Imiquimod
货号： tlrl-imqs 产品名称： Imiquimod 品牌： Invivogen 规格： 500 μg 二周到货 生化试验
Imiquimod
Imiquimod (R837), an imidazoquinoline amine analog to guanosine, is an immune response modifier with potent indirect antiviral activity. The antiviral activity of imiquimod was first shown in guinea pigs infected with herpes simplex virus [1]. Imiquimod is now an approved treatment for external genital warts caused by human papillomavirus infection.
This low molecular synthetic molecule induces the production of cytokines such as IFN-α. Unlike R848, Imiquimod activates only TLR7 but not TLR8 [2]. This activation is MyD88-dependent and leads to the induction of the transcription factor NF-κB [3].
Unlike other commercially available Imiquimod preparations, InvivoGen’s Imiquimod is controlled for TLR7 potency and TLR4/TLR2 contamination.
Imiquimod is also available on ready-to-use 8-well strips pre-coated at 7 different concentrations and a negative control.
Specificity: human/mouse TLR7 agonist
Working Concentration: 1 – 5 μg/ml
Endotoxin level: EndoFit™ (<0.001 EU/µg)
Solubility: 1 mg/ml in water
Formula: C14H16N4, HCl
Molecular weight: 276.8
