≥97% by HPLC
Chemical formula C19H19N5
CAS number 221243-82-9
Declaration
Not available for sale in the United States.
商店和运输信息
Storage ≤ -70°C
Ship Dry Ice Only
Irritant
安全标示
R Phrase R: 36/38
Irritating to eyes and skin.
≤ -70°C
539571-5MG InSolution Src Inhibitor, PP1 品牌 Merck
InSolution Src Inhibitor, PP1
货号： 539571-5MG 产品名称： InSolution Src Inhibitor, PP1 品牌： Merck 规格： *** 3周到货 生化实验
InSolution™ Src Inhibitor, PP1
A cell-permeable pyrazolopyrimidine compound that is shown to inhibit Src family tyrosine kinases Lck, Fyn, Hck, and Src (IC50 = 5, 6, 20, and 170 nM, respectively), as well as non-Src family kinases such as CSK, RIP2, and CK1δ (IC50 = 640 nM, 26 nM, 170 nM, respectively), in in vitro kinase assays. At 1 µM, in vitro kinase activity is reduced by more than 57% for p38α, p38β, CK1δ, CSK, RIP2, and GAK, while exhibiting much lower activity against more than 60 other kinases. Kinetic studies employing Src and [poly Glu-Tyr 4:1] indicate that the inhibition is mixed competitive with respect to the substrate and non-competitive with respect to ATP. PP1 also demonstrates anti-growth properties in several B lymphoma cultures of human and murine origins (IC50 = 2.5 to 8.0 µM) and pediatric brain tumor cells (IC50 = 1.1 to 9.7 µM). 1 mg of Src Inhibitor, PP1 (Cat. No. 567809) is also available.
产品信息
Form Liquid
Formulation A 50 mM (5 mg/355 µl) solution of Src Inhibitor, PP1 (Cat. No. 567809) in DMSO.
Molar mass 281.36
Protect from Light 是的
Hygrocopic 是的
Avoid freeze/thaw 是的
Packaged under inert gas 是的
Purity ≥90% by HPLC
Chemical formula C16H19N5
商店和运输信息
Storage -20°C
Ship Shipped with Blue Ice or with Dry Ice
Irritant
-20°C
539749-2MG InSolution PTP1B Inhibitor 品牌 Merck
InSolution PTP1B Inhibitor
货号： 539749-2MG 产品名称： InSolution PTP1B Inhibitor 品牌： Merck 规格： *** 三周 生化实验
InSolution™ PTP1B Inhibitor
A cell-permeable, selective, reversible, and non-competitive allosteric inhibitor of PTP1B (IC50 = 4 µM and 8 µM for PTP1B403 and PTP1B298, respectively). Binds to a novel site away from the catalytic pocket and inhibits PTP1B activity by preventing closure of the WPD loop.
产品信息
Form Liquid
Formulation A 10 mM (2 mg/270 µl) solution of PTP1B Inhibitor (Cat. No. 539741) in DMSO.
Primary Target IC50 IC50 = 4 and 8 µM for PTP1B403 and PTP1B298, respectively
Molar mass 741.5
Protect from Light 是的
Hygrocopic 是的
Avoid freeze/thaw 是的
Packaged under inert gas 是的
Cell permeable 是的
Reversible 是的
Purity ≥97% by HPLC
Chemical formula C26H19Br2N3O7S3
商店和运输信息
Storage -20°C
Ship Dry Ice Only
Irritant
-20°C
573129-5MG InSolution STAT3 Inhibitor III, WP1066 品牌 Merck
InSolution STAT3 Inhibitor III, WP1066
货号： 573129-5MG 产品名称： InSolution STAT3 Inhibitor III, WP1066 品牌： Merck 规格： *** 3周到货 生化实验
InSolution™ STAT3 Inhibitor III, WP1066
A cell-permeable AG 490 (Cat. No. 658401) tyrphostin analog that acts as an effective STAT3 pathway inhibitor and a much more potent antitumor agent than AG 490 in inhibiting malignant glioma growth both in cultures in vitro (IC50 = 5.6 and 3.7 µM in a viability assay using U87-MG and U373-MG, respectively; no inhibition against nontumor NHA at 10 µM) and in mice in vivo. Shown to cross blood-brain barrier in mice in vivo.
产品信息
Form Liquid
Formulation A 50 mM (5 mg/281 µl) solution of STAT3 Inhibitor III, WP1066 (Cat. No. 573097) in DMSO.
Molar mass 356.2
Protect from Light 是的
Hygrocopic 是的
Packaged under inert gas 是的
Purity ≥97% by HPLC
Chemical formula C17H14BrN3O
商店和运输信息
Storage -20°C
Ship Dry Ice Only
Irritant
-20°C
662009-5MG InSolution U0126 品牌 Merck
InSolution U0126
货号： 662009-5MG 产品名称： InSolution U0126 品牌： Merck 规格： *** 3周到货 生化实验
InSolution™ U0126
A potent and specific inhibitor of MEK1 (IC50 = 72 nM) and MEK2 (IC50 = 58 nM). The inhibition is noncompetitive with respect to both ATP and ERK. Has very little effect on other kinases such as Abl, Cdk2, Cdk4, ERK, JNK, MEKK, MKK-3, MKK-4/SEK, MKK-6, PKC, and Raf. Also acts as an immunosuppressant by effectively blocking IL-2 synthesis and T cell proliferation without affecting the long-term outcomes of either T cell activation or tolerance. Reported to undergo rapid isomerization in DMSO and exist as an equilibrium mixture of (Z,Z), E,E) and (Z,E) isomers with minimal loss of activity over a period of 1 month.
产品信息
Form Liquid
Formulation A 100 mM (5 mg/124 µl) solution of U0126 (Cat. No. 662005) in DMSO.
Molar mass 403.5
Protect from Light 是的
Hygrocopic 是的
Avoid freeze/thaw 是的
Packaged under inert gas 是的
Purity ≥98% by HPLC
Chemical formula C18H16N6S2•½C2H5OH
CAS number 109511-58-2
商店和运输信息
Storage ≤ -70°C
Ship Dry Ice Only
Irritant
≤ -70°C
688002-1MG InSolution Y-27632 in DMSO 品牌 Merck
InSolution Y-27632 in DMSO
货号： 688002-1MG 产品名称： InSolution Y-27632 in DMSO 品牌： Merck 规格： *** 3周到货 生化实验
InSolution™ Y-27632 in DMSO
(R)-(+)-trans-N-(4-Pyridyl)-4-(1-aminoethyl)-cyclohexanecarboxamide, 2HCl, Rho Kinase Inhibitor VI
A highly potent, cell-permeable, reversible, and selective inhibitor of Rho-associated protein kinases (Ki = 140 nM for p160ROCK). Also inhibits ROCK-II with equal potency. The inhibition is competitive with respect to ATP. Exhibits 10- to 50-fold lower affinity for PKCε than p160ROCK. Does not affect the activity of p21-activated protein kinase (PAK) even at higher concentrations (~100 µM). Also acts as a potent inhibitor of agonist-induced Ca2+ sensitization of myosin phosphorylation and smooth muscle contraction. Prevents apoptosis and enhances the survival and cloning efficiency of dissociated hES cells without affecting their pluripotency. A 5 mM (500 µg/296 µl) solution of Y-27632 (Cat. No. 688001) in H2O and the solid form of this compound (Cat. No. 688000) are also available.
产品信息
Form Liquid
Formulation A 10 mM (1 mg/296 µl) solution of Y-27632 (Cat. No. 688000)in DMSO.
Molar mass 338.3
Protect from Light 是的
Hygrocopic 是的
Avoid freeze/thaw 是的
Purity ≥95% by HPLC
Chemical formula C14H21N3O•2HCl•H2O
商店和运输信息
Storage ≤ -70°C
Ship Dry Ice Only
Irritant
≤ -70°C
171264-2MG InSolution AMPK Inhibitor Compound C2HCl 品牌 Merck
InSolution AMPK Inhibitor Compound C2HCl
货号： 171264-2MG 产品名称： InSolution AMPK Inhibitor Compound C2HCl 品牌： Merck 规格： *** 3周到货 生化实验
InSolution™ AMPK Inhibitor, Compound C•2HCl
AMPK Inhibitor I, 6-(4-(2-Piperidin-1-yl-ethoxy)-phenyl)-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine, 2HCl, H2O, Compound C, 2HCl, H2O
A cell-permeable pyrrazolopyrimidine compound that acts as a potent, selective, reversible, and ATP-competitive inhibitor of AMPK (AMP-activated protein kinase; Ki = 109 nM in the presence of 5 µM ATP and the absence of AMP). Does not affect the activities of ZAPK, Syk, PKCθ, PKA, or JAK3. Blocks celluar activities induced by AICAr (Cat. No. 123040) or Metformin (Cat. No. 317240). Induces weight loss by attenuating AMPK-mediated food intake in mice. The solid form of this compound (Cat. No. 171260) is also available.
产品信息
Form Liquid
Formulation A 10 mM (2 mg/408 µl) solution of AMPK Inhibitor, Compound C, 2HCl, (Cat. No. 171260) in H2O.
Molar mass 399.5
Protect from Light 是的
Packaged under inert gas 是的
Purity ≥98% by HPLC
Chemical formula C24H25N5O
CAS number 866405-64-3
商店和运输信息
Storage -20°C
Ship Dry Ice Only
-20°C
551476-5MG InSolution Q-VD-OPh, Non-O-methylated 品牌 Merck
InSolution Q-VD-OPh, Non-O-methylated
货号： 551476-5MG 产品名称： InSolution Q-VD-OPh, Non-O-methylated 品牌： Merck 规格： *** 3周到货 生化实验
InSolution™ Q-VD-OPh, Non-O-methylated
N-(2-Quinolyl)valyl-aspartyl-(2,6-difluorophenoxy)methyl Ketone
A cell-permeable, irreversible, broad-spectrum caspase inhibitor (IC50 = 50, 100, 430, and <25 nM for caspase-1,-8, -9, and -3, respectively) with effective antiapoptotic properties against all major caspase-mediated cellular apoptosis pathways. Exhibits no cytotoxic effects even at extremely high concentrations. Shown to reduce ischemic brain damage and stroke-induced programmed cell death in thymus and spleen.
产品信息
Peptide Sequence Q-Val-Asp-CH2-OPh
Form Liquid
Formulation Supplied as a 10 mM (1 mg/195 µl) solution in DMSO.
Primary Target caspase-1
Primary Target IC50 50 nM
Secondary target caspase-8 (IC50 = 100 nM), caspase-9 (IC50 = 430 nM)
Molar mass 513.8
Protect from Light 是的
Hygrocopic 是的
Packaged under inert gas 是的
Cell permeable 是的
Purity ≥90% by HPLC
Chemical formula C26H25F2N3O6
商店和运输信息
Storage -20°C
Ship Shipped with Blue Ice or with Dry Ice
Irritant
-20°C
553211-1MG InSolution Rapamycin 品牌 Merck
InSolution Rapamycin
货号： 553211-1MG 产品名称： InSolution Rapamycin 品牌： Merck 规格： *** 3周到货 生化实验
InSolution™ Rapamycin
mTOR Inhibitor I
Form Liquid
Formulation A 5 mM (500 µg/109 µl) solution of Rapamycin (Cat. No. 553210) in DMSO.
Molar mass 914.2
Protect from Light 是的
Hygrocopic 是的
Packaged under inert gas 是的
Purity ≥98% by TLC
Chemical formula C51H79NO13
商店和运输信息
Storage -20°C
Ship Shipped with Blue Ice or with Dry Ice
Irritant
-20°C
565784-10MG InSolution γ-Secretase Inhibitor IX 品牌 Merck
InSolution γ-Secretase Inhibitor IX
货号： 565784-10MG 产品名称： InSolution γ-Secretase Inhibitor IX 品牌： Merck 规格： *** 3周到货 生化实验
InSolution™ γ-Secretase Inhibitor IX
N-[N-(3,5-Difluorophenacetyl-L-alanyl)]-S-phenylglycine t-Butyl Ester, DAPT
Form Clear colorless liquid
Formulation A 25 mM (5 mg/462 µl or 10 mg/924 µl) solution of γ-Secretase Inhibitor IX (Cat. No. 565770) in DMSO.
Primary Target Aβtotal
Primary Target IC50 115 nM
Secondary target Aβ42 (IC50 = 200 nM)
Molar mass 432.5
Protect from Light 是的
Hygrocopic 是的
Packaged under inert gas 是的
Purity ≥95% by HPLC
Chemical formula C23H26F2N2O4
商店和运输信息
Storage +2°C to +8°C
Ship Shipped with Blue Ice or with Dry Ice
Irritant
2°C – 8°C
444968-5MG InSolution MEK1/2 Inhibitor III, PD03259 品牌 Merck
InSolution MEK1/2 Inhibitor III, PD03259
货号： 444968-5MG 产品名称： InSolution MEK1/2 Inhibitor III, PD03259 品牌： Merck 规格： *** 3周到货 生化实验
InSolution™ MEK1/2 Inhibitor III, PD0325901
PD 0325901, N-((2R)-2,3-Dihyroxypropoxy)-3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)-benzamide, PD325901
A cell-permeable benzamide compound that acts as a non-competitive, highly potent, selective MEK/MAPKK/MKK inhibitor and effectively blocks cellular Erk1/2 phosphorylation (by >90% in serum-starved HeLa after serum-stimulation and 50% in C26 with 25 and 0.33 nM inhibitor, respectively), while exhibiting little or no effect against the activity of Erk1/2 or a panel of 66 other kinases even at concentrations as high as 10 µM in cell-free kinase assays. Shown to be orally available in mice and suppress both the growth of and Erk phosphorylation in BRAF(V600E)-expressing SKMEL28 cell-derived tumor in vivo.
产品信息
Form Liquid
Formulation A 50 mM (5 mg/207 µl) solution of MEK1/2 Inhibitor III, PD0325901 (Cat. No. 444966) in DMSO.
Molar mass 482.2
Protect from Light 是的
Hygrocopic 是的
Packaged under inert gas 是的
Purity ≥95% by HPLC
Chemical formula C16H14F3IN2O4
CAS number 391210-10-9
商店和运输信息
Storage -20°C
Ship Dry Ice Only
Regulatory Review
-20°C
474788-10MG InSolution MG-132 in EtOH, ≥95% by HPLC 品牌 Merck
InSolution MG-132 in EtOH, ≥95% by HPLC
货号： 474788-10MG 产品名称： InSolution MG-132 in EtOH, ≥95% by HPLC 品牌： Merck 规格： *** 3周到货 生化实验
InSolution™ MG-132 in EtOH, ≥95% by HPLC
Proteasome Inhibitor XI
Potent, reversible, and cell-permeable proteasome inhibitor (Ki = 4 nM). Reduces the degradation of ubiquitin-conjugated proteins in mammalian cells and permeable stains of yeast by the 26S complex without affecting its ATPase or isopeptidase activities. Activates c-Jun N-terminal kinase (JNK1) which initiates apoptosis. Inhibits NF-κB activation (IC50 = 3 µM). This material is ≥95% pure by HPLC. A material with ≥98% purity by HPLC (Cat. No. 474791) and the solid form of this compound (Cat. No. 474787) are also available.
产品信息
Peptide Sequence Z-Leu-Leu-Leu-CHO
Form Liquid
Formulation A 20 mM (10 mg/1.05 ml) solution of MG-132, ≥95% by HPLC (Cat. No. 474787) in EtOH.
Primary Target Ki Ki = 4 nM for proteasomal inhibition
Secondary target IKK
Molar mass 475.6
Protect from Light 是的
Avoid freeze/thaw 是的
Packaged under inert gas 是的
Cell permeable 是的
Reversible 是的
Purity ≥95% by HPLC
Chemical formula C26H41N3O5
商店和运输信息
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping chargesmay be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage ≤ -70°C
Ship Dry Ice Only
Flammable
≤ -70°C
559292-500UG InSolution RSK Inhibitor, SL0101 品牌 Merck
InSolution RSK Inhibitor, SL0101
货号： 559292-500UG 产品名称： InSolution RSK Inhibitor, SL0101 品牌： Merck 规格： *** 3周到货 生化实验
InSolution™ RSK Inhibitor, SL0101
A cell-permeable Kaempferol (Cat. No. 420345) glycoside that targets the the N-terminal kinase domain of p90 ribosomal S6 kinase and inhibits RSK kinase activity (IC50 = 89 nM with 10 µM ATP) in a selective, reversible, and ATP-competitive (Ki = 1 µM) manner. Shown to inhibit the proliferation of MCF-7, but not the normal breast cell line MCF-10A, and specifically block PDB-induced cellular phosphorylation of RSK substrate p140, but not that of RSK or RSK upstream kinases even at concentrations as high as 100 µM. The solid form (Cat. No. 559285) is also available.
产品信息
Form Liquid
Formulation A 10 mM (500 µg/97 µl) solution of RSK Inhibitor, SL0101 (Cat. No. 559285) in DMSO.
Molar mass 516.5
Protect from Light 是的
Hygrocopic 是的
Packaged under inert gas 是的
Purity ≥95% by HPLC
Chemical formula C25H24O12
商店和运输信息
Storage -20°C
Ship Dry Ice Only
Irritant
-20°C
567022-5MG InSolution Simvastatin, Sodium Salt 品牌 Merck
InSolution Simvastatin, Sodium Salt
货号： 567022-5MG 产品名称： InSolution Simvastatin, Sodium Salt 品牌： Merck 规格： *** 3周到货 生化实验
InSolution™ Simvastatin, Sodium Salt
L-Type Calcium Channel Blocker VI
Carboxylate form of Simvastatin (Cat. No. 567020) that is active in whole cells and in cell-free assays. A lipophilic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor that blocks Ras function through inhibition of farnesylation. Also inhibits glucose-induced Ca2+-signaling and insulin secretion by blocking L-type Ca2+ channels in rat islet β-cells. Inhibits cell proliferation of human smooth muscle cells. The solid form of this compound (Cat. No. 567021) is also available.
产品信息
Form Liquid
Formulation A 10 mM (5 mg/1.09 ml) solution of Simvastatin, Sodium Salt (Cat. No. 567021) in H2O.
Molar mass 458.6
Protect from Light 是的
Avoid freeze/thaw 是的
Packaged under inert gas 是的
Cell permeable 是的
Reversible 是的
Purity ≥95% by HPLC
Chemical formula C25H39O6 •Na
商店和运输信息
Storage ≤ -70°C
Ship Dry Ice Only
Irritant
≤ -70°C
573130-5MG InSolution STAT3 Inhibitor VI, S3I-201 品牌 Merck
InSolution STAT3 Inhibitor VI, S3I-201
货号： 573130-5MG 产品名称： InSolution STAT3 Inhibitor VI, S3I-201 品牌： Merck 规格： *** 3周到货 生化实验
InSolution™ STAT3 Inhibitor VI, S3I-201
A cell-permeable amidosalicylic acid compound that binds Stat3-SH2 domain and prevents Stat3 phosphorylation/activation, dimerization, DNA-binding, and Stat3-dependent transcription. Shown to arrest Stat3-dependent tumor growth both in cultures in vitro (effective conc. ≤100 µM) and in a murine xenograft model in vivo (5 mg/kg, i.v.). The solid form of this compound (Cat. No. 573102) is also available.
产品信息
Form Liquid
Formulation A 50 mM (5 mg/274 µl) solution of STAT3 Inhibitor VI, S3I-201 (Cat. No. 573102) in DMSO.
Molar mass 365.4
Protect from Light 是的
Hygrocopic 是的
Packaged under inert gas 是的
Purity ≥95% by HPLC
Chemical formula C16H15NO7S
商店和运输信息
Storage -20°C
Ship Dry Ice Only
Irritant
-20°C
616464-5MG InSolution TGF-b RI Kinase Inhibitor VI, SB431542 品牌 Merck
InSolution TGF-b RI Kinase Inhibitor VI, SB431542
货号： 616464-5MG 产品名称： InSolution TGF-b RI Kinase Inhibitor VI, SB431542 品牌： Merck 规格： *** 3周到货 生化实验
InSolution™ TGF-β RI Kinase Inhibitor VI, SB431542
A cell-permeable triarylimidazole compound that is shown to effectively inhibit cellular Smad2 phosphorylation (>90% inhibition by 10 µM inhibitor) upon vector-mediated expression of constitutively active ALK4, ALK5, or ALK7 in NIH 3T3 cells, while exhibiting little effect against Smad1 phosphorylation by other members of type I receptors for TGF-β in NIH 3T3 cultures expressing active ALK1, 2, 3, or 6. When tested directly in cell-free kinase assays, SB431542 is demonstrated to potently inhibit the activity of ALK4 and ALK5 (IC50 = 140 nM and 94 nM, respectively) with no or much reduced potency toward a panel of 24 other kinases (IC50 ≥10 µM in the presence of 10 µM ATP), including ALK2 and ALK6. Reported to improve the efficiency of 4-TF-induced human iPSCs generation from fibroblast cultures by >200-fold when used together with PD0325901 (Cat. No. 444966) and Thiazovivin (Cat. No. 420220). The solid form of this compound (Cat. No. 616461) is also available.
产品信息
Form Liquid
Formulation A 100 mM (5 mg/119 µl) solution of SB431542 (Cat. No. 616461) in DMSO.
Molar mass 420.4
Protect from Light 是的
Hygrocopic 是的
Packaged under inert gas 是的
Purity ≥97% by HPLC
Chemical formula C22H16N4O3 • 2H2O
CAS number 301836-41-9
商店和运输信息
Storage -20°C
Ship Blue Ice Only
Irritant
-20°C
553512-10MG InSolution Rac1 Inhibitor II, Z62954982 品牌 Merck
InSolution Rac1 Inhibitor II, Z62954982
货号： 553512-10MG 产品名称： InSolution Rac1 Inhibitor II, Z62954982 品牌： Merck 规格： *** 3周到货 生化实验
InSolution™ Rac1 Inhibitor II, Z62954982
Z62954982, 3-((3,5-Dimethylisoxazol-4-yl)methoxy)-N-(4-methyl-3-sulfamoyl-phenyl)benzamide
A cell-permeable isoxazolyl-benzamide compound that is more effective than NSC23766 (Cat. Nos. 553502 & 553508) in inhibiting PDGF-BB- (Cat. No. 521225) induced cellular Rac1 activation (45.8% vs 11.1% inhibition by 4 h pretreatment of the respective compound at 50 µM) in serum-starved SMCs (human aortic smooth muscle cells) by interfering Rac1-Tiam1 interaction, while exhibiting no effect toward cellular Cdc42 and RhoA activation or Rac1 interaction to its effector Pak1. Shown to effectively prevent PDGF-BB-induced membrane ruffling and lamellipodia formation in serum-starved 3T3 cells (4 h pretreatment at 25 µM). The solid form of this compound (Cat. No. 553511) is also available.
产品信息
Form Liquid
Formulation A 100 mM (10 mg/241 µl) solution of Rac1 Inhibitor II, Z62954982 (Cat. No. 553511) in DMSO
Molar mass 415.5
Protect from Light 是的
Hygrocopic 是的
Avoid freeze/thaw 是的
Packaged under inert gas 是的
Purity ≥93% by HPLC
Chemical formula C20H21N3O5S
CAS number 1090893-12-1
商店和运输信息
Storage -20°C
Ship Blue Ice Only
Irritant
-20°C
220491-5MG InSolution Chk2 Inhibitor II 品牌 Merck
InSolution Chk2 Inhibitor II
货号： 220491-5MG 产品名称： InSolution Chk2 Inhibitor II 品牌： Merck 规格： *** 3周到货 生化实验
InSolution™ Chk2 Inhibitor II
2-(4-(4-Chlorophenoxy)phenyl)-1H-benzimidazole-5-carboxamide
A cell-permeable and reversible benzimidazolo compound that acts as a potent and ATP-competitive inhibitor of Chk2 with an IC50 of 15 nM and a Ki of 37 nM. Displays ~ 1,000-fold greater selectivity over Cdk1/B and CK1 (IC50 = 12 µM and 17 µM, respectively) and only weakly affects the activities of a panel of 31 kinases (< 25% inhibition at 10 µM), including Chk1. Shown to rescue both peripheral CD4+ and CD8+ T-cells from γ-irradiation-induced apoptosis with an EC50 of 3 µM and 7.6 µM, respectively. The solid form of this compound (Cat. No. 220486) is also available.
产品信息
Form Liquid
Formulation Supplied as a 25 mM (5 mg/550 µL) solution of Chk2 Inhibitor II (Cat. No. 220486) in DMSO.
Molar mass 363.8
Protect from Light 是的
Hygrocopic 是的
Avoid freeze/thaw 是的
Packaged under inert gas 是的
Purity ≥95% by HPLC
Chemical formula C20H14ClN3O2
CAS number 516480-79-8
商店和运输信息
Storage -20°C
Ship Dry Ice Only
Irritant
安全标示
S Phrase S: 26-36
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
R Phrase R: 36/38
Irritating to eyes and skin.
-20°C