Pro-MMP-13, human recombinant

货号： 7785-10      产品名称： Pro-MMP-13, human recombinant   品牌： Biovision 规格： 10 μg 3周到货 生化实验

Pro-MMP-13, human recombinant
A Protein involved in breakdown of extracellular matrix
Product Overview
Alternate Name/Synonyms: MMP-13, matrix metalloproteinase-13
Gene Symbol: MMP13
Accession #: P45452
Gene ID: 4322
Source: Sf9 cells
Appearance: Liquid
Physical Form Description: Liquid, 50 mM Tris pH 6.5, 250 mM NaCl, 5 mM CaCl2, 1 mM ZnCl2
Molecular Weight: 53.820 kDa
Purity by SDS-PAGE: ≥95%
Purity by HPLC: N/A
Endotoxin Level: N/A
Biological Activity: N/A
Reconstitution Instructions: N/A
Storage Temp.: -80°C
Shipping: Dry Ice
Background Information: MMP-13 (Collagenase-3) was first identified in human mammacarcinoma (Freije et al., 1994, Willmroth et al. 1998) – probably induced by IL1- alpha and IL-1 beta – and shown to be glycosylated and the inactive zymogen displaying a relative molecular weight of 60 kDa. Cleavage of the 84 residue propeptide can be catalysed by other MMPs such as MMP-2, MMP-3 and MMP-14, or by factors like plasmin. The proenzyme activated by APMA (paminohenylmercuric acteate) or MMPs, leads to the active enzyme with a relative molecular weight of app. 48 kDa which easily autodegrades into a 30 kDa form. This highly active 30 kDa form still retains the characteristics of the app. 48 kDa form. MMP-13 also plays a central role in the MMP activation cascade, both activating and being activated by several MMPs (Leeman et al., 2002)
Amino Acid Sequence: N/A
Handling: Centrifuge the vial prior to opening
USAGE: For Research Use Only! Not For Use in Humans.

-80°C