Anti-Olig2, clone 211F1.1, Alexa Fl

货号： MABN50A4      产品名称： Anti-Olig2, clone 211F1.1, Alexa Fl   品牌： Millipore 规格： EA 三周到货 生化实验

Anti-Olig2 Antibody, clone 211F1.1, Alexa Fluor®488 Conjugate
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PRODUCT FAMILY INFORMATION
Glial Cell Markers
Glial cells, sometimes called neuroglia are non-neuronal cells that maintain homeostasis, form myelin, and provide support and protection for neurons in the brain and peripheral nervous system.
Glial cells, sometimes called neuroglia are non-neuronal cells that maintain homeostasis, form myelin, and provide support and protection for neurons in the brain and peripheral nervous system.
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Species Reactivity Key Applications Host Format Antibody Type
R, M, H  ICC Mouse AlexaFluor®488 null
Description:
Anti-Olig2 Antibody, clone 211F1.1, Alexa Fluor®488 Conjugate | MABN50A4
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Molecular Weight:
The unconjugated parent antibody (Cat. No. MABN50) has an observed molecular weight at ~37 kDa.
Immunogen:
Recombinant protein corresponding to human Olig2.
Clone:
211F1.1
Isotype:
IgG2a
Background Information:
Oligodendrocyte lineage transcription factor 2 (Olig2) is a protein belonging to group A of the OLIG family of basic helix-loop-helix transcription factors (bHLH). bHLH proteins are divided into 6 groups (A-F), and characterized by their biochemical properties and structure. Olig2 is classified as group A due to its ability to form heterodimers with other bHLH proteins and binding to the E box. Olig2 has a crucial role during development in specifying the final location of motor neurons and oligodendrocytes in the spinal cord, along with the development within the hindbrain of somatic motor neurons. Olig2 expression is observed within oligodendrocytes and in developing astrocytes. Recent studies have shown strong expression of Olig2 in human oligodendrogliomas, primary tumors within the central nervous system, and moderate expression in astrocytomas. These observations have led to the proposal of Olig2 having potential as an oligodendroglioma diagnostic marker.
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Species Reactivity:
Rat
Mouse
Human
Species Reactivity Note:
Demonstrated to react with mouse and rat. Predicted to react with human based on 100% sequence homology
Control:
Rat oligodendrocyte precursor cells
Quality Assurance:
Evaluated by Immunocytochemistry in rat oligodendrocyte precursor cells.
Immunocytochemistry Analysis: A 1:100 dilution of this antibody detected Olig2 in rat oligodendrocyte precursor cells.
Purification Method:
Protein G purified
Presentation:
Purified mouse monoclonal IgG2a conjugated to Alexa Fluor® 488 in PBS with 0.1% sodium azide and 15 mg/mL BSA.
Storage Conditions:
Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.
UniProt Number:
Q13516
Entrez Gene Number:
NP_005797
Gene Symbol:
OLIG2
BHLHB1
BHLHE19
PRKCBP2
RACK17
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Alternate Names:
Oligodendrocyte transcription factor 2
Oligo2
Class B basic helix-loop-helix protein 1
bHLHb1
Class E basic helix-loop-helix protein 19
bHLHe19
Protein kinase C-binding protein 2
Protein kinase C-binding protein RACK17
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Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
2-8℃