psiRNA-hTIRAP Kit
货号： ksirna42-htirap 产品名称： psiRNA-hTIRAP Kit 品牌： Invivogen 规格： 1 kit 三周到货 生化试验
psiRNA-TIRAP
psiRNA vector expressing shRNA targeting human TIRAP gene
Name: TIRAP
Alias: Mal
Genbank: NM_052887
Backbone: psiRNA-h7SK GFPzeo
Selection: Zeocin™
psiRNA vector expressing shRNA targeting mouse TIRAP gene
Name: TIRAP
Alias: Mal
Genbank: NM_054096
Backbone: psiRNA-h7SK GFPzeo
Selection: Zeocin™
pdn-htirap pDeNy-hTIRAP 品牌 Invivogen
pDeNy-hTIRAP
货号： pdn-htirap 产品名称： pDeNy-hTIRAP 品牌： Invivogen 规格： 1 disk 二周到货 生化试验
pDeNy-TIRAP
Dominant Negative TIRAP gene in expression plasmid
Alias: MAL
Dominant negative TIRAP/Mal (P125H) was generated by mutating the proline at position 125 into a histidine. This DN TIRAP/Mal was shown to inhibit NF-κB activated by LPS-induced TLR4 but not NF-κB activated by IL-1RI or IL-18R suggesting that TIRAP/Mal is involved in TLR4 signaling [1].
1. Fitzgerald KA et al., 2001. Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction. Nature. 2001 Sep 6;413(6851):78-83.
This gene is available in pDeNy expression plasmid selectable with Zeocin™.
Contents update notification
All InvivoGen plasmids are now provided as lyophilized DNA.
Human DN-hTIRAP (pDeNy-hTIRAP)
psirna42-htirap psiRNA-hTIRAP 品牌 Invivogen
psiRNA-hTIRAP
货号： psirna42-htirap 产品名称： psiRNA-hTIRAP 品牌： Invivogen 规格： 20 μg 三周到货 生化试验
psiRNA-TIRAP
psiRNA vector expressing shRNA targeting human TIRAP gene
Name: TIRAP
Alias: Mal
Genbank: NM_052887
Backbone: psiRNA-h7SK GFPzeo
Selection: Zeocin™
psiRNA vector expressing shRNA targeting mouse TIRAP gene
Name: TIRAP
Alias: Mal
Genbank: NM_054096
Backbone: psiRNA-h7SK GFPzeo
Selection: Zeocin™
puno-htirap pUNO-hTIRAPb 品牌 Invivogen
pUNO-hTIRAPb
货号： puno-htirap 产品名称： pUNO-hTIRAPb 品牌： Invivogen 规格： 1 disk 三周到货 生化试验
TIRAP
Coding sequence in expression plasmid
Alias: MAL
TIR domain-containing adapter protein (TIRAP)
TIR domain-containing adapter protein (TIRAP), also known as Mal, is differentially involved in the signaling to NF-kB by members of the TLR family. TIRAP-deficient mice were shown to respond normally to the TLR3, TLR5, TLR7 and TLR9 ligands, but to be defective in cytokine response to LPS, a ligand for TLR4, as well as ligands for TLR2, TLR1 and TLR6[1,2]. TIRAP contributes to TLR2 and TLR4 MyD88-dependent signaling pathway but interacts only with TLR4 to activate a MyD88-independent pathway to induce IFN-β and STAT-1 dependent genes[3].
This gene is available in pUNO1 expression plasmid selectable with Blasticidin.
Human TIRAP isoform 2 (long) (pUNO1-hTIRAPb)
ORF Size: 708bp
Subclone: NcoI – NheI
Mouse TIRAP (pUNO1-mTIRAP)
ORF Size: 726bp
Subclone: NcoI – NheI