InSolution Y-27632 in DMSO

货号： 688002-1MG      产品名称： InSolution Y-27632 in DMSO   品牌： Merck 规格： *** 3周到货 生化实验

InSolution™ Y-27632 in DMSO
(R)-(+)-trans-N-(4-Pyridyl)-4-(1-aminoethyl)-cyclohexanecarboxamide, 2HCl, Rho Kinase Inhibitor VI
A highly potent, cell-permeable, reversible, and selective inhibitor of Rho-associated protein kinases (Ki = 140 nM for p160ROCK). Also inhibits ROCK-II with equal potency. The inhibition is competitive with respect to ATP. Exhibits 10- to 50-fold lower affinity for PKCε than p160ROCK. Does not affect the activity of p21-activated protein kinase (PAK) even at higher concentrations (~100 µM). Also acts as a potent inhibitor of agonist-induced Ca2+ sensitization of myosin phosphorylation and smooth muscle contraction. Prevents apoptosis and enhances the survival and cloning efficiency of dissociated hES cells without affecting their pluripotency. A 5 mM (500 µg/296 µl) solution of Y-27632 (Cat. No. 688001) in H2O and the solid form of this compound (Cat. No. 688000) are also available.
产品信息
Form  Liquid
Formulation  A 10 mM (1 mg/296 µl) solution of Y-27632 (Cat. No. 688000)in DMSO.
Molar mass  338.3
Protect from Light  是的
Hygrocopic  是的
Avoid freeze/thaw  是的
Purity  ≥95% by HPLC
Chemical formula  C14H21N3O•2HCl•H2O
商店和运输信息
Storage  ≤ -70°C
Ship  Dry Ice Only
Irritant

≤ -70°C