Anti-IRAK3 (CT) pAb
货号: B50210 产品名称: Anti-IRAK3 (CT) pAb 品牌: Agilent 规格:
![](http://thermofisher.jinpanbio.com/wp-content/uploads/2024/04/BZWZ.jpg)
B50211 Anti-IRAK4 (NT) pAb 品牌 Agilent
Anti-IRAK4 (NT) pAb
货号: B50211 产品名称: Anti-IRAK4 (NT) pAb 品牌: Agilent 规格:
![](http://thermofisher.jinpanbio.com/wp-content/uploads/2024/04/BZWZ.jpg)
B50212 Anti-IRAK4 (CT) pAb 品牌 Agilent
Anti-IRAK4 (CT) pAb
货号: B50212 产品名称: Anti-IRAK4 (CT) pAb 品牌: Agilent 规格:
![](http://thermofisher.jinpanbio.com/wp-content/uploads/2024/04/BZWZ.jpg)
ADI-905-265-100 IRAK-2 (CT), pAb 品牌 Enzo
IRAK-2 (CT), pAb
货号: ADI-905-265-100 产品名称: IRAK-2 (CT), pAb 品牌: Enzo 规格: 100 ug
![](http://thermofisher.jinpanbio.com/wp-content/uploads/2024/04/BZWZ.jpg)
14-684 IRAK1, active 10ug 品牌 Millipore
IRAK1, active 10ug
货号: 14-684 产品名称: IRAK1, active 10ug 品牌: Millipore 规格: EA
![](http://thermofisher.jinpanbio.com/wp-content/uploads/2024/04/BZWZ.jpg)
14-684-K 6His-IRAK1-(hu,194-end) Bulk 品牌 Millipore
6His-IRAK1-(hu,194-end) Bulk
货号: 14-684-K 产品名称: 6His-IRAK1-(hu,194-end) Bulk 品牌: Millipore 规格: UG
![](http://thermofisher.jinpanbio.com/wp-content/uploads/2024/04/BZWZ.jpg)
14-684M IRAK1, active 250ug 品牌 Millipore
IRAK1, active 250ug
货号: 14-684M 产品名称: IRAK1, active 250ug 品牌: Millipore 规格: EA
![](http://thermofisher.jinpanbio.com/wp-content/uploads/2024/04/BZWZ.jpg)
ADI-905-709-100 IRAK-1, pAb 品牌 Enzo
IRAK-1, pAb
货号: ADI-905-709-100 产品名称: IRAK-1, pAb 品牌: Enzo 规格: 100 ug
![](http://thermofisher.jinpanbio.com/wp-content/uploads/2024/04/BZWZ.jpg)
ADI-KAP-ST206-E IRAK-4, pAb 品牌 Enzo
IRAK-4, pAb
货号: ADI-KAP-ST206-E 产品名称: IRAK-4, pAb 品牌: Enzo 规格: 100 ug
![](http://thermofisher.jinpanbio.com/wp-content/uploads/2024/04/BZWZ.jpg)
ADI-KAP-ST207-E IRAK-M, pAb 品牌 Enzo
IRAK-M, pAb
货号: ADI-KAP-ST207-E 产品名称: IRAK-M, pAb 品牌: Enzo 规格: 100 ug
![](http://thermofisher.jinpanbio.com/wp-content/uploads/2024/04/BZWZ.jpg)
13845-1 IRAK-4 Polyclonal Antibody 品牌 Cayman
IRAK-4 Polyclonal Antibody
货号: 13845-1 产品名称: IRAK-4 Polyclonal Antibody 品牌: Cayman 规格: 1 ea
![](http://thermofisher.jinpanbio.com/wp-content/uploads/2024/04/BZWZ.jpg)
13844-1 IRAK-2 Polyclonal Antibody 品牌 Cayman
IRAK-2 Polyclonal Antibody
货号: 13844-1 产品名称: IRAK-2 Polyclonal Antibody 品牌: Cayman 规格: 1 ea
![](http://thermofisher.jinpanbio.com/wp-content/uploads/2024/04/BZWZ.jpg)
13843-1 IRAK-1 Polyclonal Antibody 品牌 Cayman
IRAK-1 Polyclonal Antibody
货号: 13843-1 产品名称: IRAK-1 Polyclonal Antibody 品牌: Cayman 规格: 1 ea
![](http://thermofisher.jinpanbio.com/wp-content/uploads/2024/04/BZWZ.jpg)
04-367 anti-IRAK-3, rb mono 品牌 Millipore
anti-IRAK-3, rb mono
货号: 04-367 产品名称: anti-IRAK-3, rb mono 品牌: Millipore 规格: EA 3周到货 生化实验
Anti-IRAK3 Antibody, rabbit monoclonal
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REFERENCES
Tumor cells deactivate human monocytes by up-regulating IL-1 receptor associated kinase-M expression via CD44 and TLR4.
del Fresno, Carlos, et al. (2005) J. Immunol., 174: 3032-40 (2005)
Rapid up-regulation of IRAK-M expression following a second endotoxin challenge in human monocytes and in monocytes isolated from septic patients.
Escoll, Pedro, et al. (2003) Biochem. Biophys. Res. Commun., 311: 465-72 (2003)
Identification and characterization of murine IRAK-M
Rosati, Olaf and Martin, Michael U (2002) Biochem Biophys Res Commun, 293:1472-7 (2002)
Species Reactivity Key Applications Host Format Antibody Type
H, M IP, WB Rabbit Purified Monoclonal Antibody
Description:
Anti-IRAK3 Antibody, rabbit monoclonal
Promotional Text:
Special Shipping Offer on Antibodies
100% Performance Guaranteed
Trade Name:
Upstate (Millipore)
Specificity:
Recognizes the C-term domain of IRAK3.
Molecular Weight:
68 kDa
Immunogen:
KLH-conjugated synthetic peptide corresponding to residues in the C-term of human IRAK-3
Isotype:
IgG
Species Reactivity:
Human
Mouse
Application Notes:
Immunoblot Analysis: A 1:2,000 dilution of the lot detected IRAK3 CT in lysates from A431 cells.
Immunoprecipitation:
A 1:50 dilution of this antibody immunoprecipitated IRAK3 CT using protein G:agarose beads.
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Quality Assurance:
Routinely evaluated by immunoblot.
Purification Method:
Serum
Presentation:
100 µL of rabbit monoclonal IgG in 30 mM Tris-Glycine (pH 7.4), 0.09 M NaCl, 0.006% sodium azide and 0.03% BSA and 40% glycerol.
Storage Conditions:
2 years at -20°C from date of shipment
UniProt Number:
Q9Y616
Entrez Gene Number:
NM_007199.1
Gene Symbol:
IRAK3
IRAKM
IRAK-3
ASRT5
IRAK-M
View All »
Alternate Names:
IRAKM
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Immunoprecipitation
Western Blotting
UniProt Summary:
FUNCTION: SwissProt: Q9Y616 # Inhibits dissociation of IRAK1 and IRAK4 from the Toll- like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex (By similarity).
COFACTOR: Magnesium.
SIZE: 596 amino acids; 67753 Da
TISSUE SPECIFICITY: Expressed predominantly in peripheral blood lymphocytes.
DISEASE: SwissProt: Q9Y616 # Defects in IRAK3 are associated with susceptibility to asthma-related traits type 5 (ASRT5) [MIM:611064]. Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing, dyspnea, bronchial hyperresponsiveness as assessed by methacholine challenge test, serum IgE levels, atopy, and atopic dermatitis.
SIMILARITY: SwissProt: Q9Y616 ## Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily. & Contains 1 death domain. & Contains 1 protein kinase domain.
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Brand Family:
Upstate
Product Name:
Anti-IRAK3 Antibody, rabbit monoclonal
Antibody Type:
Monoclonal Antibody
Qty/Pk:
100 µL
Format:
Purified
Host:
Rabbit
Applic -20°C
![](http://thermofisher.jinpanbio.com/wp-content/uploads/2024/04/BZWZ.jpg)
PSC-95-112-C050 IRAK (rec.) (E. coli) 品牌 AXXORA
IRAK (rec.) (E. coli)
货号: PSC-95-112-C050 产品名称: IRAK (rec.) (E. coli) 品牌: AXXORA 规格: 50 ug
![](http://thermofisher.jinpanbio.com/wp-content/uploads/2024/04/BZWZ.jpg)
PSC-PSI-1802-KI01 IRAK Detection Set 品牌 AXXORA
IRAK Detection Set
货号: PSC-PSI-1802-KI01 产品名称: IRAK Detection Set 品牌: AXXORA 规格: 1 Set
![](http://thermofisher.jinpanbio.com/wp-content/uploads/2024/04/BZWZ.jpg)
06-872 ANTI- IRAK ! 200UG PC 12-309 品牌 Millipore
ANTI- IRAK ! 200UG PC 12-309
货号: 06-872 产品名称: ANTI- IRAK ! 200UG PC 12-309 品牌: Millipore 规格: EA 3周到货 生化实验
Anti-IRAK Antibody
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REFERENCES
Rotavirus Non-Structural Protein-1 suppresses virus induced cellular apoptosis to facilitate viral growth by activating the cell-survival pathways during early stages of infection.
Bagchi P, Dutta D, Chattopadhyay S, Mukherjee A, Halder UC, Sarkar S, Kobayashi N, Komoto S, Taniguchi K, Chawla-Sarkar M (2010) J Virol
Candida albicans triggers activation of distinct signaling pathways to establish a proinflammatory gene expression program in primary human endothelial cells.
Verena Müller, Dorothee Viemann, Marc Schmidt, Nicole Endres, Stephan Ludwig, Martin Leverkus, Johannes Roth, Matthias Goebeler (2007) Journal of immunology (Baltimore, Md. : 1950).179:8435-45
Neutrophil signaling pathways activated by bacterial DNA stimulation.
María E Alvarez, Juan I Fuxman Bass, Jorge R Geffner, Paula X Fernández Calotti, Mónica Costas, Omar A Coso, Romina Gamberale, Mónica E Vermeulen, Gabriela Salamone, Diego Martinez, Tamara Tanos, Analía S Trevani (2006) Journal of immunology (Baltimore, Md. : 1950).177:4037-46
Developmental and tissue-specific expression of mouse pelle-like protein kinase.
Trofimova, M, et al. (1996) J. Biol. Chem., 271: 17609-12 (1996)
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Species Reactivity Key Applications Host Format Antibody Type
H, M IP, WB Rabbit Purified Polyclonal Antibody
Description:
Anti-IRAK Antibody
Promotional Text:
Special Shipping Offer on Antibodies
100% Performance Guaranteed
Trade Name:
Upstate (Millipore)
Specificity:
Recognizes IRAK.
Molecular Weight:
80 kDa
Immunogen:
Peptide (DRQGPEESDEFQS) corresponding to amino acids 700-712 of human IRAK
Isotype:
IgG
Species Reactivity:
Human
Mouse
Control:
Positive Control Included: HeLa Nuclear Extract (12-309).
Quality Assurance:
routinely evaluated by immunoblot on HeLa nuclear extract
Purification Method:
Ammonium sulfate precipitation and DEAE-cellulose chromatography
Presentation:
Protein A Purified immunoglobulin in 30% glycerol, 0.07M Tris-glycine, pH 7.4, 0.105 M NaCl, 0.035% sodium azide as a preservative.
Storage Conditions:
Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
UniProt Number:
P51617
Entrez Gene Number:
NM_001569
Gene Symbol:
IRAK1
IRAK
pelle
IRAK-1
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
View All »
Key Applications:
Immunoprecipitation
Western Blotting
Entrez Gene Summary:
This gene encodes the interleukin-1 receptor-associated kinase 1, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. This gene is partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
View All »
UniProt Summary:
FUNCTION: SwissProt: P51617 # Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. Isoform 1 bi -20°C
![](http://thermofisher.jinpanbio.com/wp-content/uploads/2024/04/BZWZ.jpg)
07-1481 Anti-IRAK-M (rabbit polyclonal) 品牌 Millipore
Anti-IRAK-M (rabbit polyclonal)
货号: 07-1481 产品名称: Anti-IRAK-M (rabbit polyclonal) 品牌: Millipore 规格: EA 三周到货 生化实验
Anti-IRAK-M Antibody, a.a. 581-596
Recommended Replacement for: 07-1481 is a recommended replacement for AB16534
Species Reactivity Key Applications Host Format Antibody Type
H, M, R WB, IH(P) Rabbit Purified Polyclonal Antibody
Description:
Anti-IRAK-M Antibody, a.a. 581-596
Replaces:
07-1481 is a recommended replacement for AB16534
Promotional Text:
Special Shipping Offer on Antibodies
100% Performance Guaranteed
Specificity:
This antibody recognizes IRAK-M at a.a. 581-596.
Molecular Weight:
~68 kDa
Epitope:
a.a. 581-596
Immunogen:
Rabbit anti-IRAK-M polyclonal antibody was raised against a peptide corresponding to amino acids 581 to 596 of human IRAK-M (3).
Isotype:
IgG
Background Information:
IRAK (IL-1 receptor associated kinase) is a serine/threonine kinase which associates with the IL-1 receptor after ligand binding to initiate a signaling cascade that ultimately results in nuclear localization of NFκB thought to be important for inflammation. Interleukin-1 (IL-1) and lipopolysaccharide (LPS) induces cellular response through IL-1 receptor (IL-1R) and Toll like receptors (TLR). IL-1 receptor-associated kinase (IRAK and IRAK2) mediates the activation of NF- κB by IL-1/Toll receptors (1,2), which is a pivotal transcription factor mediating inflammatory and immune response. A novel member in the IRAK/Pelle family was recently identified and designated IRAK-M (3). IRAKs associate with IL-1/Toll receptors after IL-1 or LPS stimulation and the dominant negative mutants of IRAKs inhibit IL-1 or LPS induced NF-κB activation. Members in IRAK/Pelle family play a central role in IL-1R/TLR mediated inflammatory responses to cytokine IL-1and LPS.
Species Reactivity:
Human
Mouse
Rat
Species Reactivity Note:
Human, mouse, and rat reactive.
Application Notes:
Optimal working dilutions must be determined by end user.
Immunohistochemistry(paraffin):
Representative images from a previous lot.
Optimal Staining of IRAKm With Citrate pH 6.0 Epitope Retrieval: Human Kidney
Western blot: 0.5 to 1.0 µg/mL of a previous lot was used on mouse spleen or rat kidney tissue lysate can be used as positive control and a 68 kDa major band can be detected.
Control:
A431 Cell Lysate, mouse spleen or rat kidney tissue lysate
Quality Assurance:
Routinely evaluated by Western Blot on A431 lysates.
Western Blot Analysis: 1:500 dilution of this lot detected IRAK on 10 μg of A431 lysates.
Purification Method:
Purified
Presentation:
Purified rabbit polyclonal IgG in PBS containing 0.02% sodium azide.
Storage Conditions:
Maintain refrigerated at 2-8°C in undiluted aliquots for up to 1 year from date of receipt.
"Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
UniProt Number:
Q9Y616
Entrez Gene Number:
NM_007199.1
Gene Symbol:
IRAK3
IRAK-3
IRAKM
ASRT5
IRAK-M
EC 2.7.11.1
Alternate Names:
IL- 1 receptor-associated kinase M
Interleukin-1 receptor-associated kinase 3
Interleukin-1 receptor-associated kinase M
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic u 2-8℃
![](http://thermofisher.jinpanbio.com/wp-content/uploads/2024/04/BZWZ.jpg)
07-1601 IRAK1 Antibody (C-term) 品牌 Millipore
IRAK1 Antibody (C-term)
货号: 07-1601 产品名称: IRAK1 Antibody (C-term) 品牌: Millipore 规格: EA 三周到货 生化实验
Anti-IRAK1, C-terminus
Species Reactivity Key Applications Host Format Antibody Type
H WB Rabbit Purified Polyclonal Antibody
Description:
Anti-IRAK1 Antibody, CT
Promotional Text:
Special Shipping Offer on Antibodies
100% Performance Guaranteed
Specificity:
This antibody recognizes the C-terminal region of IRAK1.
Molecular Weight:
~77 kDa
Epitope:
C-terminus
Immunogen:
KLH-conjugated synthetic linear peptide corresponding to the C-terminal region of IRAK1.
Background Information:
IRAK1, also known as Interleukin-1 receptor associated kinase 1, belongs to the tyrosine kinase related (TKL) family and is involved with mRNA stabilization and activation of NF-kappa B. IRAK1 is located in all tissue as 2 isoforms, with 1 binding quickly and then degrading while isoform 2 is activated by kinase, resulting in a slower more sustained response to cytokines. Phosphorylation of IRAK1 leads to recruitment of the adapter protein PELI1. IRAK1 utilizes 2 pathways, the first one allows for mediation of IL-1 inflammatory responses when TRAF6 is bound, which activates NF-kappa B, thereby inhibiting I kappa B alpha. A second pathway does not involve TRAF6 and results in the stabilization of mRNA.
View All »
Species Reactivity:
Human
Species Reactivity Note:
Human.
Control:
Jurkat lysate
Quality Assurance:
Evaluated by western blot in jurkat lysate.
Western Blot Analysis: A 1:50-1:500 dilution of this antibody detected IRAK1 on jurkat lysate.
Purification Method:
Protein G purfied
Presentation:
Purified rabbit polyclonal in buffer containing PBS and 0.09% sodium azide.
Storage Conditions:
Stable for 6 months at 2-8ºC from date of receipt. For long term storage, store at -20ºC.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
View All »
UniProt Number:
P51617
Entrez Gene Number:
NP_001020413.1
Gene Symbol:
IRAK
IRAK-1
pelle
EC 2.7.11.1
Alternate Names:
interleukin-1 receptor-associated kinase 1
Pelle homolog
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
View All »
Key Applications:
Western Blotting
Entrez Gene Summary:
This gene encodes the interleukin-1 receptor-associated kinase 1, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. This gene is partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
View All »
UniProt Summary:
Function: Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. Isoform 1 binds rapidly but is then degraded allowing isoform 2 to mediate a slower, more sustained response to the cytokine. Isoform 2 is inactive suggesting that the kinase activity of this enzyme is not required for IL-1 signaling. Once phosphorylated, IRAK1 recruits the adapter protei 2-8℃
![](http://thermofisher.jinpanbio.com/wp-content/uploads/2024/04/BZWZ.jpg)
07-1602 IRAK4 Antibody (C-term) 品牌 Millipore
IRAK4 Antibody (C-term)
货号: 07-1602 产品名称: IRAK4 Antibody (C-term) 品牌: Millipore 规格: EA 三周到货 生化实验
Anti-IRAK4, C-terminus
Species Reactivity Key Applications Host Format Antibody Type
H WB Rabbit Purified Polyclonal Antibody
Description:
Anti-IRAK4 Antibody, CT
Promotional Text:
Special Shipping Offer on Antibodies
100% Performance Guaranteed
Specificity:
This antibody recognizes IRAK4 at the C-terminus.
Molecular Weight:
~51 kDa
Epitope:
C-terminus
Immunogen:
KLH-conjugated synthetic linear peptide corresponding to the C-terminal region of IRAK4.
Background Information:
IRAK4, also known as interleukin-1 receptor associated kinase 4, and belongs to the tyrosine kinase related (TKL) family, which is important for innate immune responses. IRAK4 is the closest human homolog to Pelle and combines signals from the receptor complex in the plasma membrane with the cytosol. IRAK4 phosphorylates IRAK1 which is then recruited to the IL-1 receptor complex, resulting in mRNA stabilization. NF-kappa B is activated by the kinase activity of IRAK4 through the TLR and TCR pathways. Mutations result in deficiency of IRAK4 which leads to recurring invasive pneumoccocal disease, extracellular pyogenic bacterial and fungal infections.
View All »
Species Reactivity:
Human
Species Reactivity Note:
Human.
Control:
Jurkat lysate
Quality Assurance:
Evaluated by western blot on jurkat lysate.
Western Blot Analysis: A 1:25-1:500 dilution of this antibody detected IRAK4 on jurkat lysates.
Purification Method:
Protein G purfied
Presentation:
Purified rabbit polyclonal in buffer containing PBS and 0.09% sodium azide.
Storage Conditions:
Stable for 6 months at 2-8ºC from date of receipt. For long term storage, store at -20ºC.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
View All »
UniProt Number:
Q9NWZ3
Entrez Gene Number:
NP_001107654.1
Gene Symbol:
IRAK-4
IPD1
NY-REN-64
REN64
EC 2.7.11.1
View All »
Alternate Names:
interleukin-1 receptor-associated kinase 4
interleukin-1 receptor associated kinase 4
NY-REN-64 antigen
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
View All »
Key Applications:
Western Blotting
Entrez Gene Summary:
This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene. [supplied by RefSeq]
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UniProt Summary:
Function: Required for the efficient recruitment of IRAK1 to the IL-1 receptor complex following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. Phosphorylates IRAK1.
Catalytic activity: ATP + a protein = ADP + a phosphoprotein.
Cofactor Magnesium.
Subunit structure: IL-1 stimulation leads to the formation of a signaling complex which dissociates fro 2-8℃
![](http://thermofisher.jinpanbio.com/wp-content/uploads/2024/04/BZWZ.jpg)