2167-25   BIBF1120   品牌 Biovision

BIBF1120

货号: 2167-25      产品名称: BIBF1120   品牌: Biovision 规格: 25 mg 3周到货 生化实验

BIBF1120
A triple angiokinase inhibitor
Product Overview
Product Name: BIBF1120
Alternate Name/Synonyms: (Z)-​methyl 3-​(((4-​(N-​methyl-​2-​(4-​methylpiperazin-​1-​ yl)acetamido)phenyl)amino)(phenyl)methylene)-​2-​oxoindoline-​6-​ carboxylate
Description: BIBF1120 is a triple angiokinase inhibitor. It blocks signaling through vascular endothelial growth factor receptors (VEGFR; IC₅₀ values of 13 to 34 nM), platelet-derived growth factor receptors (PDGFR; IC₅₀ values of 59 to 65 nM), and fibroblast growth factor receptors (FGFR; IC₅₀ values of 37 to 610 nM).
Peptide Sequence: N/A
Appearance: White to off-white solid
Formulation: N/A
CAS Number: 928326-83-4
Molecular Formula: C₃₁H₃₃N₅O₄
Molecular Weight: 539.62
Purity: ≥95%
Solubility:DMSO (~ 6 mg/ml) or EtOH (~ 3 mg/ml)
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from air and light
SMILES: CN1CCN(CC1)CC(=O)N(C)C2=CC=C(C=C2)NC(=C3C4=C(C=C(C=C4)C(=O)OC)NC3=O)C5=CC=CC=C5
InChi: InChI=1S/C31H33N5O4/c1-34-15-17-36(18-16-34)20-27(37)35(2)24-12-10-23(11-13-24)32-29(21-7-5-4-6-8-21)28-25-14-9-22(31(39)40-3)19-26(25)33-30(28)38/h4-14,19,32H,15-18,20H2,1-3H3,(H,33,38)/b29-28-
InChi Key: XZXHXSATPCNXJR-ZIADKAODSA-N
PubChem CID: 9809715
MDL Number: MFCD11974012
USAGE: For Research Use Only! Not For Use in Humans.

-20°C

2169-5   Ebselen   品牌 Biovision

Ebselen

货号: 2169-5      产品名称: Ebselen   品牌: Biovision 规格: 5 mg 3周到货 生化实验

Ebselen
A glutathione peroxidase (GPx) mimetic and a peroxynitrite scavenger
Product Overview
Product Name: Ebselen
Alternate Name/Synonyms: 2-Phenyl-1,2-benzisoselenazol-3-(2H)-one
Description: An organo-selenium compound that displays potent antioxidant properties. Acts as a glutathione peroxidase (GPX) mimic as well as being an excellent scavenger of peroxynitrite. The glutathione peroxidase-like activity of ebselen inhibits cyclooxygenase (COX) and lipoxygenases at micromolar concentrations. Also acts as a histone-lysine demethylase (HKDM) inhibitor. Inhibits JARID1B protein with an IC₅₀ of 5.17 µM.
Peptide Sequence: N/A
Appearance: White to off-white solid
Formulation: N/A
CAS Number: 60940-34-3
Molecular Formula: C₁₃H₉NOSe
Molecular Weight: 274.18
Purity: ≥99%
Solubility:DMSO (~ 5 mg/ml)
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from air and light
SMILES: C1=CC=C(C=C1)N2C(=O)C3=CC=CC=C3[Se]2
InChi: InChI=1S/C13H9NOSe/c15-13-11-8-4-5-9-12(11)16-14(13)10-6-2-1-3-7-10/h1-9H
InChi Key: DYEFUKCXAQOFHX-UHFFFAOYSA-N
PubChem CID: 3194
MDL Number: MFCD00210937
USAGE: For Research Use Only! Not For Use in Humans.

-20°C

2169-25   Ebselen   品牌 Biovision

Ebselen

货号: 2169-25      产品名称: Ebselen   品牌: Biovision 规格: 25 mg 3周到货 生化实验

Ebselen
A glutathione peroxidase (GPx) mimetic and a peroxynitrite scavenger
Product Overview
Product Name: Ebselen
Alternate Name/Synonyms: 2-Phenyl-1,2-benzisoselenazol-3-(2H)-one
Description: An organo-selenium compound that displays potent antioxidant properties. Acts as a glutathione peroxidase (GPX) mimic as well as being an excellent scavenger of peroxynitrite. The glutathione peroxidase-like activity of ebselen inhibits cyclooxygenase (COX) and lipoxygenases at micromolar concentrations. Also acts as a histone-lysine demethylase (HKDM) inhibitor. Inhibits JARID1B protein with an IC₅₀ of 5.17 µM.
Peptide Sequence: N/A
Appearance: White to off-white solid
Formulation: N/A
CAS Number: 60940-34-3
Molecular Formula: C₁₃H₉NOSe
Molecular Weight: 274.18
Purity: ≥99%
Solubility:DMSO (~ 5 mg/ml)
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from air and light
SMILES: C1=CC=C(C=C1)N2C(=O)C3=CC=CC=C3[Se]2
InChi: InChI=1S/C13H9NOSe/c15-13-11-8-4-5-9-12(11)16-14(13)10-6-2-1-3-7-10/h1-9H
InChi Key: DYEFUKCXAQOFHX-UHFFFAOYSA-N
PubChem CID: 3194
MDL Number: MFCD00210937
USAGE: For Research Use Only! Not For Use in Humans.

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2170-5   PRIMA-1   品牌 Biovision

PRIMA-1

货号: 2170-5      产品名称: PRIMA-1   品牌: Biovision 规格: 5 mg 3周到货 生化实验

PRIMA-1
A p53 activator
Product Overview
Product Name: PRIMA-1
Alternate Name/Synonyms: 2,​2-​bis(hydroxymethyl)-​3-​quinuclidinone
Description: A small molecule that restores tumor suppressor function to mutant p53 proteins. PRIMA-1 acts as an inducer of apoptosis and inhibitor of growth of human tumors with mutant p53. PRIMA-1 restores sequence-specific DNA binding and transactivational activity to mutant p53 proteins at relatively high µM to mM concentrations.
Peptide Sequence: N/A
Appearance: White solid
Formulation: N/A
CAS Number: 5608-24-2
Molecular Formula: C₉H₁₅NO₃
Molecular Weight: 185.22
Purity: ≥95%
Solubility:H₂O (100 mM)
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from air and moisture
SMILES: C1CN2CCC1C(=O)C2(CO)CO
InChi: InChI=1S/C9H15NO3/c11-5-9(6-12)8(13)7-1-3-10(9)4-2-7/h7,11-12H,1-6H2
InChi Key: RFBVBRVVOPAAFS-UHFFFAOYSA-N
PubChem CID: 322968
MDL Number: MFCD04974196
USAGE: For Research Use Only! Not For Use in Humans.

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2170-25   PRIMA-1   品牌 Biovision

PRIMA-1

货号: 2170-25      产品名称: PRIMA-1   品牌: Biovision 规格: 25 mg 3周到货 生化实验

PRIMA-1
A p53 activator
Product Overview
Product Name: PRIMA-1
Alternate Name/Synonyms: 2,​2-​bis(hydroxymethyl)-​3-​quinuclidinone
Description: A small molecule that restores tumor suppressor function to mutant p53 proteins. PRIMA-1 acts as an inducer of apoptosis and inhibitor of growth of human tumors with mutant p53. PRIMA-1 restores sequence-specific DNA binding and transactivational activity to mutant p53 proteins at relatively high µM to mM concentrations.
Peptide Sequence: N/A
Appearance: White solid
Formulation: N/A
CAS Number: 5608-24-2
Molecular Formula: C₉H₁₅NO₃
Molecular Weight: 185.22
Purity: ≥95%
Solubility:H₂O (100 mM)
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from air and moisture
SMILES: C1CN2CCC1C(=O)C2(CO)CO
InChi: InChI=1S/C9H15NO3/c11-5-9(6-12)8(13)7-1-3-10(9)4-2-7/h7,11-12H,1-6H2
InChi Key: RFBVBRVVOPAAFS-UHFFFAOYSA-N
PubChem CID: 322968
MDL Number: MFCD04974196
USAGE: For Research Use Only! Not For Use in Humans.

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2172-100   DHEA   品牌 Biovision

DHEA

货号: 2172-100      产品名称: DHEA   品牌: Biovision 规格: 100 mg 3周到货 生化实验

2172-100                                                                                                                                                                                                                                                                                                                          DHEA                                                                                   品牌                                                                                                                                                         Biovision

DHEA
A G6PD (glucose 6-phosphate dehydrogenase) inhibitor
Product Overview
Product Name: DHEA
Alternate Name/Synonyms: 5-Dehydroepiandrosterone; Dehydroisoandrosterone; Prasterone
Description: DHEA is a steroid secreted by the adrenal gland with both estrogenic and androgenic properties. It is a negative modulator of GABAA receptors. DHEA inhibits the activity of G6PD (glucose 6-phosphate dehydrogenase) in a dose-dependent manner with EC₅₀ of 4 μm. However, DHEA does not inhibit the enzymatic activity of PGD (6-phosphogluconate dehydrogenase), the second enzyme in the pentose phosphate pathway.
Peptide Sequence: N/A
Appearance: White to off-white solid
Formulation: N/A
CAS Number: 53-43-0
Molecular Formula: C₁₉H₂₈O₂
Molecular Weight: 288.43
Purity: ≥99% by TLC
Solubility:DMSO
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from air and moisture
SMILES: CC12CCC3C(C1CCC2=O)CC=C4C3(CCC(C4)O)C
InChi: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h3,13-16,20H,4-11H2,1-2H3/t13-,14-,15-,16-,18-,19-/m0/s1
InChi Key: FMGSKLZLMKYGDP-USOAJAOKSA-N
PubChem CID: 5881
MDL Number: MFCD00003613
USAGE: For Research Use Only! Not For Use in Humans.

-20°C

2172-500   DHEA   品牌 Biovision

DHEA

货号: 2172-500      产品名称: DHEA   品牌: Biovision 规格: 500 mg 3周到货 生化实验

DHEA
A G6PD (glucose 6-phosphate dehydrogenase) inhibitor
Product Overview
Product Name: DHEA
Alternate Name/Synonyms: 5-Dehydroepiandrosterone; Dehydroisoandrosterone; Prasterone
Description: DHEA is a steroid secreted by the adrenal gland with both estrogenic and androgenic properties. It is a negative modulator of GABAA receptors. DHEA inhibits the activity of G6PD (glucose 6-phosphate dehydrogenase) in a dose-dependent manner with EC₅₀ of 4 μm. However, DHEA does not inhibit the enzymatic activity of PGD (6-phosphogluconate dehydrogenase), the second enzyme in the pentose phosphate pathway.
Peptide Sequence: N/A
Appearance: White to off-white solid
Formulation: N/A
CAS Number: 53-43-0
Molecular Formula: C₁₉H₂₈O₂
Molecular Weight: 288.43
Purity: ≥99% by TLC
Solubility:DMSO
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from air and moisture
SMILES: CC12CCC3C(C1CCC2=O)CC=C4C3(CCC(C4)O)C
InChi: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h3,13-16,20H,4-11H2,1-2H3/t13-,14-,15-,16-,18-,19-/m0/s1
InChi Key: FMGSKLZLMKYGDP-USOAJAOKSA-N
PubChem CID: 5881
MDL Number: MFCD00003613
USAGE: For Research Use Only! Not For Use in Humans.

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2173-5   EUK-118   品牌 Biovision

EUK-118

货号: 2173-5      产品名称: EUK-118   品牌: Biovision 规格: 5 mg 3周到货 生化实验

EUK-118
A SOD and catalase mimetic
Product Overview
Product Name: EUK-118
Alternate Name/Synonyms: (acetato-​κO)[[2,​2′-​[1,​2-​ethanediylbis[(nitrilo-​κN)methylidyne]]bis[3,​5-​dimethoxyphenolato-​κO]](2-​)]-​manganese
Description: A structural analog of EUK 8 and EUK 134 with significantly reduced activity. Acts as a synthetic catalytic scavenger of reactive oxygen species with superoxide dismutase (SOD) and catalase mimetic activity. Superoxide-mediated reduction of an electron acceptor (i.e., SOD mimetic activity) was inhibited by EUK 118 with an IC₅₀ value of 2.0 µm.
Peptide Sequence: N/A
Appearance: Off-white solid
Formulation: N/A
CAS Number: 186299-34-3
Molecular Formula: C₂₂H₂₅MnN₂O₈
Molecular Weight: 500.38
Purity: ≥95%
Solubility:DMSO (~ 20 mg/ml)
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from air and moisture
SMILES: CC(=O)[O-][Mn]123([N+](=Cc4c(cc(cc4OC)OC)[O-]1)CC[N+]2=Cc5c(cc(cc5OC)OC)[O-]3)[Mn][Mn+]
InChi: InChI=1S/C20H24N2O6.C2H4O2.3Mn/c1-25-13-7-17(23)15(19(9-13)27-3)11-21-5-6-22-12-16-18(24)8-14(26-2)10-20(16)28-4;1-2(3)4;;;/h7-12,23-24H,5-6H2,1-4H3;1H3,(H,3,4);;;/q;;;+1;+2/p-3/b21-11+,22-12+;;;;
InChi Key: NKZPUKNJLPQHHM-CAGONKBASA-K
PubChem CID: N/A
MDL Number: N/A
USAGE: For Research Use Only! Not For Use in Humans.

-20°C

2174-5   EUK-124   品牌 Biovision

EUK-124

货号: 2174-5      产品名称: EUK-124   品牌: Biovision 规格: 5 mg 3周到货 生化实验

EUK-124
A SOD and catalase mimetic
Product Overview
Product Name: EUK-124
Alternate Name/Synonyms: chloro[[2,​2’-​[1,​2-​ethanediylbis[(nitrilo-​κN)methylidyne
Description: A structural analog of EUK 8 and EUK 134 with significantly reduced activity. Acts as a synthetic catalytic scavenger of reactive oxygen species with superoxide dismutase (SOD) and catalase mimetic activity. EUK 124 inhibits superoxide-mediated reduction of an electron acceptor (i.e., SOD mimetic activity), with an IC₅₀ value of 5.0 µM.
Peptide Sequence: N/A
Appearance: Off-white solid
Formulation: N/A
CAS Number: 186299-35-4
Molecular Formula: C₂₀H₂₂ClMnN₂O₆
Molecular Weight: 476.79
Purity: ≥95%
Solubility:DMSO (~ 20 mg/ml)
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from air and moisture
SMILES: N/A
InChi: N/A
InChi Key: N/A
PubChem CID: N/A
MDL Number: N/A
USAGE: For Research Use Only! Not For Use in Humans.

-20°C

2175-5   EUK-134   品牌 Biovision

EUK-134

货号: 2175-5      产品名称: EUK-134   品牌: Biovision 规格: 5 mg 3周到货 生化实验

EUK-134
A synthetic superoxide dismutase (SOD)/catalase mimetic
Product Overview
Product Name: EUK-134
Alternate Name/Synonyms: chloro[[2,​2′-​[1,​2-​ethanediylbis[(nitrilo-​κN)methylidyne]]bis[6-​methoxyphenolato-​κO]]]-​manganese
Description: A synthetic superoxide dismutase (SOD)/catalase mimetic. EUK 134 is a salen-manganese complex that has been modified to increase its catalase activity while retaining SOD activity.
Peptide Sequence: N/A
Appearance: Off-white solid
Formulation: N/A
CAS Number: 81065-76-1
Molecular Formula: C₁₈H₁₈ClMnN₂O₄
Molecular Weight: 416.74
Purity: ≥98%
Solubility:DMSO (~ 20 mg/ml)
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from air and moisture
SMILES: COC1=CC=CC(=C1[O-])C=NCCN=CC2=C(C(=CC=C2)OC)[O-].[Cl-].[Mn+2]
InChi: InChI=1S/C18H20N2O4.ClH.Mn/c1-23-15-7-3-5-13(17(15)21)11-19-9-10-20-12-14-6-4-8-16(24-2)18(14)22;;/h3-8,11-12,21-22H,9-10H2,1-2H3;1H;/q;;+2/p-3
InChi Key: ZCNKLAVGNJEDNF-UHFFFAOYSA-K
PubChem CID: 45489809
MDL Number: MFCD08059577
USAGE: For Research Use Only! Not For Use in Humans.

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