ANTI-IRAK4 100UG

货号： 07-418      产品名称： ANTI-IRAK4 100UG   品牌： Millipore 规格： EA 三周到货 生化实验

Anti-IRAK4 Antibody
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REFERENCES
Regulation of IRAK-4 kinase activity via autophosphorylation within its activation loop.
Hong Cheng, Terri Addona, Hasmik Keshishian, Erik Dahlstrand, Chafen Lu, Marion Dorsch, Zhi Li, Anlai Wang, Timothy D Ocain, Ping Li, Thomas F Parsons, Bruce Jaffee, Yajun Xu (2007) Biochemical and biophysical research communications.352:609-16
Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4.
Suzuki, Nobutaka, et al. (2002) Nature, 416: 750-6 (2002)
IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase.
Li, Shyun, et al. (2002) Proc. Natl. Acad. Sci. U.S.A., 99: 5567-72 (2002)
Species Reactivity Key Applications Host Format Antibody Type
H  WB Rabbit Purified Polyclonal Antibody
Description:
Anti-IRAK4 Antibody
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Trade Name:
Upstate (Millipore)
Specificity:
IRAK4
Molecular Weight:
52kDa
Immunogen:
peptide corresponding to amino acids 436-459 of human IRAK4
Isotype:
IgG
Species Reactivity:
Human
Quality Assurance:
routinely evaluated by immunoblot in RIPA lysates from HeLa cells
Purification Method:
Protein A purfied
Presentation:
0.1M Tris-glycine, pH 7.4, 0.15M NaCl,0.05% sodium azide before the addition of glycerol to 30%
Storage Conditions:
2 years at -20°C
UniProt Number:
Q9NWZ3
Entrez Gene Number:
NM_016123
Gene Symbol:
IRAK4
REN64
NY-REN-64
IRAK-4
LOC51135
IPD1
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Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Western Blotting
Entrez Gene Summary:
Interleukin-1 receptor (see IL1R; MIM 147810)-associated kinases (e.g., IRAK1; MIM 300283) are important mediators in the signal transduction of Toll-like receptor (TLR, e.g., TLR4; MIM 603030) and IL1R family members, collectively referred to as TIRs. IRAK4 functions in this signal transduction pathway.[supplied by OMIM]
UniProt Summary:
FUNCTION: SwissProt: Q9NWZ3 # Required for the efficient recruitment of IRAK1 to the IL-1 receptor complex following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up- regulation and mRNA stabilization. Phosphorylates IRAK1.
COFACTOR: Magnesium.
SIZE: 460 amino acids; 51530 Da
SUBUNIT: IL-1 stimulation leads to the formation of a signaling complex which dissociates from the IL-1 receptor following the binding of PELI1. Interacts with IL1RL1.
DISEASE: SwissProt: Q9NWZ3 # Defects in IRAK4 are the cause of recurrent isolated invasive pneumococcal disease type 1 (IPD1) [MIM:610799]. Recurrent invasive pneumococcal disease (IPD) is defined as two episodes of IPD occurring at least 1 month apart, whether caused by the same or different serotypes or strains. Recurrent IPD occurs in at least 2% of patients in most series, making IPD the most important known risk factor for subsequent IPD. & Defects in IRAK4 are the cause of IRAK4 deficiency [MIM:607676]. IRAK4 deficiency causes extracellular pyogenic bacterial and fungal infections in otherwise healthy children.
SIMILARITY: SwissProt: Q9NWZ3 ## Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. -20℃