CAMK1b, Active

货号： 7729-5      产品名称： CAMK1b, Active   品牌： Biovision 规格： 5 μg 3周到货 生化实验

Active CAMK1b
Involved in many signaling cascades
Product Overview
Alternate Names / Synonyms: camk 1b, camk-1b, Active CAMK1b, CAMK1b, CAMK, CAMK1, human CAMK1, active kinase, active kinases, recombinant CAMK1, recombinant CAMK, kinase activity assay, protein kinase
Gene Symbol: CAMK1B
Accession #: NM_012040
Gene ID: 8536
Source: Baculovirus (Sf9 insect cells)
Appearance: Liquid
Physical Form Description: Recombinant protein in storage buffer (50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol).
Molecular Weight: 64.0 kDa
Purity by SDS-PAGE: ≥90%
Purity by HPLC: N/A
Endotoxin Level: N/A
Biological Activity: 223 nmol phosphate incorporated into Autocamtide 2 per minute per mg protein at 30ºC for 15 minutes using a final concentration of 50 µM ATP (0.83 µCi/assay).
Reconstitution Instructions: N/A
Storage Temp.: -80°C
Shipping: dry ice
Background Information: Many of the effects of calcium are mediated via its interaction with calmodulin and the subsequent activation of Ca(2+)/calmodulin-dependent (CaM) kinases. CaM kinases are involved in a wide variety of cellular processes including muscle contraction, neurotransmitter release, cell cycle control, and transcriptional regulation. While CaMKII has been implicated in learning and memory, the biological role of the other multifunctional CaM kinases, CaMKI and CaMKIV, is largely unknown. CaMKIβ, or pregnancy upregulated non-ubiquitously expressed CaM kinase (PNCK), is a 38-kDa serine/threonine kinase whose catalytic domain shares 45-70% identity with members of the CaM kinase family. The gene for CaMKIβ localizes to mouse chromosome X. CaMKIβ is upregulated during intermediate and late stages of murine fetal development with highest levels of expression in developing brain, bone, and gut. CaMKIβ is also expressed in a tissue-specific manner in adult mice with highest levels of expression detected in brain, uterus, ovary, and testis. Interestingly, CaMKIβ expression in these tissues is restricted to particular compartments and appears to be further restricted to subsets of cells within those compartments. The chromosomal localization of CaMKIβ, along with its tissue-specific and restricted pattern of spatial expression during development, suggests that CaMKIβ may be involved in a variety of developmental processes including development of the central nervous system (1). Also CaMKIβ2, an isoform of mCaMKIβ, was mainly identified in the nervous system, including brain, spinal cord, trigeminal ganglion, and retina. Within the CNS, the expression of CaMKIβ2 is detected in the mantle zone, but not in the ventricular zone, suggesting its possible involvement in the differentiation of neurons (2).
Handling: Centrifuge the vial prior to opening.
Usage: For Research Use Only! Not to be used in humans.

-80°C