Anti-hCD20-hIgG3
货号： hcd20-mab3 产品名称： Anti-hCD20-hIgG3 品牌： Invivogen 规格： 100 μg 二周到货 生化试验
Anti-hCD20-hIgG3
Monoclonal human IgG3 antibody against human CD20
Anti-hCD20-hIgG3 features the constant region of the human IgG3 isotype and the variable region of rituximab. Rituximab is a mouse/human chimeric monoclonal antibody that targets the CD20 antigen found on the surface of malignant and normal B lymphocytes. Binding of rituximab to CD20 results in cell destruction through different mechanisms including direct signaling of apoptosis, complement activation and cell-mediated cytotoxicity. Rituximab has been approved by the FDA for the treatment of various lymphoid malignancies, including B-cell non-Hodgkin’s lymphoma and B-cell chronic lymphocytic leukaemia. Anti-hCD20-hIgG3 was generated by recombinant DNA technology. It has been produced in CHO cells and purified by affinity chromatography with protein G.
Clonality: Monoclonal antibody
Specificity: Targets cells expressing human CD20
Isotype: Human IgG3
