AF3008-50 mg   Capsaicin   品牌 Cayman

Capsaicin

货号: AF3008-50 mg      产品名称: Capsaicin   品牌: Cayman 规格: 50 mg 3周

Capsaicin is the primary active component of the heat and pain-eliciting lipid-soluble fraction of the Capsicum pepper.1 Capsaicin is present in natural hot pepper extracts along with a number of impurities, including dihydrocapsaicin and several lesser impurities. Separation by HPLC is required in order to obtain capsaicin of consistently high purity and reproducible quality.2 VR1 is a heat-activated calcium ion channel which functions as part of the normal nociceptive pain pathway. Capsaicin elicits a sensation of burning pain by activation of VR1 on small, non-myelinated polymodal C-type nociceptive nerve fibers.3 Chronic application of capsaicin leads to desensitization of these pain fibers and has been widely exploited in various non-prescription pain remedies.

1Gannett, P.M., Nagel, D.L., Reilly, P.J., et al. The capsaicinoids: Their separation, synthesis, and mutagenicity. J Org Chem 53(5) 1064-1071 (1988).

2Hoffman, P.G., Lego, M.C., and Galetto, W.G. Separation and quantitation of red pepper major heat principles by reverse-phase high-pressure liquid chromatography. J Agric Food Chem 31(6) 1326-1330 (1983).

3Caterina, M.J., Schumacher, M.A., Tominaga, M., et al. The capsaicin receptor: A heat-activated ion channel in the pain pathway. Nature 389 816-824 (1997).

id=”data”>

Formal Name N-​[(4-​hydroxy-​3-​methoxyphenyl)methyl]-​6E-​8-​methyl-​nonenamide

CAS Number

404-86-4

Molecular Formula

C18H27NO3

Formula Weight

305.4

Formulation

A crystalline solid

Purity

≥95%

λmax

230, 281 nm

Stability

2 years

Storage

-20°C < -20°C

AF3008-1 g   Capsaicin   品牌 Cayman

Capsaicin

货号: AF3008-1 g      产品名称: Capsaicin   品牌: Cayman 规格: 100mg 3周

Capsaicin is the primary active component of the heat and pain-eliciting lipid-soluble fraction of the Capsicum pepper.1 Capsaicin is present in natural hot pepper extracts along with a number of impurities, including dihydrocapsaicin and several lesser impurities. Separation by HPLC is required in order to obtain capsaicin of consistently high purity and reproducible quality.2 VR1 is a heat-activated calcium ion channel which functions as part of the normal nociceptive pain pathway. Capsaicin elicits a sensation of burning pain by activation of VR1 on small, non-myelinated polymodal C-type nociceptive nerve fibers.3 Chronic application of capsaicin leads to desensitization of these pain fibers and has been widely exploited in various non-prescription pain remedies.

1Gannett, P.M., Nagel, D.L., Reilly, P.J., et al. The capsaicinoids: Their separation, synthesis, and mutagenicity. J Org Chem 53(5) 1064-1071 (1988).

2Hoffman, P.G., Lego, M.C., and Galetto, W.G. Separation and quantitation of red pepper major heat principles by reverse-phase high-pressure liquid chromatography. J Agric Food Chem 31(6) 1326-1330 (1983).

3Caterina, M.J., Schumacher, M.A., Tominaga, M., et al. The capsaicin receptor: A heat-activated ion channel in the pain pathway. Nature 389 816-824 (1997).

id=”data”>

Formal Name N-​[(4-​hydroxy-​3-​methoxyphenyl)methyl]-​6E-​8-​methyl-​nonenamide

CAS Number

404-86-4

Molecular Formula

C18H27NO3

Formula Weight

305.4

Formulation

A crystalline solid

Purity

≥95%

λmax

230, 281 nm

Stability

2 years

Storage

-20°C < -20°C

211275-100MG   Capsaicin   品牌 Merck

Capsaicin

货号: 211275-100MG      产品名称: Capsaicin   品牌: Merck 规格: *** 3周到货 生化实验

Capsaicin
An active constituent of cayenne pepper with excitatory and desensitizing effects on a subset of primary afferent sensory neurons. An antagonist of acetylcholine-induced responses in rat PC12 cells. Exhibits anti-nociceptive and anti-inflammatory effects. Inhibits NF-κB activation by TNF. Reversibly inhibits platelet aggregation.
产品信息
Form  Off-white solid
Molar mass  305.4
Purity  ≥98% by TLC
Solubility  EtOH
Chemical formula  C18H27NO3
RTECS  RA8530000
CAS number  404-86-4
Merck USA index 14, 1768
商店和运输信息
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping chargesmay be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage  +15°C to +30°C
Ship  Ambient Temperature Only
Toxic
安全标示
S Phrase  S: 26-36/37/39-45
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
R Phrase  R: 25-41-48
Toxic if swallowed.
Risk of serious damage to eyes.
Danger of serious damage to health by prolonged exposure.

+15°C to +30°C

C0266-1 g   Capsaicin, natural   品牌 LKT

Capsaicin, natural

货号: C0266-1 g      产品名称: Capsaicin, natural   品牌: LKT 规格: 1 g 三周到货 生化试验

Capsaicin, natural      
Description
(Capsaicin, =65%, dihydrocapsaicin, ~20%, nordihydrocapsaicin, ~4 %) Capsaicin is a powerful irritant isolated from Capsicum or Solanaceae. It has been used in the clinical treatment postherpetic neuralgia.
Specifications 
Cas No. 404-86-4
Product ID  C0266
Product Name  Capsaicin, natural
Chemical Name  (6E)-N-[(4-Hydroxy-3-methoxyphenyl)methyl]-8- methyl-6-nonenamide
Synonym Axsain; Mioton; Zacin; Zostrix
Formula Wt. 305.41
Melting Point 65oC
Boiling Point 210oC -220oC
Purity ≥95% 
Solubility Soluble in ether, benzene, and chloroform. Practically insoluble in cold water.
Store Temp +4oC
References Micko, Z. Nahr. Genussm. 1:818 (1898). Bernstein, J., et al. J. Am. Acad. Dermatol. 17:93 (1987).
 

+4oC

C0266-100 mg   Capsaicin, natural   品牌 LKT

Capsaicin, natural

货号: C0266-100 mg      产品名称: Capsaicin, natural   品牌: LKT 规格: 100 mg 三周到货 生化试验

Capsaicin, natural      
Description
(Capsaicin, =65%, dihydrocapsaicin, ~20%, nordihydrocapsaicin, ~4 %) Capsaicin is a powerful irritant isolated from Capsicum or Solanaceae. It has been used in the clinical treatment postherpetic neuralgia.
Specifications 
Cas No. 404-86-4
Product ID  C0266
Product Name  Capsaicin, natural
Chemical Name  (6E)-N-[(4-Hydroxy-3-methoxyphenyl)methyl]-8- methyl-6-nonenamide
Synonym Axsain; Mioton; Zacin; Zostrix
Formula Wt. 305.41
Melting Point 65oC
Boiling Point 210oC -220oC
Purity ≥95% 
Solubility Soluble in ether, benzene, and chloroform. Practically insoluble in cold water.
Store Temp +4oC
References Micko, Z. Nahr. Genussm. 1:818 (1898). Bernstein, J., et al. J. Am. Acad. Dermatol. 17:93 (1987).
 

+4oC

C0266-250 mg   Capsaicin, natural   品牌 LKT

Capsaicin, natural

货号: C0266-250 mg      产品名称: Capsaicin, natural   品牌: LKT 规格: 250 mg 三周到货 生化试验

Capsaicin, natural      
Description
(Capsaicin, =65%, dihydrocapsaicin, ~20%, nordihydrocapsaicin, ~4 %) Capsaicin is a powerful irritant isolated from Capsicum or Solanaceae. It has been used in the clinical treatment postherpetic neuralgia.
Specifications 
Cas No. 404-86-4
Product ID  C0266
Product Name  Capsaicin, natural
Chemical Name  (6E)-N-[(4-Hydroxy-3-methoxyphenyl)methyl]-8- methyl-6-nonenamide
Synonym Axsain; Mioton; Zacin; Zostrix
Formula Wt. 305.41
Melting Point 65oC
Boiling Point 210oC -220oC
Purity ≥95% 
Solubility Soluble in ether, benzene, and chloroform. Practically insoluble in cold water.
Store Temp +4oC
References Micko, Z. Nahr. Genussm. 1:818 (1898). Bernstein, J., et al. J. Am. Acad. Dermatol. 17:93 (1987).
 

+4oC

10010743-1   Capsaicin (technical grade)   品牌 Cayman

Capsaicin (technical grade)

货号: 10010743-1      产品名称: Capsaicin (technical grade)   品牌: Cayman 规格: 1 g 3周

Capsaicin (technical grade)
Cayman Chemical Item Number 10010743
Description Capsaicin is the primary active component of the heat and pain-eliciting lipid-soluble fraction of the Capsicum pepper.1↗ Capsaicin is present in natural hot pepper extracts along with a number of impurities, including dihydrocapsaicin and several lesser impurities. Separation by HPLC is required in order to obtain capsaicin of consistently high purity and reproducible quality.2↗ VR1 is a heat-activated calcium ion channel which functions as part of the normal nociceptive pain pathway. Capsaicin elicits a sensation of burning pain by activation of VR1 on small, non-myelinated polymodal C-type nociceptive nerve fibers.3↗ Chronic application of capsaicin leads to desensitization of these pain fibers and has been widely exploited in various non-prescription pain remedies.
Formal Name N-​[(4-​hydroxy-​3-​methoxyphenyl)methyl]-​6E-​8-​methyl-​nonenamide
CAS Number 404-86-4
Molecular Formula C18H27NO3
Formula Weight 305.4
Formulation A crystalline solid
Purity >60%
λmax 230, 281 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES COc1cc(CNC(=O)​CCCC/C=C/C(C)​C)​ccc1O

-20°C

10010743-5   Capsaicin (technical grade)   品牌 Cayman

Capsaicin (technical grade)

货号: 10010743-5      产品名称: Capsaicin (technical grade)   品牌: Cayman 规格: 5 g 3周

Capsaicin (technical grade)
Cayman Chemical Item Number 10010743
Description Capsaicin is the primary active component of the heat and pain-eliciting lipid-soluble fraction of the Capsicum pepper.1↗ Capsaicin is present in natural hot pepper extracts along with a number of impurities, including dihydrocapsaicin and several lesser impurities. Separation by HPLC is required in order to obtain capsaicin of consistently high purity and reproducible quality.2↗ VR1 is a heat-activated calcium ion channel which functions as part of the normal nociceptive pain pathway. Capsaicin elicits a sensation of burning pain by activation of VR1 on small, non-myelinated polymodal C-type nociceptive nerve fibers.3↗ Chronic application of capsaicin leads to desensitization of these pain fibers and has been widely exploited in various non-prescription pain remedies.
Formal Name N-​[(4-​hydroxy-​3-​methoxyphenyl)methyl]-​6E-​8-​methyl-​nonenamide
CAS Number 404-86-4
Molecular Formula C18H27NO3
Formula Weight 305.4
Formulation A crystalline solid
Purity >60%
λmax 230, 281 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES COc1cc(CNC(=O)​CCCC/C=C/C(C)​C)​ccc1O

-20°C

92350-1   Capsaicin   品牌 Cayman

Capsaicin

货号: 92350-1      产品名称: Capsaicin   品牌: Cayman 规格: 1 g 3周

Capsaicin
Cayman Chemical Item Number 92350
(CAS 404-86-4)
Description
Capsaicin is the primary active component of the heat and pain-eliciting lipid-soluble fraction of the Capsicum pepper.1↗ Capsaicin is present in natural hot pepper extracts along with a number of impurities, including dihydrocapsaicin and several lesser impurities. Separation by HPLC is required in order to obtain capsaicin of consistently high purity and reproducible quality.2↗ VR1 is a heat-activated calcium ion channel which functions as part of the normal nociceptive pain pathway. Capsaicin elicits a sensation of burning pain by activation of VR1 on small, non-myelinated polymodal C-type nociceptive nerve fibers.3↗ Chronic application of capsaicin leads to desensitization of these pain fibers and has been widely exploited in various non-prescription pain remedies.
Formal Name:N-​[(4-​hydroxy-​3-​methoxyphenyl)methyl]-​6E-​8-​methyl-​nonenamide
CAS Number:404-86-4
Molecular Formula:C18H27NO3
Formula Weight:305.4
Formulation:A crystalline solid
Purity:≥95%
λmax:230, 281 nm
Stability:2 years
Storage:-20°C
Shipping:Room temperature in continental US; may vary elsewhere
SMILES:COc1cc(CNC(=O)​CCCC/C=C/C(C)​C)​ccc1O
InCHI Code: ​1S/C18H27NO3/c1-14(2)​8-6-4-5-7-9-18(21)​19-13-15-10-11-16(20)​17(12-15)​22-3/h6,8,10-12,14,20H,4-5,7,9,13H2,1-3H3,(H,19,21)​/b8-6+
InCHI Key: YKPUWZUDDOIDPM-SOFGYWHQSA-N

-20°C

AB5370   CAPSAICIN RECPT, RB X-50UL   品牌 Millipore

CAPSAICIN RECPT, RB X-50UL

货号: AB5370      产品名称: CAPSAICIN RECPT, RB X-50UL   品牌: Millipore 规格: EA 三周到货 生化实验

Anti-Capsaicin Receptor Antibody, CT
Close
REFERENCES
Capsaicin-induced vasodilatation in human nasal vasculature is mediated by modulation of cyclooxygenase-2 activity and abrogated by sulprostone.
Koen Van Crombruggen,L Van Nassauw,L Derycke,J-P Timmermans,G Holtappels,D Hall,C Bachert (2011) Naunyn-Schmiedeberg’s archives of pharmacology.383
Parvalbumin and TRPV1 receptor expression in dorsal root ganglion neurons after acute peripheral inflammation.
G Zacharová, J Palecek, G Zacharová, J Palecek, G Zacharová, J Palecek (2009) Physiological research / Academia Scientiarum Bohemoslovaca.58:305-9
TRPV1 receptors on unmyelinated C-fibres mediate colitis-induced sensitization of pelvic afferent nerve fibres in rats.
H U De Schepper,B Y De Winter,L Van Nassauw,J-P Timmermans,A G Herman,P A Pelckmans,J G De Man (2008) The Journal of physiology.586
TRPV1 receptor signaling mediates afferent nerve sensitization during colitis-induced motility disorders in rats.
H U De Schepper, J G De Man, N E Ruyssers, A Deiteren, L Van Nassauw, J-P Timmermans, W Martinet, A G Herman, P A Pelckmans, B Y De Winter, H U De Schepper, J G De Man, N E Ruyssers, A Deiteren, L Van Nassauw, J-P Timmermans, W Martinet, A G Herman, P A Pelckmans, B Y De Winter (2008) American journal of physiology. Gastrointestinal and liver physiology.294:G245-53
View All
Species Reactivity Key Applications Host Format Antibody Type
H, R  IHC Rabbit Serum Polyclonal Antibody
Description:
Anti-Capsaicin Receptor Antibody, CT
Promotional Text:
Special Shipping Offer on Antibodies
100% Performance Guaranteed
Trade Name:
Chemicon (Millipore)
Specificity:
Capsaicin Receptor (Vanilloid Receptor 1, VR1).
Epitope:
C-terminus
Immunogen:
A 21 amino acid peptide corresponding to the C-terminus of the rat Capsaicin Receptor protein.
Species Reactivity:
Human
Rat
Application Notes:
Immunohistochemistry: 1:2,000. The antibody reacts well with tissue from the rat dorsal root ganglia.
Optimal working dilutions must be determined by end user.
Presentation:
Serum. Lyophilized. Contains no preservative. Reconstitute with 50 μL of sterile distilled water. Centrifuge if necessary to remove any residue.
Storage Conditions:
Maintain lyophilized material at -20°C to -70°C for up to 6 months. After reconstitution maintain frozen at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.
UniProt Number:
Q8NER1
Entrez Gene Number:
NM_018727.5
NM_080704.3
NM_080705.3
NM_080706.3
Gene Symbol:
TRPV1
VR1
OTRPC1
DKFZp434K0220
TrpV1
View All »
Alternate Names:
Vanilloid Receptor 1; VR1
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
View All »
Key Applications:
Immunohistochemistry
Entrez Gene Summary:
Capsaicin, the main pungent ingredient in hot chili peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. The protein encoded by this gene is a receptor for capsaicin and is a non-selective cation channel that is structurally related to members of the TRP family of ion channels. This receptor is also activated by increases in te -20 to70℃

AB5370P   CAPSAICIN RECPT (AP), RBX -20UG   品牌 Millipore

CAPSAICIN RECPT (AP), RBX -20UG

货号: AB5370P      产品名称: CAPSAICIN RECPT (AP), RBX -20UG   品牌: Millipore 规格: EA 三周到货 生化实验

Anti-Capsaicin Receptor Antibody, CT
Close
REFERENCES
Capsaicin-induced vasodilatation in human nasal vasculature is mediated by modulation of cyclooxygenase-2 activity and abrogated by sulprostone.
Koen Van Crombruggen,L Van Nassauw,L Derycke,J-P Timmermans,G Holtappels,D Hall,C Bachert (2011) Naunyn-Schmiedeberg’s archives of pharmacology.383
Parvalbumin and TRPV1 receptor expression in dorsal root ganglion neurons after acute peripheral inflammation.
G Zacharová, J Palecek, G Zacharová, J Palecek, G Zacharová, J Palecek (2009) Physiological research / Academia Scientiarum Bohemoslovaca.58:305-9
TRPV1 receptors on unmyelinated C-fibres mediate colitis-induced sensitization of pelvic afferent nerve fibres in rats.
H U De Schepper,B Y De Winter,L Van Nassauw,J-P Timmermans,A G Herman,P A Pelckmans,J G De Man (2008) The Journal of physiology.586
TRPV1 receptor signaling mediates afferent nerve sensitization during colitis-induced motility disorders in rats.
H U De Schepper, J G De Man, N E Ruyssers, A Deiteren, L Van Nassauw, J-P Timmermans, W Martinet, A G Herman, P A Pelckmans, B Y De Winter, H U De Schepper, J G De Man, N E Ruyssers, A Deiteren, L Van Nassauw, J-P Timmermans, W Martinet, A G Herman, P A Pelckmans, B Y De Winter (2008) American journal of physiology. Gastrointestinal and liver physiology.294:G245-53
View All
Species Reactivity Key Applications Host Format Antibody Type
H, R  IHC Rabbit Serum Polyclonal Antibody
Description:
Anti-Capsaicin Receptor Antibody, CT
Promotional Text:
Special Shipping Offer on Antibodies
100% Performance Guaranteed
Trade Name:
Chemicon (Millipore)
Specificity:
Capsaicin Receptor (Vanilloid Receptor 1, VR1).
Epitope:
C-terminus
Immunogen:
A 21 amino acid peptide corresponding to the C-terminus of the rat Capsaicin Receptor protein.
Species Reactivity:
Human
Rat
Application Notes:
Immunohistochemistry: 1:2,000. The antibody reacts well with tissue from the rat dorsal root ganglia.
Optimal working dilutions must be determined by end user.
Presentation:
Serum. Lyophilized. Contains no preservative. Reconstitute with 50 μL of sterile distilled water. Centrifuge if necessary to remove any residue.
Storage Conditions:
Maintain lyophilized material at -20°C to -70°C for up to 6 months. After reconstitution maintain frozen at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.
UniProt Number:
Q8NER1
Entrez Gene Number:
NM_018727.5
NM_080704.3
NM_080705.3
NM_080706.3
Gene Symbol:
TRPV1
VR1
OTRPC1
DKFZp434K0220
TrpV1
View All »
Alternate Names:
Vanilloid Receptor 1; VR1
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
View All »
Key Applications:
Immunohistochemistry
Entrez Gene Summary:
Capsaicin, the main pungent ingredient in hot chili peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. The protein encoded by this gene is a receptor for capsaicin and is a non-selective cation channel that is structurally related to members of the TRP family of ion channels. This receptor is also activated by increases in te -20 to70℃

AB5566   CAPSAICIN RECPT (VR1), GP X-50UL   品牌 Millipore

CAPSAICIN RECPT (VR1), GP X-50UL

货号: AB5566      产品名称: CAPSAICIN RECPT (VR1), GP X-50UL   品牌: Millipore 规格: EA 三周到货 生化实验

Anti-Capsaicin Receptor Antibody, CT
Species Reactivity Key Applications Host Format Antibody Type
R  IHC Guinea Pig Serum Polyclonal Antibody
Description:
Anti-Capsaicin Receptor Antibody, CT
Promotional Text:
Special Shipping Offer on Antibodies
100% Performance Guaranteed
Trade Name:
Chemicon (Millipore)
Specificity:
Recognizes Capsaicin Receptor (Vanilloid Receptor 1, VR1).
Epitope:
C-terminus
Immunogen:
A 22 amino acid peptide corresponding to the C-terminus of the rat Capsaicin Receptor protein (Catalog number AG298).
Species Reactivity:
Rat
Application Notes:
Immunohistochemistry: 1:1,000. The antibody reacts well with tissue from the rat dorsal root ganglia.
Optimal working dilutions must be determined by end user.
Control:
Immunogen peptide (catalog number AG298) is available for preadsorbtion control studies.
Purification Method:
Unpurified
Presentation:
Serum. Liquid. Contains no preservative.
Storage Conditions:
Maintain for 1 year at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
UniProt Number:
Q8NER1
Entrez Gene Number:
NM_018727.5
NM_080704.3
NM_080705.3
NM_080706.3
Gene Symbol:
TRPV1
VR1
OTRPC1
DKFZp434K0220
TrpV1
Alternate Names:
Vanilloid Receptor 1; VR1
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Key Applications:
Immunohistochemistry
Entrez Gene Summary:
Capsaicin, the main pungent ingredient in hot chili peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. The protein encoded by this gene is a receptor for capsaicin and is a non-selective cation channel that is structurally related to members of the TRP family of ion channels. This receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo. Four transcript variants encoding the same protein, but with different 5′ UTR sequence, have been described for this gene.
UniProt Summary:
FUNCTION: SwissProt: Q8NER1 # Receptor-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. May be involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL.
SIZE: 839 amino acids; 94938 Da
SUBUNIT: Self-associates. Probably homotetramer. May also form a heteromeric channel with TRPV3. Interacts with calmodulin, PRKCM and CSK. Interacts with PRKCG and NTRK1, probably by forming a trimeric complex (By similarity).
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein (By similarity).
TISSUE SPECIFICITY: Widely expressed at low levels. Expression is elevated in dorsal root ganglia. In skin, expressed in cutaneous sensory nerve fibers, mast cells, epidermal keratinocytes, dermal blood vessels, the inner root sheet and the infundibulum of hair follicles, d -20℃

BML-EI125-0200   Capsaicin   品牌 Biomol

Capsaicin

货号: BML-EI125-0200      产品名称: Capsaicin   品牌: Biomol 规格: 200 mg 3周到货 生化实验

Capsaicin is an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. Exhibits neuroprotective effects in a model of transient global cerebral ischemia. Induces release of substance P from afferent nociceptive specific neurons. Constituent of cayenne pepper. Powerful excitant of peropheral sensory nerve endings, specifically unmyelinated afferent neurons (C-fibers). Reversibly inhibits aggregation of platelets.
Product Specification
Formula:C18H27NO3
MW:305.4
Source:Isolated from Capsicum  fruit.
CAS:404-86-4
Purity:≥99% (TLC)
Appearance:Off-white solid.
Hazard:IRRITANT.
TOXIC.
Solubility:Soluble in 100% ethanol, methanol or chloroform. Sparingly soluble in water.
Long Term Storage:Ambient
Use/Stability:Store, as supplied, at room temperature for up to 2 years. Store solutions at -20°C for up to 3 months.

Ambient

BML-EI125-1000   Capsaicin   品牌 Biomol

Capsaicin

货号: BML-EI125-1000      产品名称: Capsaicin   品牌: Biomol 规格: 1 g 3周到货 生化实验

Capsaicin is an agonist at the TRPV1 receptor, a ligand-gated non-selective cation channel. Exhibits neuroprotective effects in a model of transient global cerebral ischemia. Induces release of substance P from afferent nociceptive specific neurons. Constituent of cayenne pepper. Powerful excitant of peropheral sensory nerve endings, specifically unmyelinated afferent neurons (C-fibers). Reversibly inhibits aggregation of platelets.
Product Specification
Formula:C18H27NO3
MW:305.4
Source:Isolated from Capsicum  fruit.
CAS:404-86-4
Purity:≥99% (TLC)
Appearance:Off-white solid.
Hazard:IRRITANT.
TOXIC.
Solubility:Soluble in 100% ethanol, methanol or chloroform. Sparingly soluble in water.
Long Term Storage:Ambient
Use/Stability:Store, as supplied, at room temperature for up to 2 years. Store solutions at -20°C for up to 3 months.

Ambient