ANTI- IRAK ! 200UG PC 12-309

货号： 06-872      产品名称： ANTI- IRAK ! 200UG PC 12-309   品牌： Millipore 规格： EA 3周到货 生化实验

Anti-IRAK Antibody
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REFERENCES
Rotavirus Non-Structural Protein-1 suppresses virus induced cellular apoptosis to facilitate viral growth by activating the cell-survival pathways during early stages of infection.
Bagchi P, Dutta D, Chattopadhyay S, Mukherjee A, Halder UC, Sarkar S, Kobayashi N, Komoto S, Taniguchi K, Chawla-Sarkar M (2010) J Virol
Candida albicans triggers activation of distinct signaling pathways to establish a proinflammatory gene expression program in primary human endothelial cells.
Verena Müller, Dorothee Viemann, Marc Schmidt, Nicole Endres, Stephan Ludwig, Martin Leverkus, Johannes Roth, Matthias Goebeler (2007) Journal of immunology (Baltimore, Md. : 1950).179:8435-45
Neutrophil signaling pathways activated by bacterial DNA stimulation.
María E Alvarez, Juan I Fuxman Bass, Jorge R Geffner, Paula X Fernández Calotti, Mónica Costas, Omar A Coso, Romina Gamberale, Mónica E Vermeulen, Gabriela Salamone, Diego Martinez, Tamara Tanos, Analía S Trevani (2006) Journal of immunology (Baltimore, Md. : 1950).177:4037-46
Developmental and tissue-specific expression of mouse pelle-like protein kinase.
Trofimova, M, et al. (1996) J. Biol. Chem., 271: 17609-12 (1996)
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Species Reactivity Key Applications Host Format Antibody Type
H, M  IP, WB Rabbit Purified Polyclonal Antibody
Description:
Anti-IRAK Antibody
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Trade Name:
Upstate (Millipore)
Specificity:
Recognizes IRAK.
Molecular Weight:
80 kDa
Immunogen:
Peptide (DRQGPEESDEFQS) corresponding to amino acids 700-712 of human IRAK
Isotype:
IgG
Species Reactivity:
Human
Mouse
Control:
Positive Control Included: HeLa Nuclear Extract (12-309).
Quality Assurance:
routinely evaluated by immunoblot on HeLa nuclear extract
Purification Method:
Ammonium sulfate precipitation and DEAE-cellulose chromatography
Presentation:
Protein A Purified immunoglobulin in 30% glycerol, 0.07M Tris-glycine, pH 7.4, 0.105 M NaCl, 0.035% sodium azide as a preservative.
Storage Conditions:
Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
UniProt Number:
P51617
Entrez Gene Number:
NM_001569
Gene Symbol:
IRAK1
IRAK
pelle
IRAK-1
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Immunoprecipitation
Western Blotting
Entrez Gene Summary:
This gene encodes the interleukin-1 receptor-associated kinase 1, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. This gene is partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
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UniProt Summary:
FUNCTION: SwissProt: P51617 # Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. Isoform 1 bi -20°C