Wnt Antagonist, C59
货号： 2063-1 产品名称： Wnt Antagonist, C59 品牌： Biovision 规格： 1 mg 3周到货 生化实验
Wnt Antagonist, C59
A potent Wnt signaling pathway inhibitor
Product Overview
Product Name: Wnt Antagonist, C59
Alternate Name/Synonyms: 2-(4-(2-Methylpyridin-4-yl)phenyl)-N-4-(pyridin-3-yl)phenyl)acetamide
Description: Cell-permeable. A potent Wnt signaling pathway inhibitor (IC₅₀ = <0.11 nM using Wnt-Luc reporter assay).
Peptide Sequence: N/A
Appearance: Pale yellow solid
Formulation: N/A
CAS Number: N/A
Molecular Formula: C₂₅H₂₁N₃O
Molecular Weight: 379.45
Purity: ≥97% by HPLC
Solubility:DMSO
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from air and light
SMILES: N/A
InChi: N/A
InChi Key: N/A
PubChem CID: N/A
MDL Number: N/A
USAGE: For Research Use Only! Not For Use in Humans.
-20°C
2063-5 Wnt Antagonist, C59 品牌 Biovision
Wnt Antagonist, C59
货号： 2063-5 产品名称： Wnt Antagonist, C59 品牌： Biovision 规格： 5 mg 3周到货 生化实验
Wnt Antagonist, C59
A potent Wnt signaling pathway inhibitor
Product Overview
Product Name: Wnt Antagonist, C59
Alternate Name/Synonyms: 2-(4-(2-Methylpyridin-4-yl)phenyl)-N-4-(pyridin-3-yl)phenyl)acetamide
Description: Cell-permeable. A potent Wnt signaling pathway inhibitor (IC₅₀ = <0.11 nM using Wnt-Luc reporter assay).
Peptide Sequence: N/A
Appearance: Pale yellow solid
Formulation: N/A
CAS Number: N/A
Molecular Formula: C₂₅H₂₁N₃O
Molecular Weight: 379.45
Purity: ≥97% by HPLC
Solubility:DMSO
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from air and light
SMILES: N/A
InChi: N/A
InChi Key: N/A
PubChem CID: N/A
MDL Number: N/A
USAGE: For Research Use Only! Not For Use in Humans.
-20°C
2154-2 Smo Antagonist, SA1 品牌 Biovision
Smo Antagonist, SA1
货号： 2154-2 产品名称： Smo Antagonist, SA1 品牌： Biovision 规格： 2 mg 3周到货 生化实验
Smo Antagonist, SA1
A Smoothened (Smo) antagonist
Product Overview
Product Name: Smo Antagonist, SA1
Alternate Name/Synonyms: 3-(3-(4-Fluorophenyl)-2,5,7-trimethylpyrazolo[1,5a]pyrimidin-6-yl)-N-(4-(furan-2-yl)butan-2-yl)propanamide
Description: A Smoothened (Smo) antagonist. SA1 inhibits Hh pathway by interacting directly with Smo. Inhibits SAG (Smoothened agonist) activation of Hh signaling in Shh-LIGHT 2 cells (IC₅₀ = 3.1 µM). Also inhibits the localization of Smo to cilia. Treatment of Ptch1-/- MEFs with SA1 suppresses the β-galactosidase activity (IC₅₀ = 3.8 µM) and inhibits the expression of Gli1 and Ptch1 in ASZ1 cells.
Peptide Sequence: N/A
Appearance: Crystalline solid
Formulation: N/A
CAS Number: N/A
Molecular Formula: C₂₆H₂₉FN₄O₂
Molecular Weight: 448.53
Purity: ≥95% by NMR
Solubility:DMSO
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from air and moisture
SMILES: CC1=C(C(=NC2=C(C(=NN12)C)C3=CC=C(C=C3)F)C)CCC(=O)NC(C)CCC4=CC=CO4
InChi: InChI=1S/C26H29FN4O2/c1-16(7-12-22-6-5-15-33-22)28-24(32)14-13-23-17(2)29-26-25(18(3)30-31(26)19(23)4)20-8-10-21(27)11-9-20/h5-6,8-11,15-16H,7,12-14H2,1-4H3,(H,28,32)
InChi Key: UTURPAUEBUIDJO-UHFFFAOYSA-N
PubChem CID: 5308963
MDL Number: N/A
USAGE: For Research Use Only! Not For Use in Humans.
-20°C
2154-5 Smo Antagonist, SA1 品牌 Biovision
Smo Antagonist, SA1
货号： 2154-5 产品名称： Smo Antagonist, SA1 品牌： Biovision 规格： 5 mg 3周到货 生化实验
Smo Antagonist, SA1
A Smoothened (Smo) antagonist
Product Overview
Product Name: Smo Antagonist, SA1
Alternate Name/Synonyms: 3-(3-(4-Fluorophenyl)-2,5,7-trimethylpyrazolo[1,5a]pyrimidin-6-yl)-N-(4-(furan-2-yl)butan-2-yl)propanamide
Description: A Smoothened (Smo) antagonist. SA1 inhibits Hh pathway by interacting directly with Smo. Inhibits SAG (Smoothened agonist) activation of Hh signaling in Shh-LIGHT 2 cells (IC₅₀ = 3.1 µM). Also inhibits the localization of Smo to cilia. Treatment of Ptch1-/- MEFs with SA1 suppresses the β-galactosidase activity (IC₅₀ = 3.8 µM) and inhibits the expression of Gli1 and Ptch1 in ASZ1 cells.
Peptide Sequence: N/A
Appearance: Crystalline solid
Formulation: N/A
CAS Number: N/A
Molecular Formula: C₂₆H₂₉FN₄O₂
Molecular Weight: 448.53
Purity: ≥95% by NMR
Solubility:DMSO
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from air and moisture
SMILES: CC1=C(C(=NC2=C(C(=NN12)C)C3=CC=C(C=C3)F)C)CCC(=O)NC(C)CCC4=CC=CO4
InChi: InChI=1S/C26H29FN4O2/c1-16(7-12-22-6-5-15-33-22)28-24(32)14-13-23-17(2)29-26-25(18(3)30-31(26)19(23)4)20-8-10-21(27)11-9-20/h5-6,8-11,15-16H,7,12-14H2,1-4H3,(H,28,32)
InChi Key: UTURPAUEBUIDJO-UHFFFAOYSA-N
PubChem CID: 5308963
MDL Number: N/A
USAGE: For Research Use Only! Not For Use in Humans.
-20°C
2155-2 Smo Antagonist, SA9 品牌 Biovision
Smo Antagonist, SA9
货号： 2155-2 产品名称： Smo Antagonist, SA9 品牌： Biovision 规格： 2 mg 3周到货 生化实验
Smo Antagonist, SA9
A Hedgehog (Hh) signaling pathway antagonist
Product Overview
Product Name: Smo Antagonist, SA9
Alternate Name/Synonyms: 3-(3-(4-Fluorophenyl)-5-oxo-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinazolin-1-yl-N-(3-methylphenethyl)propanamide
Description: SA9 inhibits Hh pathway by interacting directly with Smo. It inhibits SAG (Smoothened agonist) activation of Hh signaling in Shh-LIGHT 2 cells (IC₅₀ = 19 µM). Induces the localization of Smo to cilia in ASZ1 cells, but not in IMCD3 cells. Also treatment of Ptch1-/- MEFs with SA9 suppresses the β-galactosidase activity (IC₅₀ = 1.0 µM) and inhibits the expression of Gli1 and Ptch1 in ASZ1 cells.
Peptide Sequence: N/A
Appearance: Crystalline solid
Formulation: N/A
CAS Number: N/A
Molecular Formula: C₂₇H₂₈ClN₅O₂
Molecular Weight: 490
Purity: ≥95% by NMR
Solubility:DMSO
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from air and moisture
SMILES: C1CCC(=CC1)CCNC(=O)CCC2=NN=C3N2C4=CC=CC=C4C(=O)N3CC5=CC=C(C=C5)Cl
InChi: InChI=1S/C27H28ClN5O2/c28-21-12-10-20(11-13-21)18-32-26(35)22-8-4-5-9-23(22)33-24(30-31-27(32)33)14-15-25(34)29-17-16-19-6-2-1-3-7-19/h4-6,8-13H,1-3,7,14-18H2,(H,29,34)
InChi Key: YTDIPVZSLXYGNL-UHFFFAOYSA-N
PubChem CID: 20880974
MDL Number: N/A
USAGE: For Research Use Only! Not For Use in Humans.
-20°C
2155-5 Smo Antagonist, SA9 品牌 Biovision
Smo Antagonist, SA9
货号： 2155-5 产品名称： Smo Antagonist, SA9 品牌： Biovision 规格： 5 mg 3周到货 生化实验
Smo Antagonist, SA9
A Hedgehog (Hh) signaling pathway antagonist
Product Overview
Product Name: Smo Antagonist, SA9
Alternate Name/Synonyms: 3-(3-(4-Fluorophenyl)-5-oxo-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinazolin-1-yl-N-(3-methylphenethyl)propanamide
Description: SA9 inhibits Hh pathway by interacting directly with Smo. It inhibits SAG (Smoothened agonist) activation of Hh signaling in Shh-LIGHT 2 cells (IC₅₀ = 19 µM). Induces the localization of Smo to cilia in ASZ1 cells, but not in IMCD3 cells. Also treatment of Ptch1-/- MEFs with SA9 suppresses the β-galactosidase activity (IC₅₀ = 1.0 µM) and inhibits the expression of Gli1 and Ptch1 in ASZ1 cells.
Peptide Sequence: N/A
Appearance: Crystalline solid
Formulation: N/A
CAS Number: N/A
Molecular Formula: C₂₇H₂₈ClN₅O₂
Molecular Weight: 490
Purity: ≥95% by NMR
Solubility:DMSO
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from air and moisture
SMILES: C1CCC(=CC1)CCNC(=O)CCC2=NN=C3N2C4=CC=CC=C4C(=O)N3CC5=CC=C(C=C5)Cl
InChi: InChI=1S/C27H28ClN5O2/c28-21-12-10-20(11-13-21)18-32-26(35)22-8-4-5-9-23(22)33-24(30-31-27(32)33)14-15-25(34)29-17-16-19-6-2-1-3-7-19/h4-6,8-13H,1-3,7,14-18H2,(H,29,34)
InChi Key: YTDIPVZSLXYGNL-UHFFFAOYSA-N
PubChem CID: 20880974
MDL Number: N/A
USAGE: For Research Use Only! Not For Use in Humans.
-20°C
2158-1G MIF antagonist, p425 品牌 Biovision
MIF antagonist, p425
货号： 2158-1G 产品名称： MIF antagonist, p425 品牌： Biovision 规格： 1 g 3周到货 生化实验
MIF antagonist, p425
An allosteric MIF (macrophage migration inhibitory factor) inhibitor
Product Overview
Product Name: MIF antagonist, p425
Alternate Name/Synonyms: Chicago Sky blue 6B; 6,6′-[(3,3-Dimethoxy[1,1′-biphenyl]-4,4′-diyl)bis(azo)]bis[4-amino-5-hydroxy-1,3-napthalenedisulphonic acid] tetrasodium salt
Description: A counterstain for background autofluorescence in fluorescence and immunofluorescence histochemistry. Acts as an allosteric MIF (macrophage migration inhibitory factor) inhibitor. It occupies an interface of MIF trimers, leading to the loss of its tautomerase, receptor binding, and pro-inflammatory activities. An excellent tool to design MIF-directed therapeutics for inflammatory diseases.
Peptide Sequence: N/A
Appearance: Brown to dark brown solid
Formulation: N/A
CAS Number: 259444
Molecular Formula: C₃₄H₂₄N₆Na₄O₁₆S₄
Molecular Weight: 992.79
Purity: Dye content: ~ 80%
Solubility:H₂O (10 mg/ml)
Storage Temp.: RT
Shipping Conditions: RT
Handling: Protect from air and light
SMILES: COC1=C(C=CC(=C1)C2=CC(=C(C=C2)NN=C3C=CC4=C(C3=O)C(=C(C=C4S(=O)(=O)[O-])S(=O)(=O)[O-])N)OC)NN=C5C=CC6=C(C5=O)C(=C(C=C6S(=O)(=O)[O-])S(=O)(=O)[O-])N.[Na+].[Na+].[Na+].[Na+]
InChi: InChI=1S/C34H28N6O16S4.4Na/c1-55-23-11-15(3-7-19(23)37-39-21-9-5-17-25(57(43,44)45)13-27(59(49,50)51)31(35)29(17)33(21)41)16-4-8-20(24(12-16)56-2)38-40-22-10-6-18-26(58(46,47)48)14-28(60(52,53)54)32(36)30(18)34(22)42;;;;/h3-14,37-38H,35-36H2,1-2H3,(H,43,44,45)(H,46,47,48)(H,49,50,51)(H,52,53,54);;;;/q;4*+1/p-4/b39-21-,40-22+;;;;
InChi Key: UPKAWFACSJWKND-ZXFFUEEESA-J
PubChem CID: 5359775
MDL Number: MFCD00004020
USAGE: For Research Use Only! Not For Use in Humans.
RT
2159-2 Smo Antagonist, SA10 品牌 Biovision
Smo Antagonist, SA10
货号： 2159-2 产品名称： Smo Antagonist, SA10 品牌： Biovision 规格： 2 mg 3周到货 生化实验
Smo Antagonist, SA10
A Hedgehog (Hh) signaling pathway antagonist
Product Overview
Product Name: Smo Antagonist, SA10
Alternate Name/Synonyms: 4-((Benzo[c][1,2,5]thiadiazole-4-sulfonamido)methyl-N-(3-phenylpropyl)cyclohexanecarboxamide
Description: SA10 inhibits SAG (Smoothened agonist) activation of Hh signaling in Shh-LIGHT 2 cells (IC₅₀ = 5 µM). However, unlike SA1 and SA9, Smo antagonist SA10 does not directly bind to Smo. Inhibits the localization o Smo to cilia. Also treatment of Ptch1-/- MEFs with SA10 suppresses the β-galactosidase activity (IC₅₀ = 11.0 µM) and inhibits the expression of Gli1 and Ptch1 in ASZ1 cells.
Peptide Sequence: N/A
Appearance: Crystalline solid
Formulation: N/A
CAS Number: N/A
Molecular Formula: C₂₃H₂₈N₄O₃S₂
Molecular Weight: 472.62
Purity: ≥95% by NMR
Solubility:DMSO
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from air and moisture
SMILES: N/A
InChi: N/A
InChi Key: N/A
PubChem CID: N/A
MDL Number: N/A
USAGE: For Research Use Only! Not For Use in Humans.
-20°C
2159-5 Smo Antagonist, SA10 品牌 Biovision
Smo Antagonist, SA10
货号： 2159-5 产品名称： Smo Antagonist, SA10 品牌： Biovision 规格： 5 mg 3周到货 生化实验
Smo Antagonist, SA10
A Hedgehog (Hh) signaling pathway antagonist
Product Overview
Product Name: Smo Antagonist, SA10
Alternate Name/Synonyms: 4-((Benzo[c][1,2,5]thiadiazole-4-sulfonamido)methyl-N-(3-phenylpropyl)cyclohexanecarboxamide
Description: SA10 inhibits SAG (Smoothened agonist) activation of Hh signaling in Shh-LIGHT 2 cells (IC₅₀ = 5 µM). However, unlike SA1 and SA9, Smo antagonist SA10 does not directly bind to Smo. Inhibits the localization o Smo to cilia. Also treatment of Ptch1-/- MEFs with SA10 suppresses the β-galactosidase activity (IC₅₀ = 11.0 µM) and inhibits the expression of Gli1 and Ptch1 in ASZ1 cells.
Peptide Sequence: N/A
Appearance: Crystalline solid
Formulation: N/A
CAS Number: N/A
Molecular Formula: C₂₃H₂₈N₄O₃S₂
Molecular Weight: 472.62
Purity: ≥95% by NMR
Solubility:DMSO
Storage Temp.: -20°C
Shipping Conditions: gel pack
Handling: Protect from air and moisture
SMILES: N/A
InChi: N/A
InChi Key: N/A
PubChem CID: N/A
MDL Number: N/A
USAGE: For Research Use Only! Not For Use in Humans.
-20°C
MA120818 IL-1 Receptor Antagonist 品牌 Pierce
IL-1 Receptor Antagonist
货号： MA120818 产品名称： IL-1 Receptor Antagonist 品牌： Pierce 规格： 100 μg
100082-10MG 14-3-3 Antagonist II, BV02 品牌 Merck
14-3-3 Antagonist II, BV02
货号： 100082-10MG 产品名称： 14-3-3 Antagonist II, BV02 品牌： Merck 规格： *** 3周到货 生化实验
14-3-3 Antagonist II, BV02
2-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-ylcarbamoyl)terephthalic acid
A cell-permeable, non-peptidyl pyrazolylcarbamoyl compound that targets the amphipathic client protein-binding groove of 14-3-3 and effectively competes against cellular pro-apoptotic c-Abl and cell cycle inhibitor protein p27Kip1 (CDK inhibitor 1B) for 14-3-3σ interaction, leading to c-Abl mitochondrial membrane relocation, c-Abl and p27Kip1 nuclear translocation, sub-G1 arrest, enhanced c-Abl cleavage, caspase-9 and -8 activation (24 h 5 µM treatment), and eventual apoptotic cell death in pro-B murine Ba/F3 lines expressing wt, E255K, or T315I Bcr-Abl (LD50 = 0.41, 1.30, 1.47 µM, respectively;). Also demonstrated to exhibit antiproliferative activity against the survival of three primary IM- (Imatinib mesylate; STI571) resistant CD34+ cultures (LD50 = 0.5, 0.7, and 2.5 µM) from CML (chronic myeloid leukemia) patients with T315I Bcr-Abl mutation.
产品信息
Form Off-white powder
Molar mass 395.4
Protect from Light 是的
Packaged under inert gas 是的
Purity ≥98% by HPLC
Solubility DMSO
Chemical formula C20H17N3O6
商店和运输信息
Storage +2°C to +8°C
Ship Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Regulatory Review
2°C – 8°C
239821-10MG CXCR4 Antagonist II 品牌 Merck
CXCR4 Antagonist II
货号： 239821-10MG 产品名称： CXCR4 Antagonist II 品牌： Merck 规格： *** 3周到货 生化实验
CXCR4 Antagonist II
IT1t, 1,3-Dicyclohexyl-2-(3-methyl-6,6-dimethyl-5,6-dihydroimidazo[1,2-b]thiazole)-2-thiopseudourea, HCl, Fusin Antagonist II
A thiopseudourea compound that acts as a selective and highly potent CXCR4/Fusin antagonist (IC50 = 1.1 nM against SDF-1/CXCL12-induced Ca2+ mobilization in CEM cells) and effectively targets CXCR4-mediated binding of both CXCL12 (IC50 = 8 and 11 nM in competitive binding assays using human CEM and rat IR983F membrane, respectively) and HIV gp120 (IC50 = 7 nM in HIV attachment assays). Shown to be orally available in rat with good in vivo pharmacokinetics (32% availability, tmax = 0.5 h, Cmax= 18 ng/ml, t1/2 = 7.6 h, based on an oral dose of 1 mg/kg). Comparing to AMD3100 (Cat. No. 239820), CXCR4 Antagonist II is ~30-times more potent as a CXCR4-CXCL12 interaction blocker, while being ~2-fold less potent in blocking gp120-mediated HIV attachment.
产品信息
Form White solid
Molar mass 443.1
Protect from Light 是的
Hygrocopic 是的
Packaged under inert gas 是的
Purity ≥95% by HPLC
Solubility DMSO
Chemical formula C21H34N4S2 • HCl
CAS number 1258011-83-4
商店和运输信息
Storage -20°C
Ship Ambient Temperature Only
Standard Handling
-20°C
362330-100MG GAG Antagonist, Surfen 品牌 Merck
GAG Antagonist, Surfen
货号： 362330-100MG 产品名称： GAG Antagonist, Surfen 品牌： Merck 规格： *** 3周到货 生化实验
GAG Antagonist, Surfen
A symmetrical quinolyl-urea compound that binds GAGs (glycosaminoglycans) via electrostatic interaction with the negatively charged sulfate and carboxyl moieties present in heparan sulfate (HS), heparin, and dermatan sulfate, resulting in effective blockage of GAGs interactions with their protein binding partners. Surfen is shown to effectively neutralize HS- and heparin-mediated thrombin inhibition of Factor Xa activity as well as heparin’s anti-clotting activity. Also reported to inhibit FGF2-induced Erk phosphorylation and tubulation in murine lung endothelial cultures (IC50 ~5 µM), fibronectin HS-binding domain-dependent CHO cell adhesion (IC50 = 3 µM), and HSV-1 infection of glucosaminyl 3-O-sulfotransferase-3A-expressing CHO cells (complete inhibition at 5 µM). Surfen analogs with improved potency may serve as promising candidates as less toxic alternatives to Protamine (Cat. No. 539122) in clinical applications.
产品信息
Form White solid
Molar mass 499.4
Protect from Light 是的
Hygrocopic 是的
Packaged under inert gas 是的
Purity ≥98% by HPLC
Solubility DMSO
Chemical formula C21H20N6O • 2HCl • 3H2O
商店和运输信息
Storage +2°C to +8°C
Ship Ambient Temperature Only
Standard Handling
2°C – 8°C
373273-10MG Hh Signaling Antagonist XIV, SANT-2 品牌 Merck
Hh Signaling Antagonist XIV, SANT-2
货号： 373273-10MG 产品名称： Hh Signaling Antagonist XIV, SANT-2 品牌： Merck 规格： *** 3周到货 生化实验
Hh Signaling Antagonist XIV, SANT-2
A nanomolar Smoothened (smo) antagonist that exhibits 2.3- and 6-fold weaker biological activity than SANT-1 (Cat. No. 559303), respectively, in antagonizing ShhNp- and SAG-stimulated hedgehog pathway activation in HEK 293-based (Shh-LIGHT2) reporter assays. Competitive binding studies show full replacement of Smo-bound cyclopamine (Cat. No. 239803) by SANT-1 and SANT-2 (Ki = 2.4 and 8.4 nM, respectively), while SANT-1 and SANT-2 are shown to compete against Smo-bound SAG-1.3 (Cat. Nos. 566660 & 566661) in an allosteric manner and that only SANT-2, but not SANT-1, is able to completely compete off bound SAG-1.3 (100% vs. 40% replacement by the respective compound at 10 µM).
产品信息
Form White powder
Molar mass 480.00
Protect from Light 是的
Packaged under inert gas 是的
Purity ≥95% by HPLC
Solubility DMSO
Chemical formula C26H26ClN3O4
CAS number 329196-48-7
商店和运输信息
Storage +2°C to +8°C
Ship Ambient Temperature Only
Standard Handling
2°C – 8°C
373275-10MG Hh Signaling Antagonist XII, HPI-1 品牌 Merck
Hh Signaling Antagonist XII, HPI-1
货号： 373275-10MG 产品名称： Hh Signaling Antagonist XII, HPI-1 品牌： Merck 规格： *** 3周到货 生化实验
Hh Signaling Antagonist XII, HPI-1
A cell-permeable oxo-tetrahydroquinolinecarboxylate compound that acts as a downstream Hh (Hedgehog) pathway blocker, effectively inhibiting Gli-dependent transcription activity in both Sufu+/+ NIH 3T3 (shh-LIGHT2) and Sufu-/- fibroblast cultures (IC50 = 1.5 & 3 µM, respectively) in a manner similar to two other Hh downstream blockers, HPI-3 (Cat. No. 373276) and GANT-61 (Cat. No. 373401). However, only HPI-1, but not HPI-3 or GANT-61 (no effect at 30 µM), remains effective against Sufu-/- fibroblasts overexpressing Gli1 or Gli2 (IC50 = 6 & 4 µM, respectively). HPI-1 is also shown to inhibit the ligand-independent Hh pathway activation in SmoM2-expressing primary murine CGNPs (Cerebellar Granule Neuron Precursors) and NIH 3T3 (smoM2-LIGHT) cultures.
产品信息
Form Pale yellow solid
Molar mass 463.5
Protect from Light 是的
Packaged under inert gas 是的
Purity ≥95% by HPLC
Solubility DMSO
Chemical formula C27H29NO6
CAS number 599150-20-6
商店和运输信息
Storage -20°C
Ship Shipped with Blue Ice or with Dry Ice
Standard Handling
-20°C
373276-10MG Hh Signaling Antagonist XIII, HPI-3 品牌 Merck
Hh Signaling Antagonist XIII, HPI-3
货号： 373276-10MG 产品名称： Hh Signaling Antagonist XIII, HPI-3 品牌： Merck 规格： *** 3周到货 生化实验
Hh Signaling Antagonist XIII, HPI-3
A cell-permeable piperazinyl-quinazoline compound that acts as a downstream Hh (Hedgehog) pathway blocker, effectively inhibiting Gli-dependent transcription activity in both Sufu+/+ NIH 3T3 (shh-LIGHT2) and Sufu-/- fibroblast cultures (IC50 = 3 & 9 µM, respectively) in a manner similar to two other Hh downstream blockers, HPI-1 (Cat. No. 373275) and GANT-61 (Cat. No. 373401). However, unlike HPI-1, HPI-3’s inhibitory activity against Su(fu)-/- fibroblasts is completely abolished by Gli1 or Gli2 overexpression. While both HPI-1 and HPI-3 are shown to inhibit the ligand-independent Hh pathway activation in SmoM2-expressing NIH 3T3 cultures (IC50 = 2.5 & 1 µM, respectively), only HPI-1, but not HPI-3, is able to effectively suppress the SmoM2-induced Hh pathway activation in primary murine CGNPs (Cerebellar Granule Neuron Precursors) cultures.
产品信息
Form Beige solid
Molar mass 349.4
Protect from Light 是的
Packaged under inert gas 是的
Purity ≥95% by HPLC
Solubility DMSO
Chemical formula C20H23N5O
CAS number 796887-98-4
商店和运输信息
Storage +2°C to +8°C
Ship Ambient Temperature Only
Standard Handling
2°C – 8°C
374274-10MG Hh Signaling Antagonist XV 品牌 Merck
Hh Signaling Antagonist XV
货号： 374274-10MG 产品名称： Hh Signaling Antagonist XV 品牌： Merck 规格： *** 3周到货 生化实验
Hh Signaling Antagonist XV
A benzylphthalazinyl compound that blocks the binding of the Smoothened (Smo) agonist Hh-Ag1.5 to Smo in competitive binding assays (IC50 = 5 or 8 nM, respectively, using CHO-K1 membrane expressing murine or human Smo) and potently inhibits Gli-mediated transcription activity upon Hh-Ag1.5 stimulation in TM3-based reporter assays (IC50 = 2.7 or 35 nM, respectively, against 1 or 25 nM Hh-Ag1.5). Shown to exhibit blood-brain barrier permeability and good oral bioavailability in mice and effectively inhibit tumor growth in a dose-dependent manner in a Ptch+/-p53-/- medulloblastoma allograft model in Harlan nu/nu mice (71% regression by two 40 mg/kg oral dosages per day) in vivo.
产品信息
Form Pale yellow solid
Molar mass 439.6
Protect from Light 是的
Purity ≥95% by HPLC
Solubility DMSO
Chemical formula C27H29N5O
CAS number 1057677-92-5
商店和运输信息
Storage -20°C
Ship Ambient Temperature Only
Standard Handling
-20°C
419825-250MG Hh Signaling Antagonist X, Itraconazole 品牌 Merck
Hh Signaling Antagonist X, Itraconazole
货号： 419825-250MG 产品名称： Hh Signaling Antagonist X, Itraconazole 品牌： Merck 规格： *** 3周到货 生化实验
Hh Signaling Antagonist X, Itraconazole
Form White powder
Molar mass 705.6
Protect from Light 是的
Packaged under inert gas 是的
Purity ≥98% by HPLC
Solubility DMSO
Chemical formula C35H38Cl2N8O4
CAS number 84625-61-6
商店和运输信息
Storage +2°C to +8°C
Ship Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Harmful
2°C – 8°C
442640-25MG MBT Domain Antagonist, UNC669 品牌 Merck
MBT Domain Antagonist, UNC669
货号： 442640-25MG 产品名称： MBT Domain Antagonist, UNC669 品牌： Merck 规格： *** 3周到货 生化实验
L3MBTL1 Ligand, UNC669
5-Bromo-N-(4-(pyrrolidinyl)piperidinyl)nicotinamide
A nicotinamido-pyrrolidine compound that targets the second MBT (Malignant Brain Tumor) module of "chromatin lock" L3MBTL1 (Lethal 3 MBT-Like protein 1; Kd = 5 µM by Isothermal titration calorimetry) that "reads"/binds mono- and dimethyl-lysine modified histones as well as other proteins involved in transcription, such as p53 and Rb, via methylation-dependent recognition. Shown to effectively compete against FAM-labeled, monomethylated Histone H3 (1-15) peptide (H3K9Me1) binding to L3MBTL1 (Kd = 10 µM in a FP displacement assay) and exhibit higher affinity toward L3MBTL1 than L3MBTL3 and L3MBTL4 (IC50 = 6, 35, and 69 µM, respectively, in a luminescent peptide competitive binding assay), while displaying no detectable binding toward four other methyl-lysine-binding proteins, the BMT domain-containing SFMBT1 and MBTD1, the PHD (Plant Homeodomain) finger-containing PHF13 (PHD finger 13), and the chromo domain-containing CBX7 (chromobox 7). As of end of 2012, no published data is available regarding the molecule’s permeability or biological activity in cells.
产品信息
Form Pale orange-yellow solid
Molar mass 338.3
Protect from Light 是的
Hygrocopic 是的
Packaged under inert gas 是的
Purity ≥95% by HPLC
Solubility DMSO or H2O
Chemical formula C15H20BrN3O
商店和运输信息
Storage -20°C
Ship Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Standard Handling
-20°C
444155-10MG MDMX Antagonist, SJ-172550 品牌 Merck
MDMX Antagonist, SJ-172550
货号： 444155-10MG 产品名称： MDMX Antagonist, SJ-172550 品牌： Merck 规格： *** 3周到货 生化实验
MDMX Antagonist, SJ-172550
Methyl-2-(2-chloro-6-ethoxy-4-(E)-(3-methyl-5-oxo-1-phenyl-pyrazol-4-ylidene)methyl)phenoxy)acetate, MDMX Inhibitor II
A cell-permeable phenyl-pyrazolylidene compound that competes with p53-derived peptide (aa 15-29) binding to MDMX in cell-free binding assays (EC50 = 2.3 µM) in a reversible manner and effectively disrupts cellular p53-MDMX interaction (IC50 <20 µM in C33A, HER, and Weri1 cultures), while exhibiting much weaker affinity toward MDM2 (EC50 = 26 µM in p53 peptide competition assays). MDMX inhibition by 20 µM SJ-172550 and MDM2 inhibition by 5 µM Nutlin-3a (Cat. Nos. 444143 & 444151) are both shown to result in reduced proliferation and increased cellular caspase-3 in cultured cells, however, only MDM2, but not MDMX, inhibition results in a significant p53 protein level upregulation.
产品信息
Form Orange solid
Molar mass 428.9
Protect from Light 是的
Packaged under inert gas 是的
Purity ≥95% by NMR
Solubility DMSO
Chemical formula C22H21ClN2O5
CAS number 431979-47-4
商店和运输信息
Storage +2°C to +8°C
Ship Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Standard Handling
2°C – 8°C