pUNO-hTIRAPb

货号： puno-htirap      产品名称： pUNO-hTIRAPb   品牌： Invivogen 规格： 1 disk 三周到货 生化试验

TIRAP
Coding sequence in expression plasmid
Alias: MAL
TIR domain-containing adapter protein (TIRAP)
TIR domain-containing adapter protein (TIRAP), also known as Mal, is differentially involved in the signaling to NF-kB by members of the TLR family. TIRAP-deficient mice were shown to respond normally to the TLR3, TLR5, TLR7 and TLR9 ligands, but to be defective in cytokine response to LPS, a ligand for TLR4, as well as ligands for TLR2, TLR1 and TLR6[1,2]. TIRAP contributes to TLR2 and TLR4 MyD88-dependent signaling pathway but interacts only with TLR4 to activate a MyD88-independent pathway to induce IFN-β and STAT-1 dependent genes[3].
This gene is available in pUNO1 expression plasmid selectable with Blasticidin.
Human TIRAP isoform 2 (long) (pUNO1-hTIRAPb)
ORF Size: 708bp
Subclone: NcoI – NheI
Mouse TIRAP (pUNO1-mTIRAP)
ORF Size: 726bp
Subclone: NcoI – NheI