标签归档：pro

7780-5   Pro-MMP-2, mouse   品牌 Biovision

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Pro-MMP-2, mouse

货号： 7780-5      产品名称： Pro-MMP-2, mouse   品牌： Biovision 规格： 5 μg 3周到货 生化实验

Pro-MMP-2, mouse
A Protein involved in breakdown of extracellular matrix
Product Overview
Alternate Name/Synonyms: MMP-2, matrix metalloproteinase-2, MMP, MMP recombinant, MMP protein
Gene Symbol: MMP2
Accession #: Q3UG07
Gene ID: 17390
Source: mouse fibroblasts
Appearance: Liquid
Physical Form Description: In 50 mM Tris-HCl, pH 7; 200 mM NaCl; 5 mM CaCl₂; 1 μM ZnCl₂; 0.05% Brij 35; 0,05% NaN₃
Molecular Weight: 40/42 kDa
Purity by SDS-PAGE: ≥90%
Purity by HPLC: N/A
Endotoxin Level: N/A
Biological Activity: N/A
Reconstitution Instructions: N/A
Storage Temp.: -80°C
Shipping: Dry Ice
Background Information: The progelatinase A, a member of the matrix metalloproteinase (MMP) family, has been isolated from macrophages and fibroblasts. Gelatinase A hydrolyses several components of the extracellular matrix, e.g. the collagen types IV, V and XI and gelatin. Progelatinase A complexed via their C-terminal domain with TIMP-2 was isolated from culture media of different cell types. This complex shows both properties of its constituents: Like TIMP-2 it inhibits active matrix metalloproteinases and like gelatinase it shows proteolytic activity after activation with APMA (4-aminophenylmercury acetate). However, its proteolytic activity is less than 10% of that of gelatinase A not complexed with TIMP-2. In contrast to the other MMPs the progelatinase A cannot be activated by the serine proteinase trypsin. Until quite recently a potential natural activator that can transform latent progelatinase A into the active form was unknown. It was shown that the catalytic domain of the membrane type 2-matrix metalloproteinase activates progelatinase A as well as the progelatinase A / TIMP-2 complex, by cleaving the 72 kDa progelatinase A to yield 67 kDa gelatinase A, which is than transformed into 62 kDa gelatinase A. The 62 kDa form is about twice as active as the 67 kDa form towards the Dnp-pepitde (Masui et al.). No significant difference in activity was found between free and complexed gelatinase A forms
Amino Acid Sequence: N/A
Handling: Centrifuge the vial prior to opening
USAGE: For Research Use Only! Not For Use in Humans.

-80°C

7784-5   Pro-MMP-8, human   品牌 Biovision

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Pro-MMP-8, human

货号： 7784-5      产品名称： Pro-MMP-8, human   品牌： Biovision 规格： 5 μg 3周到货 生化实验

Pro-MMP-8, human
A Protein involved in breakdown of extracellular matrix
Product Overview
Alternate Name/Synonyms: MMP-8, matrix metalloproteinase-8, MMP, MMP recombinant, MMP protein
Gene Symbol: MMP8
Accession #: P22894
Gene ID: 4317
Source: Human neutrophil granulocytes (Buffy Coat)
Appearance: Liquid
Physical Form Description: In 50 mM Tris-HCl, pH 7; 200 mM NaCl; 5 mM CaCl₂; 1 μM ZnCl₂; 0.05% Brij 35; 0,05% NaN₃
Molecular Weight: 40/42 kDa
Purity by SDS-PAGE: N/A
Purity by HPLC: N/A
Endotoxin Level: N/A
Biological Activity: N/A
Reconstitution Instructions: N/A
Storage Temp.: -80°C
Shipping: Dry Ice
Background Information: Human neutrophil collagenase (HNC) has been purified from extracts of fresh and outdated buffy coats and from exudates of phorbol myristate acetate-stimulated neutrophils. The MMP-8 present in the starting material can either be latent or active, or have an app. relative molecular mass of 75-kDa and/or 58-kDa. The rather complex pattern of activation of the latent 58-kDa and 75-kDa species by trypsin, organomercurials and oxidants has been investigated. MMP-8 was shown to preferentially hydrolyze type I over type II, and type III collagens in solution and to be a glycoprotein that contains complex N-linked oligosaccharides leading to multiple forms of MMP-8 in SDS-PAGE. The action of endoglycosidase on the latent 58-kDa form produces 42/40-kDa species (Gao et al. 1992, Mallya et al. 1990). This indicates that MMP-8 is an N-linked, complex glycoprotein that appears to be glycosylated at multiple sites
Amino Acid Sequence: N/A
Handling: Centrifuge the vial prior to opening
USAGE: For Research Use Only! Not For Use in Humans.

-80°C

7785-10   Pro-MMP-13, human recombinant   品牌 Biovision

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Pro-MMP-13, human recombinant

货号： 7785-10      产品名称： Pro-MMP-13, human recombinant   品牌： Biovision 规格： 10 μg 3周到货 生化实验

Pro-MMP-13, human recombinant
A Protein involved in breakdown of extracellular matrix
Product Overview
Alternate Name/Synonyms: MMP-13, matrix metalloproteinase-13
Gene Symbol: MMP13
Accession #: P45452
Gene ID: 4322
Source: Sf9 cells
Appearance: Liquid
Physical Form Description: Liquid, 50 mM Tris pH 6.5, 250 mM NaCl, 5 mM CaCl2, 1 mM ZnCl2
Molecular Weight: 53.820 kDa
Purity by SDS-PAGE: ≥95%
Purity by HPLC: N/A
Endotoxin Level: N/A
Biological Activity: N/A
Reconstitution Instructions: N/A
Storage Temp.: -80°C
Shipping: Dry Ice
Background Information: MMP-13 (Collagenase-3) was first identified in human mammacarcinoma (Freije et al., 1994, Willmroth et al. 1998) – probably induced by IL1- alpha and IL-1 beta – and shown to be glycosylated and the inactive zymogen displaying a relative molecular weight of 60 kDa. Cleavage of the 84 residue propeptide can be catalysed by other MMPs such as MMP-2, MMP-3 and MMP-14, or by factors like plasmin. The proenzyme activated by APMA (paminohenylmercuric acteate) or MMPs, leads to the active enzyme with a relative molecular weight of app. 48 kDa which easily autodegrades into a 30 kDa form. This highly active 30 kDa form still retains the characteristics of the app. 48 kDa form. MMP-13 also plays a central role in the MMP activation cascade, both activating and being activated by several MMPs (Leeman et al., 2002)
Amino Acid Sequence: N/A
Handling: Centrifuge the vial prior to opening
USAGE: For Research Use Only! Not For Use in Humans.

-80°C

BML-PI139-0100   Z-Pro-Leu-Gly-NHOH   品牌 Biomol

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Z-Pro-Leu-Gly-NHOH

货号： BML-PI139-0100      产品名称： Z-Pro-Leu-Gly-NHOH   品牌： Biomol 规格： 100 mg 3周到货 生化实验

A short peptide hydroxamate that inhibits MMPs, astacin, meprin a, and likely other metzincin family members. Can also be used for purification of collagenase.
Product Specification
Sequence:Benzyloxycarbonyl-prolyl-leucyl-glycyl-hydroxamate
MW:434.5
Purity:98%
Long Term Storage:-20°C

-20°C

7490-1KIT   OmniPur SILVER PRO STAIN KIT   品牌 Merck

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OmniPur SILVER PRO STAIN KIT

货号： 7490-1KIT      产品名称： OmniPur SILVER PRO STAIN KIT   品牌： Merck 规格： *** 3周到货 生化实验

OmniPur® Silver Pro Stain Kit – Calbiochem
Specifications:
(Developer Solution) pH at 25°C: 10.00 min
Intended for laboratory and manufacturing use only. Not for drug, food, or household use.
商店和运输信息
Storage  +2°C to +8°C

2°C – 8°C

529659-10MG   Pro-survival Compound, DDD00033325   品牌 Merck

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Pro-survival Compound, DDD00033325

货号： 529659-10MG      产品名称： Pro-survival Compound, DDD00033325   品牌： Merck 规格： *** 3周到货 生化实验

Pro-survival Compound, DDD00033325
A cell-permeable, pyrrolidine small molecule that promotes single human embryonic stem cell survival up to 20-fold over background (EC50 = 3.9 µM), with equal or higher potency than Y-27632 ((Cat. No. 688000) in 5 cell lines (SA461, SA181, SA167, SA121 and SA002) tested at 10 µM. An in vitro high-content screening assay, which profiles a panel of more than 70 protein kinases, indicates that this small molecule is more selective than Y-27632 and only displays an inhibitory effect toward ROCK2 (> 83% inhibition, ROCK1 was not included in the panel) and PRK2 (76% inhibition) at 10 µM. Furthermore, it exhibits less cytotoxicity at a greater concentration of 30 µM than Y-27632 without marked adverse effects for up to 120 hours.
产品信息
Form  Yellow syrup
Molar mass  293.37
Protect from Light  是的
Packaged under inert gas  是的
Purity  ≥95% by HPLC
Solubility  DMSO
Chemical formula  C17H19N5
商店和运输信息
Storage  -20°C
Ship  Shipped with Blue Ice or with Dry Ice
Regulatory Review

-20°C