MG-132
货号： 474790-10MG 产品名称： MG-132 品牌： Merck 规格： *** 3周到货 生化实验
MG-132
Carbobenzoxy-L-leucyl-L-leucyl-L-leucinal, Z-LLL-CHO, Proteasome Inhibitor XI
A potent, reversible, and cell-permeable proteasome inhibitor (Ki = 4 nM). Reduces the degradation of ubiquitin-conjugated proteins in mammalian cells and permeable strains of yeast by the 26S complex without affecting its ATPase or isopeptidase activities. Activates c-Jun N-terminal kinase (JNK1), which initiates apoptosis. Inhibits NF-κB activation (IC50 = 3 µM). Also reported to increases the survival rate of mesenchymal stem cells following their transplantation. Prevents β-secretase cleavage. A 10 mM (1 mg/210 µl) solution of MG-132 (Cat. No. 474791) in DMSO is also available. This material is ≥98% pure by HPLC. A material with ≥95% purity by HPLC (Cat. No. 474787) is also available.
产品信息
Peptide Sequence Z-Leu-Leu-Leu-CHO
Form White solid
Primary Target proteasome
Primary Target Ki 4 nM
Secondary target NF-κB (IC50 = 3 µM)
Molar mass 475.6
Cell permeable 是的
Reversible 是的
Purity ≥98% by HPLC
Solubility DMSO or EtOH
Chemical formula C26H41N3O5
CAS number 133407-82-6
商店和运输信息
Storage -20°C
Ship Ambient Temperature Only
Standard Handling
-20°C
475851-25MG Mitaplatin 品牌 Merck
Mitaplatin
货号： 475851-25MG 产品名称： Mitaplatin 品牌： Merck 规格： *** 3周到货 生化实验
Mitaplatin
A cell-permeable Pt(IV) compound that, upon reduction inside cells, yields two molecules of the PDK (pyruvate dehydrogenase kinase) inhibitor DCA/dichloroacetate and one molecule of the apoptosis inducer Cisplatin (Cat. No. 232120). While the dual prodrug nature of Mitaplatin is shown to result in increased cell killing than Cisplatin in the human ovarian carcinoma A2780/CP70 cultures (IC50 = 3.34 and 6.0, respectively), the anticancer potency of Mitaplatin is often weaker than Cisplatin in other cancer cells tested, presumably due to insufficient prodrug reduction in these cells.
产品信息
Form Off-white to cream solid
Molar mass 702.1
Protect from Light 是的
Packaged under inert gas 是的
Purity ≥95% by NMR
Solubility DMSO
Chemical formula C10H22Cl6N4O6Pt
商店和运输信息
Storage +2°C to +8°C
Ship Ambient Temperature Only
Harmful
2°C – 8°C
475958-20MG C-Raf Inhibitor 品牌 Merck
C-Raf Inhibitor
货号： 475958-20MG 产品名称： C-Raf Inhibitor 品牌： Merck 规格： *** 3周到货 生化实验
c-Raf Inhibitor
1-(3-(1,4-dihydroimidazo[4,5-c]pyrazol-5-yl)-4-methylphenyl)-3-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)urea
A cell-permeable pyrazoloimidazole phenyl urea derivative that acts as a selective type II inhibitor of c-Raf. It shows an IC50 value of 50 nM in an enzymatic assay, and comparable anti-proliferative activities to sorafenib against A375P (GI 50 = 2.68 µM) and WM3629 (GI50 = 0.86 µM) human melanoma cell lines. When screening against a panel of 30 different kinases at a concentration of 10 µM, it exerts an inhibitory activity of 96% on c-Raf, but below 50% for most of the other kinases.
产品信息
Form Off white solid
Molar mass 480.45
Purity ≥95% by HPLC
Solubility DMSO
Chemical formula C23H19F3N8O
商店和运输信息
Storage +2°C to +8°C
Ship Ambient Temperature Only
Standard Handling
2°C – 8°C
476496-5MG ProteinLysMethyltransferaseInhibitor,UNC 品牌 Merck
ProteinLysMethyltransferaseInhibitor,UNC
货号： 476496-5MG 产品名称： ProteinLysMethyltransferaseInhibitor,UNC 品牌： Merck 规格： *** 3周到货 生化实验
Protein Lysine Methyltransferase Inhibitor, UNC0321
7-(2-(2-(Dimethylamino)ethoxy)ethoxy)-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine
A cell-permeable, quinazoline analog that potently and selectively inhibits PKMT G9a (IC50 = 6 nM and 9 nM in two biochemical assays for CLOT and ECSD, respectively, and Ki = 63 pM, which is approximately 250-fold more potent than a closely-related analog, BIX01294 (Cat. No. 382190)). It inhibits GLP with reduced potency (15 nM) and is found to be inactive (IC50 > 40 µM) toward other protein lysine and arginine methyltransferases, such as SET7/9 (aH3K4 PKMT), SET8/PreSET7 (aH4K20 PKMT), and PRMT3, as well as JMJD2E (> 1000-fold selectivity) in ECSD enzymatic assays. It also inhibits H3K9me2 accumulation (IC50 = 11,000 nM) in MDA-MB-231 cells, in comparison to BIX01294 (IC50 = 500 nM).
产品信息
Form Tan to brown solid
Molar mass 515.69
Protect from Light 是的
Packaged under inert gas 是的
Purity >95% by HPLC
Solubility DMSO
Chemical formula C27H45N7O3
商店和运输信息
Storage -20°C
Ship Shipped with Blue Ice or with Dry Ice
Standard Handling
-20°C
481908-2MG Nicotinamide Phosphoribosyltransferase I 品牌 Merck
Nicotinamide Phosphoribosyltransferase I
货号： 481908-2MG 产品名称： Nicotinamide Phosphoribosyltransferase I 品牌： Merck 规格： *** 3周到货 生化实验
Nicotinamide Phosphoribosyltransferase Inhibitor, FK866
(E)-N-(4-(1-Benzoylpiperidin-4-yl)butyl)-3-(pyridin-3-yl)acrylamide, NAMPT Inhibitor, NAPRT Inhibitor, APO866, NAMPTase Inhibitor I, PBEF Inhibitor I, Visfatin Inhibitor I
A cell-permeable pyridinylacrylamide compound that acts as a selective, allosteric NAPRT/NAMPT (nicotinamide phosphoribosyltransferase) inhibitor (Ki = 0.4 nM for the enzyme/substrate complex; Ki′ = 0.3 nM for the free enzyme), while exhibiting no effect toward NPRT (nicotinic acid phosphoribosyltransferase) activity (82% inhibition of NAPRT activity at 10 nM vs no inhibition of NPRT activity at 1 µM in K-562 extract). FK866 treatment is shown to induce cell death by depleting NAD+ (Cat. Nos. 481911 & 481915) in HepG2 and NIH-3T3 cultures (by >95% after 24 h treatment of 10 nM FK866), likewise the addition of exogenous NAD+ is demonstrated to rescue NIH-3T3 and SH-SY5Y from FK866-induced NAD+-depletion and cell death.
产品信息
Form Yellow liquid
Formulation Supplied as a 50 mM (2 mg/102.17 µl) solution in DMSO.
Molar mass 391.5
Protect from Light 是的
Packaged under inert gas 是的
Purity ≥97% by HPLC
Solubility DMSO
Chemical formula C24H29N3O2
CAS number 658084-64-1
商店和运输信息
Storage +2°C to +8°C
Ship Ambient Temperature Only
Standard Handling
2°C – 8°C
481909-1GM Niclosamide 品牌 Merck
Niclosamide
货号： 481909-1GM 产品名称： Niclosamide 品牌： Merck 规格： *** 3周到货 生化实验
Niclosamide
5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxy-benzamide, Autophagy Inducer III, STAT3 Inhibitor XV, Wnt Pathway Inhibitor XIII, mTOR Inhibitor IX
A cell-permeable salicylanilide that, in addition to its well-known antihelmintic efficacy, acts as a mammalian mTORC1, but not mTORC2, signaling inhibitor mechanistically distinct from rapamycin (Cat. Nos. 553210, 553211, & 553212). Likely a direct consequence of autophagy activation, Niclosamide is demonstrated to induce Wnt-independent Frizzled1 and Dishevelled-2 downregulation. Unrelated to its autophagy induction activity, Niclosamide is also shown to inhibit Stat3 signaling (IC50 = 0.25 µM in HeLa reporter assays). Efficiently inhibits breast cancer stem-like cells in vitro and in vivo.
产品信息
Form Pale yellow solid
Molar mass 327.1
Protect from Light 是的
Packaged under inert gas 是的
Purity ≥97% by HPLC
Solubility DMSO or EtOH
Chemical formula C13H8Cl2N2O4
CAS number 50-65-7
商店和运输信息
Storage +2°C to +8°C
Ship Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Regulatory Review
2°C – 8°C
489476-10MG LSD1 Inhibitor 品牌 Merck
LSD1 Inhibitor
货号： 489476-10MG 产品名称： LSD1 Inhibitor 品牌： Merck 规格： *** 3周到货 生化实验
LSD1 Inhibitor
LSD Inhibitor I, BHC110 Inhibitor I, Histone Lysine Demethylase Inhibitor III, KDM1 Inhibitor I
A bisguanidine polyamine analogue that exhibits noncompetitive and specific LSD1 inhibition, with 14.1% remaining LSD1 activity at 10 µM in vitro, and is shown to significantly increase methylation at the histone 3 lysine 4 chromatin mark (H3K4me1 and H3K4me2) dose-dependently from 0.25 µM to 10 µM, without affecting global H3K9me2 (which is not a LSD1 substrate) levels in HCT116 human colon carcinoma cells. This compound induces reexpression of several epigenetically silenced genes including SFRP1, SFRP4, SFRP5, and GATA5 more effectively when compared with siRNA treatment, particularly in the case of SFRP4 and SFRP5.
产品信息
Form Pale yellow to yellow solid
Molar mass 474.34
Protect from Light 是的
Packaged under inert gas 是的
Purity ≥95% by HPLC
Solubility H2O
Chemical formula C15H40Cl4N8
CAS number 927019-63-4
商店和运输信息
Storage -20°C
Ship Shipped with Blue Ice or with Dry Ice
Standard Handling
-20°C
492905-25MG Nucleozin 品牌 Merck
Nucleozin
货号： 492905-25MG 产品名称： Nucleozin 品牌： Merck 规格： *** 3周到货 生化实验
Nucleozin
A cell-permeable isoxazolylpiperazine compound that is shown to inhibit influenza A H1N1 (A/WSN/33 strain), H3N2 (clinical isolate), and H5N1 (A/Vietnam/1194/04) replication in MDCK cells in vitro (EC50 = 69, 160, and 330 nM, respectively) and significantly reduce fatality after A/Vietnam/1194/04 infection in mice in vivo (50% survial rate on day 21 with 14 b.i.d. i.p. doses of 230 µg/mouse in the first 7 days after infection) by preventing nucleoprotein (NP) nuclear accumulation via NP aggregation induction during early stages of viral infection. Virus strains with N309K or Y289H NP mutation, such as swine-origin influenza A (S-OIV) H1N1, are found to be resistant to Nucleozin, consistent with the N309-mediated hydrogen bonding and Y289-mediated hydrophobic interaction with Nucleozin as predicted by computer-aided docking studies.
产品信息
Form Yellow powder
Molar mass 426.9
Purity ≥95% by HPLC
Solubility DMSO
Chemical formula C21H19ClN4O4
商店和运输信息
Storage +2°C to +8°C
Ship Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Standard Handling
2°C – 8°C
506169-1EA InhibitorSelectp53PathwayRegulatorsPanel 品牌 Merck
InhibitorSelectp53PathwayRegulatorsPanel
货号： 506169-1EA 产品名称： InhibitorSelectp53PathwayRegulatorsPanel 品牌： Merck 规格： *** 3周到货 生化实验
InhibitorSelect™ p53 Pathway Regulators Panel
A panel containing 18 potent, selective and cell-permeable inhibitors and 1 activator that is useful for the study of p53 pathway: 2 mg of ATM Kinase Inhibitor (Cat. No. 118500), 5 mg ATM/ATR Kinase Inhibitor (Cat. No. 118501), 10 mg of Anacardic Acid (Cat. No. 172050), 5 mg of Cdk1 Inhibitor IV, RO-3306 (Cat. No. 217699), 5 mg of Casein Kinase II Inhibitor III, TBCA (Cat. No. 218710), 1 mg of Chk2 Inhibitor II (Cat. No. 220486), 5 mg of Hdm2 E3 Ligase Inhibitor (Cat. No. 373225), 5 mg of JNK Inhibitor II (Cat. No. 420119), 1 mg of MDM2 Antagonist, Nutlin-3, Racemic (Cat. No. 444143), 10 mg of MDMX Inhibitor, SJ-172550 (Cat. No. 444155), 5 mg of MG-132 (Cat. No. 474790), 5 mg of p21-Activated Kinase Inhibitor III, IPA-3 (Cat. No. 506106), 5 mg of Pifithrin-α (Cat. No. 506132), 1 mg of PI-103 (Cat. No. 528100), 1 mg of PARP Inhibitor VIII, PJ34 (Cat. No. 528150), 10 mg of PPM1D Phosphatase Inhibitor (Cat. No. 529578), 10 mg of PRIMA-1 (Cat. No. 530050), 1 mg of Caspase Inhibitor I (Cat. No. 627610), and 1 mg Trichostatin A, Streptomyces sp. (Cat. No. 647925). Also provided with 15 ml of anhydrous DMSO (Cat. No. KP31817). Supplied with a data sheet.
产品信息
Form Solid
Protect from Light 是的
Hygrocopic 是的
Packaged under inert gas 是的
商店和运输信息
Storage -20°C
Ship Shipped with Blue Ice or with Dry Ice
Regulatory Review
-20°C
524631-1SET PhosphataseInhibitorCocktailSetIII,Lyo 品牌 Merck
PhosphataseInhibitorCocktailSetIII,Lyo
货号： 524631-1SET 产品名称： PhosphataseInhibitorCocktailSetIII,Lyo 品牌： Merck 规格： *** 3周到货 生化实验
Phosphatase Inhibitor Cocktail Set III, Lyophilized
A cocktail of four phosphatase inhibitors for broad-spectrum inhibition of acid, alkaline, serine/threonine and protein tyrosine phosphatases. Available as a 1 ml vial or a set of five 1 ml vials. Each vial, when reconstituted with 1 ml H2O, contains 50 mM Sodium Fluoride, 10 mM β-Glycerophosphate (Cat. No. 35675), 10 mM Sodium Pyrophosphate, and 1 mM activated Sodium Orthovanadate.
产品信息
Form Lyophilized solid
Hygrocopic 是的
Packaged under inert gas 是的
商店和运输信息
Storage +2°C to +8°C
Ship Ambient Temperature Only
Irritant
2°C – 8°C
540020-1MG Pluripotin 品牌 Merck
Pluripotin
货号： 540020-1MG 产品名称： Pluripotin 品牌： Merck 规格： *** 3周到货 生化实验
Pluripotin
Ras GTPase-Activating Protein Inhibitor II, SC1, N-(3-(7-(1,3-dimethyl-1H-pyrazol-5-ylamino)-1-methyl-2-oxo-1,2-dihydropyrimido[4,5-d]pyrimidin-3(4H)-yl)-4-methylphenyl)-3-(trifluoromethyl)benzamide, ERK Inhibitor VII
A cell-permeable dihydropyrimido-pyrimidine compound that effectively upregulates GTP-bound active Ras level and inhibits LIF- (leukemia inhibitory factor) induced Erk1/2 phosphorylation in OG2-mES (murine Embryonic Stem) cells (1 µM) via direct interaction with Erk and RasGAP (KD = 212 and 98 nM in binding RasGAP 729-1042 catalytic domain and Erk1, respectively), without affecting cellular STAT3 or GSK-3β/Wnt signaling. Pluripotin/SC1 is shown to greatly complement and enhance the efficiency of LIF in deriving ESCs from blastocysts of several murine strains and effectively maintain the pluripotent state of the ESCs even after 11 passages in cultures. SC1-expanded ESCs effectively form EBs (embryonic bodies) in vitro upon SC1 and LIF withdrawal and are capable of generating chimeric offsprings from surrogate mice when injected into blastocysts from different strains in vivo.
产品信息
Form Yellow solid
Molar mass 550.5
Protect from Light 是的
Packaged under inert gas 是的
Purity ≥97% by HPLC
Solubility DMSO
Chemical formula C27H25F3N8O2
商店和运输信息
Storage -20°C
Ship Shipped with Blue Ice or with Dry Ice
Standard Handling
-20°C
553210-5MG Rapamycin 品牌 Merck
Rapamycin
货号： 553210-5MG 产品名称： Rapamycin 品牌： Merck 规格： *** 3周到货 生化实验
Rapamycin
mTOR Inhibitor I
Anti-fungal and immunosuppressant. Selectively inhibits the mammalian target of rapamycin (mTOR) and blocks the subsequent activation of p70 S6 kinase (IC50 = 50 pM). Specifically inhibits mTORC1, but mTORC2 that phosphorylates Akt at Ser473 appears to be insensitive to rapamycin. Prevents the translational activation of IGF-II. Also prevents resting T-cells from entering the cell cycle, but does not directly arrest cell cycle progression. Shown to inhibit later signaling events, such as p110Rb phosphorylation, p34cdc2 kinase activation, and cyclin A synthesis. Exhibits strong binding to FK-506 binding proteins. Also reported to induce apoptosis in a murine B-cell line, to inhibit lymphokine-induced cell proliferation at the G1 phase, and to irreversibly arrest Saccharomyces cerevisiae cells in the G1 phase. A 5 mM (500 µg/109 µl) solution of Rapamycin (Cat. No. 553211) in DMSO and a 10 mM (1 mg/109 µl) solution of Rapamycin (Cat. No. 553212) in EtOH is also available.
产品信息
Form Clear film
Molar mass 914.2
Purity ≥98% by HPLC
Solubility DMSO or MeOH
Chemical formula C51H79NO13
RTECS VE6250000
CAS number 53123-88-9
Merck USA index 14, 8114
商店和运输信息
Storage -20°C
Ship Ambient Temperature Only
Standard Handling
-20°C
554328-25MG Resveratrol, Triacetyl 品牌 Merck
Resveratrol, Triacetyl
货号： 554328-25MG 产品名称： Resveratrol, Triacetyl 品牌： Merck 规格： *** 3周到货 生化实验
Resveratrol, Triacetyl
trans-3,5,4′-Triacetylstilbene, 3,5,4′-Tri-O-acetylresveratrol
A cell-permeable triacetate resveratrol (Cat. No. 554325) prodrug that is easily converted to resveratrol by esterase activity and exhibits similar bioactivity as resveratrol in cell cultures. Cremophor EL is reported to protect the prodrug from fast hydrolysis and resveratrol conversion in mouse serum at 37°C (100% conversion within 20 sec vs. >300 min or T1/2 of 48 min delivered with DMSO or 1:1:8 (v/v/v) EtOH/Cremophor EL/H2O, respectively; [prodrug]t=0 = 100 µM), although the active drug resveratrol is stable for more than 27 h under the same condition without Cremophor EL. When dosed at 10 mg/kg and delivered with 1:1:8 (v/v/v) EtOH/Cremophor EL/H2O intraperitoneally before, but not after, exposure to lethal γ-irradiation (9.75 Gy), the prodrug, but not resveratrol, is shown to greatly prevent irradiation-induced death in mice in vivo (survival rate = 77.4% with 10 mg/kg prodrug vs. ≤28.3% with 10 mg/kg resveratrol, vehicle alone, or no pretreatment at all).
产品信息
Form White powder
Molar mass 354.4
Protect from Light 是的
Packaged under inert gas 是的
Purity ≥97% by HPLC
Solubility DMSO
Chemical formula C20H18O8
CAS number 42206-94-0
商店和运输信息
Storage +2°C to +8°C
Ship Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Regulatory Review
2°C – 8°C
554715-25MG Retro-2 品牌 Merck
Retro-2
货号： 554715-25MG 产品名称： Retro-2 品牌： Merck 规格： *** 3周到货 生化实验
Retro-2
Cholera Toxin Retrograde Transport Blocker, Ricin Retrograde Transport Blocker, SLT Retrograde Transport Blocker, 2-(((5-Methyl-2-thienyl)methylene)amino)-N-phenylbenzamide
A cell-permeable tricyclic imine compound that inhibits the endosome-to-Golgi retrograde transport, but not cellular uptake, of CtxB (Cholera toxin B chain), StxB (Shiga-like toxin B chain), and the plant toxin ricin from castor seed in HeLa cells (20 µM), without affecting cellular uptake and trafficking of Tf (Transferrin), EGF, and vesicular stomatitis virus glycoprotein VSVGts045. Retro-2 is demonstrated to selectively affect the cellular distribution of SNARE proteins Synt5 and Synt6, but not 24 other Golgi and endocytic pathway proteins. Retro-2 pretreatment is shown to effectively protect against ricin-, Stx1-, and Stx2-induced cytotoxicity in HeLa cultures in vitro (Fold of protection against 4 h toxin incubation = 2.7, 22, and 65, respectively, with 0.5 h 20 µM Retro-2 pretreatment), as well as ricin-induced (2 µg/kg by nasal spray) fatality in mice in vivo (0 mortality with one 200 mg/kg i.p. dose 1h prior to toxin exposure).
产品信息
Form Tan powder
Molar mass 320.4
Protect from Light 是的
Packaged under inert gas 是的
Purity ≥95% by HPLC
Solubility DMSO
Chemical formula C19H16N2OS
商店和运输信息
Storage +2°C to +8°C
Ship Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Standard Handling
2°C – 8°C
563080-2MG Salinomycin 品牌 Merck
Salinomycin
货号： 563080-2MG 产品名称： Salinomycin 品牌： Merck 规格： *** 3周到货 生化实验
Salinomycin
This product has been discontinued.
Salinomycin reduces the proportion of cancer stem cells(CSC) by >100-fold relative to paclitaxel, a commonly used breast cancer chemotherapeutic drug. Treatment of mice with salinomycin inhibits mammary tumor growth in vivo and induces increased epithelial differentiation of tumor cells. In addition, global gene expression analyses show that salinomycin treatment results in the loss of expression of breast CSC genes previously identified by analyses of breast tissues isolated directly from patients.
产品信息
Form White solid
Molar mass 751.
Hygrocopic 是的
Purity ≥96% by HPLC
Solubility MeOH
Chemical formula C42H70O11
CAS number 53003-10-4
Merck USA index 13, 8415
商店和运输信息
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping chargesmay be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage +2°C to +8°C
Ship Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxic
2°C – 8°C
616431-500MG Tranylcypromine, HCl 品牌 Merck
Tranylcypromine, HCl
货号： 616431-500MG 产品名称： Tranylcypromine, HCl 品牌： Merck 规格： *** 3周到货 生化实验
Tranylcypromine, HCl
Histone Lysine Demethylase Inhibitor I, LSD Inhibitor V, Monoamine Oxidase Inhibitor I, Parnate, 2-PCPA, TCP, (1R)-2-Phenylcyclopropan-1-amine, HCl, trans-2-Phenylcyclopropylamine, HCl, BHC110 Inhibitor V, LSD2 Inhibitor I, MOA Inhibitor I, KDM1 Inhibitor V, LSD1 Inhibitor V
A cell-permeable phenylcyclopropylamine that inhibits the monoamine oxidase and histone demethylase activities, respectively, of MAO A/B (Ki = 101.9 and 16.0 µM, respectively) and LSD1/2 (Ki = 242.7 and 180.0 µM, respectively), four members of a flavin-dependent amine oxidase family enzymes, by a covalent adduct formation with the enzyme-bound FAD. In addition to preventing LSD1-CoREST (Corepressor of RE1-Silencing Transcription factor) complex-mediated H3K4 demethylation (IC50 < 2 µM), TCP also inhibits LSD1-HCF-1 (Host Cell Factor-1) complex-mediated H3K9 demethylase activity, which is demonstrated to be an essential mechanism for the replication and latent infection of the α-herpesviruses HSV and VZV. The combined treatment of 2 µM TCP and 10 µM CHIR99061 (Cat. No. 361559) is reported to enable the reprogramming of Oct4/Klf4-transduced primary HNEKs (Human Neonatal Epidermal Keratinocytes) into iPS (induced Pluripotent Stem) cells, albeit at a 100-time lower efficiency as seen in cultures transduced with 4-TFs (Oct44, Klf4, Sox2, and c-Myc).
产品信息
Form White solid
Molar mass 169.7
Protect from Light 是的
Hygrocopic 是的
Packaged under inert gas 是的
Purity ≥97% by NMR
Solubility DMSO, EtOH and H2O
Chemical formula C9H11N •HCl
CAS number 1986-47-6
商店和运输信息
Storage +2°C to +8°C
Ship Ambient Temperature Only
Standard Handling
2°C – 8°C
662009-5MG InSolution U0126 品牌 Merck
InSolution U0126
货号： 662009-5MG 产品名称： InSolution U0126 品牌： Merck 规格： *** 3周到货 生化实验
InSolution™ U0126
A potent and specific inhibitor of MEK1 (IC50 = 72 nM) and MEK2 (IC50 = 58 nM). The inhibition is noncompetitive with respect to both ATP and ERK. Has very little effect on other kinases such as Abl, Cdk2, Cdk4, ERK, JNK, MEKK, MKK-3, MKK-4/SEK, MKK-6, PKC, and Raf. Also acts as an immunosuppressant by effectively blocking IL-2 synthesis and T cell proliferation without affecting the long-term outcomes of either T cell activation or tolerance. Reported to undergo rapid isomerization in DMSO and exist as an equilibrium mixture of (Z,Z), E,E) and (Z,E) isomers with minimal loss of activity over a period of 1 month.
产品信息
Form Liquid
Formulation A 100 mM (5 mg/124 µl) solution of U0126 (Cat. No. 662005) in DMSO.
Molar mass 403.5
Protect from Light 是的
Hygrocopic 是的
Avoid freeze/thaw 是的
Packaged under inert gas 是的
Purity ≥98% by HPLC
Chemical formula C18H16N6S2•½C2H5OH
CAS number 109511-58-2
商店和运输信息
Storage ≤ -70°C
Ship Dry Ice Only
Irritant
≤ -70°C
681677-10MG Wnt Antagonist V 品牌 Merck
Wnt Antagonist V
货号： 681677-10MG 产品名称： Wnt Antagonist V 品牌： Merck 规格： *** 3周到货 生化实验
Wnt Pathway Inhibitor XII
(E)-4-(2,6-Difluorostyryl)-N,N-dimethylaniline, FIDAS3, MAT2A Inhibitor I, Methionine S-Adenosyltransferase 2A Inhibitor I
A cell-permeable fluorinated N,N-dialkylaminostilbene (FIDAS) compound that inhibits MAT2A-catalyzed SAM (S-adenosylmethionine) synthesis by targeting SAM-binding pocket at the MAT2A dimer interface. Shown to downregulate intracellular SAM level (by 64%; 36 h;10 µM) and Wnt signaling in LS174 colorectal cancer cultures and is at least 10-fold more potent than Pterostilbene (Cat. No. 523310) and Resveratrol (Cat. No. 554325) in inhibiting LS174 proliferation both in vitro (by 90% in 4 d; 1 µM) and in mice in vivo (by 75% on d26; 20 mg/kg/day; i.p.).
产品信息
Form Off-white to pale yellow solid
Molar mass 259.3
Protect from Light 是的
Packaged under inert gas 是的
Purity ≥95% by HPLC
Solubility DMSO
Chemical formula C16H15F2N
商店和运输信息
Storage +2°C to +8°C
Ship Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Regulatory Review
2°C – 8°C
681685-10MG WP1130 品牌 Merck
WP1130
货号： 681685-10MG 产品名称： WP1130 品牌： Merck 规格： *** 3周到货 生化实验
WP1130
A cell-permeable tyrphostin compound that acts as a partially selective deubiquitinase (DUB) inhibitor and suppresses JAK-Stat signaling pathway. Reported to cause accumulation of polyubiquitinated p53, JAK2 and Bcr-Abl, and reduce c-Myc and MCL-1 protein levels in several tumor cells and downregulate Stat3 and NF-κB activities (IC50 < 1 µM in MCL cells) leading to tumor cell apoptosis (IC50 ~1.2 µM in Z138 cells). Suggested to modify active site cysteine of DUB and inhibit USP5, UCH-L1, USP9x, USP14, and UCH37 activities (≥80% inhibition at 5 µM) without affecting 20S proteasome. Reported to exert stronger antiproliferative and antitumor properties than STAT3 Inhibitor III, WP1066 (Cat. No. 573097) in xenograft mouse models of CML and melanoma.
产品信息
Form Light yellow solid
Molar mass 384.3
Protect from Light 是的
Packaged under inert gas 是的
Purity ≥97% by HPLC
Solubility DMSO
Chemical formula C19H18BrN3O
商店和运输信息
Storage +2°C to +8°C
Ship Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Standard Handling
2°C – 8°C
2017-100ML OmniPur WATER,OMNIPUR 100ML 品牌 Merck
OmniPur WATER,OMNIPUR 100ML
货号： 2017-100ML 产品名称： OmniPur WATER,OMNIPUR 100ML 品牌： Merck 规格： *** 3周到货 生化实验
OmniPur® A.C.E. Sequencing Water – CAS 7732-18-5 – Calbiochem
Formulated and proven to be an effective running buffer when used with the ABI Prism 3730, 3700, 3100 or 3010 and the Beckman CEQ 2000 automated capillary sequencing instruments.
Specifications:
Bioburden: Passes test
DNase: None detected
Protease: None detected
RNase: None detected
Intended for laboratory and manufacturing use only. Not for drug, food, or household use.
产品信息
Form Clear, colorless liquid
CAS number 7732-18-5
商店和运输信息
Storage +15°C to +30°C
Ship Ambient Temperature Only
+15°C to +30°C