InSolution MEK1/2 Inhibitor III, PD03259

货号： 444968-5MG      产品名称： InSolution MEK1/2 Inhibitor III, PD03259   品牌： Merck 规格： *** 3周到货 生化实验

InSolution™ MEK1/2 Inhibitor III, PD0325901
PD 0325901, N-((2R)-2,3-Dihyroxypropoxy)-3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)-benzamide, PD325901
A cell-permeable benzamide compound that acts as a non-competitive, highly potent, selective MEK/MAPKK/MKK inhibitor and effectively blocks cellular Erk1/2 phosphorylation (by >90% in serum-starved HeLa after serum-stimulation and 50% in C26 with 25 and 0.33 nM inhibitor, respectively), while exhibiting little or no effect against the activity of Erk1/2 or a panel of 66 other kinases even at concentrations as high as 10 µM in cell-free kinase assays. Shown to be orally available in mice and suppress both the growth of and Erk phosphorylation in BRAF(V600E)-expressing SKMEL28 cell-derived tumor in vivo.
产品信息
Form  Liquid
Formulation  A 50 mM (5 mg/207 µl) solution of MEK1/2 Inhibitor III, PD0325901 (Cat. No. 444966) in DMSO.
Molar mass  482.2
Protect from Light  是的
Hygrocopic  是的
Packaged under inert gas  是的
Purity  ≥95% by HPLC
Chemical formula  C16H14F3IN2O4
CAS number  391210-10-9
商店和运输信息
Storage  -20°C
Ship  Dry Ice Only
Regulatory Review

-20°C