MG-132

货号： 1703-25      产品名称： MG-132   品牌： Biovision 规格： 25 mg 3周到货 生化实验

MG-132
Product Overview
Product Name: MG-132
Alternate Name/Synonyms: Z-Leu-Leu-Leu-CHO; Z-LLL-CHO
Description: A cell-permeable, potent, and reversible proteasome inhibitor (Ki = 4 nM). Reduces degradation of ubiquitin-conjugated proteins in mammalian cells and permeable strains of yeast by the 26S complex without affecting its ATPase or isopeptidase activities. Activates c-Jun N-terminal kinase (JNK1), which initiates apoptosis. Inhibits NF-kB activation (IC₅₀ = 3 µM). Prevents γ-secretase cleavage.
Peptide Sequence: Z-Leu-Leu-Leu-CHO; Z-LLL-CHO
Appearance: White to off-white solid
Formulation: N/A
CAS Number: 133407-82-6
Molecular Formula: C₂₆H₄₁N₃O₅
Molecular Weight: 475.6
Purity: ≥98% by HPLC
Solubility:DMSO (10 mg/ml)
Storage Temp.: +4°C
Shipping Conditions: gel pack
Handling: Protect from air and moisture
SMILES: CC(C)CC(C=O)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)OCC1=CC=CC=C1
InChi: InChI=1S/C26H41N3O5/c1-17(2)12-21(15-30)27-24(31)22(13-18(3)4)28-25(32)23(14-19(5)6)29-26(33)34-16-20-10-8-7-9-11-20/h7-11,15,17-19,21-23H,12-14,16H2,1-6H3,(H,27,31)(H,28,32)(H,29,33)/t21-,22-,23-/m0/s1
InChi Key: TZYWCYJVHRLUCT-VABKMULXSA-N
PubChem CID: 462382
MDL Number: MFCD00674886
USAGE: For Research Use Only! Not For Use in Humans.

+4°C