标签归档：crystallin

VP-A103   Alpha B Crystallin   品牌 Vector

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Alpha B Crystallin

货号： VP-A103      产品名称： Alpha B Crystallin   品牌： Vector 规格： 1 ml 询盘

Alpha B Crystallin is expressed in a number of normal tissues including muscle, neural and epithelial tissues and in various carcinomas such as renal cell carcinoma. The protein is also found in Lewy bodies and implicated in Lewy body dementia.

ABN185   Anti-alpha B-crystallin   品牌 Millipore

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Anti-alpha B-crystallin

货号： ABN185      产品名称： Anti-alpha B-crystallin   品牌： Millipore 规格： EA 三周到货 生化实验

Anti-alpha B-crystallin
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Species Reactivity Key Applications Host Format Antibody Type
B, H, R, M, Ox, Eq, Rhesus Macaque  WB, IH(P) Rabbit Affinity Purified Polyclonal Antibody
Description:
Anti-alpha B-crystallin Antibody
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Specificity:
This antibody recognizes the N-terminus of alpha B-crystallin.
Molecular Weight:
~20 kDa observed. Uncharacterized bands at ~37 and 43 kDa may be observed in some cell lyates.
Epitope:
N-terminus
Immunogen:
KLH-conjugated linear peptide corresponding to the N-terminus human alpha B-crystallin.
Background Information:
Alpha B-crystallin is a major structural protein in the vertebrate eye lens, but is also found in cardiac and skeletal muscles, kidney, and brain. Alpha B-crystallin is also found to be a component of Rosenthal fibers and a consistent tissue marker of epileptic foci. It occurs as large aggregates of up to 106 Da, composed of two proteins, αA- and αB-crystallin. The αA gene encodes a polypeptide of 173 residues, while αB-crystallin gene encodes a 175 residue polypeptide. αB-crystallin, like the small heat shock proteins (sHsp’s), is induced by heat or osmotic shock and is upregulated by stress. α-crystallin and the sHsp’s protect other proteins from heat-induced aggregation. The two other crystallin families, β and ɣ, are homologous to each other but not to the α-family or the sHsp’s.
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Species Reactivity:
Bovine
Human
Rat
Mouse
Ox
Horse
Rhesus Macaque
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Species Reactivity Note:
Demonstrated to react with Human, Bovine, and Rat. Predicted to react with Mouse, Ox, Horse, and Rhesus Macaque based on 100% sequence homology.
Application Notes:
Immunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected Alpha-crystallin B chain in rat lens fiber tissue. A 1:2,000 dilution from a representative lot detected Alpha-crystallin B chain in strong rat lens fiber tissue (data not provided). A 1:1,000 dilution from a representative lot detected Alpha-crystallin B chain in strong muscle fiber tissue (data also not provided). It is recommended to use a 1:2,000 dilution only for strong rat lens fiber tissue.
Western Blot analysis: 0.05 µg/mL of this antibody detected Alpha-crystallin B chain in 10 µg of human kidney and calf kidney tissue lysate.
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Control:
Bovine calf lens, human kidney and calf kidney tissue lysate
Quality Assurance:
Evaluted by Western Blot in bovine calf lens tissue lysate.
Western Blot analysis: 0.05 µg/mL of this antibody detected Alpha-crystallin B chain in 10 µg of bovine calf lens tissue lysate.
Purification Method:
Affinity purified
Presentation:
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Storage Conditions:
Stable for 1 year at 2-8°C from date of receipt.
UniProt Number:
P02511
Entrez Gene Number:
NP_001876
Gene Symbol:
CRYAB
CRYA2
Alternate Names:
Alpha-crystallin B chain
Alpha(B)-crystallin
Heat shock protein beta-5
Renal carcinoma antigen NY-REN-27
Rosenthal fiber component
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Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limit 2-8℃