Epiregulin (EREG), human recombinant

货号： 4069-1000      产品名称： Epiregulin (EREG), human recombinant   品牌： Biovision 规格： 1 mg 3周到货 生化实验

Epiregulin (EREG), human recombinant
A ligand of EGFR, and most members of the ERBB family
Product Overview
Alternate Names / Synonyms: Epiregμlin, EREG
Gene Symbol: EREG
Accession #: O14944
Gene ID: 2069
Source: E. coli
Appearance: Lyophilized protein
Physical Form Description: Sterile filtered and lyophilized from 0.5 mg/ml solution containing 20 mM PBS, pH 7.4 and 130 mM NaCl.
Molecular Weight: 6.0 kDa
Purity by SDS-PAGE: ≥97%
Purity by HPLC: ≥97%
Endotoxin Level: <0.1 ng/μg
Biological Activity: The ED₅₀ as dertermined by the dose-dependent stimulation of the proliferation of murine balb/3T3 cells is <2.0 ng/ml, corresponding to a specific activity of >5 x 10⁵ units/mg
Reconstitution Instructions: Reconstitute in sterile water to 0.1–1 mg /ml. The solution can then further diluted to other aqueous solutions.
Storage Temp.: -20°C
Shipping: Gel pack
Background Information: Epiregulin is part of the EGF family. Epiregulin functions as a ligand of EGFR, as well as a ligand of most members of the ERBB (v-erb-b2 oncogene homolog) family of tyrosine-kinase receptors. Epiregulin is expressed mostly in the placenta and peripheral blood leukocytes and in specific carcinomas of the bladder, lung, kidney and colon. Epiregulin stimulates the proliferation of keratinocytes, hepatocytes, fibroblasts and Vascular smooth muscle cells. Epiregulin inhibits the growth of several tumor-derived epithelial cell lines. Human Epiregulin is initially synthesized as a glycosylated 19.0 kDa transmembrane precursor protein, which is processed by proteolytic cleavage to produce a 6.0 kDa mature secreted sequence. Recombinant human EREG produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 50 amino acids and having a molecular mass of 6 kDa.
Handling: Centrifuge the vial prior to opening.
Usage: For Research Use Only! Not to be used in humans.

-20°C