Smo Antagonist, SA9

货号： 2155-5      产品名称： Smo Antagonist, SA9   品牌： Biovision 规格： 5 mg 3周到货 生化实验

Smo Antagonist, SA9
A Hedgehog (Hh) signaling pathway antagonist
Product Overview
Product Name: Smo Antagonist, SA9
Alternate Name/Synonyms: 3-(3-(4-Fluorophenyl)-5-oxo-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinazolin-1-yl-N-(3-methylphenethyl)propanamide
Description: SA9 inhibits Hh pathway by interacting directly with Smo. It inhibits SAG (Smoothened agonist) activation of Hh signaling in Shh-LIGHT 2 cells (IC₅₀ = 19 µM). Induces the localization of Smo to cilia in ASZ1 cells, but not in IMCD3 cells. Also treatment of Ptch1-/- MEFs with SA9 suppresses the β-galactosidase activity (IC₅₀ = 1.0 µM) and inhibits the expression of Gli1 and Ptch1 in ASZ1 cells.
Peptide Sequence: N/A
Appearance: Crystalline solid
Formulation: N/A
CAS Number: N/A
Molecular Formula: C₂₇H₂₈ClN₅O₂
Molecular Weight: 490
Purity: ≥95% by NMR
Solubility:DMSO
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from air and moisture
SMILES: C1CCC(=CC1)CCNC(=O)CCC2=NN=C3N2C4=CC=CC=C4C(=O)N3CC5=CC=C(C=C5)Cl
InChi: InChI=1S/C27H28ClN5O2/c28-21-12-10-20(11-13-21)18-32-26(35)22-8-4-5-9-23(22)33-24(30-31-27(32)33)14-15-25(34)29-17-16-19-6-2-1-3-7-19/h4-6,8-13H,1-3,7,14-18H2,(H,29,34)
InChi Key: YTDIPVZSLXYGNL-UHFFFAOYSA-N
PubChem CID: 20880974
MDL Number: N/A
USAGE: For Research Use Only! Not For Use in Humans.

-20°C