Resveratrol, Triacetyl

货号： 554328-25MG      产品名称： Resveratrol, Triacetyl   品牌： Merck 规格： *** 3周到货 生化实验

Resveratrol, Triacetyl
trans-3,5,4′-Triacetylstilbene, 3,5,4′-Tri-O-acetylresveratrol
A cell-permeable triacetate resveratrol (Cat. No. 554325) prodrug that is easily converted to resveratrol by esterase activity and exhibits similar bioactivity as resveratrol in cell cultures. Cremophor EL is reported to protect the prodrug from fast hydrolysis and resveratrol conversion in mouse serum at 37°C (100% conversion within 20 sec vs. >300 min or T1/2 of 48 min delivered with DMSO or 1:1:8 (v/v/v) EtOH/Cremophor EL/H2O, respectively; [prodrug]t=0 = 100 µM), although the active drug resveratrol is stable for more than 27 h under the same condition without Cremophor EL. When dosed at 10 mg/kg and delivered with 1:1:8 (v/v/v) EtOH/Cremophor EL/H2O intraperitoneally before, but not after, exposure to lethal γ-irradiation (9.75 Gy), the prodrug, but not resveratrol, is shown to greatly prevent irradiation-induced death in mice in vivo (survival rate = 77.4% with 10 mg/kg prodrug vs. ≤28.3% with 10 mg/kg resveratrol, vehicle alone, or no pretreatment at all).
产品信息
Form  White powder
Molar mass  354.4
Protect from Light  是的
Packaged under inert gas  是的
Purity  ≥97% by HPLC
Solubility  DMSO
Chemical formula  C20H18O8
CAS number  42206-94-0
商店和运输信息
Storage  +2°C to +8°C
Ship  Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Regulatory Review

2°C – 8°C