Pro-survival Compound, DDD00033325

货号： 529659-10MG      产品名称： Pro-survival Compound, DDD00033325   品牌： Merck 规格： *** 3周到货 生化实验

Pro-survival Compound, DDD00033325
A cell-permeable, pyrrolidine small molecule that promotes single human embryonic stem cell survival up to 20-fold over background (EC50 = 3.9 µM), with equal or higher potency than Y-27632 ((Cat. No. 688000) in 5 cell lines (SA461, SA181, SA167, SA121 and SA002) tested at 10 µM. An in vitro high-content screening assay, which profiles a panel of more than 70 protein kinases, indicates that this small molecule is more selective than Y-27632 and only displays an inhibitory effect toward ROCK2 (> 83% inhibition, ROCK1 was not included in the panel) and PRK2 (76% inhibition) at 10 µM. Furthermore, it exhibits less cytotoxicity at a greater concentration of 30 µM than Y-27632 without marked adverse effects for up to 120 hours.
产品信息
Form  Yellow syrup
Molar mass  293.37
Protect from Light  是的
Packaged under inert gas  是的
Purity  ≥95% by HPLC
Solubility  DMSO
Chemical formula  C17H19N5
商店和运输信息
Storage  -20°C
Ship  Shipped with Blue Ice or with Dry Ice
Regulatory Review

-20°C