标签归档：toxin

C9903-1MG   Cholera Toxin B subunit|CTB|霍乱毒素B亚基   品牌 Sigma

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Cholera Toxin B subunit|CTB|霍乱毒素B亚基

货号： C9903-1MG      产品名称： Cholera Toxin B subunit|CTB|霍乱毒素B亚基   品牌： Sigma 规格： 1mg

C9903-1MG   Cholera Toxin B subunit|CTB|霍乱毒素B亚基   品牌 Sigma

C9903-1MG   Cholera Toxin B subunit|CTB|霍乱毒素B亚基   品牌 Sigma

Cholera Toxin B subunit 

≥95% (SDS-PAGE), lyophilized powder
assay    ≥95% (SDS-PAGE) 
form    lyophilized powder 
mol wt    mol wt ~12 kDa 
composition    Protein, ~5% Lowry 
total impurities    ≤0.5% Cholera toxin A subunit (SDS-PAGE) 
solubility    H2O: soluble10 mg/mL (stable indefinitely at 2-8 °C.) 
storage temp.    2-8°C 

2-8°C

C8052   Cholera Toxin|Cholergen|Cholera enterotoxin|霍乱毒素|   品牌 Sigma

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Cholera Toxin|Cholergen|Cholera enterotoxin|霍乱毒素|

货号： C8052      产品名称： Cholera Toxin|Cholergen|Cholera enterotoxin|霍乱毒素|   品牌： Sigma 规格： 0.5mg原装 大量现货 科研用

C8052   Cholera Toxin|Cholergen|Cholera enterotoxin|霍乱毒素|   品牌 Sigma

Cholera Toxin from Vibrio cholerae
别名: Cholera enterotoxin, Cholergen
CAS号: 9012-63-9
MDL number: MFCD00130776
包装
Package size based on protein content.
Reconstitution
When reconstituted at 1 mg/mL in water, solution will contain 0.05 M Tris buffer salts, pH 7.5, 0.2 M NaCl, 0.003 M NaN3, ａnd 0.001 M sodium EDTA. Store reconstituted solutions in the refrigerator.
Unit Definition
One unit increases adenylate cyclase activity 6-fold, measured as [3H]-cAMP present, using approx. 70,000 CHO cells after incubation for 90 min at 37 °C with [3H]-adenine followed by a 15 min incubation with 1 mM 3-isobutyl-1-methylxanthine （IBMX）.
Physical form
Lyophilized powder containing Tris buffer salts, sodium chloride, sodium azide ａnd sodium EDTA
Biochem/physiol Actions
Toxin consisting of an A subunit （27 kDa） surrounded by five B subunits （approximately 12 kDa each）, which attach the toxin to ganglioside GM1 on the cell surface. The A subunit catalyzes ADP-ribosylation of the α-subunit of the stimulatory G protein （Gαs）, reducing GTPase activity ａnd activating the α-subunit. This activation of Gαs leads to an increase in the activity of adenylyl cyclase, resulting in increased levels of cAMP. Also ADP-ribosylates transducin in the eye rod outer segments, inactivating its GTPase activity. Cholera toxin has also been reported to ADP-ribosylate tubulin. Shown to be a potent mucosal vaccine adjuvant, inducing T helper cell type 2 responses by inhibiting the production of interleukin-12.
相关类型 Bacteria, Bioactive Small Molecules, C-CH, Cell Biology, Cell Signaling ａnd Neuroscience,
G Protein Function, G Proteins ａnd Cyclic Nucleotides, Reagents, Toxins ａnd Venoms
Quality Level PREMIUM
assay ~95% （SDS-PAGE）
form lyophilized powder
composition Protein, ~5% Lowry-TCA 
solubility H2O: soluble10 mg/mL
storage temp. 2-8°C

2-8度

10576-500   HC Toxin   品牌 Cayman

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HC Toxin

货号： 10576-500      产品名称： HC Toxin   品牌： Cayman 规格： 500 碌g 3周

HC Toxin Cayman Chemical Item Number 10576 Description HC Toxin is a cell-permeable, reversible inhibitor of histone deacetylases (HDACs) (IC50 = 30 nM).1↗,2↗ Through its effects on HDACs, HC toxin has been shown to up-regulate the expression of 15-lipoxygenase-1 in colorectal cancer cells and induce fetal hemoglobin in human primary erythroid cells.3↗,4↗ HC Toxin is a cyclic tetrapeptide first isolated from H. carbonum (now C. carbonum), a pathogen of maize.5↗ Synonyms Toxin I (Helminthosporium carbonum) Formal Name (6R,​9S,​14aR)-​3,​6R-​dimethyl-​9S-​(6-​((S)-​oxiran-​2-​yl)-​6-​oxohexyl)decahydropyrrolo[1,​2-​a][1,​4,​7,​10]tetraazacyclododecine-​1,​4,​7,​10-​tetranone CAS Number 83209-65-8 Molecular Formula C21H32N4O6 Formula Weight 436.5 Formulation A crystalline solid Purity ≥95% λmax 232 nm Stability 2 years Storage -20°C Shipping Room temperature in continental US; may vary elsewhere SMILES [H]​[C@@]​12C(N([H]​)​[C@@H]​(C)​C(N([H]​)​[C@H]​(C)​C(N([H]​)​[C@]​(CCCCCC([C@@H]​3CO3)​=O)​([H]​)​C(N1CCC2)​=O)​=O)​=O)​=O InCHI Code ​1S/C21H32N4O6/c1-12-18(27)​22-13(2)​19(28)​24-14(7-4-3-5-9-16(26)​17-11-31-17)​21(30)​25-10-6-8-15(25)​20(29)​23-12/h12-15,17H,3-11H2,1-2H3,(H,22,27)​(H,23,29)​(H,24,28)​/t12-,13+,14-,15+,17-/m0/s1 InCHI Key GNYCTMYOHGBSBI-SVZOTFJBSA-N -20°C