标签归档：compound

361564-10MG   GSK3 Inhibitor, Compound A   品牌 Merck

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GSK3 Inhibitor, Compound A

货号： 361564-10MG      产品名称： GSK3 Inhibitor, Compound A   品牌： Merck 规格： *** 3周到货 生化实验

GSK-3 Inhibitor XXIII, 3F8
5-Ethyl-7,8-dimethoxy-1H-pyrrolo[3,4-c]-isoquinoline-1,3-(2H)-dione
A cell-permeable maleimide compound that acts as a potent, reversible, and ATP-competitive inhibitor against GSK-3β (Cat. No. 361524) activity (IC50 = 34, 67 and 304 nM in the presence of 10, 30 and 100 µM ATP, respectively), while exhibiting much reduced activity against Cdk2/A, KDR (71% and 53% inhibition, respectively, at 5µM inhibitor concentration), and a panel of 19 other kinases (IC50 >5 µM). Shown to potently activate cellular Wnt pathway and increase β-catenin-dependent reporter transcription (by 15-fold at 4 µM) in 293T cultures in vitro and, when applied at or prior to the shield stage of embryo, interfere with zebrafish forebrain development in vivo.
产品信息
Form  Yellow solid
Molar mass  286.3
Protect from Light  是的
Packaged under inert gas  是的
Purity  ≥95% by HPLC
Solubility  DMSO
Chemical formula  C15H14N2O4
CAS number  159109-11-2
商店和运输信息
Storage  -20°C
Ship  Ambient Temperature Only
Standard Handling

-20°C

529659-10MG   Pro-survival Compound, DDD00033325   品牌 Merck

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Pro-survival Compound, DDD00033325

货号： 529659-10MG      产品名称： Pro-survival Compound, DDD00033325   品牌： Merck 规格： *** 3周到货 生化实验

Pro-survival Compound, DDD00033325
A cell-permeable, pyrrolidine small molecule that promotes single human embryonic stem cell survival up to 20-fold over background (EC50 = 3.9 µM), with equal or higher potency than Y-27632 ((Cat. No. 688000) in 5 cell lines (SA461, SA181, SA167, SA121 and SA002) tested at 10 µM. An in vitro high-content screening assay, which profiles a panel of more than 70 protein kinases, indicates that this small molecule is more selective than Y-27632 and only displays an inhibitory effect toward ROCK2 (> 83% inhibition, ROCK1 was not included in the panel) and PRK2 (76% inhibition) at 10 µM. Furthermore, it exhibits less cytotoxicity at a greater concentration of 30 µM than Y-27632 without marked adverse effects for up to 120 hours.
产品信息
Form  Yellow syrup
Molar mass  293.37
Protect from Light  是的
Packaged under inert gas  是的
Purity  ≥95% by HPLC
Solubility  DMSO
Chemical formula  C17H19N5
商店和运输信息
Storage  -20°C
Ship  Shipped with Blue Ice or with Dry Ice
Regulatory Review

-20°C

352010-10MG   Glutaminase Inhibitor, Compound 968   品牌 Merck

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Glutaminase Inhibitor, Compound 968

货号： 352010-10MG      产品名称： Glutaminase Inhibitor, Compound 968   品牌： Merck 规格： *** 3周到货 生化实验

352010-10MG   Glutaminase Inhibitor, Compound 968   品牌 Merck

Glutaminase Inhibitor, Compound 968
A cell-permeable benzophenanthridinone compound that acts as an allosteric and reversible inhibitor of mitochondrial glutaminase activity and represses the growth and invasive activity in glutaminase upregulated fibroblasts and in tumor cells (IC50 ≤ 10 µM in NIH3T3 cells stably expressing Dbl, Cdc42-F28L, Rac-F28L or RhoC-F30L mutants and in SKBR3 and MDA-MB231 cancer cells). Shown to effectively shrink tumor size in P-493 B xenografted mouse model (200 µg per inj. i.p., 12 days). Also available as a 10 mM solution in DMSO (Cat. No. 506073).
产品信息
Form  White powder
Molar mass  475.4
Protect from Light  是的
Packaged under inert gas  是的
Purity  ≥99% by HPLC
Solubility  DMSO
Chemical formula  C27H27BrN2O
商店和运输信息
Storage  -20°C
Ship  Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Standard Handling

-20°C

ALX-270-316-C500   Compound 56   品牌 Alexis

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Compound 56

货号： ALX-270-316-C500      产品名称： Compound 56   品牌： Alexis 规格： 500.micro.g 3周到货 生化实验

Compound 56
EGFR inhibitor 
Potent and specific inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR) (IC50=6pM).
Product Specification
Alternative Name: 4-[(3-Bromophenyl)amino]-6,7-diethoxyquinazoline
Formula: C18H18BrN3O2
MW: 388.3
CAS: 171745-13-4
Purity: ≥97% (HPLC)
Appearance: White to off-white powder.
Hazard: HARMFUL.
        MAY BE MUTAGENIC.
Solubility: Soluble in DMSO (200mg/ml).
Long Term Storage: -20°C
Handling: Protect from light.

-20°C

ALX-270-415-C250   Compound E   品牌 Alexis

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Compound E

货号： ALX-270-415-C250      产品名称： Compound E   品牌： Alexis 规格： 250.micro.g 3周到货 生化实验

Compound E
γ-Secretase inhibitor  
Cell permeable, potent, selective, non-transition state and non-competitive inhibitor of γ-secretase (IC50=0.3nM for total β-amyloid) and Notch processing, which ceases cell differentiation. At higher concentrations (20-400µM), only weakly affects the presenilase activity. Activity tested!
Product Specification
Alternative Name: (2S)-2-{[(3,5-Difluorophenyl)acetyl]amino}-N-[(3S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]propanamide, γ-Secretase Inhibitor, GSI
Formula: C27H24F2N4O3
MW: 490.5
CAS: 209986-17-4
Formulation: White to off-white powder.
Purity: ≥98% (HPLC)
Solubility: Soluble in DMSO.
Short Term Storage: +4°C
Long Term Storage: -20°C
Handling: Keep under inert gas.

-20°C

ALX-270-415-M001   Compound E   品牌 Alexis

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Compound E

货号： ALX-270-415-M001      产品名称： Compound E   品牌： Alexis 规格： 1 mg 3周到货 生化实验

Compound E
γ-Secretase inhibitor  
Cell permeable, potent, selective, non-transition state and non-competitive inhibitor of γ-secretase (IC50=0.3nM for total β-amyloid) and Notch processing, which ceases cell differentiation. At higher concentrations (20-400µM), only weakly affects the presenilase activity. Activity tested!
Product Specification
Alternative Name: (2S)-2-{[(3,5-Difluorophenyl)acetyl]amino}-N-[(3S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]propanamide, γ-Secretase Inhibitor, GSI
Formula: C27H24F2N4O3
MW: 490.5
CAS: 209986-17-4
Formulation: White to off-white powder.
Purity: ≥98% (HPLC)
Solubility: Soluble in DMSO.
Short Term Storage: +4°C
Long Term Storage: -20°C
Handling: Keep under inert gas.

-20°C

ALX-270-417-C200   Compound 34   品牌 Alexis

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Compound 34

货号： ALX-270-417-C200      产品名称： Compound 34   品牌： Alexis 规格： 200.micro.g 3周到货 生化实验

Compound 34
γ-Secretase inhibitor 
Cell permeable, highly potent inhibitor of γ-secretase (IC50=0.06nM).
Product Specification
Formula: C31H24F3N3O3
MW: 543.5
Purity: ≥98%
Appearance: White to off-white powder.
Solubility: Soluble in DMSO.
Long Term Storage: -20°C
Handling: Protect from light. Hygroscopic.

-20°C

ALX-270-417-M001   Compound 34   品牌 Alexis

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Compound 34

货号： ALX-270-417-M001      产品名称： Compound 34   品牌： Alexis 规格： 1 mg 3周到货 生化实验

Compound 34
γ-Secretase inhibitor 
Cell permeable, highly potent inhibitor of γ-secretase (IC50=0.06nM).
Product Specification
Formula: C31H24F3N3O3
MW: 543.5
Purity: ≥98%
Appearance: White to off-white powder.
Solubility: Soluble in DMSO.
Long Term Storage: -20°C
Handling: Protect from light. Hygroscopic.

-20°C

ALX-270-455-M001   Compound 15e   品牌 Alexis

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Compound 15e

货号： ALX-270-455-M001      产品名称： Compound 15e   品牌： Alexis 规格： 1 mg 3周到货 生化实验

Compound 15e
PI3 kinase inhibitor
Potent and specific inhibitor of phosphoinositide 3-kinasep110α isoform (IC50=0.0020µM). p110β isoform (IC50=0.016µM)p110γ isoform (IC50=0.66µM)C2β isoform (IC50=0.22µM). Inhibits proliferation of A375 melanoma cells (IC50=0.58µM). Inhibits proliferation of U87MG human glioblastoma cells (IC50=1.10.µM).Inhibits proliferation of A2780 human ovarian cells (IC50=0.27µM).
Product Specification
Alternative Name: 3-[4-(4-Morpholinyl)thieno[3,2-d]pyrimidin-2-yl]-phenol
Formula: C16H15N3O2S
MW: 313.4
CAS: 371943-05-4
Purity: ≥99% (HPLC)
Appearance: White to off-white solid.
Solubility: Soluble in DMSO or dioxane.
Long Term Storage: -20°C

-20°C

ALX-270-455-M005   Compound 15e   品牌 Alexis

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Compound 15e

货号： ALX-270-455-M005      产品名称： Compound 15e   品牌： Alexis 规格： 5 mg 生化实验

Compound 15e
PI3 kinase inhibitor
Potent and specific inhibitor of phosphoinositide 3-kinasep110α isoform (IC50=0.0020µM). p110β isoform (IC50=0.016µM)p110γ isoform (IC50=0.66µM)C2β isoform (IC50=0.22µM). Inhibits proliferation of A375 melanoma cells (IC50=0.58µM). Inhibits proliferation of U87MG human glioblastoma cells (IC50=1.10.µM).Inhibits proliferation of A2780 human ovarian cells (IC50=0.27µM).
Product Specification
Alternative Name: 3-[4-(4-Morpholinyl)thieno[3,2-d]pyrimidin-2-yl]-phenol
Formula: C16H15N3O2S
MW: 313.4
CAS: 371943-05-4
Purity: ≥99% (HPLC)
Appearance: White to off-white solid.
Solubility: Soluble in DMSO or dioxane.
Long Term Storage: -20°C

-20°C

ALX-420-008-M100   Compound 48/80 . trihydrochloride   品牌 Alexis

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Compound 48/80 . trihydrochloride

货号： ALX-420-008-M100      产品名称： Compound 48/80 . trihydrochloride   品牌： Alexis 规格： 100 mg 3周到货 生化实验

Compound 48/80 . trihydrochloride
G protein activator
Compound 48/80 is an oligomeric mixture of condensation products of N-methyl-p-methoxyphenethylamine and formaldehyde. It activates G proteins by a mechanism analogous to that of mastoparan. It inhibits calmodulin and human platelet PLC and exhibits a concentration dependent biphasic modulation of human platelet PLA2.
Product Specification
Formula: C32H46N3O3 . 3HCl
MW: 520.7 . 109.4
CAS: 94724-12-6
Purity: ≥98%
Appearance: White to off-white solid.
Hazard: TOXIC.
Solubility: Soluble in water (100mg/ml).
Long Term Storage: -20°C
Use/Stability: Stock solutions are stable for up to 3 months when stored at -20°C.

-20°C

ALX-550-516-M005   Compound A   品牌 Alexis

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Compound A

货号： ALX-550-516-M005      产品名称： Compound A   品牌： Alexis 规格： 5 mg 3周到货 生化实验

Compound AGlucocorticoid receptor modulatorCell permeable, nonsteroidal glucocorticoid receptor modulator with high binding affinity. Exerts anti-inflammatory potential by down-modulating TNF-induced pro-inflammatory gene expression, such as IL-6 and E-selectin. Unlike dexamethasone (Prod. No. BML-EI126) it does not enhance glucocorticoid response element (GRE)-driven gene expression or induce glucocorticoid receptor (GR) binding to GRE-dependent genes in vivo. Product SpecificationAlternative Name: CpdA, 2-((4-Acetophenyl)-2-chloro-N-methyl)ethylammonium chloride Formula: C11H14ClNO2 . HCl MW: 227.7 . 36.5 CAS: 14593-25-0 Purity: ≥98% (HPLC) Appearance: White to off-white solid. Solubility: Soluble in DMSO, 100% ethanol or water. Short Term Storage: +4°C Long Term Storage: -80°C Use/Stability: Stock solutions in ethanol are stable for up to 1 month when stored at -80°C. Handling: Protect from moisture. After reconstitution, prepare aliquots and store at -80°C. -80°C