P21955 PERIOSTIN, C-TERM, RABBIT POLY 品牌 Invitrogen

Anti-IRAK-4 (N-term), clone Y279, Rabbit Monoclonal
Species Reactivity Key Applications Host Format Antibody Type
H WB, ICC Rabbit Unpurified Monoclonal Antibody
Description:
Anti-IRAK-4 (NT) Antibody, clone Y279, rabbit monoclonal
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Specificity:
This antibody recognizes the N-terminus of IRAK-4.
Molecular Weight:
~52 kDa observed
Epitope:
N-terminus
Immunogen:
Synthetic peptide corresponding to the N-terminus of human IRAK-4.
Clone:
Y279
Isotype:
IgG
Background Information:
IRAK-4 is a member of the interleukin-1 receptor-associated kinase (IRAK) family. The IRAK family is implicated in the Toll-like receptor (TLR) and Il-1R signaling pathway (1). Upon phosphorylation, IRAK-4 interacts with IRAK-1, MYD88 and TRAF6 to form a complex, and activate NF-kB and MAPK pathways (2-3). IRAK-4 phosphorylates and activates IRAK-1 at thr387 and is also known to interact with IRAK-1 but not with the other IRAK members. Additionally, like IRAK-1, IRAK-4 possesses an auto and crossphosphorylation kinase activity (4).
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Species Reactivity:
Human
Species Reactivity Note:
Demonstrated to react with Human.
Application Notes:
Immunocytochemistry Analysis: A 1:50-100 dilution from a representative lot was used in IC.
Control:
Daudi cell lysate
Quality Assurance:
Evaluated by Western Blot in Jurkat cell lysate
WesternBlot Analysis: A 1:1,000 to 1:10,000 dilution of this antibody detected IRAK-4 in Jurkat cell lysate.
Purification Method:
Unpurified
Presentation:
Rabbit Monoclonal in buffer containing glycerol, BSA, and sodium azide.
Storage Conditions:
Stable for 1 year at -20ºC from date of receipt.
Handling Recommendations: Upon first thaw, and prior to removing cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20ºC. Avoid freeze/thaw cycles, which may damage IgG and affect product performance.
Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.
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UniProt Number:
Q9NWZ3
Entrez Gene Number:
Q9NWZ3
Gene Symbol:
NY-REN-64
IRAK-4
EC 2.7.11.1
IPD1
REN64
EC 2.7.11
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Alternate Names:
interleukin-1 receptor-associated kinase 4
Renal carcinoma antigen NY-REN-64
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Western Blotting
Immunocytochemistry
Product Name:
Anti-IRAK-4 (N-term), clone Y279, Rabbit Monoclonal
Antibody Type:
Monoclonal Antibody
Qty/Pk:
100 µL
Format:
Unpurified
Host:
Rabbit
Applications:
Anti-IRAK-4 (N-term) Antibody, clone Y279, Rabbit Monoclonal is an antibody against IRAK-4 (N-term) for use in Western Blotting, ICC.

-20°C

100000-1 Optineurin (C-Term) Polyclonal Antibody 品牌 Cayman

发表于2023年11月10日由上海金畔生物科技有限公司

Optineurin (C-Term) Polyclonal Antibody

货号： 100000-1 产品名称： Optineurin (C-Term) Polyclonal Antibody 品牌： Cayman 规格： EA 3周

Optineurin (C-Term) Polyclonal Antibody
Cayman Chemical Item Number 100000
Description
Antigen:human, mouse, and rat (100% identity) optineurin amino acids 559-575 (GEVLPDIDTLQIHVMDC) · Host:rabbit · Application(s):WB; other applications not tested · Optineurin (originally named FIP-2) is a 74 kDa protein implicated in signal transduction of the tumor necrosis factor (TNF) pathway as well as membrane traffic regulation and cellular morphogenesis. Optineurin protein is also involved in apoptosis, although the exact role is currently unknown. Increased apoptosis of trabecular meshwork cells is a factor in the pathogenesis of glaucoma and mutations in the optineurin gene have been correlated with the some types of the disease. Cayman Chemical is a leading provider of prostaglandin analogs, such as latanoprost and fluprostenol, currently utilized for lowering the intraocular pressure (IOP) associated with glaucoma. Our optineurin polyclonal antibody is another research tool useful for delineating the physiology of the disease.
Synonyms:FIP-2,NRP
Formal Name
Formulation:Peptide affinity-purified IgG
Stability:1 year
Storage:-20°C
Shipping:Room temperature in continental US; may vary elsewhere
Specificity:Human optineurin
Mouse optineurin
Rat optineurin

-20°C