pDeNy-hTIRAP

货号： pdn-htirap      产品名称： pDeNy-hTIRAP   品牌： Invivogen 规格： 1 disk 二周到货 生化试验

pDeNy-TIRAP
Dominant Negative TIRAP gene in expression plasmid
Alias: MAL
Dominant negative TIRAP/Mal (P125H) was generated by mutating the proline at position 125 into a histidine. This DN TIRAP/Mal was shown to inhibit NF-κB activated by LPS-induced TLR4 but not NF-κB activated by IL-1RI or IL-18R suggesting that TIRAP/Mal is involved in TLR4 signaling [1].
1. Fitzgerald KA et al., 2001. Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction. Nature. 2001 Sep 6;413(6851):78-83.
This gene is available in pDeNy expression plasmid selectable with Zeocin™.
Contents update notification
All InvivoGen plasmids are now provided as lyophilized DNA.
Human DN-hTIRAP (pDeNy-hTIRAP)