Smo Antagonist, SA10

货号： 2159-2      产品名称： Smo Antagonist, SA10   品牌： Biovision 规格： 2 mg 3周到货 生化实验

Smo Antagonist, SA10
A Hedgehog (Hh) signaling pathway antagonist
Product Overview
Product Name: Smo Antagonist, SA10
Alternate Name/Synonyms: 4-((Benzo[c][1,2,5]thiadiazole-4-sulfonamido)methyl-N-(3-phenylpropyl)cyclohexanecarboxamide
Description: SA10 inhibits SAG (Smoothened agonist) activation of Hh signaling in Shh-LIGHT 2 cells (IC₅₀ = 5 µM). However, unlike SA1 and SA9, Smo antagonist SA10 does not directly bind to Smo. Inhibits the localization o Smo to cilia. Also treatment of Ptch1-/- MEFs with SA10 suppresses the β-galactosidase activity (IC₅₀ = 11.0 µM) and inhibits the expression of Gli1 and Ptch1 in ASZ1 cells.
Peptide Sequence: N/A
Appearance: Crystalline solid
Formulation: N/A
CAS Number: N/A
Molecular Formula: C₂₃H₂₈N₄O₃S₂
Molecular Weight: 472.62
Purity: ≥95% by NMR
Solubility:DMSO
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from air and moisture
SMILES: N/A
InChi: N/A
InChi Key: N/A
PubChem CID: N/A
MDL Number: N/A
USAGE: For Research Use Only! Not For Use in Humans.

-20°C