标签归档：sn

481480-1MG   NF-κB SN50, Cell-Permeable Inhibitor Peptide   品牌 Merck

发表于由

NF-κB SN50, Cell-Permeable Inhibitor Peptide

货号： 481480-1MG      产品名称： NF-κB SN50, Cell-Permeable Inhibitor Peptide   品牌： Merck 规格： *** 3周到货 生化实验

NF-κB SN50, Cell-Permeable Inhibitor Peptide
AAVALLPAVLLALLAPVQRKRQKLMP, NF-κB Activation Inhibitor VIII
Contains the nuclear localization sequence (NLS) of the transcription factor NF-κB p50 linked to the hydrophobic region (h-region) of the signal peptide of Kaposi fibroblast growth factor (K-FGF). The N-terminal K-FGF h-region confers cell-permeability, while the NLS (360-369) inhibits translocation of the NF-κB active complex into the nucleus. In murine endothelial LE-II cells induced by LPS, NF-κB nuclear translocation is maximally inhibited at 18 µM.
产品信息
Peptide Sequence  H-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Val-Gln-Arg-Lys-Arg-Gln-Lys-Leu-Met-Pro-OH
Form  Lyophilized
Formulation  Supplied as a trifluoroacetate salt.
Primary Target  translocation of the NF-κB active complex into the nucleus
Molar mass  2781.5
Hygrocopic  是的
Cell permeable  是的
Purity  ≥97% by HPLC
Sold on the basis of peptide content  是的
Solubility  H2O
Chemical formula  C129H230N36O29S
Declaration  Sold under license of U.S. Patents 5,807,746 and 6,043,339 for research use only. Licenses for commercial manufacture, commercial use, diagnostics, or therapeutics may be obtained by contacting Vanderbilt University, Nashville, Tennessee.
商店和运输信息
Storage  -20°C
Ship  Ambient Temperature Only
Standard Handling

-20°C

10011300-1   NBD-Stearoyl-2-Arachidonoyl-sn-glycerol   品牌 Cayman

发表于由

NBD-Stearoyl-2-Arachidonoyl-sn-glycerol

货号： 10011300-1      产品名称： NBD-Stearoyl-2-Arachidonoyl-sn-glycerol   品牌： Cayman 规格： 1 mg 3周

NBD-Stearoyl-2-Arachidonoyl-sn-glycerol Exclusive
Cayman Chemical Item Number 10011300
Description
1-Stearoyl-2-arachidonoyl-sn-glycerol is a diacylglycerol (DAG) that contains stearic acid in the sn-1 site and arachidonic acid at the sn-2 position of the glycerol backbone, as is commonly found in DAG from biological phospholipids. NBD-Stearoyl-2-arachidonoyl-sn-glycerol has the fluorophore nitrobenzoxadiazole (NBD) attached to the ω-end of the stearoyl chain of 1-stearoyl-2-arachidonoyl-sn-glycerol. Fluorescently tagged lipids have been used to study their interactions with proteins, their utilization by cells and liposomes, and for the development of assays for lipid metabolism.1↗,2↗,3↗,4↗,5↗
Synonyms NBD-SAG
Formal Name N-​[7-​(4-​nitrobenz-​2-​oxa-​1,​3-​diazole)]-​1-​octadecanoyl-​2-​(52,​82,​112,​142)-​eicosatetraenoyl-​sn-​glycerol
Molecular Formula C47H74N4O8
Formula Weight 823.1
Formulation A solution in ethanol
Purity ≥95%
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES OC[C@H]​(OC(CCC/C=CC/C=CC/C=CC/C=CCCCCC)​=O)​COC(CCCCCCCCCCCCCCCCCNC1=CC=C([N+]​([O-]​)​=O)​C2=NON=C12)​=O 
InCHI Code ​1S/C47H74N4O8/c1-2-3-4-5-6-7-8-9-10-11-13-17-20-23-26-29-32-35-45(54)​58-41(39-52)​40-57-44(53)​34-31-28-25-22-19-16-14-12-15-18-21-24-27-30-33-38-48-42-36-37-43(51(55)​56)​47-46(42)​49-59-50-47/h6-7,9-10,13,17,23,26,36-37,41,48,52H,2-5,8,11-12,14-16 
InCHI Key  PAKHIXWGWLKVNM-PRWNNGACSA-N

-20°C

10011300-5   NBD-Stearoyl-2-Arachidonoyl-sn-glycerol   品牌 Cayman

发表于由

NBD-Stearoyl-2-Arachidonoyl-sn-glycerol

货号： 10011300-5      产品名称： NBD-Stearoyl-2-Arachidonoyl-sn-glycerol   品牌： Cayman 规格： 5 mg 3周

NBD-Stearoyl-2-Arachidonoyl-sn-glycerol Exclusive
Cayman Chemical Item Number 10011300
Description
1-Stearoyl-2-arachidonoyl-sn-glycerol is a diacylglycerol (DAG) that contains stearic acid in the sn-1 site and arachidonic acid at the sn-2 position of the glycerol backbone, as is commonly found in DAG from biological phospholipids. NBD-Stearoyl-2-arachidonoyl-sn-glycerol has the fluorophore nitrobenzoxadiazole (NBD) attached to the ω-end of the stearoyl chain of 1-stearoyl-2-arachidonoyl-sn-glycerol. Fluorescently tagged lipids have been used to study their interactions with proteins, their utilization by cells and liposomes, and for the development of assays for lipid metabolism.1↗,2↗,3↗,4↗,5↗
Synonyms NBD-SAG
Formal Name N-​[7-​(4-​nitrobenz-​2-​oxa-​1,​3-​diazole)]-​1-​octadecanoyl-​2-​(52,​82,​112,​142)-​eicosatetraenoyl-​sn-​glycerol
Molecular Formula C47H74N4O8
Formula Weight 823.1
Formulation A solution in ethanol
Purity ≥95%
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES OC[C@H]​(OC(CCC/C=CC/C=CC/C=CC/C=CCCCCC)​=O)​COC(CCCCCCCCCCCCCCCCCNC1=CC=C([N+]​([O-]​)​=O)​C2=NON=C12)​=O 
InCHI Code ​1S/C47H74N4O8/c1-2-3-4-5-6-7-8-9-10-11-13-17-20-23-26-29-32-35-45(54)​58-41(39-52)​40-57-44(53)​34-31-28-25-22-19-16-14-12-15-18-21-24-27-30-33-38-48-42-36-37-43(51(55)​56)​47-46(42)​49-59-50-47/h6-7,9-10,13,17,23,26,36-37,41,48,52H,2-5,8,11-12,14-16 
InCHI Key  PAKHIXWGWLKVNM-PRWNNGACSA-N

-20°C

10009872-100   1-Stearoyl-2-Arachidonoyl-sn-Glycerol-d8   品牌 Cayman

发表于由

1-Stearoyl-2-Arachidonoyl-sn-Glycerol-d8

货号： 10009872-100      产品名称： 1-Stearoyl-2-Arachidonoyl-sn-Glycerol-d8   品牌： Cayman 规格： 100 碌g 3周

1-Stearoyl-2-Arachidonoyl-sn-Glycerol-d8Exclusive
Cayman Chemical Item Number 10009872
Description
SAG-d8 contains eight deuterium atoms at the 5, 6, 8, 9, 11, 12, 14, and 15 positions. It is intended for use as an internal standard for the quantification of SAG by GC- or LC-mass spectrometry. Many protein kinase C (PKC) isoforms require activation via second messengers including Ca2+, diacylglycerol (DAG), and/or a phospholipid in order to phosphorylate target proteins, initiating a variety of important signaling cascades.1↗ 1-Stearoyl-2-arachidonoyl-sn-glycerol (SAG) is a DAG that contains the ω-6 polyunsaturated fatty acid arachidonic acid in the sn-2 position and stearic acid in the sn-1 position of the glycerol backbone. It can potently activate PKCα, ε, and δ at nM concentrations.2↗ Independent of PKC signaling, SAG competitively binds to the Ras activator RasGRP with a Ki value of 4.49 µM in Jurkat T-cells.3↗
Synonyms SAG-d8
Formal Name 1-​octadecanoyl-​2-​(5Z,​8Z,​11Z,​14Z)-​eicosatetraenoyl-​5,​6,​8,​9,​11,​12,​14,​15-​d8-​sn-​glycerol
Molecular Formula C41H64D8O5
Formula Weight 653.1
Formulation A solution in acetonitrile
Purity ≥99% deuterated forms (d1-d8)
Stability 1 year
Storage -80°C
Shipping Dry ice in continental US; may vary elsewhere
SMILES CCCCCCCCCCCCCCCCCC(=O)​OC[C@H]​(CO)​OC(=O)​CCC/C=CC/C=CC/C=CC/C=CCCCCC 
InCHI Code 1S/C41H72O5/c1-3-5-7-9-11-13-15-17-19-20-22-24-26-28-30-32-34-36-41(44)​46-39(37-42)​38-45-40(43)​35-33-31-29-27-25-23-21-18-16-14-12-10-8-6-4-2/h11,13,17,19,22,24,28,30,39,42H,3-10,12,14-16,18,20-21,23,25-27,29,31-38H2,1-2H3/b13-11-,19-17-,24-22- 
InCHI Key NSXLMTYRMFVYNT-YVJRVKRGSA-N

-80°C

10009872-500   1-Stearoyl-2-Arachidonoyl-sn-Glycerol-d8   品牌 Cayman

发表于由

1-Stearoyl-2-Arachidonoyl-sn-Glycerol-d8

货号： 10009872-500      产品名称： 1-Stearoyl-2-Arachidonoyl-sn-Glycerol-d8   品牌： Cayman 规格： 500 碌g 3周

1-Stearoyl-2-Arachidonoyl-sn-Glycerol-d8Exclusive
Cayman Chemical Item Number 10009872
Description
SAG-d8 contains eight deuterium atoms at the 5, 6, 8, 9, 11, 12, 14, and 15 positions. It is intended for use as an internal standard for the quantification of SAG by GC- or LC-mass spectrometry. Many protein kinase C (PKC) isoforms require activation via second messengers including Ca2+, diacylglycerol (DAG), and/or a phospholipid in order to phosphorylate target proteins, initiating a variety of important signaling cascades.1↗ 1-Stearoyl-2-arachidonoyl-sn-glycerol (SAG) is a DAG that contains the ω-6 polyunsaturated fatty acid arachidonic acid in the sn-2 position and stearic acid in the sn-1 position of the glycerol backbone. It can potently activate PKCα, ε, and δ at nM concentrations.2↗ Independent of PKC signaling, SAG competitively binds to the Ras activator RasGRP with a Ki value of 4.49 µM in Jurkat T-cells.3↗
Synonyms SAG-d8
Formal Name 1-​octadecanoyl-​2-​(5Z,​8Z,​11Z,​14Z)-​eicosatetraenoyl-​5,​6,​8,​9,​11,​12,​14,​15-​d8-​sn-​glycerol
Molecular Formula C41H64D8O5
Formula Weight 653.1
Formulation A solution in acetonitrile
Purity ≥99% deuterated forms (d1-d8)
Stability 1 year
Storage -80°C
Shipping Dry ice in continental US; may vary elsewhere
SMILES CCCCCCCCCCCCCCCCCC(=O)​OC[C@H]​(CO)​OC(=O)​CCC/C=CC/C=CC/C=CC/C=CCCCCC 
InCHI Code 1S/C41H72O5/c1-3-5-7-9-11-13-15-17-19-20-22-24-26-28-30-32-34-36-41(44)​46-39(37-42)​38-45-40(43)​35-33-31-29-27-25-23-21-18-16-14-12-10-8-6-4-2/h11,13,17,19,22,24,28,30,39,42H,3-10,12,14-16,18,20-21,23,25-27,29,31-38H2,1-2H3/b13-11-,19-17-,24-22- 
InCHI Key NSXLMTYRMFVYNT-YVJRVKRGSA-N

-80°C

10008648-100   1,2-Dipalmitoyl-sn-glycerol   品牌 Cayman

发表于由

1,2-Dipalmitoyl-sn-glycerol

货号： 10008648-100      产品名称： 1,2-Dipalmitoyl-sn-glycerol   品牌： Cayman 规格： 100 mg 3周

1,2-Dipalmitoyl-sn-glycerol
Cayman Chemical Item Number 10008648
Description
1,2-Dipalmitoyl-sn-glycerol (1,2-DPG) is an analog of the protein kinase C (PKC)-activating second messenger diacylglycerol. It is a weak activator of PKC (15% at 25 µM).1↗
Synonyms 1,2-DPG
NSC 269964
Formal Name 1,​2-​bis(O-​palmitoyl)-​sn-​glycerol
CAS Number 30334-71-5
Molecular Formula C35H68O5
Formula Weight 568.9
Formulation A crystalline solid
Purity ≥95%
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES CCCCCCCCCCCCCCCC(=O)​OC[C@H]​(CO)​OC(=O)​CCCCCCCCCCCCCCC 
InCHI Code 1S/C35H68O5/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-34(37)​39-32-33(31-36)​40-35(38)​30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h33,36H,3-32H2,1-2H3/t33-/m0/s1 
InCHI Key JEJLGIQLPYYGEE-XIFFEERXSA-N

-20°C

10008648-250   1,2-Dipalmitoyl-sn-glycerol   品牌 Cayman

发表于由

1,2-Dipalmitoyl-sn-glycerol

货号： 10008648-250      产品名称： 1,2-Dipalmitoyl-sn-glycerol   品牌： Cayman 规格： 250 mg 3周

1,2-Dipalmitoyl-sn-glycerol
Cayman Chemical Item Number 10008648
Description
1,2-Dipalmitoyl-sn-glycerol (1,2-DPG) is an analog of the protein kinase C (PKC)-activating second messenger diacylglycerol. It is a weak activator of PKC (15% at 25 µM).1↗
Synonyms 1,2-DPG
NSC 269964
Formal Name 1,​2-​bis(O-​palmitoyl)-​sn-​glycerol
CAS Number 30334-71-5
Molecular Formula C35H68O5
Formula Weight 568.9
Formulation A crystalline solid
Purity ≥95%
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES CCCCCCCCCCCCCCCC(=O)​OC[C@H]​(CO)​OC(=O)​CCCCCCCCCCCCCCC 
InCHI Code 1S/C35H68O5/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-34(37)​39-32-33(31-36)​40-35(38)​30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h33,36H,3-32H2,1-2H3/t33-/m0/s1 
InCHI Key JEJLGIQLPYYGEE-XIFFEERXSA-N

-20°C