标签归档：mek

BML-SA347-0010   MEK7 (human), mAb (3F5)   品牌 Biomol

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MEK7 (human), mAb (3F5)

货号： BML-SA347-0010      产品名称： MEK7 (human), mAb (3F5)   品牌： Biomol 规格： 10 ug 3周到货 生化实验

MEK7 (human), mAb (3F5)
JNK 1&2 are specifically activated by a dual phosphorylation by MEK. MEK7 phosphorylates members of the JNK1 family on threonine.
Product Specification
Alternative Name:MKK7, MAP kinase kinase 7
Clone:3F5
Host:Mouse
Isotype:IgG1
Immunogen:Synthetic peptide corresponding to a portion of MEK7.
UniProt ID:O14733
Application:ELISA
Western Blot
Specificity:Recognizes human MEK7.
Purity Detail:Purified.
Formulation:Liquid. In PBS containing sodium azide, PEG and sucrose.
Long Term Storage:-80°C

-80°C

BML-SA347-0050   MEK7 (human), mAb (3F5)   品牌 Biomol

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MEK7 (human), mAb (3F5)

货号： BML-SA347-0050      产品名称： MEK7 (human), mAb (3F5)   品牌： Biomol 规格： 50 ug 3周到货 生化实验

MEK7 (human), mAb (3F5)
JNK 1&2 are specifically activated by a dual phosphorylation by MEK. MEK7 phosphorylates members of the JNK1 family on threonine.
Product Specification
Alternative Name:MKK7, MAP kinase kinase 7
Clone:3F5
Host:Mouse
Isotype:IgG1
Immunogen:Synthetic peptide corresponding to a portion of MEK7.
UniProt ID:O14733
Application:ELISA
Western Blot
Specificity:Recognizes human MEK7.
Purity Detail:Purified.
Formulation:Liquid. In PBS containing sodium azide, PEG and sucrose.
Long Term Storage:-80°C

-80°C

444968-5MG   InSolution MEK1/2 Inhibitor III, PD03259   品牌 Merck

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InSolution MEK1/2 Inhibitor III, PD03259

货号： 444968-5MG      产品名称： InSolution MEK1/2 Inhibitor III, PD03259   品牌： Merck 规格： *** 3周到货 生化实验

InSolution™ MEK1/2 Inhibitor III, PD0325901
PD 0325901, N-((2R)-2,3-Dihyroxypropoxy)-3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)-benzamide, PD325901
A cell-permeable benzamide compound that acts as a non-competitive, highly potent, selective MEK/MAPKK/MKK inhibitor and effectively blocks cellular Erk1/2 phosphorylation (by >90% in serum-starved HeLa after serum-stimulation and 50% in C26 with 25 and 0.33 nM inhibitor, respectively), while exhibiting little or no effect against the activity of Erk1/2 or a panel of 66 other kinases even at concentrations as high as 10 µM in cell-free kinase assays. Shown to be orally available in mice and suppress both the growth of and Erk phosphorylation in BRAF(V600E)-expressing SKMEL28 cell-derived tumor in vivo.
产品信息
Form  Liquid
Formulation  A 50 mM (5 mg/207 µl) solution of MEK1/2 Inhibitor III, PD0325901 (Cat. No. 444966) in DMSO.
Molar mass  482.2
Protect from Light  是的
Hygrocopic  是的
Packaged under inert gas  是的
Purity  ≥95% by HPLC
Chemical formula  C16H14F3IN2O4
CAS number  391210-10-9
商店和运输信息
Storage  -20°C
Ship  Dry Ice Only
Regulatory Review

-20°C

BML-SE509-0020   MEK1 (human) (recombinant) (His-tag)   品牌 Biomol

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MEK1 (human) (recombinant) (His-tag)

货号： BML-SE509-0020      产品名称： MEK1 (human) (recombinant) (His-tag)   品牌： Biomol 规格： 20 ug 3周到货 生化实验

MEK1 (human), (recombinant) (His-tag)
Product Specification
Alternative Name:MAPK2K1, MAPKK1, MAP kinase kinase 1, MAPK/ERK kinase 1
MW:~43kDa
Source:Produced in E. coli. Active full length MEK1 (MAPK2K1) with C- and N-terminal His-tags. Genbank ID No. NM_002755.
UniProt ID:Q02750
Formulation:Liquid. In 50mM TRIS-HCl, pH 8.0, containing 150mM sodium chloride, 5mM DTT, 0.03% Brij-35, 20% glycerol.
Purity:≥85% (SDS-PAGE)
Purity Detail:Purified by multi-step chromatography.
Specific Activity:≥12 pmol/min/µg. Kinase activity was measured using the non-radioactive ADP Hunter Plus kit™.
Application:Study enzyme regulation and kinetics, phosphorylate target substrates, screen for inhibitors.
Long Term Storage:-80°C
Use/Stability:After initial defrost, aliquot product into individual tubes and refreeze at -80°C. Avoid repeated freeze/defrost cycles.
Miscellaneous/General:MEK1 is a dual-specificity kinase that phosphorylates ERK1/2, activating it in response to extracellular and intracellular signals. It also acts to downregulate PPAR γ by a direct interaction that results in PPAR γ moving into the cytoplasm from the nucleus.
 

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