Optineurin (INT) Polyclonal Antibody
货号： 100002-500 产品名称： Optineurin (INT) Polyclonal Antibody 品牌： Cayman 规格： 500 碌l 3周
Optineurin (INT) Polyclonal Antibody
Cayman Chemical Item Number 100002
Description
Antigen:human optineurin amino acids 115-130 (KGKSERSSEDPTDDSR) · Host:rabbit · Application(s):WB; other applications not tested · Optineurin (originally named FIP-2) is a 74 kDa protein implicated in signal transduction of the tumor necrosis factor (TNF) pathway as well as membrane traffic regulation and cellular morphogenesis. Optineurin protein is also involved in apoptosis, although the exact role is currently unknown. Increased apoptosis of trabecular meshwork cells is a factor in the pathogenesis of glaucoma and mutations in the optineurin gene have been correlated with the some types of the disease. Cayman Chemical is a leading provider of prostaglandin analogs, such as latanoprost and fluprostenol, currently utilized for lowering the intraocular pressure (IOP) associated with glaucoma. Our optineurin polyclonal antibody is another research tool useful for delineating the physiology of the disease.
Synonyms:FIP-2,NRP
Formal Name
Formulation:300 µg of peptide affinity-purified IgG in 500 µl of TBS, pH 7.4, containing 50% glycerol, 0.5 mg/ml BSA, and 0.02% sodium azide
Stability:1 year
Storage:-20°C
Shipping:Wet ice in continental US; may vary elsewhere
-20°C
100000-1 Optineurin (C-Term) Polyclonal Antibody 品牌 Cayman
Optineurin (C-Term) Polyclonal Antibody
货号： 100000-1 产品名称： Optineurin (C-Term) Polyclonal Antibody 品牌： Cayman 规格： EA 3周
Optineurin (C-Term) Polyclonal Antibody
Cayman Chemical Item Number 100000
Description
Antigen:human, mouse, and rat (100% identity) optineurin amino acids 559-575 (GEVLPDIDTLQIHVMDC) · Host:rabbit · Application(s):WB; other applications not tested · Optineurin (originally named FIP-2) is a 74 kDa protein implicated in signal transduction of the tumor necrosis factor (TNF) pathway as well as membrane traffic regulation and cellular morphogenesis. Optineurin protein is also involved in apoptosis, although the exact role is currently unknown. Increased apoptosis of trabecular meshwork cells is a factor in the pathogenesis of glaucoma and mutations in the optineurin gene have been correlated with the some types of the disease. Cayman Chemical is a leading provider of prostaglandin analogs, such as latanoprost and fluprostenol, currently utilized for lowering the intraocular pressure (IOP) associated with glaucoma. Our optineurin polyclonal antibody is another research tool useful for delineating the physiology of the disease.
Synonyms:FIP-2,NRP
Formal Name
Formulation:Peptide affinity-purified IgG
Stability:1 year
Storage:-20°C
Shipping:Room temperature in continental US; may vary elsewhere
Specificity:Human optineurin
Mouse optineurin
Rat optineurin
-20°C
100000-1T Optineurin (C-Term) Polyclonal Antibody 品牌 Cayman
Optineurin (C-Term) Polyclonal Antibody
货号： 100000-1T 产品名称： Optineurin (C-Term) Polyclonal Antibody 品牌： Cayman 规格： Trial 3周
Optineurin (C-Term) Polyclonal Antibody
Cayman Chemical Item Number 100000
Description
Antigen:human, mouse, and rat (100% identity) optineurin amino acids 559-575 (GEVLPDIDTLQIHVMDC) · Host:rabbit · Application(s):WB; other applications not tested · Optineurin (originally named FIP-2) is a 74 kDa protein implicated in signal transduction of the tumor necrosis factor (TNF) pathway as well as membrane traffic regulation and cellular morphogenesis. Optineurin protein is also involved in apoptosis, although the exact role is currently unknown. Increased apoptosis of trabecular meshwork cells is a factor in the pathogenesis of glaucoma and mutations in the optineurin gene have been correlated with the some types of the disease. Cayman Chemical is a leading provider of prostaglandin analogs, such as latanoprost and fluprostenol, currently utilized for lowering the intraocular pressure (IOP) associated with glaucoma. Our optineurin polyclonal antibody is another research tool useful for delineating the physiology of the disease.
Synonyms:FIP-2,NRP
Formal Name
Formulation:Peptide affinity-purified IgG
Stability:1 year
Storage:-20°C
Shipping:Room temperature in continental US; may vary elsewhere
Specificity:Human optineurin
Mouse optineurin
Rat optineurin
-20°C
AB15192 OPTINEURIN, RBX,-100UG 品牌 Millipore
OPTINEURIN, RBX,-100UG
货号： AB15192 产品名称： OPTINEURIN, RBX,-100UG 品牌： Millipore 规格： EA 三周到货 生化实验
Anti-Optineurin Antibody
Species Reactivity Key Applications Host Format Antibody Type
M WB Rabbit Affinity Purified Polyclonal Antibody
Description:
Anti-Optineurin Antibody
Promotional Text:
Special Shipping Offer on Antibodies
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Trade Name:
Chemicon (Millipore)
Specificity:
Optineurin. By Western blot the antibody recognizes a band at ~67 kDa on mouse retina lysate.
Molecular Weight:
67 kDa
Immunogen:
Synthetic peptide.
Species Reactivity:
Mouse
Application Notes:
Western blot: 1:500-1:1,000 on mouse retina lysate.
Optimal working dilutions must be determined by end user.
Purification Method:
Immunoaffinity purified
Presentation:
Liquid in PBS with 0.1% sodium azide.
Storage Conditions:
Maintain at 2-8°C in undiluted aliquots for up to 6 months after date of receipt.
During shipment, small volumes of product will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 &u;L or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap.
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UniProt Number:
Q96CV9
Entrez Gene Number:
NM_001008211.1
NM_001008212.1
NM_001008213.1
NM_021980.4
Gene Symbol:
OPTN
FIP-2
FIP2
HIP7
HYPL
optineurin
Optineurin
NRP
TFIIIA-INTP
GLC1E
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Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Western Blotting
Entrez Gene Summary:
This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein.
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UniProt Summary:
FUNCTION: SwissProt: Q96CV9 # Plays a neuroprotective role in the eye and optic nerve. Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and hungtingtin (HD). May constitute a cellular target for adenovirus E3 14.7, an inhibitor of TNF-alpha functions, thereby affecting cell death.
SIZE: 577 amino acids; 65922 Da
SUBUNIT: Interacts with E3 14.7 kDa protein of group C human adenovirus. Interacts with HD. Interacts with Rab8 (RAB8A and/or RAB8B). Interacts with transcription factor IIIA (GTF3A).
SUBCELLULAR LOCATION: Cytoplasm, perinuclear region. Golgi apparatus. Note=Found in the perinuclear region and associates with the Golgi apparatus.
TISSUE SPECIFICITY: Present in acqueous humor of the eye (at protein level). Highly expressed in trabecular meshwork. Expressed nonpigmented ciliary epithelium, retina, brain, adrenal cortex, fetus, lym 2-8℃