Wnt Antagonist, C59
货号: 2063-1 产品名称: Wnt Antagonist, C59 品牌: Biovision 规格: 1 mg 3周到货 生化实验
Wnt Antagonist, C59
A potent Wnt signaling pathway inhibitor
Product Overview
Product Name: Wnt Antagonist, C59
Alternate Name/Synonyms: 2-(4-(2-Methylpyridin-4-yl)phenyl)-N-4-(pyridin-3-yl)phenyl)acetamide
Description: Cell-permeable. A potent Wnt signaling pathway inhibitor (IC₅₀ = <0.11 nM using Wnt-Luc reporter assay).
Peptide Sequence: N/A
Appearance: Pale yellow solid
Formulation: N/A
CAS Number: N/A
Molecular Formula: C₂₅H₂₁N₃O
Molecular Weight: 379.45
Purity: ≥97% by HPLC
Solubility:DMSO
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from air and light
SMILES: N/A
InChi: N/A
InChi Key: N/A
PubChem CID: N/A
MDL Number: N/A
USAGE: For Research Use Only! Not For Use in Humans.
-20°C
![](http://thermofisher.jinpanbio.com/wp-content/uploads/2024/04/BZWZ.jpg)
2063-5 Wnt Antagonist, C59 品牌 Biovision
Wnt Antagonist, C59
货号: 2063-5 产品名称: Wnt Antagonist, C59 品牌: Biovision 规格: 5 mg 3周到货 生化实验
Wnt Antagonist, C59
A potent Wnt signaling pathway inhibitor
Product Overview
Product Name: Wnt Antagonist, C59
Alternate Name/Synonyms: 2-(4-(2-Methylpyridin-4-yl)phenyl)-N-4-(pyridin-3-yl)phenyl)acetamide
Description: Cell-permeable. A potent Wnt signaling pathway inhibitor (IC₅₀ = <0.11 nM using Wnt-Luc reporter assay).
Peptide Sequence: N/A
Appearance: Pale yellow solid
Formulation: N/A
CAS Number: N/A
Molecular Formula: C₂₅H₂₁N₃O
Molecular Weight: 379.45
Purity: ≥97% by HPLC
Solubility:DMSO
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from air and light
SMILES: N/A
InChi: N/A
InChi Key: N/A
PubChem CID: N/A
MDL Number: N/A
USAGE: For Research Use Only! Not For Use in Humans.
-20°C
![](http://thermofisher.jinpanbio.com/wp-content/uploads/2024/04/BZWZ.jpg)
RLT-M10-231-C010 Wnt-3A (ms) 品牌 AXXORA
Wnt-3A (ms)
货号: RLT-M10-231-C010 产品名称: Wnt-3A (ms) 品牌: AXXORA 规格: 10 ug
![](http://thermofisher.jinpanbio.com/wp-content/uploads/2024/04/BZWZ.jpg)
4754-10 WNT-1, human recombinant 品牌 Biovision
WNT-1, human recombinant
货号: 4754-10 产品名称: WNT-1, human recombinant 品牌: Biovision 规格: 10 μg 3周到货 生化实验
WNT-1, human recombinant
A proto-oncogene implicated in oncogenesis and in several developmental processes
Product Overview
Alternate Names / Synonyms: Human WNT-1, WNT-1, WNT1, WNT 1, h-WNT-1, rh-WNT-1, recombinant human WNT-1, recombinant WNT-1, WNT
Gene Symbol: WNT1
Accession #: P04628
Gene ID: 7471
Source: E. coli
Appearance: Lyophilized protein
Physical Form Description: Sterile filtered and lyophilized with no additives
Molecular Weight: 38.4 kDa
Purity by SDS-PAGE: ≥98%
Purity by HPLC: ≥98%
Endotoxin Level: <0.1 ng/μg
Biological Activity: The ED₅₀ was determined by its ability to enhance BMP-2 induced alkaline phosphatase production by murine ATDC5 cells. The expected ED₅₀ for this effect is 1.5 – 2.5 ng/ml in the presence of 200 ng/ml of human BMP-2.
Reconstitution Instructions: Reconstitute in water to a concentration of 0.1-1.0 µg/µl. The solution can then be diluted into other aqueous buffers
Storage Temp.: -20°C
Shipping: Blue ice
Background Information: Wnt-1 is a secreted protein that signals through the Frizzled family of cell surface receptors and is required for normal embryonic development. Wnt-1 activation induces a complex signaling cascade that ultimately leads to the increased expression of over fifty genes. An important component of Wnt-1 signaling is the stabilization, and resulting accumulation, of the intraCellular signaling protein, β-catenine. Wnt signaling induces and maintains the transformed phenotype and, in certain embryonic cell lines, supports self renewal in the absence of significant differentiation. Elevated levels of Wnt proteins are associated with tumorigenesis and are present in numerous human breast cancers. Mature human Wnt-1 is a glycosylated protein containing 343 amino acid residues. Recombinant human Wnt-1 is a 38.4 kDa, non-glycosylated protein containing 343 amino acid residues.
Handling: Centrifuge the vial prior to opening.
Usage: For Research Use Only! Not to be used in humans.
-20°C
![](http://thermofisher.jinpanbio.com/wp-content/uploads/2024/04/BZWZ.jpg)
4754-50 WNT-1, human recombinant 品牌 Biovision
WNT-1, human recombinant
货号: 4754-50 产品名称: WNT-1, human recombinant 品牌: Biovision 规格: 50 μg 3周到货 生化实验
WNT-1, human recombinant
A proto-oncogene implicated in oncogenesis and in several developmental processes
Product Overview
Alternate Names / Synonyms: Human WNT-1, WNT-1, WNT1, WNT 1, h-WNT-1, rh-WNT-1, recombinant human WNT-1, recombinant WNT-1, WNT
Gene Symbol: WNT1
Accession #: P04628
Gene ID: 7471
Source: E. coli
Appearance: Lyophilized protein
Physical Form Description: Sterile filtered and lyophilized with no additives
Molecular Weight: 38.4 kDa
Purity by SDS-PAGE: ≥98%
Purity by HPLC: ≥98%
Endotoxin Level: <0.1 ng/μg
Biological Activity: The ED₅₀ was determined by its ability to enhance BMP-2 induced alkaline phosphatase production by murine ATDC5 cells. The expected ED₅₀ for this effect is 1.5 – 2.5 ng/ml in the presence of 200 ng/ml of human BMP-2.
Reconstitution Instructions: Reconstitute in water to a concentration of 0.1-1.0 µg/µl. The solution can then be diluted into other aqueous buffers
Storage Temp.: -20°C
Shipping: Blue ice
Background Information: Wnt-1 is a secreted protein that signals through the Frizzled family of cell surface receptors and is required for normal embryonic development. Wnt-1 activation induces a complex signaling cascade that ultimately leads to the increased expression of over fifty genes. An important component of Wnt-1 signaling is the stabilization, and resulting accumulation, of the intraCellular signaling protein, β-catenine. Wnt signaling induces and maintains the transformed phenotype and, in certain embryonic cell lines, supports self renewal in the absence of significant differentiation. Elevated levels of Wnt proteins are associated with tumorigenesis and are present in numerous human breast cancers. Mature human Wnt-1 is a glycosylated protein containing 343 amino acid residues. Recombinant human Wnt-1 is a 38.4 kDa, non-glycosylated protein containing 343 amino acid residues.
Handling: Centrifuge the vial prior to opening.
Usage: For Research Use Only! Not to be used in humans.
-20°C
![](http://thermofisher.jinpanbio.com/wp-content/uploads/2024/04/BZWZ.jpg)
681672-2MG Wnt/b-catenin Inhibitor, Cardamonin 品牌 Merck
Wnt/b-catenin Inhibitor, Cardamonin
货号: 681672-2MG 产品名称: Wnt/b-catenin Inhibitor, Cardamonin 品牌: Merck 规格: *** 3周到货 生化实验
Wnt/β-catenin Inhibitor, Cardamonin
(E)-1-(2,4-dihydroxy-6-methoxyphenyl)-3-phenylprop-2-en-1-one, Wnt Pathway Inhibitor VII, Cardamonin
Cardamonin, a known 2′,4′-dihydroxy-6′-methoxychalcone, was identified as an inhibitor of melanocyte differentiation, among many other pharmacology activities. Cardamonin promoted degradation of intracellular β-catenin while suppressing melanogenesis by down-regulating the expression of MITF and tyrosinase, resulting in decreased melanin content. Furthermore, it was found that cardamonin promoted the degradation of β-catenin through a GSK-3β-independent mechanism, which suggested that Siah-dependent pathway and/or a PKCα-dependent pathway, rather than a GSK-3β-dependent pathway, may mediate intracellularb-catenin degradation by cardamonin.
产品信息
Form Orange-yellow to amber solid
Molar mass 270.28
Purity ≥95% by HPLC
Solubility DMSO or EtOH
Chemical formula C16H14O4
CAS number 19309-14-9
商店和运输信息
Storage -20°C
Ship Ambient Temperature Only
Standard Handling
-20°C
![](http://thermofisher.jinpanbio.com/wp-content/uploads/2024/04/BZWZ.jpg)
681674-5MG Wnt Antagonist III, CCT036477 品牌 Merck
Wnt Antagonist III, CCT036477
货号: 681674-5MG 产品名称: Wnt Antagonist III, CCT036477 品牌: Merck 规格: *** 3周到货 生化实验
Wnt Pathway Inhibitor XI, CCT036477
A cell-permeable indole derivative that acts as an inhibitor of Wnt signaling and exhibits an inhibitory effect in a reporter cell line (IC50 = 4.6 µM) and demonstrates growth inhibition in multiple cancer cell lines, not by altering β-catenin accumulation but by blocking transcription at the β-catenin level. Displays reduced expression of Wnt target genes in myc and survivin-luciferase reporter assays, and exhibits in vivo activity by blocking the development of zebrafish at 20 µM and Xenopus embryos at 75 µM.
产品信息
Form Off-white solid
Molar mass 347.84
Protect from Light 是的
Packaged under inert gas 是的
Purity ≥95% by 1H NMR
Solubility DMSO
Chemical formula C21H18ClN3
CAS number 305372-78-5
商店和运输信息
Storage +2°C to +8°C
Ship Ambient Temperature Only
Standard Handling
2°C – 8°C
![](http://thermofisher.jinpanbio.com/wp-content/uploads/2024/04/BZWZ.jpg)
681677-10MG Wnt Antagonist V 品牌 Merck
Wnt Antagonist V
货号: 681677-10MG 产品名称: Wnt Antagonist V 品牌: Merck 规格: *** 3周到货 生化实验
Wnt Pathway Inhibitor XII
(E)-4-(2,6-Difluorostyryl)-N,N-dimethylaniline, FIDAS3, MAT2A Inhibitor I, Methionine S-Adenosyltransferase 2A Inhibitor I
A cell-permeable fluorinated N,N-dialkylaminostilbene (FIDAS) compound that inhibits MAT2A-catalyzed SAM (S-adenosylmethionine) synthesis by targeting SAM-binding pocket at the MAT2A dimer interface. Shown to downregulate intracellular SAM level (by 64%; 36 h;10 µM) and Wnt signaling in LS174 colorectal cancer cultures and is at least 10-fold more potent than Pterostilbene (Cat. No. 523310) and Resveratrol (Cat. No. 554325) in inhibiting LS174 proliferation both in vitro (by 90% in 4 d; 1 µM) and in mice in vivo (by 75% on d26; 20 mg/kg/day; i.p.).
产品信息
Form Off-white to pale yellow solid
Molar mass 259.3
Protect from Light 是的
Packaged under inert gas 是的
Purity ≥95% by HPLC
Solubility DMSO
Chemical formula C16H15F2N
商店和运输信息
Storage +2°C to +8°C
Ship Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Regulatory Review
2°C – 8°C
![](http://thermofisher.jinpanbio.com/wp-content/uploads/2024/04/BZWZ.jpg)
681679-10MG Wnt Pathway Inhibitor XII, 21H7 品牌 Merck
Wnt Pathway Inhibitor XII, 21H7
货号: 681679-10MG 产品名称: Wnt Pathway Inhibitor XII, 21H7 品牌: Merck 规格: *** 3周到货 生化实验
Iron Chelator IV, 21H7
6-Bromo-N′-(2-hydroxybenzylidene)-2-methylquinoline-4-carbohydrazide
A cell-permeable salicylaldehyde-acylhydrazone iron chelator that is 20-times more efficient than DFO/desferrioxamine (Cat. No. 252750) in depleting intracellular iron in colon cancer SW480 cells. Iron chelators exert their biological activities by affecting iron-regulated enzymes and singaling events, including HIF1α transcription activation due to inhibition of PHD- (prolyl hydroxylase) mediated HIF1α degradation, as well as altered mRNA translations due to enhanced IRP (Iron Regulatory Protein) IREs (Iron Response Elements) binding. Cellular iron depletion is also reported to inhibit the growths of colorectal adenocarcinoma cultures, DLD-1 (IC50 = 0.6 and 2.9 µM, respectively, by 21H7 and DFO) and SW480 (IC50 = 1.0 and 3.8 µM, respectively, by 21H7 and DFO), as a result of Wnt signaling pathway blockage (Effective conc. = 5 µM 21H7 or 100 µM DFO).
产品信息
Form Off-white solid
Molar mass 384.2
Protect from Light 是的
Packaged under inert gas 是的
Purity ≥97% by HPLC
Solubility DMSO
Chemical formula C18H14BrN3O2
商店和运输信息
Storage +2°C to +8°C
Ship Ambient Temperature Only
Standard Handling
2°C – 8°C
![](http://thermofisher.jinpanbio.com/wp-content/uploads/2024/04/BZWZ.jpg)
681667-25MG Wnt Agonist II, SKL2001 品牌 Merck
Wnt Agonist II, SKL2001
货号: 681667-25MG 产品名称: Wnt Agonist II, SKL2001 品牌: Merck 规格: *** 3周到货 生化实验
Wnt Agonist II, SKL2001
5-(Furan-2-yl)-N-(3-(1H-imidazol-1-yl)propyl)-1,2-oxazole-3-carboxamide, Wnt Pathway Activator VII
A cell-permeable imidazolyl-isoxazolamide that upregulates β-catenin-regulated transcription (CRT; 10 – 40 µM) by disrupting β-catenin and Axin interaction, thereby preventing β-catenin phosphorylation (Ser33/Ser37/Thr41/Ser45) and proteasomal degradation, without affecting the activities of GSK-3α/β or 18 other kinases (≤8.5% inhibition by 10 µM SKL2001). Shown to effectively promote osteoblastogenesis in both human and murine mesenchymal cultures (10 to 40 µM) as well as suppress MDI- (dexamethasone and insulin) stimulated adipogenesis of murine 3T3-L1 preadipocytes (5 to 30 µM).
产品信息
Form Pinkish red solid
Molar mass 286.3
Protect from Light 是的
Packaged under inert gas 是的
Purity ≥95% by HPLC
Solubility DMSO
Chemical formula C14H14N4O3
商店和运输信息
Storage +2°C to +8°C
Ship Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Standard Handling
2°C – 8°C
![](http://thermofisher.jinpanbio.com/wp-content/uploads/2024/04/BZWZ.jpg)
ASB-ARP41268-T100 PAb to WNT16 品牌 AXXORA
PAb to WNT16
货号: ASB-ARP41268-T100 产品名称: PAb to WNT16 品牌: AXXORA 规格: 100 ug
![](http://thermofisher.jinpanbio.com/wp-content/uploads/2024/04/BZWZ.jpg)
GF175 Recombinant Human Wnt-1, 10μg 品牌 Millipore
Recombinant Human Wnt-1, 10μg
货号: GF175 产品名称: Recombinant Human Wnt-1, 10μg 品牌: Millipore 规格: EA
![](http://thermofisher.jinpanbio.com/wp-content/uploads/2024/04/BZWZ.jpg)
ADI-905-617-1 Wnt-1, pAb 品牌 Enzo
Wnt-1, pAb
货号: ADI-905-617-1 产品名称: Wnt-1, pAb 品牌: Enzo 规格: 1 ml
![](http://thermofisher.jinpanbio.com/wp-content/uploads/2024/04/BZWZ.jpg)
MABS95 Anti-Wnt-1, clone 20C3.1 品牌 Millipore
Anti-Wnt-1, clone 20C3.1
货号: MABS95 产品名称: Anti-Wnt-1, clone 20C3.1 品牌: Millipore 规格: EA
![](http://thermofisher.jinpanbio.com/wp-content/uploads/2024/04/BZWZ.jpg)
4414100 HUMAN WNT 品牌 Invitrogen
HUMAN WNT
货号: 4414100 产品名称: HUMAN WNT 品牌: Invitrogen 规格: EACH 三周到货 生化试验
TaqMan® Array Human WNT Pathway
The Applied Biosystems® TaqMan® Array Human WNT Pathway 96-well Plate contains 92 assays to WNT signaling associated genes and 4 assays to candidate endogenous control genes. The panel of assays in this plate targets genes from the WNT family of cell-cell signaling proteins. Additionally, modifiers of WNT signaling, including members of the Frizzled GPCR family, Disheveled family, and the Secreted frizzled related family, are included. Other WNT related genes involved in regulation of WNT genes and their targets, signal transduction, embryogenesis, and cancer are also in the panel. Gene Signature Plates are 96-well plates that are pre-configured with the most appropriate TaqMan® Gene Expression Assays for a specific biological process, pathway, or disease state. Each plate contains predefined assays and endogenous controls dried-down in the wells, ready for accurate assessment of an entire gene signature in one simple experiment.
Form: Dried Down
Format: 96-well plate
Species: Human
Label or Dye: FAM™
Product Size: 1 standard plate
Purification: Standard
Reaction Speed: Standard
Research Category: Oncology,
Neurobiology,
Biomarker-Related Pathway(s),
Development,
Extracellular Matrix & Cell Adhesion,
Reproduction,
Cell Cycle & Proliferation,
Apoptosis,
Signal Transduction
Internal Probe Modification: Non-Fluorescent Quencher (3′),
MGB (Minor Groove Binder) (3′),
FAM (5′)
Regulatory Statement: For Research Use Only. Not for use in diagnostic procedures.
Each TaqMan® Array Plate well contains a single TaqMan® Assay for one 20 µL reaction. The plates can be stored at room temperature or at 4°C.
![](http://thermofisher.jinpanbio.com/wp-content/uploads/2024/04/BZWZ.jpg)
4414231 TQMN HUMAN WNT EXPRESS PLATE 品牌 Invitrogen
TQMN HUMAN WNT EXPRESS PLATE
货号: 4414231 产品名称: TQMN HUMAN WNT EXPRESS PLATE 品牌: Invitrogen 规格: EACH
![](http://thermofisher.jinpanbio.com/wp-content/uploads/2024/04/BZWZ.jpg)
4414362 CD,TQMN HU WNT EXPRESS PLATE 品牌 Invitrogen
CD,TQMN HU WNT EXPRESS PLATE
货号: 4414362 产品名称: CD,TQMN HU WNT EXPRESS PLATE 品牌: Invitrogen 规格: EACH
![](http://thermofisher.jinpanbio.com/wp-content/uploads/2024/04/BZWZ.jpg)
4418745 HS WNT, FAST 品牌 Invitrogen
HS WNT, FAST
货号: 4418745 产品名称: HS WNT, FAST 品牌: Invitrogen 规格: EACH 三周到货 生化试验
TaqMan® Array, Human WNT Pathway, Fast 96-well
These 96-well plates are pre-configured with the most appropriate TaqMan® Gene Expression Assays for a specific biological process, pathway, or disease state. Each plate contains predefined assays and endogenous controls dried-down in the wells, ready for accurate assessment of an entire gene signature in one simple experiment. The panel of assays in the TaqMan® Array 96-well Human WNT Pathway Plate targets genes from the WNT family of cell-cell signaling proteins. Additionally, modifiers of WNT signaling, including members of the Frizzled GPCR family, Disheveled family, and the Secreted frizzled related family, are included. Other WNT related genes involved in regulation of WNT genes and their targets, signal transduction, embryogenesis, and cancer are also in the panel.
Form: Dried Down
Format: 96-well plate
Species: Human
Label or Dye: FAM™
Product Size: 1 x 96 well plate
Reaction Speed: Fast
Research Category: Extracellular Matrix & Cell Adhesion,
Oncology,
Immunology,
Biomarker-Related Pathway(s),
Apoptosis,
Development
Internal Probe Modification: Non-Fluorescent Quencher (3′),
MGB (Minor Groove Binder) (3′),
FAM (5′)
Regulatory Statement: For Research Use Only. Not for use in diagnostic procedures.
Each TaqMan® Array Plate well contains a single TaqMan® Assay for one 10 µL reaction. The plates can be stored at room temperature or at 4°C.
![](http://thermofisher.jinpanbio.com/wp-content/uploads/2024/04/BZWZ.jpg)
4418877 FG,HS WNT, FAST 品牌 Invitrogen
FG,HS WNT, FAST
货号: 4418877 产品名称: FG,HS WNT, FAST 品牌: Invitrogen 规格: EACH
![](http://thermofisher.jinpanbio.com/wp-content/uploads/2024/04/BZWZ.jpg)
BML-2838-0100 Wnt Pathway library 品牌 Biomol
Wnt Pathway library
货号: BML-2838-0100 产品名称: Wnt Pathway library 品牌: Biomol 规格: Pack 3周到货 生化试验
Product Specification
Quantity: 100 µl/well or 500 µl/well
Concentration: DMSO solutions (10mM) except for Bafilomycin A which is provided at 1mM in DMSO.
Use/Stability: Stable for at least 6 months after receipt when stored at -80°C.
Handling: Avoid freeze/thaw cycles.
Long Term Storage: -80°C
Kit/Set Contains: 75 compounds with defined and diverse Wnt pathway activity. A variety of structurally and mechanistically different compound classes are included.
-80°C
![](http://thermofisher.jinpanbio.com/wp-content/uploads/2024/04/BZWZ.jpg)