A 83-01

货号： 1725-1      产品名称： A 83-01   品牌： Biovision 规格： 1 mg 3周到货 生化实验

A 83-01
A TGF-β type I receptor ALK5 kinase inhibitor
Product Overview
Product Name: A 83-01
Alternate Name/Synonyms: 3-(6-Methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-1H-p yrazole-1-carbothioamide
Description: A selective inhibitor of TGF-β type I receptor ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7 (IC₅₀ values are 12, 45 and 7.5 nM respectively). Blocks phosphorylation of Smad2 and inhibits TGF-β-induced epithelial-to-mesenchymal transition. Helps maintain homogeneity and long-term in vitro self-renewal of human induced pluripotent stem cells (iPSCs).
Peptide Sequence: N/A
Appearance: Pale yellow solid
Formulation: N/A
CAS Number: 909910-43-6
Molecular Formula: C₂₅H₁₉N₅S
Molecular Weight: 421.52
Purity: ≥98% by HPLC
Solubility:DMSO
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from air and light
SMILES: CC1=CC=CC(=N1)C2=NN(C=C2C3=CC=NC4=CC=CC=C34)C(=S)NC5=CC=CC=C5
InChi: InChI=1S/C25H19N5S/c1-17-8-7-13-23(27-17)24-21(19-14-15-26-22-12-6-5-11-20(19)22)16-30(29-24)25(31)28-18-9-3-2-4-10-18/h2-16H,1H3,(H,28,31)
InChi Key: HIJMSZGHKQPPJS-UHFFFAOYSA-N
PubChem CID: 16218924
MDL Number: MFCD08705403
USAGE: For Research Use Only! Not For Use in Humans.

-20°C