PHOSPHO-CAMKII(T305), RBX, 100UL

货号： AB3865      产品名称： PHOSPHO-CAMKII(T305), RBX, 100UL   品牌： Millipore 规格： EA 三周到货 生化实验

Anti-CaMKII Antibody, phospho-specific (Thr305)
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REFERENCES
Inhibitory autophosphorylation of CaMKII controls PSD association, plasticity, and learning.
Elgersma, Ype, et al. (2002) Neuron, 36: 493-505 (2002)
Species Reactivity Key Applications Host Format Antibody Type
Dr, H, M, R  WB Rabbit Serum Polyclonal Antibody
Description:
Anti-CaMKII Antibody, phospho-specific (Thr305)
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Trade Name:
Chemicon (Millipore)
Specificity:
Recognizes the alpha, beta and gamma isoforms of CaMKII (Ca2+/calmodulin-dependent protein kinase II) when phosphorylated at Thr305. CaMKII is a prominent serine/threonine kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release.
Epitope:
phospho-specific (Thr305)
Immunogen:
Synthetic phosphopeptide corresponding to amino acid residues surrounding the phosphorylated Thr305 of CaMKII. Sequence is identical in human, mouse, rat, bovine, chicken, Drosophila, and Limulus and in alpha, beta, and delta isoforms.
Modifications:
Phosphorylation
Species Reactivity:
Drosophila
Human
Mouse
Rat
Application Notes:
Western blot: 1:1000
Dot blots: 1:1000
Optimal working dilutions must be determined by the end user.
Presentation:
Neat serum.
Storage Conditions:
Maintain at -20ºC for up to one year from date of receipt.
UniProt Number:
Q9UQM7
Entrez Gene Number:
NM_015981.2
NM_171825.1
Gene Symbol:
CAMK2A
KIAA0968
CAMKA
EC 2.7.11.17
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Key Applications:
Western Blotting
Entrez Gene Summary:
The product of this gene belongs to the Serine/Threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This enzyme is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Two transcript variants encoding distinct isoforms have been identified for this gene.
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UniProt Summary:
FUNCTION: SwissProt: Q9UQM7 # CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity (By similarity).
SIZE: 478 amino acids; 54030 Da
SUBUNIT: CAMK2 is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. Interacts with BAALC, MPDZ, SYN1 and SYNGAP1 (By similarity).
SUBCELLULAR LOCATION: Cell junction, synapse, presynaptic cell membrane (By similarity). Cell junction, synapse (By similarity). Note=Postsynaptic lipid rafts (By similarity).
SIMILARITY: SwissProt: Q9UQM7 ## Belongs to the protein kinase supe -20℃