C-Raf Inhibitor

货号： 475958-20MG      产品名称： C-Raf Inhibitor   品牌： Merck 规格： *** 3周到货 生化实验

c-Raf Inhibitor
1-(3-(1,4-dihydroimidazo[4,5-c]pyrazol-5-yl)-4-methylphenyl)-3-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)urea
A cell-permeable pyrazoloimidazole phenyl urea derivative that acts as a selective type II inhibitor of c-Raf. It shows an IC50 value of 50 nM in an enzymatic assay, and comparable anti-proliferative activities to sorafenib against A375P (GI 50 = 2.68 µM) and WM3629 (GI50 = 0.86 µM) human melanoma cell lines. When screening against a panel of 30 different kinases at a concentration of 10 µM, it exerts an inhibitory activity of 96% on c-Raf, but below 50% for most of the other kinases.
产品信息
Form  Off white solid
Molar mass  480.45
Purity  ≥95% by HPLC
Solubility  DMSO
Chemical formula  C23H19F3N8O
商店和运输信息
Storage  +2°C to +8°C
Ship  Ambient Temperature Only
Standard Handling

2°C – 8°C