标签归档：cenp

04-205   Anti-CENP A, CT   品牌 Millipore

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Anti-CENP A, CT

货号： 04-205      产品名称： Anti-CENP A, CT   品牌： Millipore 规格： EA 3周到货 生化实验

Anti-CENP-A, clone EP800Y
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REFERENCES
Heterochromatin tells CENP-A where to go.
Durand-Dubief, Mickaël and Ekwall, Karl (2008) Bioessays, 30: 526-9 (2008)
The histone variant CENP-A and centromere specification.
Black, Ben E and Bassett, Emily A (2008) Curr. Opin. Cell Biol., 20: 91-100 (2008)
A 17-kD centromere protein (CENP-A) copurifies with nucleosome core particles and with histones.
Palmer, D K, et al. (1987) J. Cell Biol., 104: 805-15 (1987)
Species Reactivity Key Applications Host Format Antibody Type
H, R, not M  FC, ICC, IHC, IH(P), WB Rabbit Unpurified Monoclonal Antibody
Description:
Anti-CENP-A Antibody, clone EP800Y, rabbit monoclonal
Promotional Text:
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100% Performance Guaranteed
Trade Name:
Upstate (Millipore)
Specificity:
This antibody recognizes the C-terminal region of human CENP-A.
Molecular Weight:
18 kDa
Epitope:
C-terminus
Immunogen:
Synthetic peptide corresponding to the C-terminal region of CENP-A, conjugated to KLH.
Clone:
EP800Y
Isotype:
IgG
Background Information:
Centromere protein A (CENP-A) is a 17 kDa centromere-specific histone variant with 62% amino acids homology to the C-terminal of histone H3. Localized in the centromere, it plays a central role in the centromere-specific chromatin formation. The depletion of histone H3 at the CENP-A binding domain suggests CENP-A to be a possible replacement for histone H3 in the packaging process of α-satellite DNA into primary chromatin structure. CENP-A is essential in the formation of specialized nucleosomes at the centromere, implicating CENP-A as a centromere-specific epigenetic marker.
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Species Reactivity:
Human
Rat
Species Reactivity Note:
Proven to react with human and rat CENP-A. Does not react with mouse.
Non-Reactive Species:
Mouse
Application Notes:
Flow Cytometry:
1:80 dilution of a previous lot was used for flow cytometry.
Immunocytochemistry:
1:250 – 500 dilution of a previous lot was used for Immunocytochemistry.
Immunohistochemistry:
1:250 – 500 dilution of a previous lot was used for Immunohistochemistry.
Immunocytochemistry:
A previous lot was used to detect CENP-A in HeLa cells (1:250 dilution).
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Control:
HeLa Whole Cell lysate.
Quality Assurance:
Routinely evaluated by Western Blot on HeLa Whole Cell lysate.
Western Blot Analysis:
A 1:5,000 dilution of this lot was used to detect CENP-A HeLa Whole Cell lysate.
Purification Method:
Unpurified
Presentation:
Unpurified rabbit monoclonal IgG in buffer containing 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA
Storage Conditions:
Stable for 1 year at -20ºC from date of receipt. Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.
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UniProt Number:
P49450
Entrez Gene Number:
NM_001042426
Gene Symbol:
CENP-A
OTTHUMP00000122589
Alternate Names:
Centromere autoantigen A
centromere protein A
centromere protein A (17kD)
centromere protein A, 17kDa
Usage Statement:
Unless otherwise stated in our catalog or other company documentation -20°C

04-792   A-PH-CENP-A (S7), CL NL41 100UL   品牌 Millipore

发表于由

A-PH-CENP-A (S7), CL NL41 100UL

货号： 04-792      产品名称： A-PH-CENP-A (S7), CL NL41 100UL   品牌： Millipore 规格： EA 3周到货 生化实验

Anti-phospho-CENP-A (Ser7), clone NL41
Recommended Replacement for: Cat. # 05-792. 05-792 will only be availabe on a custom basis.
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REFERENCES
Cdc48/p97-Ufd1-Npl4 antagonizes Aurora B during chromosome segregation in HeLa cells.
Grzegorz Dobrynin,Oliver Popp,Tina Romer,Sebastian Bremer,Michael H A Schmitz,Daniel W Gerlich,Hemmo Meyer (2011) Journal of cell science.124
Species Reactivity Key Applications Host Format Antibody Type
H  Mplex, WB, ICC Rabbit Culture Supernatant Monoclonal Antibody
Description:
Anti-phospho-CENP-A (Ser7) Antibody, clone NL41, rabbit monoclonal
Replaces:
Cat. # 05-792. 05-792 will only be availabe on a custom basis.
Promotional Text:
Special Shipping Offer on Antibodies
100% Performance Guaranteed
Trade Name:
Upstate (Millipore)
Product Overview:
CENP-A is a variant version of histone H3 found only at centromeres. It is phosphorylated at serine 7 during mitosis.
Specificity:
CENP-A phosphorylated on serine 7
Molecular Weight:
~17kDa
Immunogen:
peptide containing the sequence RRpSRK in which pS is phospho-serine corresponding to amino acid 7 of human CENP-A (centromere protein A)
Modifications:
Phosphorylation
Clone:
clone NL41
Isotype:
IgG
Background Information:
Centromere protein A (CENP-A) is a 17 kDa centromere-specific histone variant with 62% amino acids homology to the C-terminal of histone H3. Localized in the centromere, it plays a central role in the centromere-specific chromatin formation. The depletion of histone H3 at the CENP-A binding domain suggests CENP-A to be a possible replacement for histone H3 in the packaging process of α-satellite DNA into primary chromation structure. CENP-A is essential in the formation of specialized nucleosomes at the centromere, implicating CENP-A as a centromere-specific epigenetic marker.
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Species Reactivity:
Human
Species Reactivity Note:
Human. Others not tested.
Control:
Acid extracted proteins from colcemid-arrested HeLa cells
Quality Assurance:
routinely evaluated by immunoblot on acid extracted proteins from colcemid-arrested HeLa cells (Catalog #17-306)
Presentation:
Cultured supernantant in 0.05% sodium azide
Storage Conditions:
Stable for 1 year at -20°C from date of receipt.
For maximum recovery of product, centrifuge the vial prior to removing the cap. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
UniProt Number:
P49450
Entrez Gene Number:
NM_001809
Gene Symbol:
CENPA
CENP-A
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
View All »
Key Applications:
Multiplexing
Western Blotting
Immunocytochemistry
Entrez Gene Summary:
Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. CENPA encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. CENPA is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle. Alternative splicing results in multiple transcript variants encoding distin -20°C

05-1502   Anti-CENP-E, clone 177   品牌 Millipore

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Anti-CENP-E, clone 177

货号： 05-1502      产品名称： Anti-CENP-E, clone 177   品牌： Millipore 规格： EA 3周到货 生化实验

Anti-CENP-E, clone177
Species Reactivity Key Applications Host Format Antibody Type
H  ICC, IHC, WB, IP Mouse Purified Monoclonal Antibody
Description:
Anti-CENP-E Antibody, clone177
Promotional Text:
Special Shipping Offer on Antibodies
100% Performance Guaranteed
Specificity:
This antibody recognizes CENP-E.
Molecular Weight:
312 kDa Calculated
Epitope:
Unknown
Immunogen:
Native protein corresponding to human CENP-E.
Clone:
177
Isotype:
IgG1κ
Background Information:
Centromeric protein E (CENP-E) is a mitosis-specific kinesin belonging to the kinesin-7 family. CENP-E, along with cytoplasmic dyenin, is one of two main microtubule motors known to localize at kinetochores. During mitosis, CENP-E has an active role in the migration of chromosomes toward the metaphase plate, and is directly responsible for microtubule capture and stabilization by kinetochores. Reduction in CENP-E expression results in the high occurrence of whole chromosome missegregation, and its removal or inhibition leads to the presence of unattached chromosomes near the spindle pole as well as a significant reduction in the number of microtubules captured by kinetochores.
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Species Reactivity:
Human
Species Reactivity Note:
Demonstrated to react with human.
Application Notes:
Immunohistochemistry Analysis:
1:100 dilution from a representative lot of this antibody detected CENP-E in kidney and malignant melanoma tissue.
Western Blot Analysis: A representative lot of this antibody was used by an independent laboratory in WB. (Yen, T.J., et al. (1991). EMBO J. 10(5):1245–1254.)
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Control:
HeLa cells
Quality Assurance:
Evaluated by Immunocytochemistry in HeLa cells.
Immunocytochemistry Analysis: 1:500 dilution of this antibody detected CENP-E in HeLa cells.
Purification Method:
Protein G purfied
Presentation:
Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
Storage Conditions:
Stable for 1 year at 2-8°C from date of receipt.
UniProt Number:
Q02224
Entrez Gene Number:
NP_001804
Gene Symbol:
CENP-E3
CENP-E
Alternate Names:
centromere protein E, 312kDa
kinesin family member 10
centromere protein E (312kD)
Kinesin-related protein CENPE
Centromere autoantigen E (312kD)
Centromeric protein E
centromere protein E
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Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Immunocytochemistry
Immunohistochemistry
Western Blotting
Immunoprecipitation
Entrez Gene Summary:
Centrosome-associated protein E is a kinesin-like motor protein that accumulates in the G2 phase of the cell cycle. Unlike other centrosome-associated proteins, it is not present during interphase and first appears at the centromere region of chromosomes during prometaphase. CENPE is proposed to be one of the motors responsible for mammalian chromosome movement and/or spindle elongation. [provided by RefSeq].
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UniProt Summary:
FUNCTION: Essential for the maintenance of chromosomal stability through efficient stabilization of microtubule capture at k 2°C – 8°C

07-232   ANTI-PHOSPHO-CENP-A (SER7)200UG   品牌 Millipore

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ANTI-PHOSPHO-CENP-A (SER7)200UG

货号： 07-232      产品名称： ANTI-PHOSPHO-CENP-A (SER7)200UG   品牌： Millipore 规格： EA 三周到货 生化实验

Anti-phospho-CENP-A (Ser7) Antibody
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REFERENCES
MAP kinase regulation of the mitotic spindle checkpoint.
Eva M Eves,Marsha Rich Rosner (2010) Methods in molecular biology (Clifton, N.J.).661
CENP-A is phosphorylated by Aurora B kinase and plays an unexpected role in completion of cytokinesis.
Zeitlin, S G, et al. (2001) J. Cell Biol., 155: 1147-57 (2001)
Species Reactivity Key Applications Host Format Antibody Type
H  WB Rabbit Purified Polyclonal Antibody
Description:
Anti-phospho-CENP-A (Ser7) Antibody
Promotional Text:
Special Shipping Offer on Antibodies
100% Performance Guaranteed
Trade Name:
Upstate (Millipore)
Product Overview:
CENP-A is a variant version of histone H3 found only at centromeres. It is phosphorylated at serine 7 during mitosis.
Specificity:
phosphorylated CENP-A (Ser7)
Molecular Weight:
~17kDa
Immunogen:
peptide contianing the sequence RRpSRK in which pS is phosphoserine corresponding to amino acid 7 of human CENP-A (centromere protein A)
Modifications:
Phosphorylation
Isotype:
IgG
Species Reactivity:
Human
Quality Assurance:
routinely evaluated by immunoblot on acid extracted proteins from colcemid-arrested HeLa cells
Purification Method:
Protein A purfied
Presentation:
0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
Storage Conditions:
2 years at -20°C
UniProt Number:
P49450
Entrez Gene Number:
NM_001809
Gene Symbol:
CENPA
CENP-A
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
View All »
Key Applications:
Western Blotting
Entrez Gene Summary:
Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. CENPA encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. CENPA is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
View All »
UniProt Summary:
FUNCTION: SwissProt: P49450 # Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division.
SIZE: 140 amino acids; 15991 Da
SUBUNIT: Forms a nucleosome-like histone octamer containing two molecules each of H2A, H2B, CENPA and H4 assembled in one CENPA-H4 heterotetramer and two H2A-H2B heterodimers. Nucleosomes containing CENPA also contain histone H2A variants such as macroH2A H2AFY and H2A.Z/H2AFZ. The CENPA-H4 heterotetramer is more compact and structurally more rigid than corresponding H3-H4 heterotetramers. Component of the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and MLF1IP/CENPU. Interacts directly with herpes virus HSV-1 ICP0 protein.
SUBCELLULAR LOCATION: Nucleus. Centromere. Kinetochore. Note= -20℃

07-574   ANTI-CENP-A 200UL   品牌 Millipore

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ANTI-CENP-A 200UL

货号： 07-574      产品名称： ANTI-CENP-A 200UL   品牌： Millipore 规格： EA 三周到货 生化实验

Anti-CENP-A Antibody
Species Reactivity Key Applications Host Format Antibody Type
H  WB Rabbit Affinity Purified Polyclonal Antibody
Description:
Anti-CENP-A Antibody
Promotional Text:
Special Shipping Offer on Antibodies
100% Performance Guaranteed
Trade Name:
Upstate (Millipore)
Product Overview:
CENP-A is a variant version of histone H3 found only at centromeres.
Specificity:
CENP-A
Molecular Weight:
17kDa
Immunogen:
peptide (RRRSRKPEAPRRRS) corresponding to amino acids 4-17 of human CENP-A
Isotype:
IgG
Background Information:
Centromere protein A (CENP-A) is a 17 kDa centromere-specific histone variant with 62% amino acids homology to the C-terminal of histone H3. Localized in the centromere, it plays a central role in the centromere-specific chromatin formation. The depletion of histone H3 at the CENP-A binding domain suggests CENP-A to be a possible replacement for histone H3 in the packaging process of α-satellite DNA into primary chromation structure. CENP-A is essential in the formation of specialized nucleosomes at the centromere, implicating CENP-A as a centromere-specific epigenetic marker.
Species Reactivity:
Human
Species Reactivity Note:
Broad species cross-reactivity is predicted.
Control:
Control Histones (from Hela cells) colcemid-treated or untreated
Quality Assurance:
routinely evaluated by immunoblot in acid extracted histones from HeLa cells
Purification Method:
Immunoaffinity purified
Presentation:
Affinity purified immunoglobulin in 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide.
Storage Conditions:
Stable for 1 year at 2 to 8ºC from date of receipt.
UniProt Number:
P49450
Entrez Gene Number:
NM_001809
Gene Symbol:
CENPA
CENP-A
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Key Applications:
Western Blotting
Entrez Gene Summary:
Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. CENPA encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. CENPA is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
UniProt Summary:
FUNCTION: SwissProt: P49450 # Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division.
SIZE: 140 amino acids; 15991 Da
SUBUNIT: Forms a nucleosome-like histone octamer containing two molecules each of H2A, H2B, CENPA and H4 assembled in one CENPA-H4 heterotetramer and two H2A-H2B heterodimers. Nucleosomes containing CENPA also contain histone H2A variants such as macroH2A H2AFY and H2A.Z/H2AFZ. The CENPA-H4 heterotetramer is more compact and structurally more rigid than corresponding H3-H4 heterotetramers. Component of the CENPA-NAC complex, 2-8℃

07-735   Anti-CENP-B 100ug   品牌 Millipore

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Anti-CENP-B 100ug

货号： 07-735      产品名称： Anti-CENP-B 100ug   品牌： Millipore 规格： EA 三周到货 生化实验

Anti-CENP-B Antibody
Species Reactivity Key Applications Host Format Antibody Type
H  WB Rabbit Purified Polyclonal Antibody
Description:
Anti-CENP-B Antibody
Promotional Text:
Special Shipping Offer on Antibodies
100% Performance Guaranteed
Trade Name:
Upstate (Millipore)
Specificity:
Beta galactosidase fusion protein of human CENP-B.
Molecular Weight:
80kDa
Immunogen:
Beta galactosidase fusion protein of human CENP-B.
Isotype:
IgG
Species Reactivity:
Human
Quality Assurance:
Routinely evaluated by immunoblot.
Purification Method:
Protein A purfied
Storage Conditions:
2 years at -20°C from date of shipment
UniProt Number:
P07199
Entrez Gene Number:
NM_001810.5
Gene Symbol:
CENPB
CENP-B
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Western Blotting
Entrez Gene Summary:
This gene product is a highly conserved protein that facilitates centromere formation. It is a DNA-binding protein that is derived from transposases of the pogo DNA transposon family. It contains a helix-loop-helix DNA binding motif at the N-terminus, and a dimerization domain at the C-terminus. The DNA binding domain recognizes and binds a 17-bp sequence (CENP-B box) in the centromeric alpha satellite DNA. This protein is proposed to play an important role in the assembly of specific centromere structures in interphase nuclei and on mitotic chromosomes. It is also considered a major centromere autoantigen recognized by sera from patients with anti-centromere antibodies.
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UniProt Summary:
FUNCTION: SwissProt: P07199 # Interacts with centromeric heterochromatin in chromosomes and binds to a specific subset of alphoid satellite DNA, called the CENP-B box. May organize arrays of centromere satellite DNA into a higher order structure which then directs centromere formation and kinetochore assembly in mammalian chromosomes.
SIZE: 599 amino acids; 65171 Da
SUBUNIT: Homodimer.
SUBCELLULAR LOCATION: Nucleus.
SIMILARITY: SwissProt: P07199 ## Contains 1 HTH CENPB-type DNA-binding domain. & Contains 1 HTH psq-type DNA-binding domain.
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Brand Family:
Upstate
Product Name:
Anti-CENP-B Antibody
Antibody Type:
Polyclonal Antibody
Qty/Pk:
100 µg
Format:
Purified
Host:
Rabbit
Applications:
Anti-CENP-B Antibody is a Rabbit Polyclonal Antibody for detection of CENP-B also known as Centromere autoantigen B & has been tested in WB.

-20℃

12-424   CENP-A PEPTIDE 250UG   品牌 Millipore

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CENP-A PEPTIDE 250UG

货号： 12-424      产品名称： CENP-A PEPTIDE 250UG   品牌： Millipore 规格： EA 三周到货 生化实验

CENP-A Peptide
Description:
CENP-A Peptide
Trade Name:
Upstate (Millipore)
Qty/Pk:
250 µg
Applications:
CENPA encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere.
Key Applications:
Western Blotting
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
View All »
Entrez Gene Summary:
Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. CENPA encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. CENPA is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
View All »
UniProt Summary:
FUNCTION: SwissProt: P49450 # Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division.
SIZE: 140 amino acids; 15991 Da
SUBUNIT: Forms a nucleosome-like histone octamer containing two molecules each of H2A, H2B, CENPA and H4 assembled in one CENPA-H4 heterotetramer and two H2A-H2B heterodimers. Nucleosomes containing CENPA also contain histone H2A variants such as macroH2A H2AFY and H2A.Z/H2AFZ. The CENPA-H4 heterotetramer is more compact and structurally more rigid than corresponding H3-H4 heterotetramers. Component of the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and MLF1IP/CENPU. Interacts directly with herpes virus HSV-1 ICP0 protein.
SUBCELLULAR LOCATION: Nucleus. Centromere. Kinetochore. Note=Localizes exclusively in the kinetochore domain of centromeres.
DOMAIN: SwissProt: P49450 The CATD (CENPA targeting domain) region is responsible for the more compact structure of nucleosomes containinf CENPA and is necessary and sufficient to mediate the localization into centromeres.
PTM: Ubiquitinated (Probable). Interaction with herpes virus HSV-1 ICP0 protein, leads to its degradation by the proteasome pathway. & Phosphorylation of Ser-7 by Aurora-A/STK6 and Aurora-B/STK12 during prophase is required for localization of Aurora-A/STK6 and Aurora-B/STK12 at inner centromere and is essential for kinetochore function. Initial phosphorylation during prophase is mediated by Aurora-A/STK6 and is maintained by Aurora-B/STK12.DISEASE:SwissProt: P49450 # Antibodies against CENPA are present in sera from patients with autoimmune diseases that developed autoantibodies against centrosomal proteins.
SIMILARITY: Belongs to the histone H3 family.
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Species:
Human
Brand Family:
Upstate
Presentation:
Lyophilized powder
Storage Conditions:
2 years at -20°C
Gene Symbol:
CENPA
CENP-A
Product Name:
CENP-A Peptide
Quality Assurance:
Routinely evaluated as an inhibitory agent.
UniProt Number:
P49450
Entrez Gene Number:
NM_001042426.1
NM_001809.3

-20℃