Anti-PLK3

货号： ABS89      产品名称： Anti-PLK3   品牌： Millipore 规格： EA 三周到货 生化实验

Anti-Plk3
Species Reactivity Key Applications Host Format Antibody Type
H  WB Rabbit Affinity Purified Polyclonal Antibody
Description:
Anti-Plk3 Antibody
Promotional Text:
Special Shipping Offer on Antibodies
100% Performance Guaranteed
Molecular Weight:
~72 kDa observed.
An uncharacterized band may be seen at a molecular weight of ~35 kDa in some cell lysates.
Immunogen:
KLH-conjugated linear peptide corresponding to human Plk3.
Background Information:
Plk3 is an NF-κB-regulated kinase that mediates p53-dependent and -independent pro-apoptotic responses to elevated levels of superoxide. It acts as a key regulator of the cell cycle through signaling networks that pertain to centrosome maturation and separation, mitotic entry, chromosome segregation, mitotic exit, and cytokinesis to name a few of several related cellular functions. It serves as an essential component in the hypoxia signaling pathway, demonstrates tumor-suppressing activity, and is suggested to play a role in angiogenesis in PLK3-null mice. Additionally, Plk3 is demonstrated to mediate the cell cycle through its influence on Cdc25 phosphatase function.
View All »
Species Reactivity:
Human
Species Reactivity Note:
Demonstrated to react with Human.
Control:
Human placenta tissue lysate
Quality Assurance:
Evaluated by Western Blot in Human placenta tissue lysate.
Western Blot Analysis: A 1:1,000 dilution of this antibody detected Plk3 in human placenta tissue lysate.
Purification Method:
Affinity Purified
Presentation:
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Storage Conditions:
Stable for 1 year at 2-8°C from date of receipt.
UniProt Number:
Q9H4B4
Entrez Gene Number:
NP_004064
Gene Symbol:
PLK3
CNK
FNK
PRK
Alternate Names:
Serine/threonine-protein kinase PLK3
cytokine-inducible serine/threonine-protein kinase
FGF-inducible kinase
Polo-like kinase 3
PLK-3
proliferation-related kinase
View All »
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
View All »
Key Applications:
Western Blotting
Entrez Gene Summary:
Cytokine-inducible kinase is a putative serine/threonine kinase. CNK contains both a catalytic domain and a putative regulatory domain. It may play a role in regulation of cell cycle progression and tumorigenesis.
UniProt Summary:
FUNCTION: Serine/threonine protein kinase involved in regulating M phase functions during the cell cycle. May also be part of the signaling network controlling cellular adhesion. In vitro, is able to phosphorylate CDC25C and casein.
CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
SUBUNIT STRUCTURE: Binds to the calcium/integrin-binding protein (CIB). This interaction probably occurs via the POLO-box domain.
SUBCELLULAR LOCATION: Membrane; Peripheral membrane protein.
View All »
Product Name:
Anti-Plk3
Concentration:
Please refer to the Certificate of Analysis for the lot-specific concentration.
Antibody Type:
Polyclonal Antibody
Qty/Pk:
100 µL
Format:
Affinity Purified
Host:
Rabbit
Applications:
This Anti-Plk 2-8℃