GLIAL DERV NEURO FACTOR, CHKX-100UG

货号： AB5755      产品名称： GLIAL DERV NEURO FACTOR, CHKX-100UG   品牌： Millipore 规格： EA 三周到货 生化实验

Anti-Glial Derived Neurotrophic Factor Antibody
Species Reactivity Key Applications Host Format Antibody Type
H, M, R  ELISA, WB Chicken Affinity Purified Polyclonal Antibody
Description:
Anti-Glial Derived Neurotrophic Factor Antibody
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Trade Name:
Chemicon (Millipore)
Specificity:
Glial Derived Neurotrophic Factor (GDNF).
Immunogen:
Synthetic peptides from human GDNF.
Species Reactivity:
Human
Mouse
Rat
Application Notes:
Immunoblotting: 1:500-1:2,000
Immunohistochemistry: not tested. It is recommended that you try the antibody at 1:50-1:500.
ELISA: 1:500-1:2,000
Optimal working dilutions must be determined by the end user.
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Presentation:
Affinity purified immunoglobulin. Liquid in PBS containing 0.02% sodium azide.
Storage Conditions:
Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
UniProt Number:
P39905
Entrez Gene Number:
NM_000514.2
NM_199231.1
NM_199234.1
Gene Symbol:
GDNF
HFB1-GDNF
ATF1
ATF2
hGDNF
ATF
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Alternate Names:
GDNF
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
ELISA
Western Blotting
Entrez Gene Summary:
This gene encodes a highly conserved neurotrophic factor. The recombinant form of this protein was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. The encoded protein is processed to a mature secreted form that exists as a homodimer. The mature form of the protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. In addition to the transcript encoding GDNF, two additional alternative transcripts encoding distinct proteins, referred to as astrocyte-derived trophic factors, have also been described. Mutations in this gene may be associated with Hirschsprung disease.
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UniProt Summary:
FUNCTION: SwissProt: P39905 # Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake.
SIZE: 211 amino acids; 23720 Da
SUBUNIT: Homodimer; disulfide-linked.
SUBCELLULAR LOCATION: Secreted.
TISSUE SPECIFICITY: In the brain, predominantly expressed in the striatum with highest levels in the caudate and lowest in the putamen.
DISEASE: SwissProt: P39905 # Defects in GDNF may be a cause of Hirschsprung disease (HSCR) [MIM:142623]. In association with mutations of RET gene, defects in GDNF may be involved in Hirschsprung disease. This genetic disorder of neural crest development is characterized by the absence of intramural ganglion cells in the hindgut, often resulting in intestinal obstruction. & Defects in GDNF are a cause of congenital central hypoventilation syndrome (CCHS) [MIM:209880]; also known as congenital failure of autonomic control or Ondine curse. CCHS is a rare disorder characterized by abnormal control of respiration in the absence of neuromuscular or lung disease, or an identifiable brain stem lesion. A deficiency in autonomic control of respirati -20℃