HC Toxin Cayman Chemical Item Number 10576 Description HC Toxin is a cell-permeable, reversible inhibitor of histone deacetylases (HDACs) (IC50 = 30 nM).1↗,2↗ Through its effects on HDACs, HC toxin has been shown to up-regulate the expression of 15-lipoxygenase-1 in colorectal cancer cells and induce fetal hemoglobin in human primary erythroid cells.3↗,4↗ HC Toxin is a cyclic tetrapeptide first isolated from H. carbonum (now C. carbonum), a pathogen of maize.5↗ Synonyms Toxin I (Helminthosporium carbonum) Formal Name (6R,9S,14aR)-3,6R-dimethyl-9S-(6-((S)-oxiran-2-yl)-6-oxohexyl)decahydropyrrolo[1,2-a][1,4,7,10]tetraazacyclododecine-1,4,7,10-tetranone CAS Number 83209-65-8 Molecular Formula C21H32N4O6 Formula Weight 436.5 Formulation A crystalline solid Purity ≥95% λmax 232 nm Stability 2 years Storage -20°C Shipping Room temperature in continental US; may vary elsewhere SMILES [H][C@@]12C(N([H])[C@@H](C)C(N([H])[C@H](C)C(N([H])[C@](CCCCCC([C@@H]3CO3)=O)([H])C(N1CCC2)=O)=O)=O)=O InCHI Code 1S/C21H32N4O6/c1-12-18(27)22-13(2)19(28)24-14(7-4-3-5-9-16(26)17-11-31-17)21(30)25-10-6-8-15(25)20(29)23-12/h12-15,17H,3-11H2,1-2H3,(H,22,27)(H,23,29)(H,24,28)/t12-,13+,14-,15+,17-/m0/s1 InCHI Key GNYCTMYOHGBSBI-SVZOTFJBSA-N -20°C
