标签归档：av

pfc1-mgin2   pINFUSE-mIgG2B-Fc1   品牌 Invivogen

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pINFUSE-mIgG2B-Fc1

货号： pfc1-mgin2      产品名称： pINFUSE-mIgG2B-Fc1   品牌： Invivogen 规格： 20 μg 二周到货 生化试验

pINFUSE-mIgG2b-Fc
pINFUSE-mIgG2b-Fc1 is a cloning plasmid for the generation of a Fc-fusion protein expressing the Fc region (CH2 and CH3 domains) of the murine IgG2b heavy chain and the hinge region. The hinge serves as a flexible spacer between the two parts of the Fc-fusion protein, allowing each part of the molecule to function independently. A short intron is present between each region (one intron between the hinge and CH2 and one intron between CH2 and CH3). The presence of introns is known to enhance the level of gene expression as splicing is known to promote rapid and efficient mRNA export.
pINFUSE-mIgG2b-Fc2 additionally features the IL2 signal sequence for the generation of Fc-Fusion proteins derived from proteins that are not naturally secreted
Murine IgG2b dispays high ADCC and CDC.
Both plasmids are selectable with Zeocin™.

pfc2-hgin1   pINFUSE-hIgG1-Fc2   品牌 Invivogen

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pINFUSE-hIgG1-Fc2

货号： pfc2-hgin1      产品名称： pINFUSE-hIgG1-Fc2   品牌： Invivogen 规格： 20 μg 二周到货 生化试验

pINFUSE-hIgG1-Fc
pINFUSE-hIgG1-Fc1 is a cloning plasmid for the generation of a Fc-fusion protein expressing the Fc region (CH2 and CH3 domains) of the human IgG1 heavy chain and the hinge region. The hinge serves as a flexible spacer between the two parts of the Fc-fusion protein, allowing each part of the molecule to function independently. A short intron is present between each region (one intron between the hinge and CH2 and one intron between CH2 and CH3). The presence of introns is known to enhance the level of gene expression as splicing is known to promote rapid and efficient mRNA export.
pINFUSE-hIgG1-Fc2 additionally features the IL2 signal sequence for the generation of Fc-Fusion proteins derived from proteins that are not naturally secreted
Human IgG1 displays high ADCC and CDC, and is the most suitable for therapeutic use against pathogens and cancer cells.
Both plasmids are selectable with Zeocin™.

pfuse-rtg2bfc1   pFUSE-rtIgG2B-Fc1   品牌 Invivogen

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pFUSE-rtIgG2B-Fc1

货号： pfuse-rtg2bfc1      产品名称： pFUSE-rtIgG2B-Fc1   品牌： Invivogen 规格： 20 μg 二周到货 生化试验

pFUSE-rtIgG2b-Fc (rat)
pFUSE-rtIgG2b-Fc1 is a cloning plasmid for the generation ofa Fc-fusion protein expressing the Fc region (CH2 and CH3 domains) of the rat IgG2b heavy chain and the hinge region. The hinge serves as a flexible spacer between the two parts of the Fc-fusion protein, allowing each part of the molecule to function independently.
pFUSE-rtIgG2b-Fc2 additionally features the IL2 signal sequence for the generation of Fc-Fusion proteins derived from proteins that are not naturally secreted.
Isotype : IgG2b rat
Effector Activities : ADCC++, CDC ++
Protein A binding: –
Protein G binding: ++
Protein L binding: ++++
Both plasmids are selectable with Zeocin™.

pfuse-rtg2bfc2   pFUSE-rtIgG2B-Fc2   品牌 Invivogen

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pFUSE-rtIgG2B-Fc2

货号： pfuse-rtg2bfc2      产品名称： pFUSE-rtIgG2B-Fc2   品牌： Invivogen 规格： 20 μg 二周到货 生化试验

pFUSE-rtIgG2b-Fc (rat)
pFUSE-rtIgG2b-Fc1 is a cloning plasmid for the generation ofa Fc-fusion protein expressing the Fc region (CH2 and CH3 domains) of the rat IgG2b heavy chain and the hinge region. The hinge serves as a flexible spacer between the two parts of the Fc-fusion protein, allowing each part of the molecule to function independently.
pFUSE-rtIgG2b-Fc2 additionally features the IL2 signal sequence for the generation of Fc-Fusion proteins derived from proteins that are not naturally secreted.
Isotype : IgG2b rat
Effector Activities : ADCC++, CDC ++
Protein A binding: –
Protein G binding: ++
Protein L binding: ++++
Both plasmids are selectable with Zeocin™.

10229-1   尾-Amyloid (1-8, A2V) Peptide   品牌 Cayman

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尾-Amyloid (1-8, A2V) Peptide

货号： 10229-1      产品名称： 尾-Amyloid (1-8, A2V) Peptide   品牌： Cayman 规格： 1 ea 3周

β-Amyloid (1-8, A2V) Peptide Exclusive Cayman Chemical Item Number 10229 Description β-Amyloid peptide (1-42) aggregation results in the formation of neurotoxic fibrils or globular oligomers.1↗ The amyloid precursor protein (APP) mutation Ala673Val results in disease for homozygous carriers but not for heterozygous carriers. The mutation generates β-Amyloid peptide with valine at amino acid position two. Biochemical analysis of Aβ (1-42) aggregation suggests this small peptide may be a useful guide for developing β-amyloid peptide aggregation inhibitors.2↗ Synonyms Aβ 1-8 mutant,β-amyloid (1-8) dominant negative,Aβ Formula Weight 1004.0 Formulation 1 mg lyophilized peptide Stability 1 year Storage -20°C Shipping Room temperature in continental US; may vary elsewhere -20°C

AB1923   INTEGRIN AV, RB X HU, 100UL   品牌 Millipore

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INTEGRIN AV, RB X HU, 100UL

货号： AB1923      产品名称： INTEGRIN AV, RB X HU, 100UL   品牌： Millipore 规格： EA 三周到货 生化实验

Anti-Integrin αV Antibody, cytoplasmic domain
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REFERENCES
Beta 3 integrin-mediated fibrin clot retraction by nucleated cells: differing behavior of alpha IIb beta 3 and alpha v beta 3
Chen, Y. P. et al. (1995) Blood, 86(7):2606-2615 (1995)
Species Reactivity Key Applications Host Format Antibody Type
H  ELISA, WB Rabbit Serum Polyclonal Antibody
Description:
Anti-Integrin αV Antibody, cytoplasmic domain
Promotional Text:
Special Shipping Offer on Antibodies
100% Performance Guaranteed
Trade Name:
Chemicon (Millipore)
Specificity:
Integrin alphaV
Epitope:
cytoplasmic domain
Immunogen:
Synthetic peptide corresponding to amino acids 1035-1048 of human integrin alphaV. This peptide sequence is absolutely conserved in the mouse integrin alphaV sequence.
Species Reactivity:
Human
Application Notes:
ELISA: 1:500 (direct)
Western Blot: 1:500. Antibody detects a non-reducible 155 kDa band corresponding to integrin alphaV.
Optimal dilutions must be determined by the end user.
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Presentation:
Whole rabbit serum. Liquid containing no preservative
Storage Conditions:
Maintain at -20°C in undiluted aliquots for up to 12 months from date of receipt. Avoid repeated freeze/thaw cycles.
UniProt Number:
P06756
Entrez Gene Number:
NM_002210.2
Gene Symbol:
ITGAV
DKFZp686A08142
MSK8
CD51
VNRA
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Alternate Names:
Vitronectin Receptor alpha Subunit; CD51 Antigen
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
ELISA
Western Blotting
Entrez Gene Summary:
ITAGV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The I-domain containing integrin alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8; ‘ITGB1’, ‘ITGB3’, ‘ITGB5’, ‘ITGB6’, and ‘ITGB8’), each can interact with extracellular matrix ligands; the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction.
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UniProt Summary:
FUNCTION: SwissProt: P06756 # The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and von Willebrand factor. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi’s sarcoma lesions.
SIZE: 1048 amino acids; 116038 Da
SUBUNIT: Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-V associates with either beta-1, beta-3, beta-5, beta-6 or beta-8 subunit. Interacts with HIV-1 Tat.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
SIMILARITY: SwissProt: P06756 ## Belongs to the integrin alpha chain family. & Contains 7 FG-GAP repeats.

AB1930   INTEGRIN AV, RBX-100UL   品牌 Millipore

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INTEGRIN AV, RBX-100UL

货号： AB1930      产品名称： INTEGRIN AV, RBX-100UL   品牌： Millipore 规格： EA 三周到货 生化实验

Anti-Integrin alphaV Antibody, CT, Intracellular
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REFERENCES
Cleavage of endometrial α-integrins into their functional forms is mediated by proprotein convertase 5/6.
Sarah Paule,Mohamad Aljofan,Carlos Simon,Luk J F Rombauts,Guiying Nie (2012) Human reproduction (Oxford, England).27
The importance of adequate fixation for immunofluorescent staining of bovine embryos.
K Goossens,L Vandaele,E Wydooghe,M Thys,J Dewulf,L J Peelman,A Van Soom,Lj Peelman (2011) Reproduction in domestic animals = Zuchthygiene.46
Endothelial von Willebrand factor regulates angiogenesis.
Starke, Richard D, et al. (2010) Blood, (2010)
Dual in vivo quantification of integrin-targeted and protease-activated agents in cancer using fluorescence molecular tomography (FMT).
Sylvie Kossodo,Maureen Pickarski,Shu-An Lin,Alexa Gleason,Renee Gaspar,Chiara Buono,Guojie Ho,Agnieszka Blusztajn,Garry Cuneo,Jun Zhang,Jayme Jensen,Richard Hargreaves,Paul Coleman,George Hartman,Milind Rajopadhye,Le Thi Duong,Cyrille Sur,Wael Yared,Jeffrey Peterson,Bohumil Bednar (2010) Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging.12
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Species Reactivity Key Applications Host Format Antibody Type
Ch, Eq, Gt, H, M, Ht, R, Po, Sh  ELISA, IHC, IP, RIA, WB Rabbit Serum Polyclonal Antibody
Description:
Anti-Integrin alphaV Antibody, CT, Intracellular
Promotional Text:
Special Shipping Offer on Antibodies
100% Performance Guaranteed
Trade Name:
Chemicon (Millipore)
Specificity:
Integrin alphaV. Specificity determined by immunoprecipitation from a detergent extract of 35S methonine labeled endothelial cells. No cross-reactivity to alpha1, alpha2, alpha3, alpha4, or alpha6 integrin subunits was detected. The mature alphaV protein (150 kDa) is composed of a disulfide bonded heavy (125 kDa) and a light (25 kDa) chain derived from a proteolytically cleaved precursor (Suzuki, 1987). The epitope recognized by the antibody is located on the COOH terminal portion of the light chain. By western blot under reducing conditions the antibody detects two major bands at approximately 25 and 27 kDa corresponding to the light chain. The slight differences in sizes of the light chains is thought to be caused by proteolytic cleavage at two alternative sites on the precursor. Similar sites have been reported for alpha6, alpha3, and alphalIbeta (Hogervorst, 1991).
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Molecular Weight:
130 kDa; 25 and 27 kDa (reducing conditions)
Epitope:
C-terminus, intracellular
Immunogen:
Synthetic peptide derived from the COOH terminal sequence (cytoplasmic domain) of the human alphaV integrin subunit (SwissProt Accession P06756, amino acids 1022-1034).
Background Information:
The integrin family of cell adhesion receptors consists of at least 19 membrane-associated heterodimers, composed of an alpha and beta subunit that associate in a non-covalent manner. To date, 16 different alpha-subunits and 8 different beta-subunits have been identified. The structure and functional diversity of the integrin family are based upon the pairing abilities of the individual alpha and beta subunits. Key to these molecular interactions between the integrin receptors and their respective ligands is the recognition of the Arg-Gly-Asp (RGD) sequence, known to be present in the extracellular matrix components fibronectin, vitronectin, collagen, fibrinogen, and von Willebrand factor (Cheresh, 1991). The involvement of integrins in vascular proliferation, adhesion, and wound repair has been well documented. Integrin alphaV is a type I membrane glycoptroein with no I (inserted) domain. The alphaV protein is post-translationally cleaved into a heavy and light chain, which is expressed on the cell surface as a disul -20℃