PathwayReady PI3-K/Akt/mTOR Signaling Inhibitor Panel
货号: K857-11 产品名称: PathwayReady PI3-K/Akt/mTOR Signaling Inhibitor Panel 品牌: Biovision 规格: 11 inhibitors 3周到货 生化实验
PathwayReady™ PI3-K/Akt/mTOR Signaling Inhibitor Panel
A PI3-K/Akt/mTOR Signaling Inhibitor Panel
Product Overview
Alternate Name/Synonyms: PI3-K/Akt/mTOR Signaling Inhibitor Panel, PathwayReady™
Peptide sequence: N/A
Appearance: Lyophilized solids
Formulation: N/A
CAS Number: See under the individual product
Molecular Formula: See under the individual product
Molecular Weight: See under the individual product
Purity: ≥95% by HPLC
Solubility: DMSO
Storage Temp.: -20°C
Shipping Conditions: gel pack
Description: A convenient set consisting of eleven inhibitors useful for the study of PI3-K/Akt/mTOR pathway. The 11 inhibitors are: 1 mg of Akt Inhibitor, Isozyme-selective (Cat. No. 1708-1), 5 mg of BEZ-235 (Cat. No. 1626-5), 5 mg of LY-294002 (Cat. No. 1667-5), 1 mg of mTOR Inhibitor Ku-0063794 (Cat. No. 1779-1), 1 mg of PI-103 (Cat. No. 1728-1), 1 mg of PI3-Kγ Inhibitor, AS-605240 (Cat. No. 1780-1), 1 mg of PP242 (Cat. No. 1658-1), 1 mg of Rapamycin (Cat. No. 1568-1), 1 mg of TGX-221 (Cat. No. 1781-1), 1 mg of Triciribine (Cat. No. 1707-1), and 1 mg of Wortmannin (Cat. No. 1670-1).
Handling: Protect from air and light
USAGE: For Research Use Only! Not For Use in Humans.
-20°C
MA120325 Phospho-AKT1 pSer473 品牌 Pierce
Phospho-AKT1 pSer473
货号: MA120325 产品名称: Phospho-AKT1 pSer473 品牌: Pierce 规格: 50 μg
V1911 AKT1 Kinase Enzyme System 品牌 Promega
AKT1 Kinase Enzyme System
货号: V1911 产品名称: AKT1 Kinase Enzyme System 品牌: Promega 规格: 10μg 二周到货 生化试验
说明
在 Sf9 昆虫细胞中,我们通过杆状病毒表达 N 端带 GST 标签的重组全长人源 AKT1 。 AKT1/PKBα 是 AKT 家族中的一个丝 / 苏氨酸激酶。细胞内的 AKT1 可以对激素、生长因子、胞外基质组分等多种刺激作出应答而被激活,并参与到糖类代谢、转录、存活、细胞增殖、血管生成及细胞运动等多种生命活动中。在人类的许多癌症中,如结肠癌、乳腺癌、脑癌、胰腺癌、前列腺癌、及淋巴瘤和白血病中,常常发现 AKT1 过表达并处于激活状态。
ADP-Glo™ Kinase Assay (ADP-Glo™ 激酶检测试剂盒) 是一种发光法激酶检测试剂盒,用于 检测 激酶反应产生的 ADP 含量: ADP 转化为 ATP 后, ATP 即可作为 Ultra-Glo™ 萤光素酶 催化反应的底物,产生光信号。发光信号与 ADP 的量和激酶活性正相关。该试剂盒适合检测化合物对纯化的多种激酶活性的影响,使之成为初筛和激酶选择性概况分析的理想工具。 ADP-Glo™ 激酶检测试剂盒可用于检测几乎所有可生成 ADP 的酶类 ( 如激酶或 ATP 酶 ) 的活性, ATP 浓度可高达 1 mM 。
激酶酶系统的组成:
• 激酶: AKT1 , 10μg ( 人源,重组全长蛋白 ) ; MW : ~85kDa 。
• 底物: Akt (PKB) 底物( CKRPRAASFAE );从 GSK3 的 N 末端衍生得到。
• 其它组分: 反应缓冲液, DTT 。
AKT1 NCBI Database Entry 数据库入口 。
人类激酶酶系统及其应用。
特点 • 在实验室内即可筛选更多的化合物: ADP-Glo™ 激酶检测试剂盒 与激酶酶系统的优化组合,使您可以迅速方便地开始实验。
• 完整的系统: 激酶酶系统包含重组激酶、激酶的最适底物、反应缓冲液、以及使用前需加入缓冲液的 DTT 和 MnCl2 。
• 可得到可靠结果: ADP-Glo™ 激酶检测试剂盒提供了宽广的动态范围、方便的操作方法、以及更好的灵敏度,产生的数据更可靠。
ST1088-1SET ANTI-AKT, PH DOMAIN MOUSE MAB (SKB1) 品牌 Merck
ANTI-AKT, PH DOMAIN MOUSE MAB (SKB1)
货号: ST1088-1SET 产品名称: ANTI-AKT, PH DOMAIN MOUSE MAB (SKB1) 品牌: Merck 规格: *** 3周到货 生化实验
Anti-Akt, PH Domain Mouse mAb (SKB1)
Anti-PKB, Pleckstrin Homology Domain
Recognizes the ~60 kDa Akt protein in A431 cells. Useful for the concentration of Akt in samples by immunoprecipitation prior to use in the K-LISA™ Akt Activity Kit (Cat. No. CBA019).
Antibody Target Gene Symbol: AKT1
Target Synonym: AKT, MGC99656, PKB, PKB-ALPHA, PKB/AKT, PRKBA, Protein kinase B, RAC, RAC-ALPHA, Thymoma viral proto-oncogene 1
Entrez Gene Name: v-akt murine thymoma viral oncogene homolog 1
Hu Entrez ID: 207 (Related Antibodies: 530311, PK1203, PC510 and 124001)
Mu Entrez ID: 11651
Rat Entrez ID: 24185
产品信息
Host Mouse
Isotype IgG
Immunogen a recombinant protein consisting of amino acids 1-149 of human Akt 1 fused to GST
Clone SKB1
Form Liquid
Formulation 100 µg antibody in 150 mM NaCl, 100 mM Tris-glycine, 30% glycerol, pH 7.4 and 100 µg control lysate.
Species reactivity human, mouse, rat
Preservative ≤0.1% sodium azide
Applications
Flow Cytometry
Immunoblotting (Western Blotting)
Immunoprecipitation
Avoid freeze/thaw 是的
Positive control A431 cells (included)
商店和运输信息
Storage -20°C
Ship Shipped with Blue Ice or with Dry Ice
Standard Handling
-20°C
V3861 AKT2 Kinase Enzyme System 品牌 Promega
AKT2 Kinase Enzyme System
货号: V3861 产品名称: AKT2 Kinase Enzyme System 品牌: Promega 规格: 10μg 二周到货 生化试验
说明
在 Sf9 昆虫细胞中,我们通过杆状病毒 表达 N 端带 GST 标签的 重组 全长人源 AKT2 。 AKT2 或蛋白激酶 B β ( PKBβ )是 AKT 家族中的一个丝 / 苏氨酸激酶。与其他 AKT 成员一样,细胞内的 AKT2 可以对激素、生长因子、胞外基质组分等多种刺激作出应答而被激活,并参与到糖类代谢、转录、存活、细胞增殖、血管生成及细胞运动等多种生命活动中。 AKT2 被转运到质膜上后,被 PDK-1 (磷酸肌醇依赖的激酶 1 )磷酸化和活化;其转运过程需要一个来源于 PI3K 的脂质第二信使 PIP3 (磷酯酰肌醇 -3,4,5- 三磷酸)的参与。
ADP-Glo™ Kinase Assay (ADP-Glo™ 激酶检测试剂盒) 是一种发光法激酶检测试剂盒,用于 检测 激酶反应产生的 ADP 含量: ADP 转化为 ATP 后, ATP 即可作为 Ultra-Glo™ 萤光素酶 催化反应的底物,产生光信号。发光信号与 ADP 的量和激酶活性正相关。 该试剂盒适合检测化合物对纯化的多种激酶活性的影响,使之成为初筛和激酶选择性概况分析的理想工具。 ADP-Glo™ 激酶检测试剂盒可用于检测几乎所有可生成 ADP 的酶类 ( 如激酶或 ATP 酶 ) 的活性, ATP 浓度可高达 1 mM 。
激酶酶系统的组成:
• 激酶: AKT2 , 10μg ( 人源,重组全长蛋白 ) ; MW : ~85kDa 。
• 底物: 经过修饰的 AKT 底物肽(修饰的 CKRPRAASFAE );基于 GSK3 的 N 末端。
• 其它组分: 反应缓冲液, DTT 。
AKT2 NCBI 数据库入口。
人类激酶酶系统及其应用。
特点 • 在实验室内即可筛选更多的化合物: ADP-Glo™ 激酶检测试剂盒 与激酶酶系统的优化组合,使您可以迅速方便地开始实验。
• 完整的系统: 激酶酶系统包含重组激酶、激酶的最适底物、反应缓冲液、以及使用前需加入缓冲液的 DTT 和 MnCl2 。
• 可得到可靠结果: ADP-Glo™ 激酶检测试剂盒提供了宽广的动态范围、方便的操作方法、以及更好的灵敏度,产生的数据更可靠。
7701-100 Akt1, Active 品牌 Biovision
Akt1, Active
货号: 7701-100 产品名称: Akt1, Active 品牌: Biovision 规格: 100 μg 3周到货 生化实验
Active Akt1
Protein involved in cellular survival pathways
Product Overview
Alternate Names / Synonyms: Active Akt1, Akt1, human Akt1, active kinase, active kinases, Akt, recombinant Akt1, recombinant Akt, kinase activity assay, protein kinase, akt 1, akt-1
Gene Symbol: AKT1
Accession #: P31749
Gene ID: 207
Source: Baculovirus (Sf9 insect cells)
Appearance: Liquid
Physical Form Description: Recombinant proteins in storage buffer (50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol).
Molecular Weight: ~85.0 kDa
Purity by SDS-PAGE: ≥90%
Purity by HPLC: N/A
Endotoxin Level: N/A
Biological Activity: 124 nmol phosphate incorporated into Akt substrate peptide per minute per mg protein at 30°C for 15 minutes using a final concentration of 50 µM ATP and total of 0.83 µCi/µl P-32.
Reconstitution Instructions: N/A
Storage Temp.: -80°C
Shipping: gel pack
Background Information: Akt1 or Protein Kinase B α(PKBα) is a serine/threonine kinase that belongs to the Akt family. Akt1 is activated in cells in response to diverse stimuli such as hormones, growth factors and extracellular matrix components and is involved in glucose metabolism, transcription, survival, cell proliferation, angiogenesis, and cell motility (1). The PI3K generates phosphatidylinositol-3,4,5-trisphosphate (PIP3), a lipid second messenger essential for the translocation of Akt1 to the plasma membrane where it is phosphorylated and activated by phosphoinositide-dependent kinase-1 (PDK-1) (2) and phosphoinositide-dependent kinase-2 (possibly ILK) (3). Akt1 has numerous cellular substrates including proteins, which promote the inhibition of apoptosis such as the Forkhead transcription factors and the Bcl-2 family member Bad (4). In addition, the cyclin dependent kinase inhibitors are substrates of Akt which when phosphorylated relinquish their inhibitory influence on cell cycle progression. Akt also mediates many of the stimulatory effects of insulin on glucose metabolism through deactivation of glycogen synthase kinase, activation of phosphofructo-kinase, and modulation of glucose transporter activity. Akt1 has been shown to play a role in human cancers (4). It is frequently overexpressed and active in many types of human cancers including cancers of colon, breast, brain, pancreas and prostate as well as lymphomas and leukemias (5). Akt1 plays an important role in cancer cell survival and proliferation thereby contributing to cancer progression.
Handling: Centrifuge the vial prior to opening.
Usage: For Research Use Only! Not to be used in humans.
-80°C
7701-5 Akt1, Active 品牌 Biovision
Akt1, Active
货号: 7701-5 产品名称: Akt1, Active 品牌: Biovision 规格: 5 μg 3周到货 生化实验
Active Akt1
Protein involved in cellular survival pathways
Product Overview
Alternate Names / Synonyms: Active Akt1, Akt1, human Akt1, active kinase, active kinases, Akt, recombinant Akt1, recombinant Akt, kinase activity assay, protein kinase, akt 1, akt-1
Gene Symbol: AKT1
Accession #: P31749
Gene ID: 207
Source: Baculovirus (Sf9 insect cells)
Appearance: Liquid
Physical Form Description: Recombinant proteins in storage buffer (50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol).
Molecular Weight: ~85.0 kDa
Purity by SDS-PAGE: ≥90%
Purity by HPLC: N/A
Endotoxin Level: N/A
Biological Activity: 124 nmol phosphate incorporated into Akt substrate peptide per minute per mg protein at 30°C for 15 minutes using a final concentration of 50 µM ATP and total of 0.83 µCi/µl P-32.
Reconstitution Instructions: N/A
Storage Temp.: -80°C
Shipping: gel pack
Background Information: Akt1 or Protein Kinase B α(PKBα) is a serine/threonine kinase that belongs to the Akt family. Akt1 is activated in cells in response to diverse stimuli such as hormones, growth factors and extracellular matrix components and is involved in glucose metabolism, transcription, survival, cell proliferation, angiogenesis, and cell motility (1). The PI3K generates phosphatidylinositol-3,4,5-trisphosphate (PIP3), a lipid second messenger essential for the translocation of Akt1 to the plasma membrane where it is phosphorylated and activated by phosphoinositide-dependent kinase-1 (PDK-1) (2) and phosphoinositide-dependent kinase-2 (possibly ILK) (3). Akt1 has numerous cellular substrates including proteins, which promote the inhibition of apoptosis such as the Forkhead transcription factors and the Bcl-2 family member Bad (4). In addition, the cyclin dependent kinase inhibitors are substrates of Akt which when phosphorylated relinquish their inhibitory influence on cell cycle progression. Akt also mediates many of the stimulatory effects of insulin on glucose metabolism through deactivation of glycogen synthase kinase, activation of phosphofructo-kinase, and modulation of glucose transporter activity. Akt1 has been shown to play a role in human cancers (4). It is frequently overexpressed and active in many types of human cancers including cancers of colon, breast, brain, pancreas and prostate as well as lymphomas and leukemias (5). Akt1 plays an important role in cancer cell survival and proliferation thereby contributing to cancer progression.
Handling: Centrifuge the vial prior to opening.
Usage: For Research Use Only! Not to be used in humans.
-80°C
7702-5 Akt2, Active 品牌 Biovision
Akt2, Active
货号: 7702-5 产品名称: Akt2, Active 品牌: Biovision 规格: 5 μg 3周到货 生化实验
Active Akt2
An important signaling molecule in the Insulin signaling pathway
Product Overview
Alternate Names / Synonyms: Active Akt2, Akt2, human Akt2, active kinase, active kinases, Akt, recombinant Akt2, recombinant Akt, kinase activity assay, protein kinase, akt 2, akt-2,
Gene Symbol: AKT2
Accession #: P31751
Gene ID: 208
Source: Baculovirus (Sf9 insect cells)
Appearance: Liquid
Physical Form Description: Recombinant proteins in storage buffer (50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol).
Molecular Weight: 58.0 kDa
Purity by SDS-PAGE: ≥90%
Purity by HPLC: N/A
Endotoxin Level: N/A
Biological Activity: 46 nmol phosphate incorporated into Akt/SGK substrate (RPRAATF) per minute per mg protein at 30°C for 15 minutes using a final concentration of 50 µM ATP and total of 0.83 µCi/µl P-32.
Reconstitution Instructions: N/A
Storage Temp.: -80°C
Shipping: gel pack
Background Information: Akt2 or Protein Kinase B β (PKBβ) is a serine/threonine kinase that is a member of the Akt family. Akt2 like the other Akt members is activated in cells in response to diverse stimuli such as hormones, growth factors and extracellular matrix components and is involved in glucose metabolism, transcription, survival, cell proliferation, angiogenesis, and cell motility (1). The PI3K generates phosphatidylinositol-3, 4, 5-trisphosphate (PIP3), a lipid second messenger essential for the translocation of Akt2 to the plasma membrane where it is phosphorylated and activated by phosphoinositide-dependent kinase-1 (PDK-1) (2) and phosphoinositide-dependent kinase-2. Akt1 has numerous cellular substrates including proteins, which promote the inhibition of apoptosis such as the Forkhead transcription factors and the Bcl-2 family member Bad (3).
Handling: Centrifuge the vial prior to opening.
Usage: For Research Use Only! Not to be used in humans.
-80°C
7703-5 Akt3, Active 品牌 Biovision
Akt3, Active
货号: 7703-5 产品名称: Akt3, Active 品牌: Biovision 规格: 5 μg 3周到货 生化实验
Active Akt3
A serine/threonine-protein kinase
Product Overview
Alternate Names / Synonyms: Active Akt3, Akt3, human Akt3, active kinase, active kinases, Akt, recombinant Akt3, recombinant Akt, kinase activity assay, protein kinase, akt-3, akt 3
Gene Symbol: AKT3
Accession #: NP_005456
Gene ID: 10000
Source: Baculovirus (Sf9 insect cells)
Appearance: Liquid
Physical Form Description: Recombinant proteins in storage buffer (50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol).
Molecular Weight: ~84.0 kDa
Purity by SDS-PAGE: ≥90%
Purity by HPLC: N/A
Endotoxin Level: N/A
Biological Activity: 206 nmol phosphate incorporated into Akt substrate peptide per minute per mg protein at 30°C for 15 minutes using a final concentration of 50 µM ATP and total of 0.83 µCi/µl P-32.
Reconstitution Instructions: N/A
Storage Temp.: -80°C
Shipping: gel pack
Background Information: Akt3 or Protein Kinase B γ (PKB) is a serine/threonine kinase that is a member of the Akt family. In mammals, the Akt family comprises of three highly homologous members known as Akt1 (PKB), Akt2 (PKB), and Akt 3. Akt 3 like the other family members is activated in cells exposed to diverse stimuli such as hormones, growth factors, and extracellular matrix components. The activation mechanism remains to be fully characterized but occurs downstream of phosphoinositide 3-kinase (PI3K). PI3K generates phosphatidylinositol-3,4,5-trisphosphate (PIP3), a lipid second messenger essential for the translocation of Akt family members to the plasma membrane where they are phosphorylated and activated by phosphoinositide-dependent kinase-1 (PDK-1) and phosphoinositide-dependent kinase-2 (PDK-2 possibly ILK). Akt 3 like the other family members phosphorylates and regulates the function of many cellular proteins involved in processes that include cellular metabolism, survival/apoptosis, and proliferation. Recent evidence indicates that Akt 3 is frequently overexpressed in many types of human cancers including breast and prostate. Although the mechanisms have not yet been fully characterized, increased expression and activation of Akt is believed to promote cell proliferation and survival thereby contributing to cancer progression.
Handling: Centrifuge the vial prior to opening.
Usage: For Research Use Only! Not to be used in humans.
-80°C
7035-1 Akt Negative Control Cell Lysate 品牌 Biovision
Akt Negative Control Cell Lysate
货号: 7035-1 产品名称: Akt Negative Control Cell Lysate 品牌: Biovision 规格: 1 mg 3周到货 生化实验
Akt Negative Control Cell Lysate
Product Overview
Product Highlights:
• CONCENTRATION- 4 mg/ml
Description: Jurkat cells growing in DMEM supplemented with 10% FBS were collected and washed in ice-cold PBS. Cells were then lyzed in three volume of Kinase Extraction Buffer (70002-N80M in K435-40), keep on ice for 5 min, centrifuge at top speed for 15 min. Collect the cell lysate. Extract the pellet again with one volume Kinase Extraction Buffer. Combine the cell lysate together, determine protein concentration. The cell lysate can be used as a negative control for Akt activity assays, in conjunction with the use of BioVision’s Akt Activity Assay Kit (K435-40). We recommend using 100 µg per assay.
Storage Temp.: -70°C
Shipping: dry ice
Usage: For Research Use Only! Not For Use in Humans.
-70°C
7036-1 Akt Activated Cell Lysate 品牌 Biovision
Akt Activated Cell Lysate
货号: 7036-1 产品名称: Akt Activated Cell Lysate 品牌: Biovision 规格: 1 mg 3周到货 生化实验
Akt Activated Cell Lysate
Product Overview
Product Highlights:
• CONCENTRATION- 4 mg/ml
Description: Jurkat cells (growing in DMEM supplemented with 10% serum) were washed, serum starved (0% Serum) for 3 hours. 20% serum were then added to the culture for 30 minutes to stimulate the cells. The serum-activated cells were washed with ice-cold PBS, then lyzed in three volume of Kinase Extraction Buffer (70002-N80M in K435-40), keep on ice for 5 min, vortex, centrifuge at top speed for 15 min, collect the cell lysate. Extract the pellet one more time with one volume extraction buffer. Combine the cell lysate together. Determine protein concentration. The cell lysate contains activated Akt, which can be used as a positive control in Akt activity assay, in conjunction with the use of BioVision’s Akt Activity Assay Kit (K435-40). We recommend using 100 µg per assay.
Storage Temp.: -70°C
Shipping: dry ice
Usage: For Research Use Only! Not For Use in Humans.
-70°C
BML-P129-0001 Akt Substrate 品牌 Biomol
Akt Substrate
货号: BML-P129-0001 产品名称: Akt Substrate 品牌: Biomol 规格: 1 mg 3周到货 生化实验
A sequence, RPRAATF, derived from variations on the glycogen synthase kinase-3 phosphorylation site, it conforms to the Akt/PKB consensus motif, Arg-Xaa-Arg-Xaa-Xaa-(Ser/Thr). Unlike other Akt-PKB peptide substrates, it is not phosphorylated by p70 S6 kinase or MAPKAP kinase-1.
Product Specification
Alternative Name:Protein kinase B substrate, PKB substrate, Arg-Pro-Arg-Ala-Ala-Thr-Phe
Sequence:Arg-Pro-Arg-Ala-Ala-Thr-Phe
MW:818.0
Purity:95%
Long Term Storage:-20°C
-20°C
BML-P194-0001 PAK4/AKT Peptide Substrate 品牌 Biomol
PAK4/AKT Peptide Substrate
货号: BML-P194-0001 产品名称: PAK4/AKT Peptide Substrate 品牌: Biomol 规格: 1 mg 3周到货 生化实验
Product Specification
Alternative Name:Cys-Lys-Arg-Pro-Arg-Ala-Ala-Ser-Phe-Ala-Glu, p21-activated kinase 4 substrate, Protein kinase B substrate, PKB substrate
Sequence:Cys-Lys-Arg-Pro-Arg-Ala-Ala-Ser-Phe-Ala-Glu
MW:1241
Purity:95%
Long Term Storage:-20°C
-20°C
124032-10MG Akt Inhibitor XIV 品牌 Merck
Akt Inhibitor XIV
货号: 124032-10MG 产品名称: Akt Inhibitor XIV 品牌: Merck 规格: *** 3周到货 生化实验
Akt Inhibitor XIV
4-Dodecyl-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide, PDK1 Inhibitor III, PHT-427
A cell-permeable thiadiazolyl compound that binds to PH (pleckstrin homology) domain (Kd = 40.8 µM, Ki = 2.4 µM) and acts as a competitive and reversible blocker of Akt translocation to the cellular membrane with selectivity over PDK1 (Kd = 90.1 µM, Ki = 5.5 µM). Inhibits pAkt-Ser473 (IC50 = 6.3, 8.6 and 10 µM in Panc-1, BxPC-3 and MiaPaCa-2 cells, respectively), and induces apoptosis at 20 µM (40% and 31%) and causes growth arrest (IC50 = 65 and 30 µM) in Panc-1 and MiaPaCa-2 cells, respectively. Further, suppresses tumor growth and regression in mouse xenograft model (125 mg/kg, i.p.) and reduces pGSK-3α-Ser21 and pGSK-3β-Ser9 and p70S6K-Thr389 levels.
产品信息
Form White solid
Molar mass 409.6
Purity ≥95% by HPLC
Solubility DMSO
Chemical formula C20H31N3O2S2
CAS number 1191951-57-1
商店和运输信息
Storage +2°C to +8°C
Ship Ambient Temperature Only
Standard Handling
2°C – 8°C
124034-2MG Akt Inhibitor XV, Isozyme-Selective 品牌 Merck
Akt Inhibitor XV, Isozyme-Selective
货号: 124034-2MG 产品名称: Akt Inhibitor XV, Isozyme-Selective 品牌: Merck 规格: *** 3周到货 生化实验
Akt Inhibitor XV, Isozyme-Selective
5-Hydroxy-3-phenyl-2-(4-((4-(5-pyridin-2-yl-1H-1,2,4-triazol-3-yl)piperdin-1-yl)methyl)phenyl)-1,6-naphthyridine
A cell-permeable naphthyridinone compound that acts as an allosteric Akt1/2-selective inhibitor (IC50 = 3.5, 42, and 1900 nM against Akt1, Akt2, and Akt3, respectively) in a PH domain-dependent, but not ATP-competitive, manner, with little activity against a panel of more than 160 other kinases, including the related AGC family kinases (inactive at 10 µM against GSK, PDK1, PKA, PKC, and SGK). Effectively inhibits the basal Akt phosphorylation in cancer cells with deregulated Akt pathway activation, including the HCT116 colorectal carcinoma and a panel of breast cancer cell lines (IC50 <500 nM), and suppresses Akt-dependent cell growth both in cultures in vitro (IC50 ≤1 µM) and in mice in vivo (50 to 100 mg/kg, SC). Although also referred to as AKTi-1/2, this is not the same compound as Akt Inhibitor XV (Cat. Nos. 124017 & 124018).
产品信息
Form White powder
Molar mass 539.6
Purity ≥97% by HPLC
Solubility DMSO
Chemical formula C33H29N7O
商店和运输信息
Storage +2°C to +8°C
Ship Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Standard Handling
2°C – 8°C
124038-2MG InSolution Akt Inhibitor V, Triciribine 品牌 Merck
InSolution Akt Inhibitor V, Triciribine
货号: 124038-2MG 产品名称: InSolution Akt Inhibitor V, Triciribine 品牌: Merck 规格: *** 3周到货 生化实验
InSolution™ Akt Inhibitor V, Triciribine
A cell-permeable and reversible tricyclic nucleoside that selectively inhibits the cellular phosphorylation/activation of Akt1/2/3 by targeting an Akt effector molecule other than PI 3-K or PDK. Exhibits little effect towards cellular signaling pathways mediated by PKC, PKA, SGK, Stat3, p38, ERK1/2, or JNK. Shown to preferentially induce apoptosis and growth arrest in cancer cells with aberrant Akt activity both in vitro (≥60% in cell proliferation at 20 µM) and in vivo (≥80% inhibition in tumor growth in mice at 1 mg/kg/day, i.p.).
产品信息
Form Liquid
Formulation A 2 mg/312 µl solution of Akt Inhibitor V, Triciribine (Cat. No. 124012) in DMSO.
Molar mass 320.3
Protect from Light 是的
Hygrocopic 是的
Avoid freeze/thaw 是的
Packaged under inert gas 是的
Purity ≥95% by HPLC
Chemical formula C13H16N6O4
RTECS RY8455000
CAS number 35943-35-2
商店和运输信息
Storage ≤ -70°C
Ship Dry Ice Only
Irritant
安全标示
R Phrase R: 36/38
Irritating to eyes and skin.
≤ -70°C
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