Anti-GATA3

货号： 09-076      产品名称： Anti-GATA3   品牌： Millipore 规格： EA 三周到货 生化实验

Anti-GATA3 Antibody (09-076)
Species Reactivity Key Applications Host Format Antibody Type
H, R  WB Rabbit Affinity Purified Polyclonal Antibody
Description:
Anti-GATA3 Antibody
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Trade Name:
Upstate (Millipore)
Specificity:
Recognizes GATA3
Molecular Weight:
48 kda
Epitope:
a.a. 3-17
Immunogen:
KLH conjugated synthetic peptide (VTADQPRWVSHHHPA(C) corresponding to a.a. 3-17 of human GATA3
Isotype:
IgG
Background Information:
GATA3 is a transcription factor containing a zinc finger domain. GATA3 is primarily expressed in T cells, where it thought to participate in T-cell receptor gene activation through binding to enhancers. Analysis of conditional Gata3 knockout mice confirmed the critical role of GATA-3 in helper T cell differentiation and proliferation. Cells expressing GATA-3 develop the profile of Th2 cells, secreting IL-4, IL-5 and IL-13. Binding of GATA-3 in the regulatory regions of the genes of these cytokines alters chromatin structure, increasing accessibility to other transcription factors. T cell receptor activation activates NFAT and other transcription factors that cooperate with GATA-3 in inducing Th2 cell differentiation. Blocking GATA-3 action has been suggested as a therapeutic strategy to treat asthma. GATA-3 has also been implicated in developmental processes such as the development of the inner ear.
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Species Reactivity:
Human
Rat
Quality Assurance:
Routinely evaluated by immunoblot.
Purification Method:
Immunoaffinity purified
Presentation:
Immunoaffinity purified rabbit IgG in PBS, 0.1% sodium azide.
Storage Conditions:
Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
UniProt Number:
P23771
Entrez Gene Number:
2625
Gene Symbol:
HDR
MGC2346
MGC5199
MGC5445
Alternate Names:
GATA binding protein 3
GATA-binding factor 3
HDR 2
Trans-acting T-cell-specific transcription factor GATA-3
MGC2346
MGC5199
MGC5445
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Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Western Blotting
UniProt Summary:
Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5′-AGATAG-3′.
Genatlas biochemistry entry for GATA3:
T cell specific transcription factor,GATA sequence binding protein in T cell receptor, also expressed in endothelial cell, placenta, transcriptional regulator in kidney, adrenal gland, embryonic brain, adult nervous system endocardium, associated with a special class of nuclear bodies.
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Brand Family:
Upstate
Product Name:
Anti-GATA3 Antibody (09-076)
Concentration:
Please refer to the Certificate of Analysis for the lot-specific concentration.
Antibody Type:
Polyclonal Antibody
Qty/Pk:
100 μg
Format:
Affinity Purified
Host:
Rabbit
Applications: