Smo Antagonist, SA1

货号： 2154-2      产品名称： Smo Antagonist, SA1   品牌： Biovision 规格： 2 mg 3周到货 生化实验

Smo Antagonist, SA1
A Smoothened (Smo) antagonist
Product Overview
Product Name: Smo Antagonist, SA1
Alternate Name/Synonyms: 3-(3-(4-Fluorophenyl)-2,5,7-trimethylpyrazolo[1,5a]pyrimidin-6-yl)-N-(4-(furan-2-yl)butan-2-yl)propanamide
Description: A Smoothened (Smo) antagonist. SA1 inhibits Hh pathway by interacting directly with Smo. Inhibits SAG (Smoothened agonist) activation of Hh signaling in Shh-LIGHT 2 cells (IC₅₀ = 3.1 µM). Also inhibits the localization of Smo to cilia. Treatment of Ptch1-/- MEFs with SA1 suppresses the β-galactosidase activity (IC₅₀ = 3.8 µM) and inhibits the expression of Gli1 and Ptch1 in ASZ1 cells.
Peptide Sequence: N/A
Appearance: Crystalline solid
Formulation: N/A
CAS Number: N/A
Molecular Formula: C₂₆H₂₉FN₄O₂
Molecular Weight: 448.53
Purity: ≥95% by NMR
Solubility:DMSO
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from air and moisture
SMILES: CC1=C(C(=NC2=C(C(=NN12)C)C3=CC=C(C=C3)F)C)CCC(=O)NC(C)CCC4=CC=CO4
InChi: InChI=1S/C26H29FN4O2/c1-16(7-12-22-6-5-15-33-22)28-24(32)14-13-23-17(2)29-26-25(18(3)30-31(26)19(23)4)20-8-10-21(27)11-9-20/h5-6,8-11,15-16H,7,12-14H2,1-4H3,(H,28,32)
InChi Key: UTURPAUEBUIDJO-UHFFFAOYSA-N
PubChem CID: 5308963
MDL Number: N/A
USAGE: For Research Use Only! Not For Use in Humans.

-20°C

Smo Antagonist, SA1

货号： 2154-5      产品名称： Smo Antagonist, SA1   品牌： Biovision 规格： 5 mg 3周到货 生化实验

Smo Antagonist, SA1
A Smoothened (Smo) antagonist
Product Overview
Product Name: Smo Antagonist, SA1
Alternate Name/Synonyms: 3-(3-(4-Fluorophenyl)-2,5,7-trimethylpyrazolo[1,5a]pyrimidin-6-yl)-N-(4-(furan-2-yl)butan-2-yl)propanamide
Description: A Smoothened (Smo) antagonist. SA1 inhibits Hh pathway by interacting directly with Smo. Inhibits SAG (Smoothened agonist) activation of Hh signaling in Shh-LIGHT 2 cells (IC₅₀ = 3.1 µM). Also inhibits the localization of Smo to cilia. Treatment of Ptch1-/- MEFs with SA1 suppresses the β-galactosidase activity (IC₅₀ = 3.8 µM) and inhibits the expression of Gli1 and Ptch1 in ASZ1 cells.
Peptide Sequence: N/A
Appearance: Crystalline solid
Formulation: N/A
CAS Number: N/A
Molecular Formula: C₂₆H₂₉FN₄O₂
Molecular Weight: 448.53
Purity: ≥95% by NMR
Solubility:DMSO
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from air and moisture
SMILES: CC1=C(C(=NC2=C(C(=NN12)C)C3=CC=C(C=C3)F)C)CCC(=O)NC(C)CCC4=CC=CO4
InChi: InChI=1S/C26H29FN4O2/c1-16(7-12-22-6-5-15-33-22)28-24(32)14-13-23-17(2)29-26-25(18(3)30-31(26)19(23)4)20-8-10-21(27)11-9-20/h5-6,8-11,15-16H,7,12-14H2,1-4H3,(H,28,32)
InChi Key: UTURPAUEBUIDJO-UHFFFAOYSA-N
PubChem CID: 5308963
MDL Number: N/A
USAGE: For Research Use Only! Not For Use in Humans.

-20°C

Smo Antagonist, SA9

货号： 2155-2      产品名称： Smo Antagonist, SA9   品牌： Biovision 规格： 2 mg 3周到货 生化实验

Smo Antagonist, SA9
A Hedgehog (Hh) signaling pathway antagonist
Product Overview
Product Name: Smo Antagonist, SA9
Alternate Name/Synonyms: 3-(3-(4-Fluorophenyl)-5-oxo-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinazolin-1-yl-N-(3-methylphenethyl)propanamide
Description: SA9 inhibits Hh pathway by interacting directly with Smo. It inhibits SAG (Smoothened agonist) activation of Hh signaling in Shh-LIGHT 2 cells (IC₅₀ = 19 µM). Induces the localization of Smo to cilia in ASZ1 cells, but not in IMCD3 cells. Also treatment of Ptch1-/- MEFs with SA9 suppresses the β-galactosidase activity (IC₅₀ = 1.0 µM) and inhibits the expression of Gli1 and Ptch1 in ASZ1 cells.
Peptide Sequence: N/A
Appearance: Crystalline solid
Formulation: N/A
CAS Number: N/A
Molecular Formula: C₂₇H₂₈ClN₅O₂
Molecular Weight: 490
Purity: ≥95% by NMR
Solubility:DMSO
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from air and moisture
SMILES: C1CCC(=CC1)CCNC(=O)CCC2=NN=C3N2C4=CC=CC=C4C(=O)N3CC5=CC=C(C=C5)Cl
InChi: InChI=1S/C27H28ClN5O2/c28-21-12-10-20(11-13-21)18-32-26(35)22-8-4-5-9-23(22)33-24(30-31-27(32)33)14-15-25(34)29-17-16-19-6-2-1-3-7-19/h4-6,8-13H,1-3,7,14-18H2,(H,29,34)
InChi Key: YTDIPVZSLXYGNL-UHFFFAOYSA-N
PubChem CID: 20880974
MDL Number: N/A
USAGE: For Research Use Only! Not For Use in Humans.

-20°C

Smo Antagonist, SA9

货号： 2155-5      产品名称： Smo Antagonist, SA9   品牌： Biovision 规格： 5 mg 3周到货 生化实验

Smo Antagonist, SA9
A Hedgehog (Hh) signaling pathway antagonist
Product Overview
Product Name: Smo Antagonist, SA9
Alternate Name/Synonyms: 3-(3-(4-Fluorophenyl)-5-oxo-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinazolin-1-yl-N-(3-methylphenethyl)propanamide
Description: SA9 inhibits Hh pathway by interacting directly with Smo. It inhibits SAG (Smoothened agonist) activation of Hh signaling in Shh-LIGHT 2 cells (IC₅₀ = 19 µM). Induces the localization of Smo to cilia in ASZ1 cells, but not in IMCD3 cells. Also treatment of Ptch1-/- MEFs with SA9 suppresses the β-galactosidase activity (IC₅₀ = 1.0 µM) and inhibits the expression of Gli1 and Ptch1 in ASZ1 cells.
Peptide Sequence: N/A
Appearance: Crystalline solid
Formulation: N/A
CAS Number: N/A
Molecular Formula: C₂₇H₂₈ClN₅O₂
Molecular Weight: 490
Purity: ≥95% by NMR
Solubility:DMSO
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from air and moisture
SMILES: C1CCC(=CC1)CCNC(=O)CCC2=NN=C3N2C4=CC=CC=C4C(=O)N3CC5=CC=C(C=C5)Cl
InChi: InChI=1S/C27H28ClN5O2/c28-21-12-10-20(11-13-21)18-32-26(35)22-8-4-5-9-23(22)33-24(30-31-27(32)33)14-15-25(34)29-17-16-19-6-2-1-3-7-19/h4-6,8-13H,1-3,7,14-18H2,(H,29,34)
InChi Key: YTDIPVZSLXYGNL-UHFFFAOYSA-N
PubChem CID: 20880974
MDL Number: N/A
USAGE: For Research Use Only! Not For Use in Humans.

-20°C

Smo Antagonist, SA10

货号： 2159-2      产品名称： Smo Antagonist, SA10   品牌： Biovision 规格： 2 mg 3周到货 生化实验

Smo Antagonist, SA10
A Hedgehog (Hh) signaling pathway antagonist
Product Overview
Product Name: Smo Antagonist, SA10
Alternate Name/Synonyms: 4-((Benzo[c][1,2,5]thiadiazole-4-sulfonamido)methyl-N-(3-phenylpropyl)cyclohexanecarboxamide
Description: SA10 inhibits SAG (Smoothened agonist) activation of Hh signaling in Shh-LIGHT 2 cells (IC₅₀ = 5 µM). However, unlike SA1 and SA9, Smo antagonist SA10 does not directly bind to Smo. Inhibits the localization o Smo to cilia. Also treatment of Ptch1-/- MEFs with SA10 suppresses the β-galactosidase activity (IC₅₀ = 11.0 µM) and inhibits the expression of Gli1 and Ptch1 in ASZ1 cells.
Peptide Sequence: N/A
Appearance: Crystalline solid
Formulation: N/A
CAS Number: N/A
Molecular Formula: C₂₃H₂₈N₄O₃S₂
Molecular Weight: 472.62
Purity: ≥95% by NMR
Solubility:DMSO
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from air and moisture
SMILES: N/A
InChi: N/A
InChi Key: N/A
PubChem CID: N/A
MDL Number: N/A
USAGE: For Research Use Only! Not For Use in Humans.

-20°C

Smo Antagonist, SA10

货号： 2159-5      产品名称： Smo Antagonist, SA10   品牌： Biovision 规格： 5 mg 3周到货 生化实验

Smo Antagonist, SA10
A Hedgehog (Hh) signaling pathway antagonist
Product Overview
Product Name: Smo Antagonist, SA10
Alternate Name/Synonyms: 4-((Benzo[c][1,2,5]thiadiazole-4-sulfonamido)methyl-N-(3-phenylpropyl)cyclohexanecarboxamide
Description: SA10 inhibits SAG (Smoothened agonist) activation of Hh signaling in Shh-LIGHT 2 cells (IC₅₀ = 5 µM). However, unlike SA1 and SA9, Smo antagonist SA10 does not directly bind to Smo. Inhibits the localization o Smo to cilia. Also treatment of Ptch1-/- MEFs with SA10 suppresses the β-galactosidase activity (IC₅₀ = 11.0 µM) and inhibits the expression of Gli1 and Ptch1 in ASZ1 cells.
Peptide Sequence: N/A
Appearance: Crystalline solid
Formulation: N/A
CAS Number: N/A
Molecular Formula: C₂₃H₂₈N₄O₃S₂
Molecular Weight: 472.62
Purity: ≥95% by NMR
Solubility:DMSO
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from air and moisture
SMILES: N/A
InChi: N/A
InChi Key: N/A
PubChem CID: N/A
MDL Number: N/A
USAGE: For Research Use Only! Not For Use in Humans.

-20°C