Imiquimod
货号： 1698-100 产品名称： Imiquimod 品牌： Biovision 规格： 100 mg 3周到货 生化实验
Imiquimod
Product Overview
Product Name: Imiquimod
Alternate Name/Synonyms: 1-(2-Methylpropyl)-1H-imidazo[4,5-c]quinolin-4-amine; R-837
Description: Cell-permeable. Topical immune response modifier that displays anti-angiogenic, anti-viral and anti-inflammatory properties. Up-regulates IL-18 and down-regulates MMP-9 through recognition of Toll-like receptor 7 (TLR7) and subsequent activation of MyD88-dependent pathway.
Peptide Sequence: N/A
Appearance: White to off-white solid
Formulation: N/A
CAS Number: 99011-02-6
Molecular Formula: C₁₄H₁₆N₄
Molecular Weight: 240.3
Purity: ≥95% by HPLC
Solubility:DMSO
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from air and light
SMILES: CC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2N
InChi: InChI=1S/C14H16N4/c1-9(2)7-18-8-16-12-13(18)10-5-3-4-6-11(10)17-14(12)15/h3-6,8-9H,7H2,1-2H3,(H2,15,17)
InChi Key: DOUYETYNHWVLEO-UHFFFAOYSA-N
PubChem CID: 57469
MDL Number: MFCD00866946
USAGE: For Research Use Only! Not For Use in Humans.
-20°C
1698-500 Imiquimod 品牌 Biovision
Imiquimod
货号： 1698-500 产品名称： Imiquimod 品牌： Biovision 规格： 500 mg 3周到货 生化实验
Imiquimod
Product Overview
Product Name: Imiquimod
Alternate Name/Synonyms: 1-(2-Methylpropyl)-1H-imidazo[4,5-c]quinolin-4-amine; R-837
Description: Cell-permeable. Topical immune response modifier that displays anti-angiogenic, anti-viral and anti-inflammatory properties. Up-regulates IL-18 and down-regulates MMP-9 through recognition of Toll-like receptor 7 (TLR7) and subsequent activation of MyD88-dependent pathway.
Peptide Sequence: N/A
Appearance: White to off-white solid
Formulation: N/A
CAS Number: 99011-02-6
Molecular Formula: C₁₄H₁₆N₄
Molecular Weight: 240.3
Purity: ≥95% by HPLC
Solubility:DMSO
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from air and light
SMILES: CC(C)CN1C=NC2=C1C3=CC=CC=C3N=C2N
InChi: InChI=1S/C14H16N4/c1-9(2)7-18-8-16-12-13(18)10-5-3-4-6-11(10)17-14(12)15/h3-6,8-9H,7H2,1-2H3,(H2,15,17)
InChi Key: DOUYETYNHWVLEO-UHFFFAOYSA-N
PubChem CID: 57469
MDL Number: MFCD00866946
USAGE: For Research Use Only! Not For Use in Humans.
-20°C
tlrl-imq Imiquimod 品牌 Invivogen
Imiquimod
货号： tlrl-imq 产品名称： Imiquimod 品牌： Invivogen 规格： 5 mg 二周到货 生化试验
Imiquimod
Imiquimod (R837), an imidazoquinoline amine analog to guanosine, is an immune response modifier with potent indirect antiviral activity. The antiviral activity of imiquimod was first shown in guinea pigs infected with herpes simplex virus [1]. Imiquimod is now an approved treatment for external genital warts caused by human papillomavirus infection.
This low molecular synthetic molecule induces the production of cytokines such as IFN-α. Unlike R848, Imiquimod activates only TLR7 but not TLR8 [2]. This activation is MyD88-dependent and leads to the induction of the transcription factor NF-κB [3].
Unlike other commercially available Imiquimod preparations, InvivoGen’s Imiquimod is controlled for TLR7 potency and TLR4/TLR2 contamination.
Imiquimod is also available on ready-to-use 8-well strips pre-coated at 7 different concentrations and a negative control.
Specificity: human/mouse TLR7 agonist
Working Concentration: 1 – 5 μg/ml
Endotoxin level: EndoFit™ (<0.001 EU/µg)
Solubility: 1 mg/ml in water
Formula: C14H16N4, HCl
Molecular weight: 276.8
tlrl-imqs Imiquimod 品牌 Invivogen
Imiquimod
货号： tlrl-imqs 产品名称： Imiquimod 品牌： Invivogen 规格： 500 μg 二周到货 生化试验
Imiquimod
Imiquimod (R837), an imidazoquinoline amine analog to guanosine, is an immune response modifier with potent indirect antiviral activity. The antiviral activity of imiquimod was first shown in guinea pigs infected with herpes simplex virus [1]. Imiquimod is now an approved treatment for external genital warts caused by human papillomavirus infection.
This low molecular synthetic molecule induces the production of cytokines such as IFN-α. Unlike R848, Imiquimod activates only TLR7 but not TLR8 [2]. This activation is MyD88-dependent and leads to the induction of the transcription factor NF-κB [3].
Unlike other commercially available Imiquimod preparations, InvivoGen’s Imiquimod is controlled for TLR7 potency and TLR4/TLR2 contamination.
Imiquimod is also available on ready-to-use 8-well strips pre-coated at 7 different concentrations and a negative control.
Specificity: human/mouse TLR7 agonist
Working Concentration: 1 – 5 μg/ml
Endotoxin level: EndoFit™ (<0.001 EU/µg)
Solubility: 1 mg/ml in water
Formula: C14H16N4, HCl
Molecular weight: 276.8
vac-imq Imiquimod VacciGrade 品牌 Invivogen
Imiquimod VacciGrade
货号： vac-imq 产品名称： Imiquimod VacciGrade 品牌： Invivogen 规格： 5 mg 二周到货 生化试验
Imiquimod VacciGrade™
Imidazoquinoline compound
The imidazoquinoline compound Imiquimod is a guanosine derivative and agonist for TLR7.
This TLR7 agonist, originally developed as type I IFN inducers, is an effective adjuvant by activating dendritic cells (DCs) and B cells to induce cytokines optimal for Th1 cell immunity, and antibody production.
Unlike other commercially available Imiquimod preparations, InvivoGen’s Imiquimod VacciGrade™ is controlled for TLR7/8 potency and TLR4/TLR2 contamination.
Imiquimod VacciGrade™ is suitable for preclinical studies. It is prepared under strict aseptic conditions. It is guaranteed sterile and thoroughly tested for the presence of endotoxins.
Imiquimod VacciGrade™ is for research use only, not for use in humans.
Specificity: Th1 response
Working concentration: 10 – 100 μg/mouse
Endotoxin level: <5 EU/mg (limit of detection)
Solubility: 1 mg/ml in physiological water
I5034-1 g Imiquimod 品牌 LKT
Imiquimod
货号： I5034-1 g 产品名称： Imiquimod 品牌： LKT 规格： 1 g 三周到货 生化试验
Imiquimod
Description
An immune response modifier that induces a-interferon in numerous species including human. It inhibits colon and lung tumors in mice and has antiviral activity against HSV-2 infection. Its antitumor activity is related to the induction of apoptosis.
Specifications
Cas No. 99011-02-6
Product ID I5034
Product Name Imiquimod
Chemical Name 1(2-Methyl-propyl)-1H-imidazol [4,5-c] quinolin- 4-amine
Synonym Aldara; R-837
Formula Wt. 240.3
Melting Point 292
Purity >99.5%
Solubility Insoluble in water. DMSO (4 mg/mL)
Store Temp Ambient
Ship Temp Ambient
References Sidky YA, Borden EC, Weeks CE et al. Cancer Res. 52:3528-33 (1992). Bernstein DI, Harrison CJ. Antimicrob Agents Chemotgher. 33:1511-5 (1989). Gibson SJ, Lindh JM, Riter TR et al. Cell Immunol. 218:74-86 (2002). Schon M, Bong AB, Drewniok C et al. J Natl
室温
I5034-100 mg Imiquimod 品牌 LKT
Imiquimod
货号： I5034-100 mg 产品名称： Imiquimod 品牌： LKT 规格： 100 mg 三周到货 生化试验
Imiquimod
Description
An immune response modifier that induces a-interferon in numerous species including human. It inhibits colon and lung tumors in mice and has antiviral activity against HSV-2 infection. Its antitumor activity is related to the induction of apoptosis.
Specifications
Cas No. 99011-02-6
Product ID I5034
Product Name Imiquimod
Chemical Name 1(2-Methyl-propyl)-1H-imidazol [4,5-c] quinolin- 4-amine
Synonym Aldara; R-837
Formula Wt. 240.3
Melting Point 292
Purity >99.5%
Solubility Insoluble in water. DMSO (4 mg/mL)
Store Temp Ambient
Ship Temp Ambient
References Sidky YA, Borden EC, Weeks CE et al. Cancer Res. 52:3528-33 (1992). Bernstein DI, Harrison CJ. Antimicrob Agents Chemotgher. 33:1511-5 (1989). Gibson SJ, Lindh JM, Riter TR et al. Cell Immunol. 218:74-86 (2002). Schon M, Bong AB, Drewniok C et al. J Natl
室温
I5034-500 mg Imiquimod 品牌 LKT
Imiquimod
货号： I5034-500 mg 产品名称： Imiquimod 品牌： LKT 规格： 500 mg 三周到货 生化试验
Imiquimod
Description
An immune response modifier that induces a-interferon in numerous species including human. It inhibits colon and lung tumors in mice and has antiviral activity against HSV-2 infection. Its antitumor activity is related to the induction of apoptosis.
Specifications
Cas No. 99011-02-6
Product ID I5034
Product Name Imiquimod
Chemical Name 1(2-Methyl-propyl)-1H-imidazol [4,5-c] quinolin- 4-amine
Synonym Aldara; R-837
Formula Wt. 240.3
Melting Point 292
Purity >99.5%
Solubility Insoluble in water. DMSO (4 mg/mL)
Store Temp Ambient
Ship Temp Ambient
References Sidky YA, Borden EC, Weeks CE et al. Cancer Res. 52:3528-33 (1992). Bernstein DI, Harrison CJ. Antimicrob Agents Chemotgher. 33:1511-5 (1989). Gibson SJ, Lindh JM, Riter TR et al. Cell Immunol. 218:74-86 (2002). Schon M, Bong AB, Drewniok C et al. J Natl
室温
3700-50 Imiquimod 品牌 Tocris
Imiquimod
货号： 3700-50 产品名称： Imiquimod 品牌： Tocris 规格： 50 mg
ALX-420-039-M100 Imiquimod 品牌 Alexis
Imiquimod
货号： ALX-420-039-M100 产品名称： Imiquimod 品牌： Alexis 规格： 100 mg 3周到货 生化实验
Imiquimod
TLR7 ligand
Topical immune response modifier that inhibits angiogenesis. Up-regulates IL-18 and down-regulates MMP-9 through recognition of Toll-like receptor 7 (TLR7) and subsequent activation of MyD88-dependent pathway.
Product Specification
Alternative Name: 1-(2-Methylpropyl)-1H-imidazo[4,5-c]quinolin-4-amine, R-837
Formula: C14H16N4
MW: 240.3
CAS: 99011-02-6
Identity: Identity determined by IR and HPLC.
Appearance: White to off-white powder.
Hazard: TOXIC.
Solubility: Soluble in DMSO (3mg/ml) or dimethyl formamide; slightly soluble in water (warm to 37°C, vortex); insoluble in 100% ethanol.
Long Term Storage: -20°C
Use/Stability: Stable for up to 1 year after receipt when stored at -20°C. Stock solutions are stable for up to 3 months when stored at -20°C.
Handling: After reconstitution, prepare aliquots and store at -20°C.
-20°C
ALX-420-039-M250 Imiquimod 品牌 Alexis
Imiquimod
货号： ALX-420-039-M250 产品名称： Imiquimod 品牌： Alexis 规格： 250 mg 3周到货 生化实验
Imiquimod
TLR7 ligand
Topical immune response modifier that inhibits angiogenesis. Up-regulates IL-18 and down-regulates MMP-9 through recognition of Toll-like receptor 7 (TLR7) and subsequent activation of MyD88-dependent pathway.
Product Specification
Alternative Name: 1-(2-Methylpropyl)-1H-imidazo[4,5-c]quinolin-4-amine, R-837
Formula: C14H16N4
MW: 240.3
CAS: 99011-02-6
Identity: Identity determined by IR and HPLC.
Appearance: White to off-white powder.
Hazard: TOXIC.
Solubility: Soluble in DMSO (3mg/ml) or dimethyl formamide; slightly soluble in water (warm to 37°C, vortex); insoluble in 100% ethanol.
Long Term Storage: -20°C
Use/Stability: Stable for up to 1 year after receipt when stored at -20°C. Stock solutions are stable for up to 3 months when stored at -20°C.
Handling: After reconstitution, prepare aliquots and store at -20°C.
-20°C
I5034-5 g Imiquimod 品牌 LKT
Imiquimod
货号： I5034-5 g 产品名称： Imiquimod 品牌： LKT 规格： 5 g 三周到货 生化试验
Imiquimod
Description
An immune response modifier that induces a-interferon in numerous species including human. It inhibits colon and lung tumors in mice and has antiviral activity against HSV-2 infection. Its antitumor activity is related to the induction of apoptosis.
Specifications
Cas No. 99011-02-6
Product ID I5034
Product Name Imiquimod
Chemical Name 1(2-Methyl-propyl)-1H-imidazol [4,5-c] quinolin- 4-amine
Synonym Aldara; R-837
Formula Wt. 240.3
Melting Point 292
Purity >99.5%
Solubility Insoluble in water. DMSO (4 mg/mL)
Store Temp Ambient
Ship Temp Ambient
References Sidky YA, Borden EC, Weeks CE et al. Cancer Res. 52:3528-33 (1992). Bernstein DI, Harrison CJ. Antimicrob Agents Chemotgher. 33:1511-5 (1989). Gibson SJ, Lindh JM, Riter TR et al. Cell Immunol. 218:74-86 (2002). Schon M, Bong AB, Drewniok C et al. J Natl
室温