Procathepsin K, human recombinant

货号： 1026-10      产品名称： Procathepsin K, human recombinant   品牌： Biovision 规格： 10 μg 3周到货 生化实验

Procathepsin K, human recombinant
Predominant proteinase responsible for the resorption of the bone matrix.
Product Overview
Alternate Name/Synonyms: CTSK, CTSO, CTSO3
Gene Symbol: CATK
Accession #: P43235
Gene ID: 1513
Source: E. Coli
Appearance: Liquid
Physical Form Description: 1 mg/ml solution in 25 mM Na2HPO4 and 500 mM NaCl (pH 7.0).
Molecular Weight: 35.9 kDa
Purity by SDS-PAGE: ≥95%
Purity by HPLC: N/A
Endotoxin Level: N/A
Biological Activity: The specific activity is >1000 mU/mg (1U = 1 µmole/min/mg) as measured by Cathepsin K Activity Assay Kit (Catalog #K141-100)
Reconstitution Instructions: N/A
Storage Temp.: -80°C
Shipping: Gel Pack
Background Information: Cathepsin K, a member of the papain cysteine proteinase family is the predominant proteinase responsible for the resorption of the bone matrix. Cathepsin cleaves proteins such as collagen type I, collagen type II and osteonectin, thereby playing a role in bone remodeling and resorption in osteoporosis, osteolytic bone metastasis and rheumatoid arthritis (Bromme and Okamoto, 1995; Drake, F. et al 1996; Bossard et al, 1996). Cathepsin K is synthesized as an inactive proenzyme (35.1 kDa) that is converted to its mature active form (23.6 kDa) by proteolytic cleavage of its 99-amino-acid propeptide domain. The in-vitro processing of procathepsin K to mature cathepsin K is autocatalytic.
Amino Acid Sequence: N/A
Handling: Centrifuge the vial prior to opening
USAGE: For Research Use Only! Not For Use in Humans.

-80°C